Navigation Links
Researchers identify new drug target for treating jet lag and shift work disorders
Date:8/30/2013

University of Notre Dame researchers, as part of a collaborative effort, have identified a protein that potentially could be a target for drugs that that would help people recover faster from jet lag and better adjust their circadian rhythms during rotational shift work. The study appears in the Aug. 29th issue of the journal Cell. It can be found at: http://www.sciencedirect.com/science/article/pii/S0092867413009616

An internal circadian body clock helps virtually all creatures synchronize their bodily functions to the 24-hour cycle of light and dark in a day. However, travel to a different time zone, or shift work, disrupts the body's clock. Furthermore, it can take up to a day for the body to adjust to each hour that the clock is shifted, resulting in several days of fatigue, indigestion, poorer cognitive performance and sleep disturbance.

Giles Duffield, associate professor of biological sciences at Notre Dame and a member of the University's Eck Institute for Global Health, and Kevin Flanagan, a University alumnus and now a doctoral student at Washington University in St. Louis, characterized the protein SIK1, revealing that it plays a pivotal role in preventing the body from adjusting too quickly to changes in the environment.

Duffield and Flanagan, along with researchers from University of Oxford and F. Hoffman La Roche, and led by senior research scientist Stuart Peirson at the Nuffield Department of Clinical Neurosciences, identified roughly 100 genes that the body switches on in response to light, initiating a series of events that help to retune the body clo
'/>"/>

Contact: Giles Duffield
Giles.E.Dufield.2@nd.edu
574-631-1834
University of Notre Dame
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. NIH awards $20 million over 5 years to train next generation of global health researchers
2. Researchers develop a new cell and animal model of inflammatory breast cancer
3. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
4. Researchers Find Gene Mutations That May Be a Key to Autism
5. Researchers find evidence of banned antibiotics in poultry products
6. NJ stroke researchers report advances in spatial neglect research at AAN Conference
7. Autism by the numbers: Yale researchers examine impact of new diagnostic criteria
8. Researchers Map Brain Regions Linked to Intelligence
9. Researchers ID Genes That May Determine Mental Illness
10. Researchers Develop Blood Test for Depression
11. University of Cincinnati researchers win $3.7M grant from US Department of Defense
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/26/2014)... Peoria, Il (PRWEB) November 27, 2014 ... is excited to announce the kick-off of its ... AlignLife encourages people to go to donate to ... will partner with local organizations to distribute the ... December 20th, participating AlignLife locations will be accepting ...
(Date:11/26/2014)... 2014 Recently, DressVe , the ... dresses, has unveiled its 2014 Cyber Monday Sales. Also, ... dresses, up to 90 percent off. The special offer ... Free delivery is provided for orders above $69. , ... shoes, handbags and other fashion accessories. The mission of ...
(Date:11/26/2014)... Boxing Day is traditionally the day following Christmas ... as a "Christmas box", from their bosses or employers. ... of Boxing Day, some people may worry about the ... opportunity, and it has recently announced its “ Tbdress ... its global customers. Then people can buy cheap pants, ...
(Date:11/26/2014)... Norwalk Hospital is pleased to announce ... the American Nurses Credentialing Center (ANCC). , The ... work environments where nurses can flourish. The designation ... Hospital and identifies it as one of the ... organizations’ commitment to nurses and their contributions toward ...
(Date:11/26/2014)... HealthDay Reporter WEDNESDAY, Nov. 26, ... more likely to achieve remission if they maintain a healthy ... that those who were heaviest had almost 65 percent reduced ... of remission. "Medication for rheumatoid arthritis is not as ... study,s lead author and a rheumatologist at the Hospital for ...
Breaking Medicine News(10 mins):Health News:DressVe.com: Best 2014 Special Monday Sales Online 2Health News:Tbdress.com: Best Boxing Day Sales For Ladies Worldwide 2Health News:Norwalk Hospital Announces American Nurses Credentialing Center PATHWAY TO EXCELLENCE® DESIGNATION 2Health News:Norwalk Hospital Announces American Nurses Credentialing Center PATHWAY TO EXCELLENCE® DESIGNATION 3Health News:Weight Could Influence Rheumatoid Arthritis Relief 2Health News:Weight Could Influence Rheumatoid Arthritis Relief 3
... (HealthDay News) -- Cancer patients are often faced with ... effects and even mean the difference between life and ... doctors use plain language in explaining the options, ... medicine at the University of Michigan Medical School and ...
... -- The American College of Physicians (ACP) and the ... commend the Centers for Medicare and Medicaid Services on ... "The American College of Physicians believes that the ... the kind of personalized and coordinated care that patients ...
... Wearable sensors that allow the blind to "see" with ... horizon, thanks to a $2 million award from the ... College of New York and Georgia Institute of Technology ... Frontiers in Research and Innovation" program, will fund a ...
... at the University of California, San Francisco (UCSF) Medical Center ... occurs as healthy brain cells begin to form tumors. ... a common type of brain tumor, at its earliest stage, ... will have to prove safe and effective in clinical trials, ...
... prevention trial evaluating two antiretroviral (ARV)-based approaches for preventing the ... one of two different ARV tablets or of a vaginal ... from the study. The decision to discontinue use of tenofovir ... data concluded that the trial will not be able to ...
... of the American Physical Society,s (APS) Division of Fluid ... from across the physical sciences, engineering, and medicine. Topics ... the quirks of flying; why coffee spills; and how ... The meeting will take place November 20-22, ...
Cached Medicine News:Health News:Cancer Patients Should Ask Doctors to Use Simple Terms 2Health News:Consumers and physicians together applaud Comprehensive Primary Care Initiative 2Health News:City College of New York-led research could lead to wearable sensors for the blind 2Health News:City College of New York-led research could lead to wearable sensors for the blind 3Health News:How normal cells become brain cancers 2Health News:Major HIV prevention trial in women to drop oral tenofovir arm 2Health News:Major HIV prevention trial in women to drop oral tenofovir arm 3Health News:Major HIV prevention trial in women to drop oral tenofovir arm 4Health News:Major HIV prevention trial in women to drop oral tenofovir arm 5Health News:APS Division of Fluid Dynamics meeting: Highlights and media registration 2Health News:APS Division of Fluid Dynamics meeting: Highlights and media registration 3Health News:APS Division of Fluid Dynamics meeting: Highlights and media registration 4Health News:APS Division of Fluid Dynamics meeting: Highlights and media registration 5
(Date:11/26/2014)... -- CARsgen, a leader in the development of Chimeric Antigen ... of cancers, today announced the completion of a series ... -based healthcare private equity fund.   ... of new therapeutics for liver, lung, stomach and brain ... Renji Hospital, the company plans to initiate clinical studies ...
(Date:11/26/2014)... According to the new ... (Electric, Battery, Pneumatic), by Product (Drill, Saw, Stapler, ... Application (Orthopedic, ENT, Oral, Thoracic, Neurology) - Global ... Surgical Instruments Market is estimated to be worth ... is expected to grow at a moderate CAGR ...
(Date:11/26/2014)... YORK , Nov. 25, 2014  Medtronic,s ... Covidien has been widely discussed in the ... it,s also creating a stronger leading player in ... to Kalorama Information.  The healthcare market research firm ... systems will feature a diverse set of solutions ...
Breaking Medicine Technology:CARsgen Completes Series A Financing 2Powered Surgical Instruments Market Worth $2.1 Billion by 2019 2Powered Surgical Instruments Market Worth $2.1 Billion by 2019 3Powered Surgical Instruments Market Worth $2.1 Billion by 2019 4Medtronic - Covidien: Beyond Taxes, Deal Will Create Patient Monitoring Power, according to Kalorama Information 2Medtronic - Covidien: Beyond Taxes, Deal Will Create Patient Monitoring Power, according to Kalorama Information 3
... opens new windows for the laboratory in ... easily move from one function to another. ... tests, and add a new patient record ... keep track of all the open functions ...
... DxC systems are built to ... laboratory. The systems have ... lab thrive in todays environment. ... workflow interruptions and maximize user-friendliness, ...
... Wedge Suture Anchors are titanium anchors that ... The Wedge anchors are simple to use ... staff. The following sizes and styles are ... Single Eyelet 2 Sutures, 5.0mm Double Eyelet ...
... an absorbable co-polymer synthesized from all-natural ... glycolic acid. Unlike the homopolymers in ... acid (PLLA) or 100% poly-glycolic acid ... (without crystallinity), meaning that its degradation ...
Medicine Products: