Novel protein may help detect Lou Gehrig's disease and dementia, Mayo Cl... ( JACKSONVILLE Fla. Researchers at Ma...)

Novel protein may help detect Lou Gehrig's disease and dementia, Mayo Clinic finds

Date:2/12/2013

JACKSONVILLE, Fla. Researchers at Mayo Clinic have discovered an abnormal protein that accumulates in the brains of many patients affected with two common neurodegenerative disorders amyotrophic lateral sclerosis, also known as ALS or Lou Gehrig's disease, and frontotemporal dementia. They say their findings have uncovered a potentially new therapeutic target and biomarker that would allow clinicians to confirm diagnosis of the diseases. The study is published online today in the journal Neuron.

The Mayo research team, led by scientists at Mayo Clinic's campus in Florida, discovered the abnormal protein pathology that they call C9RANT. An error in the highly regulated cellular process through which proteins are generated causes the abnormal production of C9RANT. The team developed an antibody that can detect the specific, insoluble protein that clumps together and is present in patients with mutations in the C9ORF72 gene, which was previously identified by Mayo Clinic researchers as the most common genetic cause of ALS and frontotemporal dementia.

"This new finding sheds light on how the mutation causes these disorders, and it provides us with a marker that helps us track disease progression in patients with this disorder and potentially combat the disease," says senior author Leonard Petrucelli, Ph.D., a molecular neuroscientist and director of the Department of Neuroscience at Mayo Clinic in Florida.

If it is shown that, as suspected, these protein clumps are the cause of neur
'/>"/>

Contact: Kevin Punsky
punsky.kevin@mayo.edu
904-953-2299
Mayo Clinic
Source:Eurekalert

0

GOOD

Page: 1 2
Related medicine news :

1. Novel radiation therapy method shortens prostate cancer treatment time
2. Novel gene-searching software improves accuracy in disease studies
3. New Novel Looks at British NHS from the Inside
4. Fox Chase researchers discover novel role of the NEDD9 gene in early stages of breast cancer
5. IRSF awards $1.5 million for novel basic and translational research programs
6. Nobel laureate James Watson publishes novel hypothesis on curing late-stage cancers
7. PolyU Researchers Develop Novel Treatment for People with Hemiplegic Arms
8. 2 novel treatments for retinitis pigmentosa move closer to clinical trials
9. Neurological Wellness Center's Novel Neuro-Inflammation Inhibition Procedure that Induces Rapid Recovery from Alzheimer's, Stroke and Brain Injury is Now Being Taught in a Newly Released Video
10. Novel test identifies patients most likely to benefit from ALK inhibition therapy
11. Novel drug therapy targets aggressive form of non-Hodgkins lymphoma

Post Your Comments:

(Date:5/21/2013)... 2013 Parker Waichman LLP, a national law ... defective medical devices, is offering remarks on the closing argument ... of Fred E. Taylor v. Intuitive Surgical, 09-2-03136-5, Superior Court, ... 2013, Bloomberg report noted that the plaintiff’s attorney, ... dealership” in how it deployed its strategy to train doctors ...

(Date:5/21/2013)... 21, 2013 Mecklenburg EMS Agency (Medic) ... hold a free Community Wellness Fair to educate the public ... will be held on Wednesday, May 22, 2013 from 4:00 ... (8100 Old Mallard Creek Road, Charlotte, NC 29262). ... and the Mecklenburg County Department of Social Services ...

(Date:5/21/2013)... (PRWEB) May 21, 2013 Arizona ... inventors who want to develop their ideas into ... program. , The university is recruiting participants ... new “formation space” that provides early-stage entrepreneurs with ... AREA48 is open to anyone, ASU is particularly ...

(Date:5/21/2013)... Diversity Focus, a non-profit organization striving ... residents in the Creative Corridor region, is releasing results ... news conference on Thursday, May 23rd at 10:30 a.m. ... 2008. , The survey is a critical ... efforts that attract, nurture and retain people of diverse ...

(Date:5/21/2013)... proteins, thrombospondin-1 and prosaposin, play in discouraging cancer ... five-amino acid fragment of prosaposin that significantly reduces ... and lung cancer. The findings suggest that a ... variety of cancers. , The study team, ... Hospital, Vivek Mittal, PhD, at Weill Cornell Medical ...

Breaking Medicine News(10 mins):Health News:Da Vinci Robotic Surgery Lawsuit: Parker Waichman LLP Reacts to Plaintiff’s Attorney’s Closing Argument in Which He Describes Intuitive Surgical as a Car Dealership 2 Health News:Da Vinci Robotic Surgery Lawsuit: Parker Waichman LLP Reacts to Plaintiff’s Attorney’s Closing Argument in Which He Describes Intuitive Surgical as a Car Dealership 3 Health News:Mecklenburg EMS Agency Teams Up with the YMCA of Greater Charlotte and Others to Educate the Public on Health Related Initiatives 2 Health News:ASU Launches Summer Program for Aspiring Entrepreneurs, Innovators and Inventors 2 Health News:ASU Launches Summer Program for Aspiring Entrepreneurs, Innovators and Inventors 3 Health News:ASU Launches Summer Program for Aspiring Entrepreneurs, Innovators and Inventors 4 Health News:Diversity Focus Announces Results from 2013 Creative Corridor Survey at News Conference on Thursday, May 23rd at 10:30 a.m. 2 Health News:Changing cancer's environment to halt its spread 2 Health News:Changing cancer's environment to halt its spread 3

[0] Da Vinci Robotic Surgery Lawsuit: Parker Waichman LLP Reacts to Plaintiff’s Attorney’s Closing Argument in Which He Describes Intuitive Surgical as a Car Dealership [0] Mecklenburg EMS Agency Teams Up with the YMCA of Greater Charlotte and Others to Educate the Public on Health Related Initiatives [0] ASU Launches Summer Program for Aspiring Entrepreneurs, Innovators and Inventors [0] Diversity Focus Announces Results from 2013 Creative Corridor Survey at News Conference on Thursday, May 23rd at 10:30 a.m.[0] Changing cancer's environment to halt its spread

... insight into the mechanisms involved in resistance to treatment ... published by Cell Press in the October issue of ... may help to identify patients who are unlikely to ... for treating these patients. , Trastuzumab is an antibody ...

... AUSTIN, Texas, Oct. 15 Nine of Texas, ... Advocacy Tribute,award in recognition of their accomplishments on ... the Texas Legislature. The Texas Hospital,Association created the ... other,public officials who demonstrate outstanding leadership on issues ...

... Authors, Researchers and Health Professionals Gather at Mental ... Friday, November 2nd, NEW YORK, Oct. 15 ... Annual Long Island Mental Illness,Awareness Day presented by Clubhouse ... 2007 at the Huntington Hilton in Melville, NY from ...

... U.S. Food and Drug Administration (FDA) has ... treatment for complicated,intra-abdominal and complicated urinary tract ... a wide range of,Gram-positive and Gram-negative bacteria ... infections. According to the CDC, in ...

... ten HIV positive African-American men could be putting their partners at ... UK-based Journal of Advanced Nursing. , A study of 130 ... the 40 to 65 year-olds were engaging in high-risk sexual practices. ... 25 per cent having unprotected vaginal sex and 22 per cent ...

... Donates Hotel Points to Benefit More Transplant Patients and Family ... ... The National Foundation for,Transplants (NFT) announced today that it will extend free ... to,pre- and post-transplant care through an expansion of its Home Away From,Home ...

Cached Medicine News:Health News:Genetic approach provides new insight into trastuzumab resistance in breast cancer 2 Health News:THA Honors Nine Legislators for Contributions to Health Care 2 Health News:Clubhouse of Suffolk to Host 15th Annual Mental Illness Awareness Day 2 Health News:MultiVu Video Feed: FDA Approves DORIBAX(TM) (doripenem for injection) for the Treatment of Complicated Intra-abdominal and Complicated Urinary Tract Infections 2 Health News:Older African-American men with HIV often have sex without condoms 2 Health News:National Foundation for Transplants to Expand Program Providing Hotel Accommodations to Patient Families 2 Health News:National Foundation for Transplants to Expand Program Providing Hotel Accommodations to Patient Families 3

Genetic approach provides new insight into trastuzumab resistance in breast cancer THA Honors Nine Legislators for Contributions to Health Care Clubhouse of Suffolk to Host 15th Annual Mental Illness Awareness Day MultiVu Video Feed: FDA Approves DORIBAX(TM) (doripenem for injection) for the Treatment of Complicated Intra-abdominal and Complicated Urinary Tract Infections Older African-American men with HIV often have sex without condoms National Foundation for Transplants to Expand Program Providing Hotel Accommodations to Patient Families

(Date:5/21/2013)... 21, 2013 The North Shore-LIJ Health System is ... hand-washing compliance at North Shore University Hospital in ... operating rooms at Forest Hills ... The new pilot program strengthens patient safety by ... (ORs), the first time in the US that remote ...

(Date:5/21/2013)... May 21, 2013 Accuray Incorporated ... publication of study results involving hundreds of prostate ... System, the most widely used form of prostate ... 304 patients for a median of 5 years, ... that 97 percent of patients with low-risk and ...

(Date:5/21/2013)... ST. LOUIS , May 21, 2013 ... to treat chronic, complex diseases such as cancer, multiple ... 67 percent by the end of 2015, according to ... (Logo: http://photos.prnewswire.com/prnh/20080827/EXPRESSSCRIPTSLOGO ) ... time for employers and health plans to act so ...

Breaking Medicine Technology:North Shore-LIJ Extends Use of 3rd Party Remote Video Auditing into ORs 2 North Shore-LIJ Extends Use of 3rd Party Remote Video Auditing into ORs 3 North Shore-LIJ Extends Use of 3rd Party Remote Video Auditing into ORs 4 New Data Validates CyberKnife SBRT for Prostate Cancer Treatment 2 New Data Validates CyberKnife SBRT for Prostate Cancer Treatment 3 U.S. Spending on Specialty Medications Likely to Increase 67 Percent Through 2015 2 U.S. Spending on Specialty Medications Likely to Increase 67 Percent Through 2015 3 U.S. Spending on Specialty Medications Likely to Increase 67 Percent Through 2015 4 U.S. Spending on Specialty Medications Likely to Increase 67 Percent Through 2015 5

[0] North Shore-LIJ Extends Use of 3rd Party Remote Video Auditing into ORs [0] New Data Validates CyberKnife SBRT for Prostate Cancer Treatment [0] U.S. Spending on Specialty Medications Likely to Increase 67 Percent Through 2015

... Maine, Jan. 11 IDEXX Laboratories, Inc. (Nasdaq: ... of 2,000 Catalyst Dx® chemistry analyzers in 2009, bringing ... in the first quarter of 2008, is a next ... integrated suite of analyzers and significantly expands the range ...

... , SAN DIEGO, Jan 11 Volcano Corporation (Nasdaq: ... of products for the diagnosis and treatment of coronary and ... for fiscal 2009 will be approximately $228.0 million, with revenues ... approximately $71.0 million. , The revenue expectations for fiscal 2009 ...

Cached Medicine Technology:IDEXX Laboratories Announces Catalyst Dx(R) Placement Total for 2009 and Installed Base of SmartService(TM) Customers 2 Volcano Corporation Announces Preliminary Record Revenues for Fourth Quarter 2009; Total Year Revenues are Expected to Exceed Prior Guidance 2 Volcano Corporation Announces Preliminary Record Revenues for Fourth Quarter 2009; Total Year Revenues are Expected to Exceed Prior Guidance 3 Volcano Corporation Announces Preliminary Record Revenues for Fourth Quarter 2009; Total Year Revenues are Expected to Exceed Prior Guidance 4

IDEXX Laboratories Announces Catalyst Dx(R) Placement Total for 2009 and Installed Base of SmartService(TM) Customers Volcano Corporation Announces Preliminary Record Revenues for Fourth Quarter 2009; Total Year Revenues are Expected to Exceed Prior Guidance

Single-Piece PMMA Intraocular Lenses....

Single Piece PMMA Lens (Refractive and Bifocal). Anterior chamber Lens....

Hydrophilic Acrylic Intraocular Lens (Refractive and Bifocal). Anterior Chamber Lens....

STABIBAG Hydrophilic Acrylic Lens....

Medicine Products:

Single-Piece Intraocular Lens with haptic eyelets Single Piece PMMA Lens (Refractive and Bifocal)NaturaLens™ Series Hydrophilic Acrylic Intraocular Lens (Refractive and Bifocal)STABIBAG Hydrophilic Acrylic Lens