Navigation Links
Research suggests molecular 'switch' may play role in tumor suppression
Date:1/13/2013

BLOOMINGTON, Ind. -- Newly published research by Indiana University structural biologist Joel Ybe and colleagues identifies a "topology switch" in the protein clathrin, the function of which may shed light on molecular processes involved in tumor suppression.

The paper, available in and featured on the front cover of the Jan. 16, 2013, issue of FEBS Letters, a journal of the Federation of European Biochemical Societies, could broaden scientists' understanding of the importance of clathrin and potentially lead to new strategies for controlling cancer.

"This is a totally unexpected but wonderful finding," Ybe said. "It has exciting implications for understanding the role that clathrin may play in the growth or suppression of tumors."

Ybe is a senior research scientist in the Department of Molecular and Cellular Biochemistry in the IU College of Arts and Sciences. Co-authors of the paper are postdoctoral researchers Sarah Fontaine and Xiaoyan Lin; IU chemist Todd Stone; Sanjay Mishra, formerly at IU and now at Vanderbilt University; and Jay Nix of Lawrence Berkeley National Laboratory.

Typically found in a three-legged form called a trimer, clathrin is best understood for its role in endocytosis, the process by which cells absorb proteins and other molecules. But recent research has suggested that clathrin in a one-legged form, or monomer, may have a role in suppressing tumors. Ybe and his team show how a "switch" in clathrin can be flipped to produce non-trimeric clathrin molecules.

"Clathrin is known to function as a trimer in receptor-mediated endocytosis, but the existence of the monomeric form and its role in tumor suppression is less well-accepted," said Alexandra Ainsztein, who oversees membrane trafficking grants at the National Institute of General Medical Sciences of the National Institutes of Health. "By providing evidence for a model in which a molecular shift de-trimerizes clathrin and changes its ce
'/>"/>

Contact: Steve Hinnefeld
slhinnef@iu.edu
812-856-3488
Indiana University
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Canada In Vitro Diagnostics Market Analysis and Forecasts to 2017 in New Research Report at RnRMarketResearch.com
2. ZijaExtreme.com Researches Vitamin D Deficiency & Using a More Natural Approach
3. Spectacles Market - New Industry Research Report is Now Available for Pre Order at Transparency Market Research
4. Game-based economics research explains why we roll the dice on flu shots
5. Experts aim to redefine healthcare and research ethics
6. Heart Muscle Cells Regenerate in Kids, Research Shows
7. Research Reveals Which Learning Methods Get an A
8. Researchers use iPSCs to define optimal treatment for managing life-threatening arrhythmias
9. Dental Implants Market - New Industry Research Report is Now Available for Pre Order at Transparency Market Research
10. UT Arlington receives Grand Challenges Explorations grant for research in global health
11. Book co-authored by USF Nursing Dean named 2012 Nursing Research Book of the Year
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... 24, 2014 July 22, 2014 ... sealant and anesthesia reversal products to National Children’s ... save young smiles. The donation of over 1,000 ... was distributed to America’s ToothFairy Affiliate clinical programs ... oral health services. The America’s ToothFairy Affiliate network ...
(Date:7/24/2014)... Dennis Thompson HealthDay ... Most blood cancer patients in the United States who need ... the National Marrow Donor Program, a new study has determined. ... study found that 66 percent to 97 percent of patients ... the registry. Even hard-to-match ethnic groups can find a ...
(Date:7/24/2014)... 2014 (HealthDay News) -- A new study estimates that ... over the past year due to the Affordable Care ... expanded eligibility for Medicaid, the federal insurance program for ... Obamacare, states had a choice about expanding eligibility. ... set us on a path toward achieving that goal," ...
(Date:7/24/2014)... Come see, swim in, and soak in what Michael ... and to continue to be the most decorated athlete of all ... on display at The Toledo Hot Tub, Swim Spa, Pool & ... Tim Baele, Regional Sales Manager for Master Spas, said, "The Hot ... to see hundreds of great products and build your dream backyard ...
(Date:7/24/2014)... With the recent appointment of Frank ... further strengthens its reputation as a leader in the ... current president of the National Association of Locum Tenens ... of Sales, Operations and Quality Assurance for Interim Physicians. ... 25 years ago, Mr. Phillips first served as the ...
Breaking Medicine News(10 mins):Health News:Septodont Donation Helps Children in Need 2Health News:Good Odds for Those Who Need Bone Marrow Donor, Study Finds 2Health News:Good Odds for Those Who Need Bone Marrow Donor, Study Finds 3Health News:More Than 10 Million People Gained Coverage Under Obamacare, Study Finds 2Health News:See the New Michael Phelps Swim Spas and Hot Tubs at The Toledo Hot Tub, Swim Spa, Pool & Patio Show at the Lucas County Rec Center this Weekend 2Health News:Frank Phillips Appointed President of Medical Doctor Associates 2
... a leader,in the development and marketing of disposable ... announced today that,BSSI has been purchased by Linden ... to Microflex(R), BSSI also owns MicroActive Corporation and,FoodHandler(R), ... leading supplier,of health and safety barrier products to ...
... and special initiatives encourage smokers to say ,I Quit, at The ... ... There,s some,ash-kicking, going on at the BODY WORLDS exhibit. Lung Cancer ... California,s,6-session Ash Kickers Quit Smoking Class and BODY WORLDS, I Quit ...
... Americans Have No Long Term Care Plans, WASHINGTON, ... long term care has on American families, the U.S. ... resolution proclaiming its,support for national Long Term Care Awareness ... one of the nation,s leading providers of,individual long term ...
... raising goal for United Way of ... ... Company,(NYSE: LLY ) chairman and chief executive officer Sidney Taurel ... Lilly,s,commitment to the agency,s 2008 fundraising campaign. For the United Way ...
... researchers find , TUESDAY, Nov. 6 (HealthDay News) -- ... of preclinical cardiovascular disease, U.S researchers report.. , Researchers ... women (who were free of cardiovascular disease at the ... intima media thickness (cIMT), a measure of the ...
... a mother with Alzheimers disease appear to be at higher risk ... according to a new study by NYU School of Medicine researchers. ... in this weeks online edition of the Proceedings of the National ... among cognitively normal people who have a father, a mother, or ...
Cached Medicine News:Health News:Microflex(R) Corporation Acquired by Linden and Edgewater 2Health News:BODY WORLDS 2 & Breathe California Pair Up for Some 'Ash Kicking' 2Health News:BODY WORLDS 2 & Breathe California Pair Up for Some 'Ash Kicking' 3Health News:Congress Proclaims Support for Long Term Care Awareness Week; Recent Poll Shows Voters Want Long Term Care Included in Presidential Candidates' Healthcare Proposals 2Health News:Congress Proclaims Support for Long Term Care Awareness Week; Recent Poll Shows Voters Want Long Term Care Included in Presidential Candidates' Healthcare Proposals 3Health News:Lilly Contributes $10.8 Million to United Way Annual Campaign 2Health News:A maternal link to Alzheimer's disease 2Health News:A maternal link to Alzheimer's disease 3
(Date:7/24/2014)... Second Quarter and Recent Highlights: , ... effective September 2, 2014 , Product revenues grew ... ® revenues grew 14 percent year-over-year to $15.3 ... percent year-over-year to $1.1 million , HeRO ® ... million , Tissue processing revenues decreased 6 percent ...
(Date:7/24/2014)... , July 24, 2014  As part of its ongoing ... will host its annual Pharmacy Ownership Boot Camp on July ... in Washington, D.C. ... knowledge and confidence needed to own their own pharmacies.  Now ... the industry,s leading event for women pharmacists who dream of ...
(Date:7/24/2014)... July 24, 2014  Bayer HealthCare today announced ... evaluated a 15% foam formulation of its compound ... inflammatory papules and pustules of rosacea. An AzA ... complement the currently available AzA gel formulation. Papulopustular ... (papules and pustules) as well as erythema (redness) ...
Breaking Medicine Technology:CryoLife Second Quarter 2014 Revenues Increase 3 Percent to a Record $34.7 Million 2CryoLife Second Quarter 2014 Revenues Increase 3 Percent to a Record $34.7 Million 3CryoLife Second Quarter 2014 Revenues Increase 3 Percent to a Record $34.7 Million 4CryoLife Second Quarter 2014 Revenues Increase 3 Percent to a Record $34.7 Million 5CryoLife Second Quarter 2014 Revenues Increase 3 Percent to a Record $34.7 Million 6CryoLife Second Quarter 2014 Revenues Increase 3 Percent to a Record $34.7 Million 7CryoLife Second Quarter 2014 Revenues Increase 3 Percent to a Record $34.7 Million 8CryoLife Second Quarter 2014 Revenues Increase 3 Percent to a Record $34.7 Million 9CryoLife Second Quarter 2014 Revenues Increase 3 Percent to a Record $34.7 Million 10CryoLife Second Quarter 2014 Revenues Increase 3 Percent to a Record $34.7 Million 11CryoLife Second Quarter 2014 Revenues Increase 3 Percent to a Record $34.7 Million 12CryoLife Second Quarter 2014 Revenues Increase 3 Percent to a Record $34.7 Million 13CryoLife Second Quarter 2014 Revenues Increase 3 Percent to a Record $34.7 Million 14CryoLife Second Quarter 2014 Revenues Increase 3 Percent to a Record $34.7 Million 15CryoLife Second Quarter 2014 Revenues Increase 3 Percent to a Record $34.7 Million 16CryoLife Second Quarter 2014 Revenues Increase 3 Percent to a Record $34.7 Million 17'Women in Pharmacy' Program Seeks to Expand Pharmacy Ownership 2'Women in Pharmacy' Program Seeks to Expand Pharmacy Ownership 3'Women in Pharmacy' Program Seeks to Expand Pharmacy Ownership 4Phase III Investigational Trial of Azelaic Acid 15% Foam Meets Both Co-Primary Endpoints in Subjects with Papulopustular Rosacea 2Phase III Investigational Trial of Azelaic Acid 15% Foam Meets Both Co-Primary Endpoints in Subjects with Papulopustular Rosacea 3
... , MADISON, N.J., Nov. 18 Quest Diagnostics Incorporated ... testing, information and services, today announced that the Simplexa Influenza A ... CE marked and is now available as a test kit for ... the test at MEDICA 2009, November 18 to 21, 2009, at ...
... , NASHVILLE, Tenn., Nov. 17 Emdeon (NYSE: EM ... solutions, today announced that it will participate in the Piper Jaffray ... 2, 2009 in New York. , The "fireside chat", featuring Tracy ... Tuesday, December 1, 2009. A live audio webcast will be ...
Cached Medicine Technology:2009 H1N1 Flu Test From Quest Diagnostics Now CE Marked For International Distribution Under The Simplexa(TM) Brand Name 22009 H1N1 Flu Test From Quest Diagnostics Now CE Marked For International Distribution Under The Simplexa(TM) Brand Name 32009 H1N1 Flu Test From Quest Diagnostics Now CE Marked For International Distribution Under The Simplexa(TM) Brand Name 42009 H1N1 Flu Test From Quest Diagnostics Now CE Marked For International Distribution Under The Simplexa(TM) Brand Name 5
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: