Navigation Links
Plant researchers locate transporter used for nicotine metabolism
Date:11/1/2011

The next time you take aspirin for a headache, thank a willow tree. Salicylic acid, a compound chemically similar to aspirin, is found in willow tree bark and is made by the plant as a chemical defense against pathogens. By mimicking the chemical production processes of plants, scientists have been able to synthetically produce and engineer many important alkaloid drug products, including caffeine, atropine (an anti-spasmodic used to treat heart arrhythmia), nicotine, morphine and quinine.

The trick, however, is to understand how a plant produces these compounds and then transports them through the plant. A team of Virginia Tech and Purdue University scientists have identified a distinct transporter used by tobacco plant cells for nicotine metabolism. The research appears in the Oct. 17 online before print issue of the Proceedings of the National Academy of Sciences (PNAS) in the article, "A tobacco nicotine uptake permease effects alkaloid metabolism."

The transporter, called nicotine uptake permease (NUP1) allows alkaloids nitrogen-containing compounds to pass into plant cells. The transporter is a tubular structure found in the outer boundary of the plant cell, known as the plasma membrane. Passage of alkaloids from one cell to another in an assembly line fashion is crucial to the biosynthesis of many medicinal plant alkaloids. However, prior to the study, it was not known exactly how the alkaloids were able to move either in or out of the cell.

"We knew that the general process of going in and out is important for alkaloid metabolism, but we didn't know the details," said John Jelesko, associate professor of plant pathology, physiology, and weed science at Virginia Tech. "The NUP1 transporter is very specific for nicotine other closely related alkaloids don't use this transporter. That degree of specificity is rather unusual."

Identif
'/>"/>

Contact: Lindsay Key
ltkey@vt.edu
540-231-6594
Virginia Tech
Source:Eurekalert

Page: 1 2

Related medicine news :

1. UK HealthCare surgeons are first to perform novel procedures prior to transplant
2. High-dose melphalan and autologous stem cell transplantation increases survival
3. Lab-made skin cells will aid transplantation, cancer, drug discovery research
4. Research finds gallium nitride is non-toxic, biocompatible - holds promise for implants
5. Heart transplant surgery safe and effective: A Canadian retrospective spanning 3 decades
6. Biomarker detects graft-versus-host-disease in cancer patients after bone marrow transplant
7. Successful pregnancy possible after kidney transplant
8. Public reporting hasnt improved transplant centers care
9. Study uncovers why anti-rejection drugs for transplant patients cause hypertension
10. Stem Cell Therapy Might Help Kidney Transplant Patients
11. Transforming medical implants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2014)... Nancy Chiaravalloti, PhD, of Kessler Foundation was named ... Jersey City, New Jersey. Dr. Chiaravalloti spoke on April ... the topic of "Treating Cognitive Deficits Following Neurological Illness ... be a part of the long legacy of the ... Chiaravalloti. "The field of rehabilitation research is a rewarding ...
(Date:4/24/2014)... yeast is giving scientists a better understanding of drug ... illness world-wide. , When two or more medications ... or enhance the effectiveness of the other. Similarly, ... types of interactions are a major cause of illness ... on the practical scope of drug studies in humans. ...
(Date:4/24/2014)... ,Take me out to the ballgame, doesn,t exactly ... The more likely culprits include French fries, soda and ... children who play youth baseball, eating unhealthy food during ... according to researchers at Wake Forest Baptist Medical Center. ... Childhood Obesity , found that high-calorie snacks and ...
(Date:4/24/2014)... be boring and irrelevant, could offer an alternative to ... Dr Milena Furtado, and her team from the Australian ... heart cell fibroblast is a close relative to a ... , In research published today in Circulation Research ... unique cells due to their genetic program, and will ...
(Date:4/24/2014)... than to receive at least if you,re an adolescent ... study found that 15- and 16-year-olds who find pleasure in ... are less likely to become depressed than those who get ... for themselves. , The researchers detail their findings in the ... The study focused on the ventral striatum, a brain region ...
Breaking Medicine News(10 mins):Health News:Kessler Foundation scientist named 63rd Mendel Lecturer by St. Peter's University 2Health News:Large-scale identification and analysis of suppressive drug interactions 2Health News:Take the bat, leave the candy 2Health News:Boring cells could hold the key to heart disease 2Health News:Study: Altruistic adolescents less likely to become depressed 2
... should,we die? Finding grace in life and death is an eternal ... Finding Grace on a Less Traveled Road is both an autobiography, ... a journey through the life of,a cancer physician who learns early, ... suffering. It is through the author,s own,understanding of what it means ...
... workers, sit-in shifted,national attention to the plight of laid-off workers, ... nightmarish loss of health,coverage benefits in layoffs and should know ... of Outten & Golden LLP. , ... the New York office of Outten &,Golden LLP which represents ...
... WEST PALM BEACH, Fla., Dec. 10 The Cosmetic ... for core cosmetic,physicians and their office staff will begin ... meeting has seen strong attendance and industry sponsorship.,According to ... the meeting,is recognized as the essential meeting for specialists ...
... New York and Wisconsin Among States with Hurdles Ahead, ... , NASHVILLE, Tenn., Dec. ... market intelligence, reports that states will face pressure to ... as commercially-insured members lose their jobs or come off ...
... Skilled Nursing Facilities , , ... 18-month selection process, a proven commitment to clinical quality ... (EMR) throughout Metropolitan Jewish Health System,s (Metropolitan) skilled nursing ... Metropolitan, a nationally recognized nonprofit organization, operates Metropolitan Jewish ...
... contracting portfolio, e-commerce exchange and clinical services , ... ... that Jordan Health Systems in Plymouth, Massachusetts has selected Broadlane as ... services to help manage its approximate $35 million in annual ...
Cached Medicine News:Health News:Finding Grace on a Less Traveled Road: A Cancer Doctor Reflects on Living and Dying 2Health News:Chicago Sit-In Highlights Laid-Off Workers, Employers' Obligations, and WARN Act, According to Outten & Golden LLP 2Health News:Chicago Sit-In Highlights Laid-Off Workers, Employers' Obligations, and WARN Act, According to Outten & Golden LLP 3Health News:Economic Downturn Means Increased Demands on Budget-Challenged State Health Coverage Initiatives 2Health News:Economic Downturn Means Increased Demands on Budget-Challenged State Health Coverage Initiatives 3Health News:Metropolitan Jewish Health System Awards Electronic Medical Records Contract to SigmaCare(R) 2Health News:Metropolitan Jewish Health System Awards Electronic Medical Records Contract to SigmaCare(R) 3Health News:Jordan Health Systems Selects Broadlane to Provide Comprehensive Supply Chain Services 2Health News:Jordan Health Systems Selects Broadlane to Provide Comprehensive Supply Chain Services 3
(Date:1/14/2014)... HARRISBURG, Pa. , Jan. 14, 2014 Dynamic Healthcare ... ("GMH"), announced today that it acquired Progressive Home Medical Equipment, ... January 7, 2014. The terms of the acquisition were not ... medical equipment ("DME") company providing a wide range of sleep, ...
(Date:1/14/2014)... 2014 Animal Emergency Critical Care, a LifeCentre partner practice, located ... is the first in Loudoun County ... Dr. Susan M. Barnes , Medical Director, is a well-seasoned ... Cole Taylor , are avid scuba divers. "As altitude skiers ...
(Date:1/14/2014)... CLEVELAND , Jan. 14, 2014 NineSigma ... will hold its Innovation Leadership Summit , May ... in Cleveland Ohio . ... innovators and organizations committed to breakthrough achievements through open ...
Breaking Medicine Technology:Dynamic Healthcare Services Completes Progressive Home Medical Equipment of Clarion, PA Investment 2Dynamic Healthcare Services Completes Progressive Home Medical Equipment of Clarion, PA Investment 3Hyperbaric Veterinary Medicine (hvm) Announces Animal Emergency Critical Care Installs A Small Animal Hyperbaric Chamber 2Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 2Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 3Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 4
... HARBIN, China , July 6 ... WKBT) ("Weikang" or the,"Company"), a leading developer, manufacturer and ... pharmaceuticals and other,health and nutritional products in the ... participate in the Global Hunter 2010 China Conference,on ...
... WARSAW, Ind. , July 6 Zimmer Holdings, Inc. (NYSE: ... earnings conference call will be broadcast live over the Internet on Thursday, ... release detailing the quarterly results will be made available at 7:00 a.m. ... , , ...
Cached Medicine Technology:Weikang Bio-Technology to Present at Global Hunter 2010 China Conference on July 13, 2010 2Weikang Bio-Technology to Present at Global Hunter 2010 China Conference on July 13, 2010 3Zimmer Holdings Announces Live Audio Webcast and Conference Call of Second Quarter 2010 Results 2
The Becton™ Colles Fracture Plate has proven clinical outcomes and has excellent patient acceptance compared to external fixation. It provides a cost effective treatment option through a simple...
X-Hair Trephines...
Coronet Donor Punch Set - Unique design providing precise control and full visualization throughout the procedure. Corneal marking pen included....
Stainless Steel. Sterile. 2 pieces/box...
Medicine Products: