Navigation Links
Novel protein may help detect Lou Gehrig's disease and dementia, Mayo Clinic finds
Date:2/12/2013

JACKSONVILLE, Fla. Researchers at Mayo Clinic have discovered an abnormal protein that accumulates in the brains of many patients affected with two common neurodegenerative disorders amyotrophic lateral sclerosis, also known as ALS or Lou Gehrig's disease, and frontotemporal dementia. They say their findings have uncovered a potentially new therapeutic target and biomarker that would allow clinicians to confirm diagnosis of the diseases. The study is published online today in the journal Neuron.

The Mayo research team, led by scientists at Mayo Clinic's campus in Florida, discovered the abnormal protein pathology that they call C9RANT. An error in the highly regulated cellular process through which proteins are generated causes the abnormal production of C9RANT. The team developed an antibody that can detect the specific, insoluble protein that clumps together and is present in patients with mutations in the C9ORF72 gene, which was previously identified by Mayo Clinic researchers as the most common genetic cause of ALS and frontotemporal dementia.

"This new finding sheds light on how the mutation causes these disorders, and it provides us with a marker that helps us track disease progression in patients with this disorder and potentially combat the disease," says senior author Leonard Petrucelli, Ph.D., a molecular neuroscientist and director of the Department of Neuroscience at Mayo Clinic in Florida.

If it is shown that, as suspected, these protein clumps are the cause of neuronal death and toxicity in these diseases, it may be possible to design therapies to break the clumps apart or to prevent the protein from accumulating in the first place, Dr. Petrucelli says.

Because the protein is found throughout the central nervous system in patients with ALS and frontotemporal dementia but not in other neurodegenerative diseases the researchers hope that in the future it can be tested through a spinal tap.

After Alzheimer's disease, frontotemporal dementia is the most common form of early onset neurodegenerative dementia. It is characterized by changes in personality, behavior and language due to loss of gray matter in the brain's frontal lobe. ALS destroys motor neuron cells that control essential muscle activity such as speaking, walking, breathing and swallowing.

This new discovery stems from a key finding, reported simultaneously in 2011 by Mayo researchers and scientists from the National Institutes of Health, that an unusual mutation a short DNA sequence repeated hundreds to thousands of times was found in almost 12 percent of familial frontotemporal dementia and more than 22 percent of familial ALS samples studied.


'/>"/>
Contact: Kevin Punsky
punsky.kevin@mayo.edu
904-953-2299
Mayo Clinic
Source:Eurekalert

Related medicine news :

1. Novel radiation therapy method shortens prostate cancer treatment time
2. Novel gene-searching software improves accuracy in disease studies
3. New Novel Looks at British NHS from the Inside
4. Fox Chase researchers discover novel role of the NEDD9 gene in early stages of breast cancer
5. IRSF awards $1.5 million for novel basic and translational research programs
6. Nobel laureate James Watson publishes novel hypothesis on curing late-stage cancers
7. PolyU Researchers Develop Novel Treatment for People with Hemiplegic Arms
8. 2 novel treatments for retinitis pigmentosa move closer to clinical trials
9. Neurological Wellness Center's Novel Neuro-Inflammation Inhibition Procedure that Induces Rapid Recovery from Alzheimer's, Stroke and Brain Injury is Now Being Taught in a Newly Released Video
10. Novel test identifies patients most likely to benefit from ALK inhibition therapy
11. Novel drug therapy targets aggressive form of non-Hodgkins lymphoma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/31/2016)... Linda, CA (PRWEB) , ... May 31, 2016 , ... ... both a primary screening tool and as an orthogonal tool for RNAi hit validation. ... highly functional and specific guide RNAs—allows rapid generation of CRISPR RNA (crRNA) collections in ...
(Date:5/31/2016)... Aviv (PRWEB) , ... May 31, 2016 , ... ... the May 4, 2016 Cool Vendors in Security Infrastructure Protection report by Gartner1 ... and publishes a series of research reports evaluating these innovative vendors and their ...
(Date:5/31/2016)... ... May 31, 2016 , ... CURE Media Group , ... has added Cancer and Careers to its Advocacy Spotlight Partnership ... continuing successful careers while fighting cancer. , As partners, both organizations will supply ...
(Date:5/30/2016)... Lake City, Utah (PRWEB) , ... May 30, ... ... insurance reimbursement for small businesses, announced today the publication of an original infographic, ... business owners and health insurance professionals understand how Zane Benefits complies with various ...
(Date:5/29/2016)... Carolina (PRWEB) , ... May 29, 2016 , ... Whole ... via Amazon.com, their new KlipPro KP-240L clipper is available to the public. This is ... which is substantially wider than the average clipper. , Everything about this product is ...
Breaking Medicine News(10 mins):
(Date:5/27/2016)... , May 27, 2016 ... instances of hypertension is driving ambulatory blood pressure monitoring ... their elasticity and their ability to respond to different ... This condition can lead to various cardiovascular disorders such ... vascular disease. These diseases are growing in prevalence each ...
(Date:5/27/2016)... 2016 The healthcare sector is ... companies all falling under its umbrella.  A rather overlooked ... often talked about, these healthcare companies are still trying ... is by far the largest consumer of the ... (OTC: ADMD), Nutranomics Inc. (OTC: NNRX), KollagenX Corp. (OTCQB: ...
(Date:5/26/2016)... 26, 2016   Change Healthcare , ... network solutions and technology-enabled services designed to ... into a strategic channel partnership with SourceMed, ... solutions and revenue cycle management services that ... rehabilitation clinics to optimize revenue, operational efficiency ...
Breaking Medicine Technology: