Navigation Links
Powerful free radical causes lung damage from oxygen therapy
Date:10/5/2010

AUGUSTA, Ga. The most toxic free radical appears responsible for much of the lung damage that can result from oxygen therapy in the critically ill or injured, Medical College of Georgia researchers report.

Within just a few days, ventilators and oxygen chambers used to significantly increase oxygen levels can also dramatically increase levels of peroxynitrite, an oxidant powerful enough to break down DNA and cause proteins to malfunction, said Dr. Yunchao Su, pharmacologist in the MCG Schools of Medicine and Graduate Studies.

Oxygen toxicity is the most severe side effect of oxygen therapy in newborns and adults. The lungs take the brunt of the damage, which can include inflammation, hemorrhaging and swelling that may result in death or chronic lung problems, said Su, corresponding author of the study published in the Journal of Biological Chemistry.

"We knew it was bad but we did not know why," Su said. The good news is they may also have a solution.

Researchers found that within five days, mice placed in small oxygen chambers that mimic oxygen levels given in intensive care have dramatically elevated levels of peroxynitrite in their lungs. Free radicals, such as peroxynitrite, result from oxygen use and are safe at low levels. While it's a given that oxygen therapy produces free radicals, the significant increase in peroxynitrite was not known.

The trouble begins when high oxygen levels prompt endothelial cells that line blood vessels and tiny airs sacs in the lung to make more nitric oxide, the precursor of peroxynitrite. At high levels, nitric oxide, most often a helpful compound, combines with other free radicals produced by excess oxygen use to form the powerful peroxynitrite. "As oxygen levels increase, nitric oxide levels increase and so peroxynitrite levels do as well," Su said.

But he appears to have identified a break point in the destructive cycle. Su found that in the face of high oxygen levels, the enzyme tha
'/>"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Breaching the blood-brain barrier to create powerful new tools for fighting cancer
2. doeLegal and Zapproved Sign Alliance to Add Legal Hold Pro to Suite of Powerful Online Legal Solutions
3. New Book Reveals the Powerful and Undermining Impact of Stress on Good Decision Making and What Leaders Can Do About It
4. Powerful People Often Too Optimistic About Task Time
5. Adapting to clogged airways makes common pathogen resist powerful drugs
6. American Council on Exercise (ACE) Study Reveals Kettlebells Provide Powerful Workout in Short Amount of Time
7. Plant compound resveratrol shown to suppresses inflammation, free radicals in humans
8. Lumenis Announced Today it is Sponsoring the Endometriosis Foundation of America's Symposium 'Advancing the Art and Science of Endometriosis: Stem Cells to Radical Excision Surgery'
9. Henry Ford Health System goes radical: Creating the hospital of the future
10. Cigarette smoke causes harmful changes in the lungs even at the lowest levels
11. Scientists closer to finding what causes the birth of a fat cell
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Powerful free radical causes lung damage from oxygen therapy
(Date:9/16/2014)... Triad Semiconductor, Inc. today announced that David ... former President of Linear Technology Corporation was appointed to ... technology and business expertise, and we are delighted that ... Hayden, Triad CEO and chairman. , Mr. Bell brings ... semiconductor experience to Triad's board. From 2008 to 2012, ...
(Date:9/16/2014)... The Fertility Centers of New England is ... The collaboration will give patients access to high-quality frozen ... the Fertility Centers of New England. , Fairfax Egg ... largest selection of frozen donor eggs. Access to frozen ... , The Donor is already screened and her ...
(Date:9/16/2014)... BamboofloorChina.com, a famous online supplier of bamboo products, has ... bamboo panels . The firm is now offering big ... high quality items. Please note that the big sale ... , According to the company’s chief executive officer, ... visit BamboofloorChina.com before September 28. BamboofloorChina.com is offering more ...
(Date:9/15/2014)... September 16, 2014 With the variety ... is difficult to know the details on each one. ... the potential substances falling into their teen’s hands. ... marijuana itself among high school students. With varied, misleading ... and elsewhere, it can be difficult for parents to ...
(Date:9/15/2014)... Hastings and Hastings, an experienced and established ... flat attorney fee for personal injury cases. The firm ... portion possible of their settlement or recovery as a ... personal property. In addition, Hastings and Hastings makes an ... that no fees are due unless a settlement or ...
Breaking Medicine News(10 mins):Health News:David Bell Joins Triad Semiconductor's Board of Directors 2Health News:FCNE Announces Partnership with Fairfax Egg Bank 2Health News:Cheap Bamboo Panels Unveiled By Famous Online Supplier BamboofloorChina.com 2Health News:Teen Rehab Center CEO Releases Top 4 Facts Parents Must Know About Synthetic Marijuana 2Health News:Teen Rehab Center CEO Releases Top 4 Facts Parents Must Know About Synthetic Marijuana 3Health News:Hastings And Hastings Announces One Flat Attorney Fee For Personal Injury Cases 2Health News:Hastings And Hastings Announces One Flat Attorney Fee For Personal Injury Cases 3
... is a potentially debilitating childhood disease. Early detection ... term joint damage and disability. Research has shown ... assessments in joint activity and sub-clinical disease, according ... Roentgen Ray Society,s annual meeting. The study, performed ...
... HealthDay Reporter , WEDNESDAY, May 4 (HealthDay News) -- ... prescribed inhaled steroids, British researchers found that the oral ... The oral medications, known as leukotriene-receptor antagonists, "have shown ... be considered for any patient, not as a last ...
... May 4 (HealthDay News) -- A gene essential to cardiac ... defects that cause a major proportion of childhood death from ... defects -- all malformations of the left ventricular outflow tract ... may play a role. "It is estimated that there ...
... LOUIS and DES MOINES, Iowa, May 4, 2011 The ... $4 million grant from the Howard G. Buffett Foundation to ... The grant will help fund the completion of the development ... Africans who depend upon sorghum as their staple diet. ...
... for cancer during childhood have an increased risk ... according to a new study in Gastroenterology ... Association (AGA) Institute. Compared with their siblings, cancer ... of the upper GI tract, lower GI tract ...
... 4 (HealthDay News) -- Vigorous exercise offers more of ... study finds. U.K. researchers compared 11 sedentary people ... assessed before, during, immediately following, and 20 minutes after ... more negative during and immediately after high-intensity exercise, compared ...
Cached Medicine News:Health News:Sonography complements physical exam in identifying juvenile inflammatory arthritis in children 2Health News:Asthma Pills Work as Well as Inhaled Steroids: Study 2Health News:Asthma Pills Work as Well as Inhaled Steroids: Study 3Health News:New Gene Linked to Congenital Heart Defects 2Health News:Grant funds next phase in bringing healthier sorghum closer to underserved communities 2Health News:Childhood cancer survivors are at increased risk for ongoing post-therapy GI complications 2
(Date:9/15/2014)... 2014 /PRNewswire-iReach/ -- "Spain Aesthetic Lasers and Energy ... data on the Spain Aesthetic Lasers and Energy ... of US dollars, volume (in units) and average ... Body Contouring Devices (Laser-Assisted Liposuction (LAL) Devices (Nd:YAG ... Ultrasound-Assisted Liposuction (UAL) Devices and Power Assisted Liposuction ...
(Date:9/15/2014)... /PRNewswire-iReach/ -- On September 8, 2014, Dr. ... a Citizen Petition to Dr. Margaret Hamburg ... another Black Box Warning to Levaquin, Cipro, and ... a Black Box Warning for the following psychiatric ... or acts, loss of consciousness, delirium, depressed level ...
(Date:9/15/2014)... BRUSSELS , Sept. 15, 2014 ... Brussels:UCB) today announced results from several exploratory analyses of ... with low bone mineral density (BMD). Romosozumab is an ... inhibiting the protein sclerostin, thereby increasing bone formation and ... American Society for Bone and Mineral Research (ASBMR) 2014 ...
Breaking Medicine Technology:Spain Aesthetic Lasers and Energy Devices Market (LAL, RFAL, PAL, HIFU) Outlook to 2020 2Spain Aesthetic Lasers and Energy Devices Market (LAL, RFAL, PAL, HIFU) Outlook to 2020 3Spain Aesthetic Lasers and Energy Devices Market (LAL, RFAL, PAL, HIFU) Outlook to 2020 4Spain Aesthetic Lasers and Energy Devices Market (LAL, RFAL, PAL, HIFU) Outlook to 2020 5Quinolone Vigilance Foundation Supports Citizen Petition Requesting Another Black Box Warning for Levaquin, Cipro, Avelox 2Quinolone Vigilance Foundation Supports Citizen Petition Requesting Another Black Box Warning for Levaquin, Cipro, Avelox 3New Analyses Of Phase 2 Study Presented At ASBMR Show Romosozumab Treatment Resulted In Continued Increases In Bone Mineral Density 2New Analyses Of Phase 2 Study Presented At ASBMR Show Romosozumab Treatment Resulted In Continued Increases In Bone Mineral Density 3New Analyses Of Phase 2 Study Presented At ASBMR Show Romosozumab Treatment Resulted In Continued Increases In Bone Mineral Density 4New Analyses Of Phase 2 Study Presented At ASBMR Show Romosozumab Treatment Resulted In Continued Increases In Bone Mineral Density 5New Analyses Of Phase 2 Study Presented At ASBMR Show Romosozumab Treatment Resulted In Continued Increases In Bone Mineral Density 6New Analyses Of Phase 2 Study Presented At ASBMR Show Romosozumab Treatment Resulted In Continued Increases In Bone Mineral Density 7New Analyses Of Phase 2 Study Presented At ASBMR Show Romosozumab Treatment Resulted In Continued Increases In Bone Mineral Density 8New Analyses Of Phase 2 Study Presented At ASBMR Show Romosozumab Treatment Resulted In Continued Increases In Bone Mineral Density 9New Analyses Of Phase 2 Study Presented At ASBMR Show Romosozumab Treatment Resulted In Continued Increases In Bone Mineral Density 10New Analyses Of Phase 2 Study Presented At ASBMR Show Romosozumab Treatment Resulted In Continued Increases In Bone Mineral Density 11New Analyses Of Phase 2 Study Presented At ASBMR Show Romosozumab Treatment Resulted In Continued Increases In Bone Mineral Density 12New Analyses Of Phase 2 Study Presented At ASBMR Show Romosozumab Treatment Resulted In Continued Increases In Bone Mineral Density 13New Analyses Of Phase 2 Study Presented At ASBMR Show Romosozumab Treatment Resulted In Continued Increases In Bone Mineral Density 14New Analyses Of Phase 2 Study Presented At ASBMR Show Romosozumab Treatment Resulted In Continued Increases In Bone Mineral Density 15
... Laboratories Platelia Aspergillus EIA is a one-stage ... monoclonal antibody EBA-2 to detect circulating galactomannan ... 3 hours. , ,When used in conjunction ... is an aid in the diagnosis of ...
... The GreenLight PV Laser System ... the Prostate) Procedure for the ... (BPH) allows the urologist to ... a TURP with the safety ...
... diagnosis is generally confirmed by a positive heterophil ... however, is not indicated by the heterophil antibody ... - 20 percent of children. Detection and ... fully ascertain the stage of EBV infection. ...
... Bard® Biopsy Instrument and Needle is specially ... goal: a large quality, reliable core sample. ... featuring ultra-sharp tips and polished surfaces for ... of biopsy systems and needle sizes assures ...
Medicine Products: