Navigation Links
Research suggests molecular 'switch' may play role in tumor suppression
Date:1/13/2013

llular distribution, this work will spur further research into unanticipated roles for this important molecule in healthy and diseased cells."

In endocytosis, trimeric clathrin molecules bind together to form molecular packages that allow other substances to enter cells. Several years ago, researchers in Japan published evidence that clathrin can also serve as an activator of the protein p53, a known tumor suppressor.

For the activation to take place, clathrin and p53 must both be present in the cell's nucleus. The catch is that clathrin molecules cannot penetrate the nucleus in their usual, three-legged form. To enter, the three-legged clathrin molecule must be altered or "de-trimerized."

Using X-ray crystallography, Ybe and his team discovered a "topology switch" in the clathrin molecule. They showed they could break the switch by mutating one key amino acid that is part of the switch. The result: Clathrin was "detrimerized"; three-legged molecules were broken into one-legged ones.

Experimenting with both cancer and non-cancer cells, the researchers found the three-legged clathrin only in the cytoplasm of the cells, not the nucleus. But with the "switch" broken, clathrin formed monomers and was also present in the nucleus, where it could potentially activate tumor suppression.

Ybe said the results point to the need for additional research to better understand the structure and function of clathrin and the role it plays in cellular processes, including those involved in cancer. With the clathrin "switch" identified, researchers can attempt to better understand how it can be activated, with the goal of developing new therapies for suppressing the growth of tumors. Ybe has a patent pending on the idea to use the mutated form of clathrin to stimulate the natural anti-cancer activities of human cells.

The finding developed from Ybe's research on the role of clathrin in Huntington's disease, a genetic disorder that c
'/>"/>

Contact: Steve Hinnefeld
slhinnef@iu.edu
812-856-3488
Indiana University
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Canada In Vitro Diagnostics Market Analysis and Forecasts to 2017 in New Research Report at RnRMarketResearch.com
2. ZijaExtreme.com Researches Vitamin D Deficiency & Using a More Natural Approach
3. Spectacles Market - New Industry Research Report is Now Available for Pre Order at Transparency Market Research
4. Game-based economics research explains why we roll the dice on flu shots
5. Experts aim to redefine healthcare and research ethics
6. Heart Muscle Cells Regenerate in Kids, Research Shows
7. Research Reveals Which Learning Methods Get an A
8. Researchers use iPSCs to define optimal treatment for managing life-threatening arrhythmias
9. Dental Implants Market - New Industry Research Report is Now Available for Pre Order at Transparency Market Research
10. UT Arlington receives Grand Challenges Explorations grant for research in global health
11. Book co-authored by USF Nursing Dean named 2012 Nursing Research Book of the Year
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/23/2014)... 2014 AngelWeddingDress.com has recently ... selection of beach wedding dresses. “If you are looking ... AngelWeddingDress.com as soon as possible. Here you can enjoy ... manager says. , Holding a big marriage ceremony is ... a beautiful beach wedding dress is uppermost priority. Ophelia, ...
(Date:11/23/2014)... The FDA is Watching: , What Twitter, ... Dec. 11, 2014 ? Any Time at Your Convenience ... promotional activities is no longer limited to magazine and ... websites, Twitter, journal articles, TV appearances, Facebook and more. ... for On-Demand access to Timothy Ayers and Michelle Axelrod’s ...
(Date:11/23/2014)... (PRWEB) November 23, 2014 BambooFlooringChina.com , ... new click strand woven bamboo flooring collection. Now, ... According to the company’s CEO, the promotion is valid until ... flooring comes with a smooth and dust-free surface, which makes ... companies in the industry, the company wants to make its ...
(Date:11/22/2014)... A new AlignLife Chiropractic & Natural Health ... Greenville area. Dr. Chelsea Sineath, owner and chiropractor at ... her own clinic after working in another AlignLife office ... , AlignLife believes that the body can heal itself ... chiropractic care and rehabilitation to allow the spine to ...
(Date:11/22/2014)... November 23, 2014 Recently, UWDress.com, a successful ... formal wedding guest attire in order to prepare for ... prices, up to 70% off. , UWDress.com is a ... are very beautiful, especially the new items -- formal wedding ... in the current market, including superstar and princess. As one ...
Breaking Medicine News(10 mins):Health News:Beach Wedding Dresses Added to Outstanding Online Dress Company AngelWeddingDress.com 2Health News:FDAnews Announces The FDA is Watching: What Twitter, Tradeshows and TV Have in Common, On-Demand Webinar, Dec. 11, 2014 2Health News:FDAnews Announces The FDA is Watching: What Twitter, Tradeshows and TV Have in Common, On-Demand Webinar, Dec. 11, 2014 3Health News:FDAnews Announces The FDA is Watching: What Twitter, Tradeshows and TV Have in Common, On-Demand Webinar, Dec. 11, 2014 4Health News:FDAnews Announces The FDA is Watching: What Twitter, Tradeshows and TV Have in Common, On-Demand Webinar, Dec. 11, 2014 5Health News:Click Strand Woven Bamboo Flooring From Famous Bamboo Flooring Company BambooFlooringChina.com 2Health News:AlignLife of Downtown Greenville is Now Open and Accepting New Patients 2Health News:Formal Wedding Guest Attire Added to UWDress.com 2
... the American Society of Hematology (ASH) have selected Ingmar ... Research Exchange Award, which serves to strengthen ties between ... Bruns is a resident physician and research scientist in ... the University of Dsseldorf in Germany. After graduating from ...
... pathway , TUESDAY, March 30 (HealthDay News) -- A ... diabetes has been discovered by U.S. researchers. , The ... fails because of obesity. Artificial activation of this pathway ... according to the report published online March 28 ...
... for blood sugar disease earlier cut complications, costs, , TUESDAY, ... for type 2 diabetes start at age 45, especially for ... can begin between the ages of 30 and 45 for ... and 45 and was repeated between every year to five ...
... can be the difference between life and death. Yet, people ... Carolina State University has found that changes in daily behavior ... our medication and that these changes influence older and ... something we can do about it. "We,ve found that ...
... ... Twitter , ... 2010 -- As part of its ongoing effort to educate consumers and the media, the ... on Facebook and Twitter profile., , ,USApple,s fan page on Facebook and ...
... comment on risks from scans , TUESDAY, March 30 (HealthDay ... much radiation will get a public airing this week as ... meetings on what should be done to increase the safety ... seeking ideas to get manufacturers of the devices used for ...
Cached Medicine News:Health News:European hematologist receives award to conduct research in US 2Health News:Novel Method Eyed for Normalizing Blood Sugar 2Health News:Diabetes Screening Should Start Sooner 2Health News:Diabetes Screening Should Start Sooner 3Health News:Research shows why we forget to take our medicine, and what we can do about it 2Health News:Get your Virtual ‘Apple a Day' 2Health News:Too Much Radiation? The FDA Wants to Know 2Health News:Too Much Radiation? The FDA Wants to Know 3
(Date:11/21/2014)...  Alere Inc. (NYSE: ALR ), a ... Juliet Cunningham as Vice President, Investor Relations. In ... driving communications with the investment community. "As ... to increase shareholder value, it is critical that we ... Chief Executive Officer. "We are delighted that Juliet ...
(Date:11/21/2014)... 21, 2014  Tandem Diabetes Care ® , ... device company and manufacturer of the t:slim ® ... Tidepool, a non-profit dedicated to improving diabetes therapy ... that increases diabetes data accessibility. This partnership will ... currently under development, to download and access data ...
(Date:11/21/2014)... SAN MARCOS, Texas , Nov. 21, 2014 /PRNewswire/ ... industrial hemp containing low THC, announces they are now ... is comparable to Charlotte,s Web type strains grown in ... symptoms from other neurological disorders, such as Parkinson,s, MS, ... waiting for US laws to pass, because imported CBD ...
Breaking Medicine Technology:Alere Appoints Juliet Cunningham to Lead Investor Relations 2Tandem Diabetes Care Announces Partnership with Tidepool to Further Expand Access to Diabetes Device Data 2Tandem Diabetes Care Announces Partnership with Tidepool to Further Expand Access to Diabetes Device Data 3New CBD Oil From Industrial Hemp is Comparable to Charlotte's Web, Legal In All 50 States 2New CBD Oil From Industrial Hemp is Comparable to Charlotte's Web, Legal In All 50 States 3
... The U.S. Food and Drug Administration today approved Soliris ... (aHUS), a rare and chronic blood disease that can ... with increased risk of death and stroke. ... HUS accounts for 5 to 10 percent of all ...
... Internal Fixation Systems, Inc. (OTC QB: IFIX), manufacturer ... podiatric implants announced today that the company has been ...  DTC eligibility allows ownership of the company,s shares to ... Depository Trust Company is a member of the U.S. ...
Cached Medicine Technology:FDA Approves Soliris for Rare Pediatric Blood Disorder 2FDA Approves Soliris for Rare Pediatric Blood Disorder 3Internal Fixation Systems, Inc. Announces DTC Eligibility 2
... automated solution for Western Blot analysis ... fully automated Western Blot Analyzer for many ... reveal the presence of infectious diseases such ... fast and accurate screening of allergies and ...
... Advantages of using the Antigen-Antibody Pens-Using a ... and developed specialized fountain pens, called Antigen-Antibody ... or write/mark the blotting membranes in any ... formulated antigen-bonded colored dyes helps to see ...
... the Antigen-Antibody Pens-Using a proprietary and patented ... fountain pens, called Antigen-Antibody pens-TM, that will ... blotting membranes in any form or shape ... dyes helps to see antigen being written ...
... to 350 Liters of pure water, Complete, ... of Purified Water,Millipores compact S.D.S. Storage and ... to 350 liters of purified water produced ... maintain consistent purity of stored water, provide ...
Medicine Products: