Navigation Links
Oxygen diminishes the heart's ability to regenerate, researchers discover
Date:4/24/2014

DALLAS April 24, 2014 Scientific research at UT Southwestern Medical Center previously discovered that the newborn animal heart can heal itself completely, whereas the adult heart lacks this ability. New research by the same team today has revealed why the heart loses its incredible regenerative capability in adulthood, and the answer is quite simple oxygen.

Yes, oxygen. It is well-known that a major function of the heart is to circulate oxygen-rich blood throughout the body. But at the same time, oxygen is a highly reactive, nonmetallic element and oxidizing agent that readily forms toxic substances with many other compounds. This latter property has now been found to underlie the loss of regenerative capacity in the adult heart.

This groundbreaking new finding, published in today's issue of Cell, finds that the oxygen-rich postnatal environment results in cell cycle arrest of cardiomyocytes, or heart cells.

"Knowing the key mechanism that turns the heart's regenerative capacity off in newborns tells us how we might discover methods to reawaken that capacity in the adult mammalian heart," said Dr. Hesham Sadek, Assistant Professor of Internal Medicine at UT Southwestern and senior author of the study.

Due to the oxygen-rich atmosphere experienced immediately after birth, heart cells build up mitochondria the powerhouse of the cell which results in increased oxidization. The mass production of oxygen radicals by mitochondria damages DNA and, ultimately, causes cell cycle arrest.

"We have uncovered a previously unrecognized protective mechanism that mediates cardiomyocyte cell cycle arrest and that arises as a consequence of oxygen-dependent aerobic metabolism," said Dr. Sadek.

Physiologically speaking, Dr. Sadek said, mammals likely had to make the choice early on between being energy efficient or retaining
'/>"/>

Contact: Lisa Warshaw
lisa.warshaw@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Low oxygen levels could drive cancer growth
2. Oxygen Therapy Slows Type 1 Diabetes in Mice, Study Says
3. Should oxygen be used for patients with chronic heart failure?
4. Cooling Helps Oxygen-Deprived Newborns: Study
5. New anti-inflammatory drugs pinch off reactive oxygen species at the source
6. Lack of oxygen in cancer cells leads to growth and metastasis
7. COPD patients experience poorer sleep quality and lower blood oxygen levels
8. Should hyperbaric oxygen therapy be used to treat combat-related mild traumatic brain injury?
9. Study finds association between oxygen deprivation before birth and ADHD
10. Oxygen Deprivation in the Womb May Raise ADHD Risk
11. Oxygen Treatment May Improve the Odds for Extreme Preemies
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Oxygen diminishes the heart's ability to regenerate, researchers discover
(Date:8/20/2014)... August 21, 2014 Medical Alert Systems, ... and reviews of some of the most popular medical ... pleased to announce that it is now offering special ... seniors who are on a fixed income but would ... announcement comes as very welcome news. , As a ...
(Date:8/20/2014)... 21, 2014 Recently, UWDress.com, the distinguished ... selection of birthday party dresses for girls . ... are well-designed and exquisitely handmade by experienced specialists. Now, ... percent off. , The company’s new items come in ... short knee length frocks, long elegant backless gowns and ...
(Date:8/20/2014)... Park Avenue Dental, a leading Florida-based ... a top graduate of the University of Detroit School ... its website through an ultra-informative blog focused on dental ... parkavenuedentalfl.com, the blog page is chock full of topics ... instead concentrating on important dental care tips ...
(Date:8/20/2014)... August 20, 2014 Locating rates for insurance ... the Quotes Pros website. A new source of term life ... review rates good for all 50 states at http://quotespros.com/life-insurance.html ... one of the new methods available for the public to ... that are supplied. The instant quotations that are available are ...
(Date:8/20/2014)... HealthDay Reporter WEDNESDAY, Aug. 20, 2014 (HealthDay ... of rhesus monkeys from deadly Marburg virus, a very close ... of those it infects, researchers report. The drug protected ... when it was given three days after infection, according to ... Translational Medicine . This is the first drug ever ...
Breaking Medicine News(10 mins):Health News:Medical Alert Systems Website Now Offering Special Prices on the Popular Medical Guardian Product 2Health News:Medical Alert Systems Website Now Offering Special Prices on the Popular Medical Guardian Product 3Health News:Cheap Birthday Party Dresses for Girls Now Available at UWDress.com 2Health News:Park Avenue Dental Provides Dental Care Tips for World Wide Community on New Website Blog 2Health News:Park Avenue Dental Provides Dental Care Tips for World Wide Community on New Website Blog 3Health News:Term Life Insurance Price Database Now Helps Quote Prices for Adults in 50 States Online 2Health News:Drug for Ebola-Like Virus Shows Promise in Monkeys 2Health News:Drug for Ebola-Like Virus Shows Promise in Monkeys 3
... NANJING, China, Aug. 24 /PRNewswire-Asia/ -- Simcere ... "Company"), a leading manufacturer and supplier,of branded generic and ... Sun Yat-Sen University Cancer Center. , ... is one of,China,s renowned cancer research institutions, prominent in ...
... , , ... Inc., announced today that it has received European CE Mark ... System. The device is now approved for use in improving ... disease. , , The novel vProtect(TM) Luminal ...
... SHENZHEN, China, Aug. 24 /PRNewswire-Asia-FirstCall/ -- China Nepstar,Chain Drugstore ... the largest,retail drugstore chain in China based on the number ... the quarter ended,June 30, 2009. , ... Nepstar terminated a voting rights assignment agreement,which assigned 30% of ...
... SHENZHEN, China, Aug. 24 /PRNewswire-Asia-FirstCall/ ... ) ("Nepstar" or the "Company"), the largest,drugstore chain in ... announced the resignation of Mr. Jiannong Qian as the ... effective on August 20, 2009,upon the expiration of Mr. ...
... for active tuberculosis (TB) disease, according to a new study ... data from nearly 17,000 individuals in Taiwan as part of ... studies have reported increased mortality among TB patients who smoke, ... of smoking on active TB incidence using a longitudinal design ...
... ... disabilities and health limitations spurs need for rehabilitation professionals , ... (Vocus) August 23, 2009 -- An aging ... professionals, and the National Rehabilitation Awareness Foundation (NRAF) is honoring the difference ...
Cached Medicine News:Health News:Simcere Announces Strategic Partnership with Sun Yat-Sen University Cancer Center 2Health News:vProtect Luminal Shield (TM) from Prescient Medical Receives CE Mark 2Health News:China Nepstar Chain Drugstore Reports Second Quarter 2009 Financial Results 2Health News:China Nepstar Chain Drugstore Reports Second Quarter 2009 Financial Results 3Health News:China Nepstar Chain Drugstore Reports Second Quarter 2009 Financial Results 4Health News:China Nepstar Chain Drugstore Reports Second Quarter 2009 Financial Results 5Health News:China Nepstar Chain Drugstore Reports Second Quarter 2009 Financial Results 6Health News:China Nepstar Chain Drugstore Reports Second Quarter 2009 Financial Results 7Health News:China Nepstar Chain Drugstore Reports Second Quarter 2009 Financial Results 8Health News:China Nepstar Chain Drugstore Reports Second Quarter 2009 Financial Results 9Health News:China Nepstar Chain Drugstore Reports Second Quarter 2009 Financial Results 10Health News:China Nepstar Chain Drugstore Reports Second Quarter 2009 Financial Results 11Health News:China Nepstar Chain Drugstore Reports Second Quarter 2009 Financial Results 12Health News:China Nepstar Chain Drugstore Reports Second Quarter 2009 Financial Results 13Health News:China Nepstar Chain Drugstore Announces Management Change 2Health News:China Nepstar Chain Drugstore Announces Management Change 3Health News:Smoking increases risk of developing active TB 2Health News:Smoking increases risk of developing active TB 3Health News:Medical Advances, Population Changes Fuel Demand for Rehabilitation Professionals 2
(Date:8/20/2014)... Aug. 20, 2014  The National Association of ... results achieved by the real-time, pseudoephedrine (PSE) blocking ... Precursor Log Exchange (NPLEx), automatically blocks unlawful PSE ... meth offenders and make arrests. Data released by ... blocked the sale of more than ...
(Date:8/20/2014)...  The National Association of Drug Diversion Investigators ... the real-time, pseudoephedrine (PSE) blocking system in Missouri. The ... (NPLEx), automatically blocks unlawful pseudoephedrine sales and helps ... make arrests. Data released by NPLEx shows electronic ... the sale of more than 19,030 boxes of medicine ...
(Date:8/20/2014)... , Aug. 20, 2014 PTC Therapeutics, Inc. (NASDAQ: ... two upcoming investor conferences: - FBR 1 st ... Boston on Wednesday, September 3 rd ... The Mandarin Oriental Boston on Thursday, September 4 th ... update at the Bank of America Merrill Lynch Global Healthcare ...
Breaking Medicine Technology:Kentucky's Stop-Sale System Achieves Significant Results In Battle Against Meth 2Missouri's Stop-Sale System Achieves Significant Results In Battle Against Meth 2PTC Therapeutics to Participate at Upcoming Investor Conferences 2
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: