Navigation Links
Oxygen diminishes the heart's ability to regenerate, researchers discover
Date:4/24/2014

the heart's ability to regenerate.

"The choice was clear," said Dr. Sadek. "More than any organ in the body, the heart needs to be energy efficient in order to pump blood throughout life."

Heart muscle contains the highest amount of mitochondria in the body and consumes 30 percent of the body's total oxygen in a resting state alone. Unfortunately, the energy that comes from massive oxygen consumption comes with a price in the form of oxidation of DNA that makes the heart cells unable to divide and regenerate.

Dr. Sadek, along with co-first authors Dr. Bao "Robyn" Puente, postdoctoral trainee in Pediatrics, and Dr. Wataru Kimura, visiting senior researcher in Internal Medicine, found that if they subjected mice to a low-oxygen atmosphere, the cardiomyocytes divided longer than normal. The opposite was true when mice were born in a higher-oxygenated atmosphere. In that case, the cardiomyocytes stopped dividing earlier than normal.

This study comes on the heels of findings published in the Feb. 25, 2011, edition of Science, in which Dr. Sadek found that if a portion of a mouse heart was removed during the first week after birth, that portion grew back wholly and correctly. In contrast, an adult heart was irreversibly damaged by removal of even a small amount of tissue.

Because the adult mammal's heart is not able to regenerate following injury, this represents a major barrier in cardiovascular medicine. Having a promising new understanding of what arrests cardiomyocyte cell cycle could be an important component of cardiomyocyte proliferation-based therapeutic approaches.


'/>"/>
Contact: Lisa Warshaw
lisa.warshaw@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Low oxygen levels could drive cancer growth
2. Oxygen Therapy Slows Type 1 Diabetes in Mice, Study Says
3. Should oxygen be used for patients with chronic heart failure?
4. Cooling Helps Oxygen-Deprived Newborns: Study
5. New anti-inflammatory drugs pinch off reactive oxygen species at the source
6. Lack of oxygen in cancer cells leads to growth and metastasis
7. COPD patients experience poorer sleep quality and lower blood oxygen levels
8. Should hyperbaric oxygen therapy be used to treat combat-related mild traumatic brain injury?
9. Study finds association between oxygen deprivation before birth and ADHD
10. Oxygen Deprivation in the Womb May Raise ADHD Risk
11. Oxygen Treatment May Improve the Odds for Extreme Preemies
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Oxygen diminishes the heart's ability to regenerate, researchers discover
(Date:1/22/2015)... IPSWICH, Mass. (PRWEB) January 22, 2015 ... Association (AMA) are expanding their relationship in an effort ... journals around the world. While EBSCO has long made AMA ... as a sales agent for The JAMA Network. ...
(Date:1/22/2015)... is a famous dress online store for wedding dresses and ... collection of wedding dresses , and launches a site-wide women’s ... dress on your big day; the wedding gown is the ... to find the most suitable wedding dress. Now, we are ...
(Date:1/22/2015)... a new blog post explaining the importance of keeping a first ... an auto insurance policy . , Clients who driver safer ... vehicle insurance policies. The safety a vehicle offers from its driver ... this, drivers should always carry a first aid kit in their ...
(Date:1/22/2015)... 2015 State Forestry Institute of Mecklenburg-Vorpommern ... with support from GEOSYSTEMS, a dedicated Hexagon Geospatial and ... leverage Hexagon Geospatial’s ERDAS APOLLO for cataloging, ... as point clouds and documents. This effort will enable ...
(Date:12/26/2014)... 26, 2014 It is said that nothing ... Today, UWDress.com, the famous wedding dress supplier, shows its ... site-wide cocktail gown promotion. , UWDress.com’s navy cocktail gowns ... they come in high fashion styles. Simple dresses in bright ...
Breaking Medicine News(10 mins):Health News:EBSCO Expands Partnership with the American Medical Association 2Health News:EBSCO Expands Partnership with the American Medical Association 3Health News:EBSCO Expands Partnership with the American Medical Association 4Health News:Find The Most Suitable Wedding Dress At JJsHouse.com 2Health News:Driving Safe And Other Factors That Make Auto Insurance Affordable! 2Health News:State Forestry Institute Mecklenburg-Vorpommern, Germany Embraces Hexagon Geospatial Technology 2Health News:State Forestry Institute Mecklenburg-Vorpommern, Germany Embraces Hexagon Geospatial Technology 3Health News:UWDress.com Shows Its New Navy Cocktail Dresses For 2015 2
... difference appears to be how their bodies react to protein, study ... shape is more difficult for older women than men because it,s ... age, say U.S. and British researchers. , The study of 29 ... were less able to use protein to build muscle mass -- ...
... 26 Target Data Research (TDR),President R.J. Slutz announced ... Forward fund raising campaign which will be held at ... support Step,N Forward and the Office of Public,Guardianship, Advanced ... quality of life and develop strategies to raise the ...
... 911,s Nanny Stella, ,Notes From the Underbelly, star Rachael Harris and ... fun ... fundraiser, LOS ANGELES, March 26 The ... - 4pm at the Loews Santa,Monica Hotel. The event will raise funds for ...
... first in country to use new technique, CHICAGO, March ... Diane Long, of Homewood, Illinois. On Sunday, she struggled with,double ... a nerve,that controls eye movement. On Monday, she became one ... noninvasive procedure and a newly developed,material called Onyx. On Wednesday ...
... Co-founder and CEO Gary Alpert to Lead Company,s Partnership ... and ... Caring.com is pleased to,announce the arrival of Gary Alpert as ... responsible for the company,s,partnership and content licensing programs., (Photo: ...
... company,s largest free health screening and service ... ... launches this week to provide more than $35 million in free health,screenings ... vehicles, compared to the,four-vehicle tour in 2007. This is the tour,s fourth ...
Cached Medicine News:Health News:Older Women Have Harder Time Preserving Muscle Than Men 2Health News:Celebrities From All Walks of Life Put Their Best Foot Forward for the Fourth Annual Open Toe Shoe Party 2Health News:Revolutionary New Technique Uses Onyx to Fill Hard-To-Treat Aneurysms 2Health News:Caring.com Adds Vice President of Business Development 2Health News:Video: Walgreens to Provide $35 Million in Free Health Screenings with The Take Care Health Tour 2
(Date:1/23/2015)... , Jan. 23, 2015  iMD Companies, Inc. (ICBU) has ... increase market share and grab a foothold in the hydroponic, ... production capabilities and a presence in the sector, and recently ... the growth of hemp and medical marijuana, iMD is committing ...
(Date:1/23/2015)... Cord Blood America, Inc. ( www.cordblood-america.com ) (OTC Bulletin ... a Preliminary Proxy Statement, Schedule 14A, with the U.S. Securities ... update for shareholders detailing why a "YES" vote to increase ... Shareholders, As we reflect upon the 2014 fiscal ...
(Date:1/23/2015)... JUNCTION, N.J. , Jan. 23, 2015  CytoSorbents ... company commercializing its CytoSorb® extracorporeal cytokine adsorber to ... patients, announced the receipt of $385,642, net of ... participant of the Technology Business Tax Certificate Transfer ...
Breaking Medicine Technology:iMD Companies Poised to Make Impact in Multi-Billion Dollar Medical Marijuana Sector With Recent Investments and Strategic Partnerships 2Cord Blood America Announces Preliminary Proxy Filing and Details Why a "YES" Vote to Increase Authorized Shares Is Requested 2Cord Blood America Announces Preliminary Proxy Filing and Details Why a "YES" Vote to Increase Authorized Shares Is Requested 3Cord Blood America Announces Preliminary Proxy Filing and Details Why a "YES" Vote to Increase Authorized Shares Is Requested 4CytoSorbents Receives $385,000 in Non-Dilutive Funding from the New Jersey Technology Business Tax Certificate Transfer Program 2CytoSorbents Receives $385,000 in Non-Dilutive Funding from the New Jersey Technology Business Tax Certificate Transfer Program 3
... EAST RUTHERFORD, N.J., LONDON, and HYDERABAD, India, Jan. 6, ... announced today that Cambrex Zenara is supplying product for ... smoking cessation product, in India.  The Nicorette® product is ... Hyderabad, India facility. "Nicotine Replacement Therapeutics represent ...
... Century Park Capital Partners is pleased to announce ... Systems, LLC ("Cirtec") along with Charter Oak Equity ... provider of client focused, comprehensive medical product design, ... with highly technical solutions, utilizing its expertise in ...
Cached Medicine Technology:Cambrex Zenara Supplies Product for Launch of Nicorette® in India 2Century Park Capital Partners Announces the Recapitalization of Cirtec Medical Systems, LLC 2Century Park Capital Partners Announces the Recapitalization of Cirtec Medical Systems, LLC 3
Power Supply E865 is ideal for electrophoresis and semi-dry blotting applications. The electrical leads from Hoefer Gel apparatus are fully compatible with this new E865 power supply and there is no ...
... C.B.S.SCIENTIFIC offers four different Series ... EPS-3000-II, the EPS-4000-II, and the EPS-6000-II. ... voltage, constant current, and constant power ... a powerful 300 milliamps maximum current/300 ...
... supply replaces the PowerPac 200. With increased output ... the PowerPac HC drives all high-current applications. The ... blotting with any of Bio-Rad's extensive line of ... cell for large format gels up to 26.5 ...
Agarose L03 is recommended for separations of DNA fragments = 1,000 bp....
Medicine Products: