Navigation Links
Quality control mechanism tags defective sperm cells inside the body
Date:1/23/2008

COLUMBIA, Mo. Defective sperm cells do not pass through the body unnoticed. A new University of Missouri study provides evidence that the body recognizes and tags defective sperm cells while they undergo maturation in the epididymis, a sperm storage gland attached to the testis. According to researchers, only the best sperm that have the highest chance of succeeding in fertilization will survive the production process without a tag.

A small protein called ubiquitin marks abnormal sperm cells, including cells that have two heads, two tails or are otherwise misshaped. This recycling tag on the sperm cell tells the body which cells need to be broken back down into amino acids. This provides evidence that there is an active removal process or marking of defective sperm during the epididymal passage.

Fertilization is, in a way, a numbers game, said Peter Sutovsky, associate professor of animal sciences, clinical obstetrics and gynecology in the MU College of Agriculture, Food and Natural Resources. You need a certain number of normal sperm cells to reach the egg. If too many are tagged with ubiquitin, there may be not enough to fertilize an egg.

This study suggests that the male reproductive system must be able to evaluate and control the quality of the sperm to insure an optimal chance of fertilization. High levels of ubiquitin in the sperm can indicate low-sperm count or infertility. This process of quality control has been found in both humans and other mammals including bulls, boars and rats.

In many cases, the cells that are tagged with ubiquitin are obviously abnormal with two tails or two heads, but many of them look like they dont have defects, Sutovsky said. Oftentimes, these cells may look normal but lack proteins that are important to fertility.

Once sperm cells are tagged as defective, it is unlikely that the process can be reversed. Sutovsky stresses the importance of a healthy lifestyle to reduce the likelihood of abnormal sperm cells. He suggests avoiding exposure to toxic chemicals, abstaining from smoking and maintaining a healthy diet. He suggests people who work with toxins on a daily basis should minimize their exposure by wearing protective clothing and respirators.


'/>"/>

Contact: Jennifer Faddis
FaddisJ@missouri.edu
573-882-6217
University of Missouri-Columbia
Source:Eurekalert

Related medicine news :

1. Governor Rendell Offers Coverage to 29,000 on AdultBasic Waiting List; Unveils New Policy to Improve Quality of Care for the Low-Income and Pennsylvanians With Disabilities
2. National Business Coalition on Health Awards Grants to 14 Coalitions for Diabetes Quality Programs
3. States Patient Safety Report a Valuable Tool For Hospitals Quality Improvement Work
4. Virginia Cares Uninsured Program (VCUP) Announces Early Successes in Helping Uninsured Virginians Access Quality Healthcare
5. Anyone can save a life: Penn researchers lead national efforts to improve CPR quality
6. Heavy metal slips down UK air quality charts
7. Integrating Quality into Business Systems for High Performance, Complimentary Excerpt Available from Best Practices, LLC
8. Michigan Quality Council (MQC) Names Oakwood Healthcare Inc. 2007 State Quality Award Recipient
9. Tonsillectomy significantly improves quality of life in adult and pediatric patients
10. Michigan Quality Council (MQC) Names Henry Ford Health System 2007 State Quality Award Recipient
11. New Web Site Opens Window on Charges, Payments, Quality of Care at Michigan Hospitals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2017)... ... ... From June 20-22, EarQ and Widex held an exclusive training event ... is headquartered. , Together, the organizations educate hearing care professionals on how to ... latest in hearing technology. At the event, EarQ members got an in-depth look ...
(Date:6/27/2017)... ... June 27, 2017 , ... PR ... an upcoming case studies guidebook. This guidebook offers an excellent branding and exposure ... include articles, case studies and how-to’s that fall into the following categories:, ...
(Date:6/27/2017)... ... June 27, 2017 , ... Hammer Strength, the world’s leading performance strength training ... of the Houston Rockets the NBSCA Strength & Conditioning Coach of the Year. ... members who vote to select the coach who embodies the highest level of excellence ...
(Date:6/27/2017)... ... June 27, 2017 , ... Children’s National Health System received top honors in ... program ranking #1 out of more than 1500 neonatal intensive care units coast ... Roll, a distinction given to the top performing children’s hospitals in the country. ...
(Date:6/26/2017)... ... 26, 2017 , ... The Centers for Advanced Orthopaedics (The ... Richard Robinson as chief operating officer (COO). In this role, Robinson brings more ... record of simplifying business processes and developing growth strategies to increase market share. ...
Breaking Medicine News(10 mins):
(Date:5/26/2017)... 2017  Endo International plc (NASDAQ: ENDP ) ... will represent the Company in a fireside chat at Goldman ... June 13, 2017 at 10:40 a.m. PT / 1:40 p.m. ... Rancho Palos Verdes, CA. ... be available on the Company,s website at http://www.endo.com/investors/overview . ...
(Date:5/23/2017)... , May 23, 2017  Leaf Healthcare, ... innovative medical devices for pressure ulcer prevention, will ... American Association of Critical Care Nurses, National Teaching ... 22-25. The Leaf Patient Monitoring System ... for the hospital environment.  The system seamlessly tracks ...
(Date:5/18/2017)...  Two Bayer U.S. Pharmaceutical leaders received top awards ... 28 th Woman of the Year ... longstanding mission of furthering the advancement and impact of ... Cindy Powell-Steffen , senior director of brand activation and ... Libby Howe , a regional business manager for New ...
Breaking Medicine Technology: