Navigation Links
Obese men at high risk for prostate cancer even after benign biopsy
Date:4/23/2013

Obese men were more likely to have precancerous lesions detected in their benign prostate biopsies compared with non-obese men, and were at a greater risk for subsequently developing prostate cancer, according to researchers at Columbia University's Mailman School of Public Health. The findings will be published online in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research.

"Our study is focused on a large group of men who have had a prostate biopsy that is benign but are still at a very high risk for prostate cancer," said Andrew Rundle, DrPH, associate professor of Epidemiology and the first author of the paper. "Studies conducted in the past have attempted to determine if there are subpopulations of men diagnosed with benign conditions that may be at a greater risk for developing prostate cancer. Here we were able to show that obesity is associated with a significantly higher risk of prostate cancer after an initial benign biopsy, particularly in the first few years after a biopsy. This was also one of the first studies to assess the association between obesity and precancerous abnormalities in the benign biopsy tissue specimens."

Dr. Rundle and his colleagues investigated the association between obesity and future prostate cancer incidence within a cohort of 6,692 men at the Henry Ford Health System who were followed for 14 years after a biopsy or transurethral resection of the prostate with benign findings. The investigation was part of a larger study for prostate cancer funded through a research grant by the National Institutes of Health to the Henry Ford Health System.

The researchers conducted a case-control study among 494 of these patients and 494 matched controls; they found precancerous abnormalities in 11% of the patients' benign specimens. These abnormalities were significantly associated with obesity at the time of the procedure, according to Dr. Rundle.

After accounting for several variables, including family history of prostate cancer, prostate-specific antigen (PSA) levels during the initial procedure, and the number of PSA tests and digital rectal exams during follow-up, the researchers found that obesity at the time of the initial procedure was associated with a 57% increased incidence of prostate cancer during follow-up.

Dr. Rundle noted, however, that this association was only apparent for tumors occurring earlier in the follow-up period. "We don't absolutely know what the true biology is," he said. "In some ways, this reflects the association between the body size and larger prostate size, which is thought to reduce the sensitivity of the needle biopsy. It is possible that the tumors missed by initial biopsy grew and were detected in a follow-up biopsy."

The association observed between body size and prostate cancer risk is greater than that seen in prior studies, according to Dr. Rundle. He attributed the discrepancy to differences between the cohorts studied; the current study was composed only of men at high risk for prostate cancer. In addition, since these high-risk men were members of the comprehensive Henry Ford Medical System, they underwent increased medical surveillance, which included repeated biopsy and regular PSA screening.

"We need some guidance on when or for whom a full follow-up is required," said Dr. Rundle. "Obesity should be considered a factor for more intensive follow-up after a benign prostate biopsy."


'/>"/>

Contact: stephanie berger
sb2247@columbia.edu
212-305-4372
Columbia University's Mailman School of Public Health
Source:Eurekalert

Related medicine news :

1. Some Slightly Obese May Gain From Weight-Loss Surgery, Guidelines Say
2. Scientists identify gene that is consistently altered in obese individuals
3. Lung Transplant Hazard May Rise With Obese Recipients, Smoking Donors
4. Obese New Mothers May Have Higher Heart Attack, Stroke Risk
5. Weight loss may prevent, treat osteoarthritis in obese patients
6. Procedure Lowers Hunger Hormone to Help Obese Lose Weight
7. Babies Born to Obese Women Show Thicker Arteries: Study
8. Exercise May Stave Off Depression in Severely Obese
9. Obese Black Women at Higher Risk for Having Very Large Babies
10. Caloric restriction, exercise help prevent weight gain, other complications in obese women
11. USC research finds certain contraceptive may pose risk of Type 2 diabetes for obese women
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/28/2016)... ... May 28, 2016 , ... "Color Grading media can be ... a preset onto their media," said Christina Austin - CEO of Pixel Film Studios. ... quickly and easily add stylish color grades to their footage. A LUT is a ...
(Date:5/27/2016)... CA (PRWEB) , ... May 27, 2016 , ... More ... Health, so it is not surprising that bariatric surgery has received increased attention in ... Journal explains. Of course, when it comes to weight loss, most people are familiar ...
(Date:5/27/2016)... ... ... An influential resource amongst nurses and professionals in the health care world, ... of topics detailing why we appreciate nurses in so many different ways. From exclusive ... being in a major recession to one of the hottest growing professions in any ...
(Date:5/27/2016)... ... May 27, 2016 , ... In response to meager ... are unaware of the plight of aphasia. In collaboration with the American Aphasia ... campaign. , The link between stroke and aphasia is relatively unknown, but through ...
(Date:5/27/2016)... ... May 27, 2016 , ... Each year Standard Process ... Outerbridge is this year’s Life University winner of a $2,500 scholarship ... Student Leadership Awards ceremony. , Outerbridge is approaching her last quarter at Life ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... , May 25, 2016 Digital ... issuance to it by the US Patent and ... company,s technology includes proprietary processes for electronic opt-­in ... health and wellness programs, HIPAA compliance and otherwise. ... "Our technology allows ...
(Date:5/24/2016)... Niederländische Chirurgen haben eine ... Ärzten erlaubt, ihre Expertise weltweit zu teilen und ... Streaming mit einer Instant-Messaging-Funktion und der Möglichkeit, in ... Europa, Afrika, Asien und den USA ... registriert. Information und Weiterbildung   ...
(Date:5/24/2016)... May 24, 2016  Diana Russell suffers from a ... from the inside out.  This disease has put her ... her children and grandchildren to leave her home.  Because ... family cannot haul the wheelchair.  So if there is ... and Diana is left to wait for the bus. ...
Breaking Medicine Technology: