Navigation Links
Potential new drug for some patients with treatment-resistant lung cancer
Date:10/20/2013

BOSTON The investigational drug AZD9291, a third-generation EGFR inhibitor, showed promise in preclinical studies and provides hope for patients with advanced lung cancers that have become resistant to existing EGFR inhibitors, according to results presented here at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, held Oct. 19-23.

Mutations in the growth factor gene EGFR are present in about 10 to 15 percent of patients with the most common form of lung cancer, non-small cell lung cancer (NSCLC). Most NSCLCs harboring these EGFR mutations, called activating mutations, respond to the EGFR inhibitor drugs erlotinib and gefitinib. A majority of such cancers, however, develop resistance to these drugs within about nine to 11 months. In many cases, this is due to the cancer cells acquiring a second mutation called EGFR T790M, also known as the "resistance mutation."

"There are no approved therapies to treat lung cancer patients who develop the second mutation in the EGFR that stops the currently available medicines from working," said Susan Galbraith, M.D., Ph.D., head of the Oncology Innovative Medicines Unit at AstraZeneca. "The innovative breakthrough was finding a series of molecules that could target both the activating and resistance mutant forms of EGFR more potently than normal EGFR, which led to development of the new EGFR kinase inhibitor, AZD9291.

"AZD9291 is highly active in preclinical models and is well tolerated in animal models. It inhibits both activating and resistant EGFR mutations while sparing the normal form of EGFR that is present in normal skin and gut cells, thereby reducing the side effects encountered with currently available medicines," she added.

The AstraZeneca scientists first showed that AZD9291 potently inhibited lung cancer cells with mutant EGFR, grown in lab dishes. They then tested the drug on mice bearing lung tumors with activating mutations and mice bea
'/>"/>

Contact: Lauren Riley
lauren.riley@aacr.org
215-446-7155
American Association for Cancer Research
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Study identifies potential treatment for lethal childhood leukemia
2. McMaster researchers find potential for new uses of old drug
3. Army researcher develops potential vaccine carrier
4. UNC study shows potential to revive abandoned cancer drug by nanoparticle drug delivery
5. New study of NIH funding allocations suggests potential efficiency gains
6. A closer look at PARP-1 reveals potential new drug targets
7. Hybrid vaccine demonstrates potential to prevent breast cancer recurrence
8. VCU Massey Cancer Center sees potential in novel leukemia treatment
9. Misuse of over-the-counter pain medication is potential health threat
10. Mutations in JAK3 gene identified in subtype of lymphoma provide potential drug target
11. Bioinformatics experts at the CNIO explore additional coding potential hidden in the human genome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/2/2015)... , ... July 02, 2015 ... ... janitorial supply company , announced today that it has reached an ... acquisition will make CleanItSupply.com the largest distributor of Rubbermaid Commercial Products on ...
(Date:7/2/2015)... ... 02, 2015 , ... Breakthrough technologies are now available in ... Kalika, founder of New York Dynamic Neuromuscular Rehabilitation & Physical Therapy Clinic ... of back, hip, knee and shoulder pain as well as sports injury disorders, ...
(Date:7/2/2015)... ... July 02, 2015 , ... ... for Domestic Preparedness (CDP) in Anniston for specialized disaster training. The team – ... individuals from the Southern California Hospital Association who attended the training, which is ...
(Date:7/2/2015)... Kan. (PRWEB) , ... July 02, 2015 , ... ... dedicated exclusively to healthcare providers, has been retained to lead a national ... of the top executive search firms in the healthcare industry, B. E. Smith ...
(Date:7/2/2015)... ... , ... Throughout the month of April, Casey’s General Stores invited customers to ... July 7, Casey’s General Stores Chairman and CEO, Bob Myers, will present a check ... national nonprofit dedicated to restoring a sense of self, restoring the family unit, and ...
Breaking Medicine News(10 mins):Health News:CleanItSupply.com Acquires eRubbermaid.com 2Health News:Breakthrough Technologies for Carpal Tunnel Treatment in New York City 2Health News:Breakthrough Technologies for Carpal Tunnel Treatment in New York City 3Health News:Breakthrough Technologies for Carpal Tunnel Treatment in New York City 4Health News:Team from Loma Linda University Health Receives Specialized Disaster Training at FEMA’s Center for Domestic Preparedness 2Health News:Team from Loma Linda University Health Receives Specialized Disaster Training at FEMA’s Center for Domestic Preparedness 3Health News:Indiana Blood Center Retains B. E. Smith to Recruit New Chief Executive Officer 2Health News:Indiana Blood Center Retains B. E. Smith to Recruit New Chief Executive Officer 3Health News:Casey’s General Stores to Present Donation from “Dog Tag” Campaign to Hope For The Warriors® 2Health News:Casey’s General Stores to Present Donation from “Dog Tag” Campaign to Hope For The Warriors® 3
... explain the increased cases , FRIDAY, Nov. 6 (HealthDay News) ... people at higher risk of getting a type of thyroid ... related to cancer, but researchers suspect that the toxic compounds ... also unsure of why thyroid cancer rates are rising around ...
... motor skills later, study suggests, , THURSDAY, Nov. 5 ... at birth often go on to have lifetime disabilities, ... prevent problems. , Now, a new study reports that ... in the babies. , Oxygen starvation at birth ...
... Water has designated the week of November 9, 2009 as ... area as part of a national campaign sponsored by public ... pharmaceutical pollution in our source water supplies. , Sacramento County ... , , Household Hazardous Waste ...
... HeartWare International, Inc. (Nasdaq: HTWR ... less invasive, miniaturized circulatory support technologies revolutionizing the treatment ... scheduled to make presentations at two upcoming investor conferences ... at the Third Annual Canaccord Adams Cardiovascular Conference at ...
... ... procedure that allows almost anyone to sustain life in the first critical minutes ... enough to keep vital organs alive until professional rescuers arrive. AED (Automated External ... get to return to a normal heartbeat. AEDs are very accurate and easy ...
... ... Testing Recommendations Are Expected To Become A Law Very Soon For Commercial ... Apnea Lab Testing Could Cost About $2,000 With A Waiting Period Of ... Not Tolerate Standard CPAP Treatment. Dr. Jin Zhou Of SleepApneaUSA.net Proposed An ...
Cached Medicine News:Health News:Thyroid Cancer Higher in Volcanic Areas 2Health News:California American Water Celebrates 'No Drugs Down the Drain' Week in Sacramento 2Health News:HeartWare to Present at Upcoming Investment Conferences in November 2Health News:A New Era of E-Learning in the Comfort and Convenience of Your Home or Office Without the Classroom Environment 2Health News:SleepApneaUSA.net Announced An Immediate Alternative Sleep Apnea Solution In Response To The NTSB's Sleep Apnea Testing Recommendations 2Health News:SleepApneaUSA.net Announced An Immediate Alternative Sleep Apnea Solution In Response To The NTSB's Sleep Apnea Testing Recommendations 3Health News:SleepApneaUSA.net Announced An Immediate Alternative Sleep Apnea Solution In Response To The NTSB's Sleep Apnea Testing Recommendations 4Health News:SleepApneaUSA.net Announced An Immediate Alternative Sleep Apnea Solution In Response To The NTSB's Sleep Apnea Testing Recommendations 5
(Date:7/2/2015)... , and DURHAM, N.C. , ... Inc. today announced its acquisition of assets related to ... PFE ) that had previously been obtained as ... Sciences also acquired all of Pfizer,s rights to the ... Icagen brand and will provide comprehensive services for ion ...
(Date:7/2/2015)... de 2015 BGI anunció hoy que su ... rendimiento en Hong Kong ha ... instalación de BGI en Hong Kong ... generación que recibe la certificación CAP en ... prácticas de laboratorio clínico. Junto con el exitoso proceso ...
(Date:7/2/2015)... -- Research and Markets( http://www.researchandmarkets.com/research/9q4d5d/veterinary_ ) ... Animal Vaccines Market by Product, Diseases & Technology - ... The global animal vaccines market is poised ... in 2015, at a CAGR of 5.5% from 2015 ... are growing prevalence of animal diseases, increasing incidences of ...
Breaking Medicine Technology:Icagen Re-launched through XRpro Sciences Acquisition of Pfizer Team and Technology for Ion Channel and Transporter Drug R&D 2Icagen Re-launched through XRpro Sciences Acquisition of Pfizer Team and Technology for Ion Channel and Transporter Drug R&D 3Icagen Re-launched through XRpro Sciences Acquisition of Pfizer Team and Technology for Ion Channel and Transporter Drug R&D 4BGI recibe la acreditación del College of American Pathologists (CAP) 2Veterinary / Animal Vaccines Market 2015 - Global Forecast to 2020 for the $7.19 Billion Industry 2
... today announced the launch of the CELLTRACKS® Circulating Melanoma ... convenient and reliable way to capture CMCs for research ... CMCs, the CELLTRACKS® CMC kit is designed to offer ... based on a specific protein or mutation. ...
... May 24, 2011 TetraLogic Pharmaceuticals, a biopharmaceutical company ... announced that is has closed a $6 million investment ... based oncology focused venture capital fund.  Combined with the ... raised $43 million in the past year. The company ...
Cached Medicine Technology:Veridex Launches CELLTRACKS® Circulating Melanoma Cell Kit for Research Use 2Veridex Launches CELLTRACKS® Circulating Melanoma Cell Kit for Research Use 3TetraLogic Closes $6 Million Series C-1 Investment with Nextech Invest Ltd. 2TetraLogic Closes $6 Million Series C-1 Investment with Nextech Invest Ltd. 3TetraLogic Closes $6 Million Series C-1 Investment with Nextech Invest Ltd. 4
... Narkotron II is a comprehensive vital sign monitor. , ... quality, affordable products for efficiency in patient care., ... 2 - Temp - Multi-gas Sensor (HAL, ... )., ,Optional Functions: ,5-Lead ECG - FiO 2 ...
... monitor is a low-cost, multi-parameter monitor designed ... and surgery. The large display provides bright ... from across the room. The intuitive design ... the monitor in just minutes., ,Standard ...
... the features needed for quality, comprehensive portable ... color display allows you to see up ... ECG. The touch screen allows easy navigation ... gloves or temperature., ,Standard features include ...
... Compact all-in-one anesthesia monitor., ... monitor designed for use in the ... room and PACU. The Cardiocap/5 offers ... the monitoring of oxygenation and circulation ...
Medicine Products: