Navigation Links
Prickly protein
Date:2/6/2014

A genetic mechanism that controls the production of a large spike-like protein on the surface of Staphylococcus aureus (staph) bacteria alters the ability of the bacteria to form clumps and to cause disease, according to a new University of Iowa study.

The new study is the first to link this genetic mechanism to the production of the giant surface protein and to clumping behavior in bacteria. It is also the first time that clumping behavior has been associated with endocarditis, a serious infection of heart valves that kills 20,000 Americans each year. The findings were published in the Dec. 2103 issue of the journal PLOS Pathogens.

Under normal conditions, staph bacteria interact with proteins in human blood to form aggregates, or clumps. This clumping behavior has been associated with pathogenesis -- the ability of bacteria to cause disease. However, the mechanisms that control clumping are not well understood.

In the process of investigating how staph bacteria regulate cell-to-cell interactions, researchers at the UI Carver College of Medicine discovered a mutant strain of staph that does not clump at all in the presence of blood proteins.

Further investigation revealed that the clumping defect is due to disruption of a genetic signaling mechanism used by bacteria to sense and respond to their environment. The study shows that when the mechanism is disrupted, the giant surface protein is overproduced -- giving the cells a spiny, or "porcupine-like" appearance -- and the bacteria lose their ability to form clumps.

Importantly, the researchers led by Alexander Horswill, PhD, associate professor of microbiology, found that this clumping defect also makes the bacteria less dangerous in an experimental model of the serious staph infection, endocarditis.

Specifically, the team showed that wild type bacteria cause much larger vegetations (aggregates of bacteria) on the heart valves and are mor
'/>"/>

Contact: Jennifer Brown
jennifer-l-brown@uiowa.edu
319-356-7124
University of Iowa Health Care
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. NIH scientists find mechanism that helps HIV evade antibodies, stabilize key proteins
2. Critical protein discovered for healthy cell growth in mammals
3. Researchers find changes to protein SirT1
4. 2 proteins compete for 1 port on a growth factor; 1 promotes metastasis, the other blocks it
5. NCCS scientists discover gene regulation is dependent on protein ANP32E
6. Better protein capture a boon for drug manufacturers
7. Homemade Protein Bar Recipe Looks to Cut Out Extra Additives from Health Foods, Believes Carol Newman of The BioGirl Health Show
8. New NuGo Stronger: First Non-GMO High Protein Bar with rBGH-Free Whey Protein for Serious Athletes
9. Tricky protein may help HIV vaccine development
10. Research shows molecular, protein targeting therapies may be best treatment for certain lung cancer
11. Rock And Rho: Proteins that help cancer cells groove
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Prickly protein
(Date:1/22/2015)... Oceanside,CA (PRWEB) January 22, 2015 For over 20 ... the Oceanside and Vista area has treated just about ... other personal injury circumstances. And for those same twenty-plus years, ... victims of all those injuries with the best possible doctor. ...
(Date:1/22/2015)... 22, 2015 Yesterday, Senator Holly ... and Kristin Olsen (R-Modesto) were honored by the ... advancing biotechnology, biomedical science, medical device and pharmaceutical ... received the “2014 Life Sciences Champion” award from ...
(Date:1/22/2015)... Payday lending practices in four southern states ... distress to the states that permit them, according to ... on Race and Wealth. , While they generate hundreds ... at the same time substantially depress economic activity, according ...
(Date:1/22/2015)... released a new blog post presenting a list of vehicles that ... , Some types of vehicles cannot be covered under an ordinary ... to see if their vehicle qualifies for auto insurance coverage. ... cars that cannot be covered by a plan. Clients have little ...
(Date:12/26/2014)... 2014 The US represents the largest market ... 2013, GlobalData’s forecast estimates that sales of branded therapies were ... to the high incidence of the disease, high drug treatment ... and China. Increased sales of CRC therapies over the forecast ...
Breaking Medicine News(10 mins):Health News:Industry Leading Chiropractor in Oceanside Joins the Doctors on Liens Network 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 3Health News:Howard University Spotlights the Economic Impact of Payday Lending in Southern States 2Health News:Some Vehicles Cannot Be Covered By An Auto Insurance Policy! 2Health News:US Colorectal Cancer Drug Market Analysis and Forecast to 2023 Report Available at ReportsnReports.com 2Health News:US Colorectal Cancer Drug Market Analysis and Forecast to 2023 Report Available at ReportsnReports.com 3Health News:US Colorectal Cancer Drug Market Analysis and Forecast to 2023 Report Available at ReportsnReports.com 4
... For those living with aphasia, autism, and other conditions that ... be a challenge. MyVoice, a mobile app and server system ... these conditions a voice by simply tapping words and pictures ... about the fear and isolation they sometimes feel because they ...
... By Alan Mozes HealthDay Reporter , ... determine how much caffeine one craves, new research indicates, ... consume more -- or less -- of the world,s ... who carry a so-called "high-consumption" variation of either gene ...
... In a large multi-center clinical trial, a new PSA ... men with prostate cancer -- particularly the aggressive form ... compared to the two,currently available commercial PSA tests, according ... only currently available Food and Drug Administration-approved screening tests ...
... Hoboken, NJ, April 6, 2011On Thursday, March 31, John ... Wiley Psychology Roundtable focused on developmental psychology, entitled Putting ... 2011 Society for Research and Child Development Biennial Meeting ... and methods of making research in developmental psychology more ...
... News) -- Poor children with autism are less likely than ... has decreased in recent years, according to a new study. ... that the average age of autism diagnosis fell from 5.9 ... those born in 2000. Of the 4,906,926 children born ...
... in French . , Montreal, April 6, 2011 ... The Middle East and North Africa face unprecedented change as ... it remains unclear whether these nations will experience more equity ... that require monumental thought. "What the world needs now, especially ...
Cached Medicine News:Health News:New mobile app gives a voice to those with communications challenges 2Health News:Coffee Addiction May Be Grounded in Genes 2Health News:Coffee Addiction May Be Grounded in Genes 3Health News:New prostate cancer test gives more accurate diagnosis 2Health News:Wiley hosts developmental psychology roundtable at SRCD 2Health News:Autism Diagnoses Still More Likely in Richer Neighborhoods 2Health News:What the world needs now? More wisdom 2Health News:What the world needs now? More wisdom 3
(Date:1/23/2015)... , Jan. 23, 2015 Tianyin Pharmaceutical Inc. ... that specializes in the development and sale of patented ... and active pharmaceutical ingredients (API) today announced the business ... API operation. 1. Following the September 2014 ...
(Date:1/22/2015)... Jan. 22, 2015  Uroplasty, Inc. (NASDAQ: UPI ), ... innovative proprietary products to treat voiding dysfunctions, today reported ... 31, 2014.  Global revenue for the Company,s ... million, a new quarterly revenue record, as compared to ...
(Date:1/22/2015)... , Jan. 22, 2015  Amgen (NASDAQ: AMGN ) today ... 2014 financial results on Tuesday, Jan. 27, 2015, after the close ... a conference call with the investment community at 2 p.m. PT. ... Bradway , chairman and chief executive officer, and other members of ...
Breaking Medicine Technology:TPI's JCM Updates on Import Registration for International Clients 2TPI's JCM Updates on Import Registration for International Clients 3TPI's JCM Updates on Import Registration for International Clients 4Uroplasty Reports Record Revenue in Fiscal Third Quarter 2Uroplasty Reports Record Revenue in Fiscal Third Quarter 3Uroplasty Reports Record Revenue in Fiscal Third Quarter 4Uroplasty Reports Record Revenue in Fiscal Third Quarter 5Uroplasty Reports Record Revenue in Fiscal Third Quarter 6Uroplasty Reports Record Revenue in Fiscal Third Quarter 7Uroplasty Reports Record Revenue in Fiscal Third Quarter 8Uroplasty Reports Record Revenue in Fiscal Third Quarter 9Uroplasty Reports Record Revenue in Fiscal Third Quarter 10Uroplasty Reports Record Revenue in Fiscal Third Quarter 11Uroplasty Reports Record Revenue in Fiscal Third Quarter 12Uroplasty Reports Record Revenue in Fiscal Third Quarter 13Uroplasty Reports Record Revenue in Fiscal Third Quarter 14Uroplasty Reports Record Revenue in Fiscal Third Quarter 15Uroplasty Reports Record Revenue in Fiscal Third Quarter 16Uroplasty Reports Record Revenue in Fiscal Third Quarter 17Uroplasty Reports Record Revenue in Fiscal Third Quarter 18Amgen Announces Webcast of 2014 Fourth Quarter and Full Year Financial Results 2
... 2011 Omnicell, Inc . (NASDAQ: ... management solutions to healthcare facilities, today announced its fourth ... advance medication and supply automation management. The new platform ... medications maintained in automated dispensing cabinets with a new ...
... HealthWarehouse.com, Inc. (ticker: HEWA) a leading VIPPS-accredited, ... President and CEO, will present at RetailInvestorConferences.com. Company ... virtual conference.DATE: , May 5, 2011TIME: ... the red "register/ watch event now" button.This will ...
Cached Medicine Technology:Omnicell Unveils Largest Ever Medication and Supply Automation Product Launch: the G4 Platform 2Omnicell Unveils Largest Ever Medication and Supply Automation Product Launch: the G4 Platform 3Omnicell Unveils Largest Ever Medication and Supply Automation Product Launch: the G4 Platform 4Omnicell Unveils Largest Ever Medication and Supply Automation Product Launch: the G4 Platform 5Omnicell Unveils Largest Ever Medication and Supply Automation Product Launch: the G4 Platform 6HealthWarehouse.com, Inc. to Present Live at RetailInvestorConferences.com on May 5th 2
... and ETS-FLEX45 Endoscopic Linear Cutters provide a ... shaft length makes the device suitable for ... are intended for transection, resection, and/or creation ... invasive surgical procedures., ,The LONG45A Endocutter ...
ENDO CLIP II ML, 10 mm Pistol Grip Single Use Clip Applier with Medium - Large Super Interlock Titanium Clips...
... is designed with opposing male/female interlocking features. ... and improved hemostasis., ,By comparison, The ... percent greater angle allowing for maximum visibility ... ELC has an automatic, direct drive clip ...
Pilling-Weck, medium clip size, 10mm, rotatable take apart...
Medicine Products: