Navigation Links
Ovarian Tumors May Develop Years After Fertility Therapy
Date:10/27/2011

THURSDAY, Oct. 27 (HealthDay News) -- Women who undergo ovarian stimulation to produce extra eggs for in-vitro fertilization (IVF) are at increased risk for a type of growth known as "borderline ovarian tumors," new research suggests.

Borderline ovarian tumors are typically not aggressive, according to the U.S. National Cancer Institute. Even if the tumor does spread, the vast majority of women survive borderline ovarian tumors.

Even so, treating borderline ovarian tumors can require extensive surgery, explained lead researcher Flora van Leeuwen, head of the epidemiology department in The Netherlands Cancer Institute.

For the study, researchers examined data from over 19,000 infertile women in the Netherlands who underwent ovarian stimulation prior to IVF and about 6,000 infertile women who did not undergo IVF.

After 15 years of follow-up, the women who underwent ovarian stimulation were four times more likely to develop a borderline ovarian tumor, according to the findings published in the Oct. 27 online edition of the journal Human Reproduction.

"Our data clearly show that ovarian stimulation for IVF is associated with an increased risk of borderline ovarian tumors and this risk remains elevated up to more than 15 years after the first cycle of treatment," van Leeuwen explained in a journal news release.

Overall, however, the number of women developing any sort of ovarian tumor was low. The cumulative risk in the general population of an ovarian malignancy for women under age 55 in the Netherlands is 0.45 percent. For women who undergo IVF, it's 0.71 percent, "with the increase being due to borderline tumors of the ovary," van Leeuwen added.

The low number of women in the study who developed ovarian malignancies prevented the researchers from determining if repeated IVF cycles increased the risk of ovarian malignancies. They noted in the news release that they are expanding their study population to examine that issue.

"If we find out that women who receive several IVF cycles or large doses of ovarian-stimulating drugs are at a greater risk of ovarian cancer, then these women would need to be informed about these risks when continuing IVF treatment and possibly advised to discontinue treatment after three to six cycles (depending on which number of cycles would be associated with the high risk of ovarian malignancies)," van Leeuwen noted.

The International Federation of Fertility Societies (IFFS) issued a statement in response to the new study findings. In it, general secretary of the IFFS, Richard Kennedy of Coventry, England, said: "Over the last decade, several reports have considered the long-term risks of ovarian stimulation practiced as part of the IVF process. These reports have been generally reassuring in terms of risk of ovarian cancer."

However, Kennedy added, "This new research has highlighted the presence of an increased risk of borderline tumors . . . and has once again posed a question about the long-term risks of ovarian stimulation further confounded by the known underlying risks for these patients. The IFFS remains of the view that the long-term risks are low but calls for continued vigilance through reporting of long-term outcomes with international collaboration."

More information

The American Cancer Society has more about ovarian cancer.

-- Robert Preidt

SOURCES: Human Reproduction, news release, Oct. 26, 2011; International Federation of Fertility Societies, statement, Oct. 26, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Linking of mutations in 12 genes to ovarian cancer may lead to more effective prevention
2. Terry Fox Research Institute aims to change diagnosis and management of ovarian cancer worldwide
3. Mutant Gene That Ups Risk for Ovarian Cancer May Aid Survival
4. Early detection is key in the fight against ovarian cancer
5. Moffitt researchers find possible key to preventing chemotherapy resistance in ovarian cancer
6. New hybrid imaging device shows promise in spotting hard-to-detect ovarian cancer
7. FDA clears biomarker test for ovarian cancer
8. Key function of mutation in hereditary breast and ovarian cancer gene discovered
9. Plants could pave the way for new ovarian cancer treatments
10. Trial Drug Shows Preliminary Promise Against Ovarian Cancer
11. Blood Antibody May Signal Start of Ovarian Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Ovarian Tumors May Develop Years After Fertility Therapy
(Date:6/23/2017)... , ... June 23, 2017 , ... Military Connection ... recently denied entry to the JFK Virgin Atlantic lounge. , Bensko is no ... wheelchair six years ago, Bensko dedicated her life to supporting our wounded veterans. A ...
(Date:6/23/2017)... ... 2017 , ... Georgia State University will host the First ... two-day conference is focused on advancing scientific knowledge about the aggressive triple negative ... racial breast cancer-related disparities. The conference theme is “Illuminating Actionable Biology.” , Conference ...
(Date:6/23/2017)... ... 23, 2017 , ... American Farmer, will feature Chr. Hansen, Inc (CHR Hansen) ... fourth quarter 2017. American Farmer airs Tuesdays at 8:30aET on RFD-TV. Check your local ... Hansen in Denmark in 1874 after a groundbreaking discovery of how to industrialize enzymes. ...
(Date:6/23/2017)... ... June 23, 2017 , ... Radabaugh ... planning to families and business owners in North Central West Virginia, is embarking ... services to differently abled residents in the region. , The Stepping Stones organization ...
(Date:6/22/2017)... ... June 22, 2017 , ... Groove Ring is excited ... about their high performance silicon wedding bands and all-purpose rings. Whether you’re an athlete, ... silicone rings designed just for you. , From the rock face to the auto ...
Breaking Medicine News(10 mins):
(Date:6/16/2017)... Corp. is voluntarily performing a worldwide field correction of certain Intra-Aortic Balloon Pumps ... ... CS100i IABP ... 0998-UC-0446HXX; 0998-UC-0479HXX 0998-00-3013-XX;  0998-UC-3013-XX 0998-00-3023-XX;  0998-UC-3023-XX ... This field correction also applies to any System 98 or ...
(Date:6/14/2017)...  In 2016, Embodied Labs took top ... and came away with $25,000 in seed-fund investment. Embodied ... as "entering the life of another" and by the ... to medical professionals in an entirely new dimension." Building ... finalist for the Department of Education,s EdSimChallenge, where they ...
(Date:6/10/2017)... BESSEMER, Ala. , June 9, 2017  Shane K. Burchfield, ... Member recognized for excellence as a Podiatrist in Alabama ... of Podiatry at Family First Foot Care. He brings over 20 ... sports medicine, pain management and healthcare, to his role. ... Family First Foot Care, PC is pleased to welcome ...
Breaking Medicine Technology: