Navigation Links
Patent awarded for method to dampen immune response
Date:1/18/2011

National Jewish Health has been issued a US patent claiming a method to desensitize B cells by inactivating antigen receptors on their surfaces. The method, discovered by John Cambier, PhD, Chairman of the Integrated Department of Immunology at National Jewish Health, holds promise for treatment of B-cell mediated diseases, such as lymphoma and leukemia, rheumatoid arthritis, lupus and rejection of organ transplants. This therapeutic approach has the potential advantage of inactivating B cells instead of killing them as current treatments do. Therefore, this potential therapy could be more rapidly adjusted in response to the changing needs of patients.

B cells are a crucial part of the adaptive immune response, responsible for making antibodies that can neutralize and destroy pathogens. Several diseases, however, are associated with malfunction of B cells. For example, B cells can turn cancerous in diseases such as lymphoma and leukemia. In autoimmune diseases, such as rheumatoid arthritis or lupus, B cells turn against their own bodies and attack their tissues. B cells can also attack transplanted organs, which they recognize as foreign and potentially harmful.

The recently issued patent describes a method to inactivate B cells by disassembling their B-cell receptors. B cells begin producing antibodies after their B-cell receptors encounter foreign protein fragments, known as antigens. The B-cell receptor contains two distinct subunits; a receptor, which engages antigens, and a transducer, which transmits an activating signal to the interior of the cell.

About a decade ago, Dr. Cambier's laboratory, discovered that the two subunits could be separated, which disables the B cell's ability to recognize antigens and produce antibodies. In 2003, National Jewish Health received a patent (#6,503,509) for this method of B -cell desensitization. The most recent patent (#7,825,224) related to this technology claims the use of antibodies that bi
'/>"/>

Contact: William Allstetter
allstetterw@njhealth.org
303-398-1002
National Jewish Health
Source:Eurekalert

Page: 1 2

Related medicine news :

1. National Jewish Health receives patent for diagnostic method of autoimmune chronic urticaria
2. National Jewish Health receives patent for liposome-based vaccine
3. K-State receives patent for noncontroversial source of stem cells
4. 15 new US patents awarded this past year to NJIT researchers
5. UR discovers new way to boost vaccines, seeks patent
6. Brookhaven Lab and BioSET Inc. patent improved growth factor technology
7. USF receives patent for technology to improve treatment for neurodegenerative diseases
8. Quincy Bioscience Receives Patent for Jellyfish Protein Aequorin
9. Greenway Awarded U.S. Patent For EHR Functionality and Workflow
10. Volumetrics Medical Imaging, LLC and Medison Co., Ltd. Announce Technology License and Settlement of Patent Litigation
11. Mobile and Patented: DATA-TO-CAMERA TOGGLE on handheld device replaces old camera and clipboard approach everywhere! Beats IPAD to camera punch too.....
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/29/2015)... ... June 29, 2015 , ... San Fernando Valley skin doctor , Dr. ... Ulthera is a special treatment that offers a way to firm sagging facial and ... collagen production. Ulthera is highly targeted and precise to help reduce treatment time and ...
(Date:6/29/2015)... ... June 29, 2015 , ... New research released ... than 10 percent of U.S. state and local governments have implemented Next Generation ... deadline for NG9-1-1. , “Mobile phones have surpassed land lines as the ...
(Date:6/29/2015)... ... ... Celebrities have many skincare secrets, and skin expert, Holly CaSaroll details how to ... People don’t have to be famous to have fabulous skin. CaSaroll suggests anyone can ... avoid breakouts, and take skin health and wellness to a new level. , 1. ...
(Date:6/29/2015)... ... June 29, 2015 , ... DISC, a method of behavioral ... focus for corporate training seminars. As many as seventy percent of Fortune 500 ... and increase productivity. , With the demand for in-house DISC training continuing ...
(Date:6/29/2015)... , ... June 29, 2015 , ... ... pharmacist guided, safe, informed, responsible and legal access to Health Canada's medical cannabis ... , NAC provides education on how Health Canada's medical marijuana system works. Members ...
Breaking Medicine News(10 mins):Health News:Dermatologist, Dr. Peyman Ghasri, is Now Offering Non-Invasive Skin Tightening Procedures 2Health News:Dermatologist, Dr. Peyman Ghasri, is Now Offering Non-Invasive Skin Tightening Procedures 3Health News:State and Local Governments Are Slow to Adopt Next Generation 9-1-1 Systems, According to New Research from General Dynamics Information Technology 2Health News:State and Local Governments Are Slow to Adopt Next Generation 9-1-1 Systems, According to New Research from General Dynamics Information Technology 3Health News:State and Local Governments Are Slow to Adopt Next Generation 9-1-1 Systems, According to New Research from General Dynamics Information Technology 4Health News:Skin Guru Shares Celebrity FACE Secrets For Summer-Proofing The Skin 2Health News:Skin Guru Shares Celebrity FACE Secrets For Summer-Proofing The Skin 3Health News:As Demand for DISC Trainers Rises, PeopleKeys Offers Support with “THE DISC FACTOR—Train the Trainer” Webinar 2Health News:National Access Cannabis Opens Flagship Ottawa Care Centre 2Health News:National Access Cannabis Opens Flagship Ottawa Care Centre 3
... The Anti-Aging Market, VIRGINIA BEACH, Va., Feb. ... science of LED (light emitting diode),Photomodulation, announced today ... a 510(k) over-the-counter (OTC) clearance from the United ... of periorbital,wrinkles. This clearance paves the way for ...
... Year-Round Immune Support is Best to Ensure the Body,s Peak ... Performance When You Need it ... against infection requires a strong and healthy immune system.,Keeping the immune ... cold season., "It is believed that our immune system is ...
... SAP solutions in the ... healthcare industry., ORLANDO, ... Society (HIMSS) 2008,Conference & Exhibition, Microsoft Corp. announced it has signed ... AG, through,which the companies have agreed to work together to deliver ...
... to chemotherapy may offer a new strategy for ... starting treatment, according to a new study by ... of print in Nature Medicine, the researchers report ... recognizes tumors responding to chemotherapy. They show that ...
... Bequest Ever to the Lesbian, Gay, Bisexual and Transgender ... (LGBT) Movement By Early Microsoft Employee ... Feb. 24 Pride Foundation of Seattle is honored,to announce ... of Ric,Weiland. Mr. Weiland,s gift of $65 million is the ...
... Throughout the past,decade, Florida Detox(TM) has successfully ... seen an exorbitant increase,in the ratio of patients ... drugs. Ten years ago, 50% of our patients,were ... of our,patients were treated for prescription medication addiction. ...
Cached Medicine News:Health News:FDA Grants Over-The-Counter Clearance to GentleWaves(R) for the First Home Use Light-Based Device to Treat Wrinkles 2Health News:FDA Grants Over-The-Counter Clearance to GentleWaves(R) for the First Home Use Light-Based Device to Treat Wrinkles 3Health News:FDA Grants Over-The-Counter Clearance to GentleWaves(R) for the First Home Use Light-Based Device to Treat Wrinkles 4Health News:Prime Your Immune System During the Peak of Cold Season and Beyond 2Health News:Microsoft Joins Forces with SAP America for Healthcare IT 2Health News:Microsoft Joins Forces with SAP America for Healthcare IT 3Health News:Protein shines light on cancer response 2Health News:Ric Weiland Leaves $65 Million to Support Gay Rights and HIV/AIDS Organizations 2Health News:Ric Weiland Leaves $65 Million to Support Gay Rights and HIV/AIDS Organizations 3Health News:Drugs, Doctors and Death: Heath Ledger Becomes Another Victim 2
(Date:6/29/2015)...  Trovagene, Inc. (NASDAQ: TROV ), a developer ... is now included in the Russell 3000®, the Russell ... to the indexes occurred at the close of trading ... its comprehensive set of U.S. and global indexes. ... Cap and Global Indexes coincides with the progress we ...
(Date:6/29/2015)... , June 29, 2015  Relmada Therapeutics, ... therapies for the treatment of chronic pain, announced ... study with novel formulations of oral, enteric-coated buprenorphine ... chronic pain and opioid dependence indications has reached ... company anticipates reporting top-line results in the second ...
(Date:6/29/2015)... England , June 29, 2015  Eli ... Immunocore Limited today announced that they have entered ... the utility of Immunocore,s lead T cell receptor-based ... (LY2157299) and merestinib (LY2801653) for the treatment of ... identify combination regimens that provide synergies in efficacy ...
Breaking Medicine Technology:Trovagene Upgraded to Russell 3000, Small Cap and Global Indexes 2Trovagene Upgraded to Russell 3000, Small Cap and Global Indexes 3Enrollment in Relmada Therapeutics' Proof-of-Concept Clinical Study for Novel Oral Formulations of Buprenorphine Reaches Halfway Mark 2Enrollment in Relmada Therapeutics' Proof-of-Concept Clinical Study for Novel Oral Formulations of Buprenorphine Reaches Halfway Mark 3Lilly and Immunocore Announce Immunotherapy-based Clinical Trial Collaboration in Melanoma 2Lilly and Immunocore Announce Immunotherapy-based Clinical Trial Collaboration in Melanoma 3Lilly and Immunocore Announce Immunotherapy-based Clinical Trial Collaboration in Melanoma 4Lilly and Immunocore Announce Immunotherapy-based Clinical Trial Collaboration in Melanoma 5Lilly and Immunocore Announce Immunotherapy-based Clinical Trial Collaboration in Melanoma 6Lilly and Immunocore Announce Immunotherapy-based Clinical Trial Collaboration in Melanoma 7
... Seating & Mobility (USM) is excited to announce today ... (CKM) to acquire and merge its complex mobility business with ... as central, eastern and southern Kentucky. "The addition ... a core market for us and supports our regional initiative. ...
... Clinical Diagnostics (OCD) today announced the launch of ... that delivers high-quality, reliable test results for mid- ... that drive reliability and efficiency throughout OCD,s portfolio ... x600 Family of Systems, which includes the VITROS® ...
Cached Medicine Technology:Ortho Clinical Diagnostics Launches VITROS® 4600 Chemistry System for Mid- to High-Volume Laboratories 2Ortho Clinical Diagnostics Launches VITROS® 4600 Chemistry System for Mid- to High-Volume Laboratories 3Ortho Clinical Diagnostics Launches VITROS® 4600 Chemistry System for Mid- to High-Volume Laboratories 4
Solid lower plate with outside width 15 mm. Open serrated upper plate with inside dimensions 9 x 12 mm. Serrated handle with locking thumb screw and polished finish....
Narrow smooth jaws. Serrated handle with polished finish....
14 mm oval solid lower plate and straight 9 mm serrated upper jaw. Locking thumb screw and serrated handle with polished finish....
Round solid 10 mm wide lower plate. Open upper plate with inside diameter 8 mm. Serrated handle with locking thumb screw and polished finish. Most popular size or model....
Medicine Products: