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Obese men at high risk for prostate cancer even after benign biopsy
Date:4/23/2013

After accounting for several variables, including family history of prostate cancer, prostate-specific antigen (PSA) levels during the initial procedure, and the number of PSA tests and digital rectal exams during follow-up, the researchers found that obesity at the time of the initial procedure was associated with a 57% increased incidence of prostate cancer during follow-up.

Dr. Rundle noted, however, that this association was only apparent for tumors occurring earlier in the follow-up period. "We don't absolutely know what the true biology is," he said. "In some ways, this reflects the association between the body size and larger prostate size, which is thought to reduce the sensitivity of the needle biopsy. It is possible that the tumors missed by initial biopsy grew and were detected in a follow-up biopsy."

The association observed between body size and prostate cancer risk is greater than that seen in prior studies, according to Dr. Rundle. He attributed the discrepancy to differences between the cohorts studied; the current study was composed only of men at high risk for prostate cancer. In addition, since these high-risk men were members of the comprehensive Henry Ford Medical System, they underwent increased medical surveillance, which included repeated biopsy and regular PSA screening.

"We need some guidance on when or for whom a full follow-up is required," said Dr. Rundle. "Obesity should be considered a factor for more intensive follow-up after a benign prostate biopsy."


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Contact: stephanie berger
sb2247@columbia.edu
212-305-4372
Columbia University's Mailman School of Public Health
Source:Eurekalert

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