Navigation Links
Prenatal exposure to common household chemical increases risk for childhood eczema, study says
Date:6/25/2012

Prenatal exposure to a ubiquitous household chemical called butylbenzyl phthalate (BBzP) can increase a child's risk for developing eczema, according to research conducted at the Columbia Center for Children's Environmental Health at the Mailman School of Public Health.

Widely used in vinyl flooring, artificial leather and other materials, BBzB can be slowly released into air in homes.

Details are published in the advance online edition of Environmental Health Perspectives, a journal of the National Institute of Environmental Health Sciences.

Eczema, which is characterized by dry, itchy red skin on the face, scalp, or extremities, is common in early childhood. "While hereditary factors, allergens, and exposure to tobacco smoke are known to contribute to the condition, our study is the first to show that prenatal exposure to BBzB is a risk factor," says Allan C. Just, PhD, first author on the Mailman School study and currently a postdoctoral researcher at the Harvard School of Public Health.

The study looked at 407 nonsmoking African-American and Dominican women and their children in New York City. Exposure to BBzB was measured through a urine test during the third trimester of pregnancy. Following birth, the mothers were asked if their child had been diagnosed with eczema. The result: onset of eczema by age 2 was 52 percent more likely in children whose mothers had been exposed to higher concentrations of BBzP, compared with those whose mothers had been exposed to lower concentrations. All but one of the women in the study showed some level of exposure to the chemical.

How BBzP might induce eczema remains murky. To explore that question, the researchers looked at allergies as a possible mechanism. Children were tested for three common indoor allergens: cockroaches, dust mites, and mice, as well as for total IgE, a biomarker for an immune response to all allergens. But they found no evidence of a link between BBzP exposure and allergy.

"We know allergies are a factor with some childhood eczema, but our data suggest that is not the case when BBzP is involved," says senior author Rachel Miller, MD, Director of the Allergy and Immunology fellowship program and Associate Professor of Medicine (in Pediatrics) and Environmental Health Sciences, NewYork-Presbyterian Hospital/Columbia University Medical Center; and a Co-Deputy Director of the Columbia Center for Children's Environmental Health. "However, these are important findings, given that eczema is a common and uncomfortable disease of early childhood."

The researchers also found that while African-American mothers in the study were twice as likely as their Dominican-American counterparts to report that their child had been diagnosed with eczema, both groups had a similar association between BBzP exposure and the disease.

Previous research by study co-author Robin M. Whyatt, DrPH, Professor of Clinical Environmental Health Sciences and Co-Deputy Director of the Columbia Center for Children's Environmental Health, found that exposure to BBzP and other phthalates was shown to delay motor skill development in young children and to increase risk for behavioral problems. Phthalates are also known to disrupt the body's endocrine system.


'/>"/>
Contact: Timothy S. Paul
tp2111@columbia.edu
212-305-2676
Columbia University's Mailman School of Public Health
Source:Eurekalert

Related medicine news :

1. Prenatal exposure to pollution especially dangerous for children with asthma
2. Antibody therapy prevents gastrointestinal damage following radiation exposure in mice
3. Genetic variants, tobacco exposure and lung cancer risk
4. Leaded Gas Exposure Linked to Later Violence: Study
5. Majority of states fail to address youth exposure to alcohol marketing
6. Novel biomarkers reveal evidence of radiation exposure
7. Education May Protect Brain From Exposure to Solvents
8. Taking Anti-HIV Meds Prior to Exposure May Help Prevent Infection
9. New research showing how real-life exposure to violence disrupts a childs sleep habits
10. BPA exposure effects may last for generations
11. How MyTownInsurance.com Helps Insurance Carriers Manage their Loss Exposure through On-Line Marketing
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/19/2017)... ... ... WhoHaha , a digital media company dedicated to creating and delivering female-centric, ... three-part video series that uses humor to highlight ways to improve heart health and ... For Good™ movement, which is designed to inspire all Americans to make small changes ...
(Date:1/19/2017)... ... January 19, 2017 , ... Cosmetic Town, an online plastic ... in order to make it easier for their readers to get the information they ... impact as well as the techniques used on those particular areas. , “We are ...
(Date:1/19/2017)... N.J. (PRWEB) , ... January 19, 2017 , ... ... delivery technologies and development solutions for drugs, biologics and consumer health products, today ... with Lipids,” with Gattefossé, the leader in innovative excipients and drug delivery solutions ...
(Date:1/19/2017)... ... January 19, 2017 , ... ... provided a new $11,250,000 senior credit facility to Sunrise, Florida-based Management Health Systems, ... were used to facilitate a recapitalization of MedPro led by Harren Equity Partners. ...
(Date:1/19/2017)... ... 19, 2017 , ... In 2009, Carol Bryan endured immense ... severe facial disfiguration. After four frightening years of isolation and emotional and physical ... who removed the substances in a partial facial transplant through eight surgeries. ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... Jan. 18, 2017 The Global Therapy Partnering ... access to partnering deals and agreements entered into by ... partnering deals - Top deals by value - Deals ... technology type The report provides understanding and access ... the world,s leading healthcare companies. The report provides ...
(Date:1/19/2017)... , Jan. 18, 2017   Synthetic Biologics, ... company developing therapeutics designed to preserve the microbiome ... today confirmed plans to initiate a Phase 2b/3 ... reformulation of lovastatin lactone designed to reduce methane ... in the gut to treat the underlying cause ...
(Date:1/19/2017)... 2017 The Academy of Managed Care ... (FDA) for its release today of draft guidance ... makers can proactively share clinical and economic information ... emerging therapies awaiting FDA approval. ... AMCP developed during two multi-stakeholder meetings last year ...
Breaking Medicine Technology: