Navigation Links
Researchers find 2 new methods to determine ALK status
Date:7/1/2013

DENVER The implementation of personalized health care in cancer relies on the identification and characterization of cancer biomarkers and the availability of accurate detection systems and therapies for those biomarkers. Anaplastic lymphoma kinase (ALK), a tyrosine kinase, is a more recently characterized cancer biomarker in nonsmall-cell lung cancer (NSCLC). To identify NSCLC patients with ALK gene rearrangement in clinical trials, researchers have used the methods known as fluorescence in situ hybridization (FISH) or immunohistochemistry (IHC). While IHC is a less complex and less costly technology than FISH, both methods present challenges.

Now research published in the August issue of the Journal of Thoracic Oncology (JTO), describes the development and evaluation of two new methodologies.

To improve IHC assay sensitivity, the researchers incorporated the novel, nonendogenous hapten 3-hydroxy-2-quinoxaline and tyramide amplification into a diaminobenzidine and horseradish peroxidasebased assay. The new detection system proved to be very useful for detecting low levels of ALK protein expression in NSCLC.

They also developed a brightfield IHCin situ hybridization combination assay (geneprotein assay) for the concurrent visualization of ALK protein and ALK gene arrangement. This allows the concurrent visualization of ALK gene and ALK protein status in single cells, allowing more accurate ALK status determination even in heterogeneous specimens.

The authors say, "this tool for simultaneously assessing both ALK protein expression (IHC) and ALK gene rearrangement (ISH) in NSCLC will be valuable for research on the mechanisms driving ALK-dependent malignancies and as a model of new diagnostic approach for identifying patients who might benefit from ALK-targeted therapies. More generally, it also provides proof of concept for the development of new methodologies for the simultaneous assessment of gene structure and protein-expres
'/>"/>

Contact: Kristal Griffith
Kristal.Griffith@iaslc.org
720-325-2952
International Association for the Study of Lung Cancer
Source:Eurekalert

Page: 1 2

Related medicine news :

1. CWRU researchers trace inner-city womens health issues to childhood traumas
2. Penn Medicine researchers discover link between fear and sound perception
3. UCI researchers awarded $2.27 million to create novel diabetes treatments
4. MS researchers determine that brain reserve independently protects against cognitive decline in MS
5. Notre Dame and Harper researchers developing novel method to test for HPV and oral cancers
6. PhD Thesis Writing Expands the Scope of its Services for Doctoral Researchers
7. Researchers Identify New Genes Linked to the Origins of Alzheimer’s, Says Cure Alzheimers Fund
8. Researchers identify master coordinator for aortic rupture
9. Fate of the heart: Researchers track cellular events leading to cardiac regeneration
10. Moffitt Cancer Center researchers identify genetic variants predicting aggressive prostate cancers
11. Timely treatment after stroke is crucial, UCLA researchers report
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2015)... (PRWEB) May 27, 2015 Readers who ... may find help in author Chester Litvin ’s ... : Litvin’s Code” (published by Trafford Publishing). , Litvin, ... approach for stimulating the brain. This book will guide ... reeducate their sensory brain cells . He shares ...
(Date:5/26/2015)... 2015 This summer, ChopChop: The Fun ... communities at key events in Greater Boston with a custom ... copies of ChopChop Magazine, healthy snacks and other giveaways to ... , “We want to get our message of eating and ... memorable and fun way,” explains Sally Sampson, Founder of ChopChop. ...
(Date:5/26/2015)... In God’s Unstoppable Favor, Grace Vidrine Sibley ... an unforgettable story of how God has blessed her ... black student to desegregate Evangeline Parish School District in ... treated harshly by a few teachers, and shot at ... with Dr. Martin Luther King, Jr. ignited a renewed ...
(Date:5/26/2015)... 2015 Dermatologic surgeons performed nearly 9.5 ... to survey results released today by the American Society ... treatments and several cosmetic categories, 2014 totals were 21 ... overall compared to 2013 figures. , For the ... as the most-performed procedure (3.08 million) by ASDS members ...
(Date:5/26/2015)... York (PRWEB) May 26, 2015 The ... http://www.xareltolawsuit2015.com/ ) filed on behalf of individuals who were ... the litigation’s June 11th Science Day. According to an ... of Louisiana, on May 21st, topics to be addressed ... drug, the use of blood test based testing with ...
Breaking Medicine News(10 mins):Health News:Chester Litvin’s New Book Offers ‘Tune-Up’ for Brain Cells 2Health News:Chester Litvin’s New Book Offers ‘Tune-Up’ for Brain Cells 3Health News:Award-Winning Cooking Magazine for Kids Takes Healthy Cooking and Eating to the Streets with One-of-a-Kind Bike Campaign 2Health News:Grace Sibley Releases Second Book, God's Unstoppable Favor 2Health News:New ASDS Survey: 9.5 Million Treatments Performed in 2014 2Health News:New ASDS Survey: 9.5 Million Treatments Performed in 2014 3Health News:New ASDS Survey: 9.5 Million Treatments Performed in 2014 4Health News:Federal Xarelto Lawsuits Move Forward, as Court Establishes Procedures for Upcoming Science Day 2Health News:Federal Xarelto Lawsuits Move Forward, as Court Establishes Procedures for Upcoming Science Day 3Health News:Federal Xarelto Lawsuits Move Forward, as Court Establishes Procedures for Upcoming Science Day 4
... school staff , SATURDAY, Aug. 22 (HealthDay News) -- There ... asthma can prepare for flu season and the new school ... the best and first line of defense against any type ... your mouth when coughing or sneezing," Dr. Norman H. Edelman, ...
... , , SOLON, ... of the U.S. marketplace, Nestle USA is pleased to announce that ... week. , , (Photo: http://www.newscom.com/cgi-bin/prnh/20090818/SF63053-a ) , (Photo: ... for both retail partners and consumers to identify the new batch ...
... gene promoters in fecal DNA showed promise as a ... to a new study published online August 21 in ... Because many patients are reluctant to undergo ... development of nonintrusive screening tests is desirable. Especially in ...
... , WASHINGTON, Aug. 21 Teen pop idol ... Jonas Brothers, will address a National Press Club luncheon on Monday, August ... 13 will discuss his personal fight against diabetes and efforts to raise ... , (Logo: http://www.newscom.com/cgi- b in/prnh/20080917/NPCLOGO ...
... , , , ... in the home and office bottled water, filtration and office coffee delivery ... Susan G. Komen for the Cure(R), the world,s largest breast cancer advocacy ... DS Waters will make a $30.00 donation to Komen for the Cure ...
... , SILVER SPRING, Md., Aug. 21 ... for the Ethical Treatment of Animals (PETA) promoting vegetarianism at the ... displays an image of an overweight woman in a bikini, with ... Vegetarian ." This ad is an unmistakable example of stigma and ...
Cached Medicine News:Health News:Going Back to School With Asthma Takes Extra Work 2Health News:Updated With Photos: NESTLE(R) TOLL HOUSE(R) Re-launches With 'New Batch' Label 2Health News:Fecal DNA methylation detects gastric and colorectal cancers 2Health News:Nick Jonas to Speak on Juvenile Diabetes at National Press Club August 24 2Health News:DS Waters of America, Inc. Partners With Susan G. Komen for the Cure(R) 2Health News:DS Waters of America, Inc. Partners With Susan G. Komen for the Cure(R) 3Health News:DS Waters of America, Inc. Partners With Susan G. Komen for the Cure(R) 4Health News:The Obesity Society Calls Billboard Campaign Offensive and Off-Target 2
(Date:5/26/2015)... , England and PITTSBURGH , May ... a leading global pharmaceutical company, today announced that Mylan ... the Bernstein Strategic Decisions Conference, Friday, May 29, 2015 ... can access a live webcast of the presentation via ... http://mylan.com/investors . An archived version will also be available ...
(Date:5/26/2015)... May 26, 2015  Juniper Pharmaceuticals, Inc. (Nasdaq: ... focused on developing therapeutics that address unmet medical ... George Elston will present at the ... 28, 2015Time: , 4:00 PM EDTLocation: , The ... , www.juniperpharma.com, under  ,Investor, or  click ...
(Date:5/26/2015)... Fla. , May 26, 2015  Advanzeon ... subsidiary, Pharmacy Value Management Solutions, Inc. ("PVMS"), (sometimes, ... that effective immediately Mr. Matt Capps ... Public Relations Consultant to the Company,s Community Outreach ... position in Advanzeon.  This engagement provides for Mr. ...
Breaking Medicine Technology:Juniper Pharmaceuticals to Present at Investor Conference on May 28, 2015 2Advanzeon Solutions, Inc. And Its Wholly-Owned Subsidiary, Pharmacy Value Management Solutions, Inc., Welcome Major League Baseball Great Matt Capps As Senior Public Relations Consultant 2Advanzeon Solutions, Inc. And Its Wholly-Owned Subsidiary, Pharmacy Value Management Solutions, Inc., Welcome Major League Baseball Great Matt Capps As Senior Public Relations Consultant 3Advanzeon Solutions, Inc. And Its Wholly-Owned Subsidiary, Pharmacy Value Management Solutions, Inc., Welcome Major League Baseball Great Matt Capps As Senior Public Relations Consultant 4
... an icon of scientific skincare development, continues to provide award ... Kinerase Restructure Firming Eye Cream has ... Beauty Awards, appearing in the magazine,s October 2011 issue. ... over 236 beauty products were chosen as winners across a ...
... WOODLANDS, Texas, Sept. 27, 2011 In today,s ... provide excellent, efficient care while ensuring the ongoing ... Specialty Health , a division of McKesson ... Select Program , it is now offering Innovative ...
Cached Medicine Technology:Kinerase Wins Allure Best of Beauty Award for 2nd Consecutive Year 2New McKesson Specialty Health Program Helps Providers Thrive In Today's Quality-Driven Healthcare Environment 2New McKesson Specialty Health Program Helps Providers Thrive In Today's Quality-Driven Healthcare Environment 3
... The 5mm AEM Laparoscopic Instruments incorporate ... AEM Instruments are shielded and monitored to ... of the instrument caused by insulation failure ... risk. The protective shield built into all ...
... AEM Laparoscopic Instruments incorporate a layered design ... shielded and monitored to prevent stray electrosurgical ... caused by insulation failure or capacitive coupling; ... shield built into all AEM Instruments provides ...
... The 5mm AEM Laparoscopic Instruments incorporate ... AEM Instruments are shielded and monitored to ... of the instrument caused by insulation failure ... risk. The protective shield built into all ...
... Laparoscopic Instruments incorporate a layered design unique ... and monitored to prevent stray electrosurgical burns ... by insulation failure or capacitive coupling; a ... built into all AEM Instruments provides a ...
Medicine Products: