Navigation Links
Nobel laureate James Watson publishes novel hypothesis on curing late-stage cancers
Date:1/8/2013

Cold Spring Harbor, NY "Although mortality from many cancers has been steadily falling, particularly those of the blood [i.e., leukemias], the more important statistic may be that so many epithelial cancers (carcinomas) and effectively all mesenchymal cancers (sarcomas) remain largely incurable."

With these words as preface, Nobel laureate James D. Watson, Ph.D., in a newly published paper that he regards "among my most important work since the double helix," sets forth a novel hypothesis regarding the role of oxidants and antioxidants in cancers that are currently incurable, notably in late-stage metastatic cancers.

At the heart of his thesis are the group of molecules that scientists call reactive oxygen species, or ROS. Noting their fundamental two-sidedness, Watson calls ROS "a positive force for life" because of their role in apoptosis an internal program that highly stressed cells use to commit suicide. It's one of the key mechanisms that have arisen through eons of evolution to weed out biological dysfunction that poses a threat to the survival of organisms. On the other hand, ROS are also well understood indeed are notorious "for their ability to irreversibly damage key proteins and nucleic acid molecules [e.g., DNA and RNA]."

When they're not needed to curb wayward or out of control cells, which is to say under normal circumstances, ROS are constantly being neutralized by anti-oxidative proteins. We are often urged to eat foods rich in antioxidants such as blueberries; but, if Watson is correct about the role of ROS and antioxidants in late-stage cancer, as he writes in his new paper, "blueberries best be eaten because they taste good, not because their consumption will lead to less cancer."

Understanding why this might be so why antioxidants can in late-stage cancers actually promote cancer progression -- is central to Watson's paper, which appears online January 9 in Open Biology, a journal of Gr
'/>"/>

Contact: Peter Tarr
tarr@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Sanford-Burnhams Erkki Ruoslahti named to Thomson Reuters Nobel Prize watch list
2. Nobel laureate to keynote international pharmaceutical conference at URI
3. NAI Fellows Robert Langer, Leroy Hood and Member James Wynne receive US National Medals
4. Before Skyfall: 46 years of violence in James Bond movies
5. James George, MD: 2012 ASH Wallace H. Coulter Award for Lifetime Achievement in Hematology
6. Medical Tourism: Uncharted Territory for Patients James Goldberg, Author of the American Medical Money Machine, Is Offering a New Consulting Service to Medical Patients Considering “Medical Tourism” Treatment
7. Same-Sex Couples Might File Tax Refund Claims According to Watson CPA Group
8. Few Hours Left for Charitable Tax Deductions According to Watson CPA Group
9. Astro Clairvoyant Norah Guide for Premium Astrology Publishes New Blog Series on 2013 Predictions
10. Atlanta Surgeon for LASIK Eye Surgery Publishes Study on Website About Car Technology to Monitor Drowsiness
11. Zane Benefits Publishes "The Crisis in Employee Health Benefits 1999-2012"
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2014)... April 18, 2014) Benaroya Research Institute at Virginia ... blocking a particular molecule in metastatic breast cancer reduces ... of lung metastases. BRI scientists have found in models ... tumors by 60 - 80 percent and can keep ... The $1.8 million five-year grant comes from the National ...
(Date:4/17/2014)... presence of chronic inflammation in benign prostate tissue ... and this association was found even in those ... a study published in Cancer Epidemiology, Biomarkers ... Association for Cancer Research. , An analysis of ... the placebo arm of the Prostate Cancer Prevention ...
(Date:4/17/2014)... today in PLOS Pathogens , children who live ... can mount an immune response to infection with malaria ... of high fever and illness and partially control the ... may help researchers develop future interventions that prevent or ... Each year, approximately 200 million cases of malaria occur ...
(Date:4/17/2014)... McCullers, MD, was recently invited to submit a ... Reviews Microbiology , one of the world,s foremost ... disease specialist, and chair of the Department of ... Center, analyzed the epidemiology and microbiology of co-infections ... well as more recent 2009 novel H1N1 pandemic. ...
(Date:4/17/2014)... cause of neuronal death in Parkinson,s disease is still ... be mistaken for foreign invaders and killed by the ... diseases like type I diabetes, celiac disease, and multiple ... April 16, 2014, in Nature Communications . , ... Parkinson,s disease; but if true, it could lead to ...
Breaking Medicine News(10 mins):Health News:Benaroya Research Institute evaluates immunology approach to blocking breast cancer 2Health News:Chronic inflammation may be linked to aggressive prostate cancer 2Health News:Chronic inflammation may be linked to aggressive prostate cancer 3Health News:Study sheds light on how the immune system protects children from malaria 2Health News:Is Parkinson's an autoimmune disease? 2
... submit abstracts to present their research at the ... to molecular imaging and nuclear medicineJune 13-17, 2009, ... molecular imaging is vital and state-of-the-art," said SNM ... society,s more than 17,000 molecular imaging and nuclear ...
... associated with an increased risk of fetal growth restriction ... bmj.com today. , Although some previous studies ... that any amount and type of caffeine intakefrom tea, ... as coffeeis linked with relatively slower fetal growth. ...
... Nov. 3 Pregis Corporation, a leading,international ... and specialty packaging solutions, will conduct an ... quarter results on Friday,November 14, 2008 at ... 800-591-6942;,International: 617-614-4909; Participant Passcode: 68623125. A replay ...
... QIAGEN N.V.,(Nasdaq: QGEN ) today announced the Webcast of ... at 9:30 a.m. EST on,Tuesday, November 11, and will include remarks ... Chief Financial Officer., What: Webcast ... 9:30 a.m. EST on November 11, Where: ...
... common correction techniques yield positive results, ROSEMONT, ... used to correct the condition known as clubfoot,have ... new study published,in the November 2008 issue of ... ). While both treatment strategies use different,approaches, each ...
... ANGELES, Nov. 3 World Champion athlete and ... debut as a member of the,California Governor,s Council ... speaking to the student body of NEW Academy ... and healthy lifestyles., (Photo: http://www.newscom.com/cgi-bin/prnh/20081103/AQM074 ), ...
Cached Medicine News:Health News:SNM to showcase the latest research in molecular imaging and nuclear medicine 2Health News:Consuming small amounts of caffeine when pregnant may affect the growth of an unborn child 2Health News:Webcast of QIAGEN N.V.'s (Nasdaq: QGEN) Third Quarter 2008 Financial Results Call Set for November 11 2Health News:Non-Surgical Clubfoot Treatments Bring High Level of Success 2Health News:Non-Surgical Clubfoot Treatments Bring High Level of Success 3Health News:Laila Ali Debuts as Member of California Governor's Council on Physical Fitness and Sports 2
(Date:1/15/2014)... N.J. , Jan. 15, 2014  Celsion Corporation (the "Company") ... has received commitments from institutional investors to purchase an ... stock in an at-the-market registered direct offering, led by ... entered into definitive purchase agreements with these investors pursuant ...
(Date:1/15/2014)... Shire plc (LSE: SHP, NASDAQ: SHPG ) ... approval condition to the announced tender offer for all of the ... a result of the waiver, the transaction is no longer conditional ... on January 24, 2014 following the currently scheduled expiration time, subject ...
(Date:1/15/2014)... 15, 2014 BreedIT Corp (OTC: BRDT), ... distributor of highly sophisticated agro-breeding solutions for plant breeders ... the Company,s board of directors appointed chemistry and pharmaceutical ... new member of the board. From 1975 ...
Breaking Medicine Technology:Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 2Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 3Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 2Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 3BreedIT (OTC: BRDT) Appoints Chemistry and Pharmaceutical Industry Expert Dr. Ben-Zion Weiner to Its Board of Directors 2BreedIT (OTC: BRDT) Appoints Chemistry and Pharmaceutical Industry Expert Dr. Ben-Zion Weiner to Its Board of Directors 3
... --   Masimo (NASDAQ: MASI ... Acoustic Monitoring™, and Masimo SET ® Measure-Through Motion ... Medical Devices, Inc. dismissed all outstanding claims against Masimo ... and Cercacor.   Masimo did not incur any liability to ...
... QBC Diagnostics, a global manufacturer of hematology ... the company has been awarded a U.S. General ... Equipment and Services. GSA,s Scientific Equipment ... with scientific instruments for a wide variety of ...
Cached Medicine Technology:Essential Medical Dismisses Patent Case against Masimo and Cercacor 2Essential Medical Dismisses Patent Case against Masimo and Cercacor 3Essential Medical Dismisses Patent Case against Masimo and Cercacor 4QBC Diagnostics Awarded GSA Contract 2
... Sorvall DiscoveryTMM150 SE Micro-ultra centrifuge continues to ... sample processing, now with 1,048,000 x g ... rotor. DiscoveryTMM150SE processes sample sizes from ... small floor footprint, brushless direct drive, very ...
... and environmental safety are the ... K Ultracentrifuge from Beckman Coulter. ... centrifugation technology, the LE-80 K ... provide advanced capability for your ...
... Optima L-XP ultracentrifuge is designed to ... discovery process if research involves proteomics, ... sophisticated on-board computer, enhanced firmware, powerful ... touch screen, Optima L-XP delivers superior ...
... chemistry system brings versatility in a ... laboratory. A model of innovation and ... system features state-of-the-art Dimension testing technology, ... in a flexible. affordable, easy-to-use system ...
Medicine Products: