Navigation Links
Researchers decode biology of blood and iron disorders mapping out novel future therapies
Date:3/25/2013

NEW YORK (March 25, 2013) -- Two studies led by investigators at Weill Cornell Medical College shed light on the molecular biology of three blood disorders, leading to novel strategies to treat these diseases.

The two new studies -- one published online March 17 by Nature Medicine and the other March 25 in the online edition of the Journal of Clinical Investigation -- propose two new treatments for beta-thalassemia, a blood disorder which affects thousands of people globally every year. In addition, they suggest a new strategy to treat thousands of Caucasians of Northern European ancestry diagnosed with HFE-related hemochromatosis and a novel approach to the treatment of the rare blood disorder polycythemia vera.

These research insights were only possible because two teams that included 24 investigators at six American and European institutions decoded the body's exquisite regulation of iron, as well as its factory-like production of red blood cells.

"When you tease apart the mechanisms leading to these serious disorders, you find elegant ways to manipulate the system," says Dr. Stefano Rivella, associate professor of genetic medicine in pediatrics at Weill Cornell Medical College.

For example, Dr. Rivella says, two different gene mutations lead to different outcomes. In beta-thalassemia, patients suffer from anemia -- the lack of healthy red blood cells -- and, as a consequence, iron overload. In HFE-related hemochromatosis, patients suffer of iron overload. However, he adds, one treatment strategy that regulates the body's use of iron may work for both disorders.

Additionally, investigators found another strategy, based on manipulating red blood cell production, could also potentially treat beta-thalassemia as well as a very different disorder, polycythemia vera.

Revealing the Third Crucial Player

In the Nature Medicine study, Dr. Rivella and his colleagues tackled
'/>"/>

Contact: Lauren Woods
Law2014@med.cornell.edu
646-317-7401
Weill Cornell Medical College
Source:Eurekalert

Page: 1 2 3 4 5 6

Related medicine news :

1. NIH awards $20 million over 5 years to train next generation of global health researchers
2. Researchers develop a new cell and animal model of inflammatory breast cancer
3. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
4. Researchers Find Gene Mutations That May Be a Key to Autism
5. Researchers find evidence of banned antibiotics in poultry products
6. NJ stroke researchers report advances in spatial neglect research at AAN Conference
7. Autism by the numbers: Yale researchers examine impact of new diagnostic criteria
8. Researchers Map Brain Regions Linked to Intelligence
9. Researchers ID Genes That May Determine Mental Illness
10. Researchers Develop Blood Test for Depression
11. University of Cincinnati researchers win $3.7M grant from US Department of Defense
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/31/2014)... Daily Gossip writes in its Xtreme Fat Loss review that ... loss program ever developed. It promises to provide users the ... no wonder after all that this has become the most ... and workout fat loss program was created by Joel Marion, ... the author of this fat loss system, the method can ...
(Date:10/31/2014)... Activz Whole-Food Nutrition is ... line offering natural silver healing support† in liquid supplements, ... silver has been used to support natural healing, and ... the most advanced version available. This latest formula, backed ... that supports the existing healing mechanisms in the human ...
(Date:10/31/2014)... terms of duration of treatment and cost, patients ... accelerated partial breast irradiation (APBI) with proton therapy ... research from The University of Texas MD Anderson ... cost analysis study based on typical patient characteristics, ... charges for eight different types of partial and ...
(Date:10/31/2014)... The Suspension Revolution review published by Daily ... by Dan Long, a suspension training specialist. , ... and life coach. The author of this program claims ... not impossible , The Suspension Revolution review reveals that ... promises efficiency when it comes to burning fat, building ...
(Date:10/31/2014)... New York, NY (PRWEB) October 31, 2014 ... on one of the most remarkable gifts of life ... a platform for matching extraordinary surrogate mothers and donors ... stories about individuals in unforeseen circumstances. , It’s a ... sperm donors, surrogacy agencies, surrogacy lawyers, and fertility clinics ...
Breaking Medicine News(10 mins):Health News:Xtreme Fat Loss Diet Review Reveals How to Transform Your Body in 25 Days 2Health News:New Collection of Nano-particle Natural Silver Products by Activz Whole-Food Nutrition 2Health News:New Collection of Nano-particle Natural Silver Products by Activz Whole-Food Nutrition 3Health News:New Collection of Nano-particle Natural Silver Products by Activz Whole-Food Nutrition 4Health News:Proton therapy shown to be less costly than some alternative radiotherapy techniques 2Health News:Proton therapy shown to be less costly than some alternative radiotherapy techniques 3Health News:Suspension Revolution Review Reveals Dan Long's New Suspension Workout Plan 2Health News:Over 800 New Surrogate Mother Members at FindSurrogateMother.com Helping Create Pathways to Parenthood 2Health News:Over 800 New Surrogate Mother Members at FindSurrogateMother.com Helping Create Pathways to Parenthood 3
... the rage among doctors treating patients with blocked arteries, ... link them with a low, but serious risk of ... research by American scientists in two different studies published ... that many doctors have stretched the limit of their ...
... recalling 1.75 quart cartons of Mayfield Turtle Tracks ice cream ... code of 75243-20120. The recall was initiated because the affected ... No other Mayfield Dairy Farms products are involved in this ... the risk of a serious reaction if they consume this ...
... may be the most promising area of research for ... according to a new review in the International Journal ... confirmed the role of hormone therapy in recurrent ovarian ... review author Dr. Siqing Fu, an assistant professor of ...
... its efforts to prevent the spread of drug-resistant ... the public health sector and providing health care ... Skweyiya said at a media briefing on Tuesday, ... that the country is expanding hospital isolation wards ...
... Ministry of External Affairs, informed the Lok Sabha today that ... passports. ,At first these passports will be ... the end of 2007. Based on the experience gained from this ... the ordinary category by the end of 2008. , ...
... the thought that doctors could be on the payrolls of ... rampant in many developing countries. But things are no difference ... repeated visits by representatives of pharmaceutical firms resulted in prescription ... venerable New York Times wrote, doctors who have close relationships ...
Cached Medicine News:Health News:Studies Reveal Inappropriate Use Of Drug-Coated Stents 2Health News:Studies Reveal Inappropriate Use Of Drug-Coated Stents 3Health News:South Africa Increasing Efforts To Contain Drug-Resistant TB, Minister Says 2Health News:Nexus Between Psychiatrists and Drug Firms Dangerous, Say Critics 2Health News:Nexus Between Psychiatrists and Drug Firms Dangerous, Say Critics 3Health News:Nexus Between Psychiatrists and Drug Firms Dangerous, Say Critics 4
(Date:10/31/2014)... 31, 2014  Zacks.com announces the list of stocks featured in ... the latest news and events impacting stocks and the financial markets. ... AMGN - Free Report ), Celgene (Nasdaq: CELG ... - Free Report ), Market Vectors Biotech ETF (AMEX: ... ETF (AMEX: XBI - Free Report ). ...
(Date:10/31/2014)... , October 31, 2014 Multigate Medical ... patents of B. Braun Melsungen AG (B. Braun) by selling ... safety IV catheters manufactured by Poly Medicure Ltd (Polymed). The ... proceeding number VID 463 of 2013 can be ... detailed judgment, Multigate was found to have infringed claim 1 ...
(Date:10/31/2014)... Oct. 30, 2014 Electronic prescribing ... transmission of prescription related information between prescriber, ... allows a physician and nurse practitioner to ... medication error occurs during pharmacy operations. E-Prescribing ... It provides complete medical lists, conducts all ...
Breaking Medicine Technology:The Zacks Analyst Blog Highlights: Amgen, Celgene, Biogen Idec, Market Vectors Biotech ETF and SPDR S&P Biotech ETF 2The Zacks Analyst Blog Highlights: Amgen, Celgene, Biogen Idec, Market Vectors Biotech ETF and SPDR S&P Biotech ETF 3The Zacks Analyst Blog Highlights: Amgen, Celgene, Biogen Idec, Market Vectors Biotech ETF and SPDR S&P Biotech ETF 4The Zacks Analyst Blog Highlights: Amgen, Celgene, Biogen Idec, Market Vectors Biotech ETF and SPDR S&P Biotech ETF 5The Zacks Analyst Blog Highlights: Amgen, Celgene, Biogen Idec, Market Vectors Biotech ETF and SPDR S&P Biotech ETF 6The Zacks Analyst Blog Highlights: Amgen, Celgene, Biogen Idec, Market Vectors Biotech ETF and SPDR S&P Biotech ETF 7B. Braun Wins Patent Disputes Against Poly Medicure Ltd's Australian Distributor Multigate Medical Devices Pty. Ltd. and Spanish Distributor Dextromédica S. L. 2E-Prescribing Market - Global Industry Analysis, Size, Share, Growth, Trends and Forecast, 2013 - 2019 2
... Building Comprehensive HIV/AIDS Care Programs in,Resource-Limited Settings" ... Health,Experts, MEXICO CITY, Aug. 5 ... from the "A Day in the Life ... and others, unveiled today a comprehensive guide ...
... and safety of once-daily TMC278 in ... treatment-naive adults with HIV-1 ... IIb data from Tibotec,Pharmaceuticals Ltd. provides additional information on ... reverse transcriptase inhibitor (NNRTI), as part of HIV,combination therapy ...
Cached Medicine Technology:Landmark HIV/AIDS Publication Launches at International AIDS Society Conference in Mexico City 2Landmark HIV/AIDS Publication Launches at International AIDS Society Conference in Mexico City 3Ninety-Six Week Data on Tibotec Investigational NNRTI, TMC278, Presented at AIDS 2008 2
... is a neurosurgical OR that fully ... tools, including iMRI, necessary to treat ... neurosurgical treatments are performed in a ... for MR compatibility and safety, BrainSUITE ...
... Quality EEG recording is assured even in ... has high performance, high sensitivity amplifiers, ... rejection filter, shielded electrodes and a high ... Neurofax is a complete and ready ...
... the world's first Windows 2000 notebook ... It allows data sharing with other ... with Microsoft Office 2000. Data and ... the large, sharp 14.1-inch TFT screen ...
... Physiological lesion assessment using Fractional ... proven and cost effective solution ... location of stenosis). Radi's new ... offer fast, easy and accurate ...
Medicine Products: