Navigation Links
Researchers find possible genetic keys to surviving epithelial ovarian cancer
Date:3/6/2012

TAMPA, Fla. (March 6, 2012) Researchers at Moffitt Cancer Center and colleagues from 11 other institutions in the United States and the United Kingdom have used two genome-wide association studies (GWAS) one from the U.S. and one from the U.K. to detect a novel set of genes found to be associated with epithelial ovarian cancer patient survival. The discovery could open the door to new therapies for treating epithelial ovarian cancer (EOC), the most lethal kind of gynecologic malignancy.

The study appeared in a recent issue of Cancer Epidemiology, Biomarkers & Prevention published by the American Association for Cancer Research.

The research team applied gene set analysis (GSA) for the first time to epithelial ovarian cancer gene databases. The gene set analysis mapped 857genes related to EOC that pass signals "downstream" to components in the cell which, in turn, are activated and trigger a change in the state of the cell.

One of the most significant gene sets they analyzed was comprised of a set of eight genes involved in macrolide (a class of drugs) "binding" which interact with immune suppressant FK506 and involve intracellular signaling.

Other studies have indicated that the binding protein (FKBP65) was "highly expressed in ovarian epithelium." FKBP65 has also been found to be inversely associated with the expression of tumor suppressor gene P53.

Researchers expect that the results of their GSA can be used to focus on the role and function of these specific gene sets and may ultimately help uncover additional genetic causes of complex traits.

"Epithelial ovarian cancer is the fifth leading cause of cancer mortality among women in the U.S.," said study co-author Thomas A. Sellers, Ph.D., M.P.H., Moffitt executive vice president and director of the Moffitt Research Institute. "Because women may vary in their ability to eradicate disease or tolerate treatment, genetic association studies like ours are needed to identify the genetic bases related to outcome. Until this study, GWAS have not uncovered any outcome-associated genetic traits for EOC."

The gene set analysis the researchers used in this study focused specifically on EOC survival data in the genome-wide association studies. According to Sellers, GSA helps to systematically narrow the search for relevant genes.

"Unfortunately, GSA does not allow us to determine the gene set's effect on outcome," explained Sellers. "GSA does, however, contribute to our understanding of the relationship between EOC genetic variation and mortality. Our results using GSA may lead to the discovery of other possible gene sets and novel genes related to EOC that can be followed up in future studies."


'/>"/>

Contact: Ferdie De Vega
Ferdinand.DeVega@moffitt.org
813-745-7858
H. Lee Moffitt Cancer Center & Research Institute
Source:Eurekalert

Related medicine news :

1. Researchers discover possible approach to the treatment of aggressive breast cancer
2. Researchers ID gene behind primary cervical dystonia, a neck-twisting disorder
3. Researchers find sarcoma tumor immune response with combination therapy
4. Mayo researchers provide atomic view of a histone chaperone
5. Researchers find potential solution to melanomas resistance to vemurafenib
6. Kessler Foundation researchers present at DC Conference on Race, Ethnicity and Disabilities
7. Researchers Spot Genes Behind Macular Degeneration
8. 90 percent of firefighters exhibit symptoms of PTSD according to Ben-Gurion University researchers
9. New blood test for early cancer detection developed by Ben-Gurion University researchers
10. UC Davis MIND Institute researchers to present on autism at AAAS Annual Meeting in Vancouver
11. Nasty superbug is being studied by UB researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/7/2020)... ... 07, 2020 , ... Belle Meade Family Dentistry, a full-service ... implants with no referral necessary. This will make it easier for those patients ... location. This advantage is especially crucial during the COVID-19 pandemic because it allows ...
(Date:8/7/2020)... ... August 07, 2020 , ... Alexandria Dental Health & ... Dr. Mojgan Mazhari, this well-respected practice offers advanced smile solutions to meet all ... among an exclusive group of dental practices with a large number of five-star ...
(Date:8/7/2020)... ... August 07, 2020 , ... Mary J's Cannabis , Kingston’s premium ... dicentra Cannabis Consulting . , The store, which operates out of a ... first of many locations as the company plans to expand across Canada. , ...
(Date:8/5/2020)... ... August 05, 2020 , ... Atlanta Magazine partnered with Castle ... the “Top Doctor” survey. The mission of Castle Connolly Medical Ltd. is to ... and key medical leaders were asked to identify outstanding doctors in their respective ...
(Date:8/5/2020)... ... August 05, 2020 , ... ... has repeatedly risen to unprecedented challenges. Regardless of the obstacle - shortages of ... protective equipment (PPE) and the cancellation or postponement of all nonessential services - ...
Breaking Medicine News(10 mins):
(Date:8/5/2020)... NEW YORK (PRWEB) , ... August 04, 2020 , ... ... been treating cardiovascular, pulmonary and complex medical patients for nearly three decades, today announced ... , Officially called COVID Bootcamp 101, the program kicked off Sunday, August 2 and ...
(Date:8/3/2020)... ... August 03, 2020 , ... ... agreement has been reached, to amend and restate IDRI’s license with Immune Design, ... States and Canada). Under the amendment, the parties have agreed to modify the ...
(Date:7/31/2020)... Ariz. (PRWEB) , ... July 31, 2020 , ... ... received FDA clearance for reprocessing the St. Jude Medical BRK Transseptal Needle and ... transseptal needles is a milestone in single-use device reprocessing, as no other company ...
Breaking Medicine Technology: