Navigation Links
Reassuring evidence: Anticancer drug does not accelerate tumor growth after treatment ends
Date:2/7/2013

Studies in animals have raised concerns that tumors may grow faster after the anticancer drug sunitinib is discontinued. But oncologists and physicists who collaborated to analyze data from the largest study of patients with kidney cancer convincingly demonstrate that such tumor acceleration does not occur in humans. The findings, publishing online on February 7th in the Cell Press journal Cell Reports, suggest that sunitinib does not cause lingering risks for patients after their treatment ends.

"We were able to demonstrate that this applied across all patients and that those who had the greatest benefit from the drug while it was administered retained this benefit," says senior author Dr. Tito Fojo, of the National Cancer Institute at the National Institutes of Health.

Sunitinib, which is approved around the world for the treatment of several different cancers, works by targeting proteins on the blood vessels that feed tumors. Animal studies have suggested that treatment with sunitinib may induce changes in tumor vessels or adaptations within tumors themselves that could promote cancer growth and spread.

When Dr. Fojo and his colleagues analyzed more than 10,000 data points from the pivotal randomized phase 3 clinical trial that led to sunitinib's approval, the evidence clearly showed that no matter how long patients took sunitinib, it was not harmful, did not accelerate tumor growth, and did not shorten survival after treatment ended. During treatment, the drug slowed tumor growth and prolonged the patients' survival.

"Last year, I was approached by two patients who had grave concerns about taking sunitinib due to an article conducted in animals. I realized that if clinical data exist that refute basic science, they must be published," recalls Dr. Fojo.

The researchers' findings indicate that sunitinib can benefit patients without altering tumor biology after the drug is stopped. "We hope this can be ge
'/>"/>

Contact: Mary Beth OLeary
moleary@cell.com
617-397-2802
Cell Press
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Potential new technique for anticancer radiotherapy could provide alternative to brachytherapy
2. Taiho Pharmaceutical unveils data on 8 novel anticancer compounds
3. Enzyme accelerates malignant stem cell cloning in chronic myeloid leukemia
4. Fat Loss 4 Idiots: Review Examining New "Accelerated Fat Loss Diet" Released By DietsAndFitnessGuides.com
5. EzW2 Software From Halfpricesoft.com Updated To Accelerate Tax Reporting For Startups
6. Studying marrow, URMC researchers accelerate blood stem cells
7. Topical simvastatin shown to accelerate wound healing in diabetes
8. Concussions and head impacts may accelerate brain aging
9. Accelerated resolution therapy significantly reduces PTSD symptoms, researchers report
10. Higher energies for laser-accelerated particles possible
11. Accelerated radiation treatment effective for noninvasive breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Reassuring evidence: Anticancer drug does not accelerate tumor growth after treatment ends
(Date:5/29/2015)... New England Peptide, Inc. (NEP), ... Tumor Analysis Consortium (CPTAC) and others, today announced ... line of peptide stable isotope standards for biomarker ... labeled tryptic peptides, offers thousands of fragments spanning ... readily accessible to the biomedical research community. ...
(Date:5/28/2015)... 2015 Recently, KORT Richmond, 5006 Atwood Drive, ... their quality of life. The program works with those new ... for years, but are still having difficulty. , According to ... people living with limb loss in the United States. The ... diabetes and peripheral arterial disease – trauma (45%) and cancer ...
(Date:5/28/2015)... May 28, 2015 The partners of ... proud to present Dr. Alicia Almendral as their chief ... big part of the newly opened facility’s plan to ... modern cosmetic treatments. , Dr. Almendral is a board ... latest anti-aging and cosmetic enhancement techniques. Her areas of ...
(Date:5/28/2015)... On Sunday, June 21, 2015, Colorado ... event to honor the strength, passion and endurance of ... the duration of this sunrise-to-sunset event symbolizes the challenging ... caregivers. Participants raise funds and awareness to advance the ... , Teams are encouraged to create their own experience ...
(Date:5/28/2015)... (PRWEB) May 28, 2015 Dr. ... announced an exclusive deal to patients looking to undergo ... 1 through 30, patients will be able to get ... procedure, for just $600. For a three-treatment package, which ... treatment at no cost. , Dr. Juanita Jenyons, M.D., ...
Breaking Medicine News(10 mins):Health News:New England Peptide Announces New Tryptides™ Catalog 2Health News:New England Peptide Announces New Tryptides™ Catalog 3Health News:KORT Richmond Physical Therapy Adds New Program to Help Amputees 2Health News:Bella Diosa Med Spa Welcomes Botox Specialist to Yonkers Community 2Health News:Dr. Jenyons’ Medical Weight Loss & Rejuvenation Center Now Offering Skin Treatment Specials 2Health News:Dr. Jenyons’ Medical Weight Loss & Rejuvenation Center Now Offering Skin Treatment Specials 3
... MinnesotaMINNEAPOLIS, March 12 A new survey released ... majority (72 percent) of Minnesotans support increasing state ... primary reason for their support is that higher ... kids from becoming smokers, and 35 percent cited ...
... 11 Solta Medical, Inc. (Nasdaq: SLTM ), ... that Silicon Valley Bank, a member company of SVB Financial ... with a $9 million credit facility. "We are very ... to pursue our strategic initiatives in the aesthetic marketplace," said ...
... diagnosis simpler for disease than can strike younger adults ... reporting a promising new test for quick diagnosis of ... a leading cause of sudden death in young people. ... in which a genetic flaw causes the muscle cells ...
... Society Institute,s Closing the Addiction Treatment Gap (CATG) today ... the Office of National Drug Control Policy (ONDPC) to ... problem of addiction. Timed with today,s announcement of Seattle ... nation,s "drug czar," the CATG initiative called on the ...
... research into disease afflicting 7.5 million AmericansWASHINGTON, March ... her personal story on Capitol Hill today about ... to support much-needed research and enact legislation to ... with psoriasis at age 2 and throughout my ...
... Just 1 less gram a day could produce dramatic results, study ... just one gram of salt from their daily diet, there would ... 200,000 fewer deaths over a decade, a new study suggests. , ... linked with high blood pressure and heart disease, Americans are using ...
Cached Medicine News:Health News:New Poll: 72 Percent of Minnesotans Support Tobacco Tax Increase 2Health News:New Poll: 72 Percent of Minnesotans Support Tobacco Tax Increase 3Health News:Solta Medical, Inc. Secures $9M Credit Facility from Silicon Valley Bank 2Health News:New Test Seems to Spot Deadly Heart Condition 2Health News:New Test Seems to Spot Deadly Heart Condition 3Health News:Closing the Addiction Treatment Gap Initiative Highlights Opportunities for New 'Drug Czar' 2Health News:LeAnn Rimes Shares Her Personal Struggle With Psoriasis in Nation's Capital 2Health News:LeAnn Rimes Shares Her Personal Struggle With Psoriasis in Nation's Capital 3Health News:LeAnn Rimes Shares Her Personal Struggle With Psoriasis in Nation's Capital 4Health News:Slight Cut in Salt Intake Would Mean Fewer Heart Attacks, Deaths 2Health News:Slight Cut in Salt Intake Would Mean Fewer Heart Attacks, Deaths 3
(Date:5/28/2015)... SOUTH SAN FRANCISCO, Calif. , May 28, 2015 ... today announced the appointment of Ronald A. Martell ... currently serves as a member of the KaloBios Board ... directly with the company,s senior management team to refine ... to a focused monoclonal antibody company developing therapeutics for ...
(Date:5/28/2015)... 28, 2015 Compassion & Choices today is pleased ... bill that would authorize the option of medical aid in ... The legislation, the ... allow mentally competent adults with six months or less to ... to painlessly and peacefully end an unbearable dying process. A ...
(Date:5/28/2015)... MONICA, Calif. , May 28, 2015 ... doctors to check a state prescription database before prescribing ... addiction and thousands of overdose deaths. SB ... Bell Gardens , will require prescribers to ... (CURES) before prescribing Schedule II and III drugs, like ...
Breaking Medicine Technology:KaloBios Appoints Ronald A. Martell Executive Chairman 2KaloBios Appoints Ronald A. Martell Executive Chairman 3KaloBios Appoints Ronald A. Martell Executive Chairman 4KaloBios Appoints Ronald A. Martell Executive Chairman 5California Committee Sends Medical Aid-in-Dying Bill to Senate Floor 2California Committee Sends Medical Aid-in-Dying Bill to Senate Floor 3California Senate Approves Legislation Requiring Physicians To Check State Database Before Prescribing Powerful, Addictive Medications, Says Consumer Watchdog 2
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: