Navigation Links
Pancreatic Islets in Forefront of Diabetes Research

Cells could play major role in treatment, if supply is adequate, study finds

TUESDAY, April 14 (HealthDay News) -- Pancreatic islets, which are hormone-producing cells, are becoming more prominent in diabetes research and could play a major role in future treatments, according to U.S. experts.

"The primary objective of islet-based research is to cure diabetes," John S. Kaddis, of the City of Hope National Medical Center, in Duarte, Calif., and his colleagues wrote in the April 15 issue of the Journal of the American Medical Association, a themed issue on diabetes.

"Perhaps the most prominent clinical application of this research is currently in the form of cell replacement therapy," they noted. "With the exception of one report in a type 2 diabetes cohort, islet transplantation has been used exclusively for a subset of individuals with type 1 diabetes mellitus and was shown, at least temporarily, to improve glucose control and, in a few cases, to lead to insulin independence."

Cell replacement therapy involves the transplantation of pancreatic islets from a donated pancreas to a person with diabetes. The goal is to restore the function of beta cells in the pancreas. The destruction of these cells causes type 1 diabetes.

"Although islet transplantation has been shown to offer both protection against long-term complications of the disease and significant improvement in quality of life, several obstacles remain, such as limited engraftment [acceptance of the islets within the recipient], chronic immunosuppression and inconsistent supply of human islets," the researchers noted. "These issues must be addressed if the procedure is to be used as a standard of care for qualified individuals."

To meet the increasing demand for human islets for transplantation and research, islet-sharing networks have been established. Between September 2001 and August 2008, 297.6 million islets were produced by 14 laboratories in the Islet Cell Resource (ICR) consortium, with 67 percent of the islets used for basic science research and 31 percent for clinical purposes, according in background information in a news release from the journal.

"The importance of human pancreatic islets, clinically or for basic science research, is substantiated by the number and quality of studies being performed that rely on these preparations," the authors wrote. "Data available through the ICR as of August 2008 indicate that a total of 151 national and international scientists received human islets for use in both intramural research performed by the consortium as well as 182 clinical and basic science projects submitted to the consortium for support."

"Human pancreatic islets will be critical for restoration of beta-cell function in patients with diabetes," they concluded. "Even given adequate funding levels, the ongoing challenges to supplying human islets must be addressed for the successful exploration of therapeutic options for this chronic and debilitating disease."

More information

The American Diabetes Association has more about islet transplantation.

-- Robert Preidt

SOURCE: Journal of the American Medical Association, news release, April 14, 2009

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New technique invented to reveal pancreatic stem cells
2. Fox Chase performs the world’s first successful ViKY robot-assisted surgery for pancreatic tumors
3. Obesity Tied to Poor Pancreatic Cancer Surgery Outcomes
4. NCCN Announces Updates to Pancreatic Adenocarcinoma Guidelines
5. Study Links Blood Type and Pancreatic Cancer
6. Personalized genome sequencing reveals coding error in gene for inherited pancreatic cancer
7. Alcohol consumption may increase pancreatic cancer risk
8. Georgetown researcher: 2 or more drinks a day may increase pancreatic cancer risk
9. U-M Researchers ID Gene Involved in Pancreatic Cancer
10. Optical techniques show continued promise in detecting pancreatic cancer
11. Determining risk for pancreatic cancer
Post Your Comments:
Related Image:
Pancreatic Islets in Forefront of Diabetes Research
(Date:6/25/2016)... ... June 25, 2016 , ... ... and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the Hynes ... important health care topics including advance care planning, healthcare costs and patient and ...
(Date:6/25/2016)... ... , ... As a lifelong Southern Californian, Dr. Omkar Marathe earned his Bachelors ... Geffen School of Medicine at UCLA. He trained in Internal Medicine at Scripps Green ... hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the opportunity to train ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic events may ... to unhealthy avenues, such as drug or alcohol abuse, as a coping mechanism. To ... for healthy coping following a traumatic event. , Trauma sufferers tend to feel a ...
(Date:6/24/2016)... Francisco, CA (PRWEB) , ... June 24, 2016 ... ... CitiDent, is now offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive ... self-ligating Damon brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... proud to recognize Dr. Barry M. Weintraub as a prominent plastic surgeon and ... women in the world, and the most handsome men, look naturally attractive. Plastic ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... HILL, N.C. , June 24, 2016 /PRNewswire/ ... healthcare decisions and regulators/payers have placed more emphasis ... new environment, patient support programs in the pharmaceutical ... for patients, medications. Consequently, pharmaceutical companies are focusing ... ensure they are providing products and services that ...
(Date:6/24/2016)... , June 24, 2016  Global Blood ... biopharmaceutical company developing novel therapeutics for the treatment ... today announced the closing of its previously announced ... stock, at the public offering price of $18.75 ... offering were offered by GBT. GBT estimates net ...
(Date:6/24/2016)... June 24, 2016 ... announced the addition of the " Global Markets ... This report focuses ... an updated review, including its applications in various applications. ... market, which includes three main industries: pharmaceutical and biotechnology, ...
Breaking Medicine Technology: