Navigation Links
Personal epigenetic 'signatures' found consistent in prostate cancer patients' metastases
Date:1/23/2013

In a genome-wide analysis of 13 metastatic prostate cancers, scientists at the Johns Hopkins Kimmel Cancer Center found consistent epigenetic "signatures" across all metastatic tumors in each patient. The discovery of the stable, epigenetic "marks" that sit on the nuclear DNA of cancer cells and alter gene expression, defies a prevailing belief that the marks vary so much within each individual's widespread cancers that they have little or no value as targets for therapy or as biomarkers for treatment response and predicting disease severity.

A report of the discovery, published in the Jan. 23 issue of Science Translational Medicine, describes a genomic analysis of 13 men who died of metastatic prostate cancer and whose tissue samples were collected after a rapid autopsy.

Samples from three to six metastatic sites in each of the patients and one to three samples of their normal tissue were analyzed to determine the amount of molecular marks made up of methyl groups that attach to sites along the genome in a process known as DNA methylation. The process is part of an expanding target of scientific study called epigenetics, known to help drive cell processes by regulating when and how genes are activated. Mistakes in epigenetic processes also are known to trigger or fuel cancers.

"Knowing both the genetic and epigenetic changes that happen in lethal prostate cancers can eventually help us identify the most aggressive cancers earlier and develop new therapies that target those changes," says Srinivasan Yegnasubramanian, M.D., Ph.D., assistant professor of oncology at The Johns Hopkins University School of Medicine. "But there has been an open question of whether epigenetic changes are consistently maintained across all metastatic sites of an individual's cancer."

The research team found that while methylation patterns vary from one patient to another, many methylation patterns occur "very consistently" within different metastatic sites in an individual patient. They identified more than 1,000 regions of the genome where various types of DNA methylation were consistently maintained within their 13 subjects' genomes.

"As they evolve and grow, cancer cells acquire and maintain changes that enable them to continue thriving," says Yegnasubramanian. "We know that cancer cells maintain and pass along genetic changes in the nucleus of cells across metastatic sites, and our research now shows that epigenetic changes also are maintained to nearly the same degree."

The scientists say that the consistent methylation changes they found appear to represent so-called driver changes critical to the cancer's development and could be targets for treatment. By contrast, other methylation changes found only sporadically in the metastatic sites are more likely what are called passenger changes that occur by chance and are less promising as treatment targets or biomarkers than driver changes.

"Our study shows that for prostate cancer, at least, each person develops his own path to cancer and metastasis, and we can find a signature of that path in the epigenetic marks within their tumors," says Yegnasubramanian, who envisions that certain epigenetic changes can be grouped into clusters to be used as biomarkers signaling a lethal cancer.

Yegnasubramanian and his team also plan to study how each of the driver changes work and how they influence cancer metastasis.


'/>"/>

Contact: Vanessa Wasta
wasta@jhmi.edu
410-614-2916
Johns Hopkins Medicine
Source:Eurekalert

Related medicine news :

1. PMD Healthcare Announces that Spiro PD Personal Spirometer May Help Increase Flu Vaccination Rates as Epidemic Surges
2. Understanding personality for decision-making, longevity, and mental health
3. Fitness Celebrity and one of Canada’s Inside Fitness Hot and Fit Women of 2012, Nancy Di Nino, brings her Media Personality to host the Hot & Fit Release Party
4. The Olive Oil Source Introduces Valentine’s Day Labels for Personalized Olive Oil and Vinegar Gifts
5. McGill University Launches a Major New Study on HPV Prevention Using Divine 9 Personal Lubricants with Carragel
6. PMD Healthcare Announces how Spiro PD Personal Spirometer Supports New Year’s Resolution to Exercise and Lose Weight, Complementing ACAAI Recommendations
7. Business Review Takes Notice of New Phone App "PumpUp" as a Personal Training Aid
8. Chemical Bank Conducts Personal Finance Classes for Passages Program at Eagle Village
9. Swimovate Watches Can Replace a Personal Swim Coach in the New Year Reports SwimovateUSA
10. Citizen's Bank Conducts Personal Banking Classes at Eagle Village
11. Dr. Steve Young Launches PSA on New Jersey Personal Trainers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/1/2020)... ... , ... Dexur’s analysis of Medicare claims of hospitals within a ... Hospital , and Sky Ridge Medical Center had the best value ... tracks a patient’s episode of care from the date of admission for 90 days ...
(Date:7/1/2020)... EVANSTON, Ill. (PRWEB) , ... July 01, 2020 ... ... today announced that Doug Salvador, MD, Associate Professor of Medicine at the University ... Healthcare Risk and Safety Strategies, LLC have joined the SIDM Board of Directors. ...
(Date:6/28/2020)... ... 2020 , ... Medisend College of Biomedical Engineering Technology, a ... that prepares graduates for professional careers as field service engineers and biomedical equipment ... , Ms. Williams currently serves as Associate Vice Chancellor of Workforce and Community ...
(Date:6/28/2020)... ... June 26, 2020 , ... The Coronavirus pandemic ... public. As a supplier of top-quality masks, sanitizers and thermometers, Trusted PPE is ... President Priya Agarwal observed, “All of our masks are manufactured to medical standards ...
(Date:6/28/2020)... ... June 28, 2020 , ... ... the world, dedicates World Allergy Week, from June 28 to July 4, 2020, ... SARS CoV-2. , COVID-19, short for “coronavirus disease 2019”, is a disease spreading ...
Breaking Medicine News(10 mins):
(Date:6/25/2020)... ... June 25, 2020 , ... The Heritage Downtown Active Senior Living ... of COVID-19. With over 100,000 positive cases of the coronavirus in the United States ... reside at The Heritage Downtown, their family members, as well as the Walnut Creek ...
(Date:6/25/2020)... ... June 25, 2020 , ... Drs. Gregory ... Dentist list within the Periodontics category. As specialists, this team of periodontists ... and Westerly, RI. Laser gum disease therapy, minimally invasive gum recession treatment, and ...
(Date:6/24/2020)... , ... June 24, 2020 , ... ... a number of common questions on County Line Chiropractic’s YouTube channel. ... questions. , County Line Chiropractic has six locations in the South Florida area, ...
Breaking Medicine Technology: