Navigation Links
Reprogramming patients' cells offers powerful new tool for studying, treating blood diseases
Date:7/30/2013

esearchers corrected the genetic defect that causes DBA, the iPSCs developed into red blood cells in normal quantities. "This showed that in principle, it's possible to repair a patient's defective cells," said Weiss.

Weiss cautioned that this proof-of-principle finding is an early step, with many further studies to be done to verify if this approach will be safe and effective in clinical use.

However, he added, the patient-derived iPSCs are highly useful as a model cell system for investigating blood disorders. For instance, DBA is often puzzling, because two family members may have the same mutation, but only one may be affected by the disease. Because each set of iPSCs is specific to the individual from whom they are derived, researchers can compare the sets to identify molecular differences, such as a modifier gene active in one person but not the other.

Furthermore, the cells offer a renewable, long-lasting model system for testing drug candidates or gene modifications that may offer new treatments, personalized to individual patients.

The second study in Blood provides a concrete example of using iPSCs for drug testing, specifically for the often-aggressive childhood leukemia, JMML. First the study team generated iPSCs from two children with JMML, and then manipulated the iPSCs in cell cultures to produce myeloid cells that multiplied uncontrollably, much as the original JMML cells do.

They then tested the cells with two drugs, each able to inhibit a separate protein known to be highly active in JMML. One drug, an inhibitor of the MEK kinase, reduced the proliferation of cancerous cells in culture. "This provides a rationale for a potential targeted therapy for this specific subtype of JMML," said Weiss.

A stem cell core facility at CHOP, directed by study co-author Deborah French under the auspices of the hospital's Center for Cellular and Molecular Therapeutics, generated the iPSCs lines used in these
'/>"/>

Contact: John Ascenzi
Ascenzi@email.chop.edu
267-426-6055
Children's Hospital of Philadelphia
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Reprogramming cells to fight diabetes
2. A relationship between cancer genes and the reprogramming gene SOX2 discovered
3. Doctors urged to talk to patients about parking cellphones
4. Inhalable gene therapy may help pulmonary arterial hypertension patients
5. Requiring some patients to get mental health treatment saves money
6. Looking at outcomes important to patients may improve results of cataract surgery
7. Diet Doc Medical Weight Loss Plans Now Encourages Natural Weight Loss With Fruits and Vegetables that Help Patients Lose Weight Fast and Live Longer
8. Itani Dental Explains How to Choose a Dentist for Special Needs Patients
9. Active Family Chiropractic of Gaithersburg, MD Introduces Nutra Disc, a New Dietary Supplement Designed to Support Patients’ Spinal Disc and Connective Tissue Health
10. Diet Doc Medical Weight Loss Plans Now Help Patients Eliminate Junk Food From Their Weight Loss Diets with Fat Burning Snack Ideas
11. PositiveSingles.com and The Henne Group Partner to Conduct a Study on HIV Patients in LA and DC in Hopes to Support the Creation of a Campaign in the Fight Against HIV
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/3/2015)... March 03, 2015 Raritan Bay Medical ... of Health,” an interactive photo contest held at the ... 8, 2015. To raise awareness for health and wellness ... to share their best health and wellness tips. , ... Bay Medical Center’s website and Facebook page where Facebook ...
(Date:3/3/2015)... Miami, FL (PRWEB) March 03, 2015 ... to be an international keynote presenter at the ... at the Melbourne Convention and Exhibition Centre March ... on Wednesday, March 11, at 11 am (Melbourne ... Emotions and Interests,” will discuss making each customer’s ...
(Date:3/3/2015)... Mercy Health (formerly Catholic Health Partners) – a Catholic healthcare ... of its monthly Mercy Health: Helping You Be Well videos ... disorders in the United States, affecting an estimated 16 million ... Mercy Health’s YouTube channel , Mercy Health experts explain ... you can help someone with the illness get the help ...
(Date:3/3/2015)... 2015 After the holiday season, many ... fitness and exercise. Community Health Center of Snohomish County ... ways that families in Everett, Marysville, and the entire ... , CHC says, “While it’s relatively simple to ... veggies, many families wonder how to keep exercise fun ...
(Date:3/3/2015)... T-System Inc. today announced ... CPHQ, FABC as the company’s chief nursing officer along ... episodic care. , “Today’s patients are demanding ... including urgent care and freestanding emergency centers one of ... Davis, T-System’s chief executive officer. “We have a ...
Breaking Medicine News(10 mins):Health News:Raritan Bay Medical Center Announces Winners of “Picture of Health” Photo Contest 2Health News:South Florida-based PureFormulas will discuss personalization at ecommerce Conference and Expo in Melbourne, Australia 2Health News:New Videos Tackle Widespread Problem of Depression 2Health News:6 Wintertime Weight Loss Tips for Family Fitness Presented by Community Health Center of Snohomish County in Recent Article 2Health News:T-System Renews Commitment to Clinically-Driven Innovation and Appoints Industry Leader as CNO 2Health News:T-System Renews Commitment to Clinically-Driven Innovation and Appoints Industry Leader as CNO 3
... June 30 The California Center for Cardiothoracic ... with cutting edge heart operations. For patients facing cardiac issues, ... Due to the delicate nature of cardiothoracic surgeries ... the field is critical to a successful surgical outcome, which ...
... Denver Zoo and HealthONE,s Rocky Mountain ... mascot, Jack, the Rocky Mountain river otter. Jack, named after ... new pediatric hospital. , , (Photo: ... and neonatal surgeon, retired from active medical practice, was among ...
... engage and motivate their patients with the goal of ... Roche, the maker of ACCU-CHEK blood glucose monitoring ... of its Behavior Change through Patient Engagement (sm) program. ... fights the growing epidemic of diabetes by improving dialogue ...
... premiums, greater peace of mind , , PHILADELPHIA, June ... finding themselves in a serious predicament: less than 20 percent ... employment offers, according to the National Association of Colleges and ... , , As a result, many recent grads are ...
... Calif., June 30 Dr. Andrew Ordon, co-host of the ... the latest in thermage treatments, a non-invasive skin contouring procedure, ... Mirage. , , "Thermage is the perfect option for ... to go under the knife," explains Ordon. "There is little ...
... President and CEO Bergman to depart effective July 3; Board member ... , , CHICAGO, June 30 Janet Anixter, chairperson of ... I. Bergman, Anixter Center president and CEO, announced today that Bergman ... served in this role since his appointment following a national search ...
Cached Medicine News:Health News:Specialized California Medical Center (Heart411.com) Offers Top-Notch Cardiothoracic Surgery 2Health News:Rocky Mountain Hospital for Children & Denver Zoo Announce Mascot Contest Winner 2Health News:Rocky Mountain Hospital for Children & Denver Zoo Announce Mascot Contest Winner 3Health News:Roche Diabetes Care Announces Unique Coaching Program for Diabetes Educators as Part of Long-Term Commitment to Fight the Disease 2Health News:Roche Diabetes Care Announces Unique Coaching Program for Diabetes Educators as Part of Long-Term Commitment to Fight the Disease 3Health News:Graduates Needing Health Insurance Have Cost-Effective Options 2Health News:Graduates Needing Health Insurance Have Cost-Effective Options 3Health News:Anixter Center Announces Leadership Changes 2Health News:Anixter Center Announces Leadership Changes 3
(Date:3/3/2015)... -- - CPhI and P-MEC China 2015 ... Shanghai, China - The 15th ... held at Shanghai New International Expo Center, on 24th June, ... Worldwide and was introduced to China in 2001. It has ... companies and global pharmaceutical industry over the past 15 years. ...
(Date:3/3/2015)... , Mar. 03, 2015 Research and Markets ... Jain PharmaBiotech,s new report "Cardiovascular Drug Delivery - ... , Drug delivery to the cardiovascular system ... the anatomy and physiology of the vascular system; it ... body. Drugs can be introduced into the vascular system ...
(Date:3/3/2015)... , March 3, 2015  HeartIT is pleased ... first Cardiac Magnetic Resonance Solution in the market ... a standard web browser. Precession™ combines zero footprint ... unmatched in the industry. This provides CMR professionals ... the critical functions of a successful CMR program. ...
Breaking Medicine Technology:15th Anniversary, Be Part of Chinese Pharma Dream 215th Anniversary, Be Part of Chinese Pharma Dream 3Global Cardiovascular Drug Delivery Technologies, Markets and Companies 2014-2024 2Global Cardiovascular Drug Delivery Technologies, Markets and Companies 2014-2024 3Precession Advances Medical Imaging by Delivering a Complete Cardiac Magnetic Resonance Platform in a Web Browser 2
... well as humidification, try Flo-Mist™., ,Flo-Mist™, ... continuous medication nebulizer (CMN), engineered to deliver ... ml reservoir and jet flow design allow ... medication delivery at 25 ml/hr. Particles are ...
Nebulizer Custom Kit...
... Innovators in Anesthesia and Respiratory Products, ... quality medical devices for Anesthesia and Respiratory ... manufacture products that enhance the clinician's ability ... close attention to the bottom line. , ...
... nebulizer achieves optimum lung penetration for maximum ... is 1.04-1.10 µ at 6-8 LPM. Latex-free ... ,As the world leader in airway ... assurance of proven technology by offering top ...
Medicine Products: