Navigation Links
Research suggests molecular 'switch' may play role in tumor suppression
Date:1/13/2013

BLOOMINGTON, Ind. -- Newly published research by Indiana University structural biologist Joel Ybe and colleagues identifies a "topology switch" in the protein clathrin, the function of which may shed light on molecular processes involved in tumor suppression.

The paper, available in and featured on the front cover of the Jan. 16, 2013, issue of FEBS Letters, a journal of the Federation of European Biochemical Societies, could broaden scientists' understanding of the importance of clathrin and potentially lead to new strategies for controlling cancer.

"This is a totally unexpected but wonderful finding," Ybe said. "It has exciting implications for understanding the role that clathrin may play in the growth or suppression of tumors."

Ybe is a senior research scientist in the Department of Molecular and Cellular Biochemistry in the IU College of Arts and Sciences. Co-authors of the paper are postdoctoral researchers Sarah Fontaine and Xiaoyan Lin; IU chemist Todd Stone; Sanjay Mishra, formerly at IU and now at Vanderbilt University; and Jay Nix of Lawrence Berkeley National Laboratory.

Typically found in a three-legged form called a trimer, clathrin is best understood for its role in endocytosis, the process by which cells absorb proteins and other molecules. But recent research has suggested that clathrin in a one-legged form, or monomer, may have a role in suppressing tumors. Ybe and his team show how a "switch" in clathrin can be flipped to produce non-trimeric clathrin molecules.

"Clathrin is known to function as a trimer in receptor-mediated endocytosis, but the existence of the monomeric form and its role in tumor suppression is less well-accepted," said Alexandra Ainsztein, who oversees membrane trafficking grants at the National Institute of General Medical Sciences of the National Institutes of Health. "By providing evidence for a model in which a molecular shift de-trimerizes clathrin and changes its ce
'/>"/>

Contact: Steve Hinnefeld
slhinnef@iu.edu
812-856-3488
Indiana University
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Canada In Vitro Diagnostics Market Analysis and Forecasts to 2017 in New Research Report at RnRMarketResearch.com
2. ZijaExtreme.com Researches Vitamin D Deficiency & Using a More Natural Approach
3. Spectacles Market - New Industry Research Report is Now Available for Pre Order at Transparency Market Research
4. Game-based economics research explains why we roll the dice on flu shots
5. Experts aim to redefine healthcare and research ethics
6. Heart Muscle Cells Regenerate in Kids, Research Shows
7. Research Reveals Which Learning Methods Get an A
8. Researchers use iPSCs to define optimal treatment for managing life-threatening arrhythmias
9. Dental Implants Market - New Industry Research Report is Now Available for Pre Order at Transparency Market Research
10. UT Arlington receives Grand Challenges Explorations grant for research in global health
11. Book co-authored by USF Nursing Dean named 2012 Nursing Research Book of the Year
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2015)... ... September 02, 2015 , ... Alameda County Community Food Bank ... Month” during the entire month of September. In the spirit of the ... efforts this September to an awareness campaign educating legislators and the public on ...
(Date:9/2/2015)... Beach, Calif. (PRWEB) , ... September 02, 2015 ... ... injection therapy clinic combining both naturopathic and allopathic medicine, opens its second location ... The new clinic features roughly 1000 square feet of lounge space for patients ...
(Date:9/2/2015)... ... September 02, 2015 , ... ... at Children's Healthcare of Atlanta to help support childhood cancer research. On ... upcoming WSB Radio Care-A-Thon , which is the fund-raising event DoMyOwnPestControl.com sponsors ...
(Date:9/2/2015)... KY (PRWEB) , ... September 02, 2015 , ... Ericson ... the CDI Education Director for HCPro and Associate Director of Education for the Association ... CDI, Advancing CDI and ICD-10 for CDI Boot Camps. She serves as a CDI ...
(Date:9/2/2015)... ... September 02, 2015 , ... Medical ... has completed a recapitalization with new investment partners Beecken Petty O’Keefe & ... each offer extensive expertise and connections within the healthcare industry, which makes ...
Breaking Medicine News(10 mins):Health News:#IfOnlyYouKnew: Alameda County Community Food Bank Commemorates September as National Hunger Action Month 2Health News:#IfOnlyYouKnew: Alameda County Community Food Bank Commemorates September as National Hunger Action Month 3Health News:#IfOnlyYouKnew: Alameda County Community Food Bank Commemorates September as National Hunger Action Month 4Health News:The Hydration Room Opens New Location In Laguna Beach, California 2Health News:The Hydration Room Opens New Location In Laguna Beach, California 3Health News:The Hydration Room Opens New Location In Laguna Beach, California 4Health News:DoMyOwnPestControl.com Goes Gold for Childhood Cancer Awareness Month 2Health News:ezDI Names Noted CDI Educator Cheryl Ericson as Company’s Clinical Documentation Manager 2Health News:ezDI Names Noted CDI Educator Cheryl Ericson as Company’s Clinical Documentation Manager 3Health News:ezDI Names Noted CDI Educator Cheryl Ericson as Company’s Clinical Documentation Manager 4Health News:Medical Solutions Completes Recapitalization with Beecken Petty O’Keefe & Company and Heritage Group 2Health News:Medical Solutions Completes Recapitalization with Beecken Petty O’Keefe & Company and Heritage Group 3Health News:Medical Solutions Completes Recapitalization with Beecken Petty O’Keefe & Company and Heritage Group 4
... staff members working in a hospital,s fast-paced emergency department ... involved in medication errors that harm patients, new Johns ... serious issues related to temporary nursing staff in particular ... of the health care workforce owing to the national ...
... SUNY Downstate Medical Center have received a $50,000 grant ... develop a diagnostic test for the folate receptor autoantibody. ... cerebral folate deficiency in infants and autism spectrum disorders. ... United States, neural tube defects result in the brain ...
... to make people "tear up," but a new study led by ... nasal spray containing an ingredient derived from hot chili peppers ( ... sinus inflammation. The study, which appears in the August ... compares the use of the Capsicum annum nasal spray ...
... (HealthDay News) -- Interbreeding between modern humans, Neanderthals and ... boost peoples, immune systems today, researchers report. Modern ... share a common African ancestor, the team of scientists ... Science . However, the groups diverged into separate, distinct ...
... hormone receptor guanylyl cyclase C (GCC) has been established ... evidence from Thomas Jefferson University suggests it ... pandemics: obesity. Reporting in the August 25 ... Scott Waldman, M.D., Ph.D., chairman of the ...
... , THURSDAY, Aug. 25 (HealthDay News) -- For kids, the end ... sleeping until noon: It also signals the beginning of brand new ... your child is a preschooler or a teen, some anxiety about ... is to know how to ease your children,s stress and manage ...
Cached Medicine News:Health News:Temporary ER staff poses increased safety risk to patients 2Health News:Temporary ER staff poses increased safety risk to patients 3Health News:Researchers developing new test to measure risk for birth defects and neuro-developmental disorders 2Health News:Thank Neanderthals for That Healthy Immune System, Scientists Say 2Health News:Could a tumor suppressor also fight obesity? 2Health News:Parents Can Ease Back-to-School Stress 2Health News:Parents Can Ease Back-to-School Stress 3
(Date:9/2/2015)... 2015 Boston Scientific Corporation (NYSE: BSX ) ... Healthcare Conference on September 17, in New York ... executive officer, and Dan Brennan , executive vice president ... and answer session regarding the company with the host analyst ... webcast of the question and answer session will be available ...
(Date:9/2/2015)... ROCKVILLE, Md. , Sept. 2, 2015 /PRNewswire/ ... "RegeneRx"), a clinical-stage drug development company focused on ... J.J. Finkelstein , President and Chief Executive ... Rodman & Renshaw Global Investment Conference, sponsored by ... will be held September 8-10, 2015 at the ...
(Date:9/2/2015)... China Biologic Products, Inc. (NASDAQ: CBPO, ... integrated plasma-based biopharmaceutical company in China ... Guizhou Taibang Biological Products Co., Ltd. ("Guizhou Taibang") ... with Xinjiang Deyuan Bioengineering Co., Ltd. ("Xinjiang Deyuan") ... Taibang to source no less than 500 tonnes ...
Breaking Medicine Technology:Boston Scientific To Participate In 2015 Morgan Stanley Global Healthcare Conference 2RegeneRx to Present at Rodman & Renshaw Global Investment Conference 2RegeneRx to Present at Rodman & Renshaw Global Investment Conference 3China Biologic Enters into Strategic Collaboration Agreement to Source Raw Materials 2China Biologic Enters into Strategic Collaboration Agreement to Source Raw Materials 3China Biologic Enters into Strategic Collaboration Agreement to Source Raw Materials 4China Biologic Enters into Strategic Collaboration Agreement to Source Raw Materials 5
... N.J., Sept. 28 Watson Pharmaceuticals, Inc. (NYSE: ... today that Paul Bisaro, Watson,s President and Chief Executive ... Company,s business in London at the Jefferies 2010 Global ... 2010 at 10:00am (BST), (5:00am EDT). The presentation will ...
... The 96th Annual Clinical Congress of the American College of ... the world, will convene October 3-7 at the Walter E. ... first time that the ACS Clinical Congress has ever been ... Congress provides a prime opportunity for writers, editors, and producers ...
Cached Medicine Technology:American College of Surgeons Clinical Congress Convenes in Washington, DC, October 3-7, 2010 2
Thesystem combines an exclusive dual light-source design and a versatile sample compartment to provide solid, reliable performance....
Inquire...
The Spex SkinSkan is the only in-vivo, fibre-optic spectrofluorometer designed specifically for skin-fluorescence measurements. It is also ideal for many remote sensing steady-state fluorescence appl...
The unique RF-1501 optical design provides exceptional sensitivity in an incredibly compact instrument....
Medicine Products: