Navigation Links
Open source DNA
Date:8/31/2009

In the chilling science fiction movie Gattaca, Ethan Hawke stars as a man with "inferior genes" who assumes another's genetic identity to escape a dead-end future. The 1997 film illustrates the very real fear swirling around today's genome research fear that private genetic information could be used negatively against us.

Last year, after a published paper found serious security holes in the way DNA data is made publicly available, health institutes in the United States and across the world removed all genetic data from public access.

"Unfortunately, that knee-jerk response stymied potential breakthrough genetic research," says Dr. Eran Halperin of Tel Aviv University's Blavatnik School of Computer Sciences and Department of Molecular Microbiology and Biotechnology. He wants to put this valuable DNA information back in circulation, and has developed the tool to do it safely.

Working with colleagues at the University of California in Berkeley, Dr. Halperin devised a mathematical formula that can be used to protect genetic privacy while giving researchers much of the raw data they need to do pioneering medical research. Reported in this month's issue of Nature Genetics, the tool could keep millions of research dollars-worth of DNA information available to scientists.

New security to restart genetic research

"We've developed a mathematical formula and a software solution that ensures that malicious eyes will have a very low chance to identify individuals in any study," says Dr. Halperin, who is also affiliated with the International Computer Science Institute in Berkeley.

The mathematical formula that Dr. Halperin's team devised can determine which SNPs ― or small pieces of DNA - that differ from individual to individual in the human population ― are accessible to the public without revealing information about the participation of any individual in the study. Using computer software that implements the formula, the National Institutes of Health and similar institutes around the world can distribute important research data, but keep individual identities private.

"We've been able to determine how much of the DNA information one can reveal without compromising a person's identity," says Dr. Halperin. "This means the substantial effort invested in collecting this data will not have been in vain."

Why is this information so important? Genome association studies can find links in our genetic code for conditions like autism and predispositions for cancer. Armed with this information, individuals can avoid environmental influences that might bring on disease, and scientists can develop new gene-based diagnosis and treatment tools.

A new track for government policymakers

Examining SNP positions in our genetic code, Dr. Halperin and his colleagues demonstrated the statistical improbabilities of identifying individuals even when their complete genetic sequence is known. "We showed that even when SNPs across the entire genome are collected from several thousand people, using our solution the ability to detect the presence of any given individual is extremely limited," he says.

Dr. Halperin hopes his research will reverse the NIH policy, and he will provide access to the software so that researchers can use it to decide which genetic information can be safely loaded into a public database. He also hopes it will quell raging debates about DNA usage and privacy issues.

The Tel Aviv University-Berkeley research was done while Dr. Halperin was working with the International Computer Science Institute (ICSI), a non-profit research institute with close relations to the University of California (UC) and Tel Aviv University. Other coauthors of the study include Sriram Sankararaman, and Prof. Michael Jordan from UC, and Dr. Guillaume Obozinski from Willow, a joint research team between INRIA Rocquencourt, cole Normale Suprieure de Paris and Centre National de la Recherche Scientifique.


'/>"/>

Contact: George Hunka
ghunka@aftau.org
212-742-9070
American Friends of Tel Aviv University
Source:Eurekalert  

Related medicine news :

1. The Pharma & Life Sciences Best Practice Database: an Industry Resource for Successful Techniques and Performance Benchmarks for Reaching the Top
2. Psoriasis Cure Now offers Back to School Resources for Parents of Children with Psoriasis
3. ADDAS Awareness Campaign Offers Resources and Education to Adults Living with AD/HD and Professionals Working With Them
4. MassMutual Promotes Debra Palermino to Senior Vice President of Human Resources
5. AWWA, National Association of Water and Sanitation of Mexico, Agree to Share Expertise and Resources for Improved Water Supply
6. Briefing on a new Web resource to address global drinking water crisis
7. Regional Center of Orange County Expands Family Support Resources to Meet Growing Needs
8. Recovery Resources Collaborates with Two Nonprofit Agencies for Children of Alcoholics Outreach Program
9. MEDEX Global Group & Harvard Medical International Join Forces to Create the Most Comprehensive Health Information Resource for International Travelers
10. Office-Based Medical Treatment and Internet Resources Are Potential Solution to Rising Painkiller Misuse Among Teens, Young Adults
11. Broker a Suite of Research & Advisory Services to Enhance Human Resources
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Open source DNA
(Date:2/24/2017)... (PRWEB) , ... February 24, 2017 , ... Yisrayl Hawkins, ... focuses on Bible Prophecy concerning this present generation. Yisrayl makes an astounding statement ... current generation. He explains that the Bible details the current times so plainly ...
(Date:2/24/2017)... ... February 24, 2017 , ... Rosica Communications, a national ... leadership , media relations, social media, content marketing and SEO, is now offering ... Act-On, an intuitive marketing automation platform. , Rosica will now offer the platform ...
(Date:2/23/2017)... (PRWEB) , ... February 23, 2017 , ... ... Department of Justice jointly issued a letter to withdraw previous guidance ... with their gender identity. The guidance issued in May 2016 by the Obama ...
(Date:2/23/2017)... NC (PRWEB) , ... February 23, 2017 , ... The ... Sponsor for ACPA’s 74th Annual Meeting. KLS is a longtime supporter of the ... as an exhibitor and Platinum Sponsor," said Dr. Bob Havlik, 2017 ACPA President. "KLS ...
(Date:2/23/2017)... ... February 23, 2017 , ... ... content provider for the National Institute for Health and Care Excellence ... organizations in the National Health Service (NHS) to search, order and purchase medical ...
Breaking Medicine News(10 mins):
(Date:2/24/2017)... 24, 2017 Following receiving ... Israel , s AMAR is a major milestone ... M w ound care market in ... BST for inclusion in the National Health Basket ...   E-QURE Corp. (OTCQB: EQUR), a leader in ...
(Date:2/24/2017)... WARSAW, Ind. , Feb. 24, 2017 ... global leader in musculoskeletal healthcare, will present at the ... Conference at the Boston Marriott Copley Place on Tuesday, ... A live webcast of the presentation can ... be archived for replay following the conference via Zimmer ...
(Date:2/24/2017)... DUBLIN , Feb 24, 2017 Research and ... and Strategies - 2016" report to their offering. ... The latest research Hemophilia Drugs Price Analysis ... global Hemophilia market. The research answers the following questions: ... their clinical attributes? How are they positioned in the Global Hemophilia market? ...
Breaking Medicine Technology: