Navigation Links
Pathologists identify patterns of mutations to help inform design of future trials
Date:3/22/2013

DENVER Molecular driven therapeutic targets have resulted in a paradigm shift in the treatment of advanced lung adenocarcinoma. However, in early non-small cell lung cancer (NSCLC), surgical resection remains the treatment of choice with adjuvant chemotherapy. In a recent study published in the April 2013 issue of the International Association for the Study of Lung Cancer's (IASLC) Journal of Thoracic Oncology, researchers identified patterns of mutations in early stage node negative lung adenocarcinoma.

They retrospectively reviewed 204 patients with stage IB primary lung adenocarcinoma who underwent surgical resection between January 1990 and May 2008. Patients who received neoadjuvant or adjuvant treatments were excluded.

The study demonstrates that mutations are common in resected early node-negative, treatment-naive lung adenocarcinoma with 54 percent of patients having tumors which harbor at least one biologically relevant mutation. Although mutations in KRAS, EGFR and ALK were mutually exclusive, some tumors harbored synchronous mutations within a single oncogene such as double EGFR mutations or within two different oncogenes in the case of comutations.

The researchers unexpectedly found that there were also mutations associated with drug resistance despite the fact that this was a cohort of early stage disease patients who had not been treated with chemotherapy or targeted agents.

They concluded that their data provides, "compelling evidence for comprehensive tumor mutation profiling as an essential element of adjuvant trial design as DNA changes present in advanced cancer cohorts do not necessarily match those from early stage disease."


'/>"/>

Contact: Kristal Griffith
Kristal.Griffith@iaslc.org
720-325-2952
International Association for the Study of Lung Cancer
Source:Eurekalert

Page: 1

Related medicine news :

1. ASHA Approved Continuing Education Provider HomeCEUConnection.com Announces Two New Live, Interactive Webinars for California Speech-Language Pathologists.
2. Continuing Education Provider HomeCEUConnection.com Announces Full Schedule of Live Webinars for California Speech-Language Pathologists
3. NIH grant moves pathologists to the forefront of genomic medicine
4. Scientists identify gene that is consistently altered in obese individuals
5. Lung Cancer Asbestos Victims Center Now Urges Families To Help Them Identify A Nonsmoker Loved One Who Had Exposure To Asbestos In The Workplace And Now Has Lung Cancer
6. NIH-supported researchers identify new class of malaria compounds
7. University of Maryland researchers identify fish protein that may inhibit cancer metastasis
8. Researchers identify a promising target for multiple sclerosis treatments
9. Genetic testing may be used to identify BPH patients with increased risk of prostate cancer
10. Trio of biomarkers may help identify kidney cancer in early stages
11. Novel marker helps identify preeclampsia risk in pregnancy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2016)... ... May 05, 2016 , ... ... ultraviolet light A (UV-A) for photosynthesis, researchers Juntian Xu and Kunshan Gao tested ... seaweeds. The pair observed that when photosynthetically active radiation (i.e. the white light ...
(Date:5/5/2016)... ... 05, 2016 , ... Derrin Doty Group has unveiled the latest charity campaign ... communities west of Seattle. The insurance provider’s caring team has been so moved by ... due to complications from the flu, that they have decided to extend their original ...
(Date:5/5/2016)... ... May 05, 2016 , ... ... Association (SACA) is slated to host the 2016 National SACA Leadership Conference on ... SACA national officers and chapter officers to come together and develop skills to ...
(Date:5/5/2016)... ... 05, 2016 , ... Vitenas Cosmetic Surgery has been named as one of ... Institute of Architects and the Academy of Architecture for Health. The building, brainchild of ... opened to patients in October of 2014. , The prestigious Healthcare ...
(Date:5/5/2016)... Georgia (PRWEB) , ... May 05, 2016 , ... Dr. ... latest in non-surgical hair loss treatment. Dr. Stong is double board certified and ... Injections for the treatment of hair loss. Non-surgical therapies such as stem cells ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... 2016  As a teenager, an active and athletic ... damaged his heart. He continued enjoying sports and recreation ... Shepherd,s heart was giving out and he was a ... 2013, the Mesa, Arizona resident ... a heart transplant, the SynCardia TAH-t is the only ...
(Date:5/3/2016)... 3, 2016  While you may be familiar with watching a film or TV show in ... ultra-high-definition or 8MP in the Medical Industry.  Ampronix  is a renowned authorized reseller of the ... Photo - http://photos.prnewswire.com/prnh/20160502/362730 ... ... ...
(Date:5/3/2016)... -- Pharmaceutical giant Johnson & Johnson has ... who says its talc-based powder products caused ovarian cancer. ... $5 million in compensatory damages and $50 million in ... ) , This is the second in ... the same court awarded $72 million to the family ...
Breaking Medicine Technology: