Navigation Links
New theory on cause of endometriosis
Date:3/7/2014

Changes to two previously unstudied genes are the centerpiece of a new theory regarding the cause and development of endometriosis, a chronic and painful disease affecting 1 in 10 women.

The discovery by Northwestern Medicine scientists suggests epigenetic modification, a process that enhances or disrupts how DNA is read, is an integral component of the disease and its progression. Matthew Dyson, research assistant professor of obstetrics and gynecology at Northwestern University Feinberg School of Medicine and and Serdar Bulun, MD, chair of obstetrics and gynecology at Feinberg and Northwestern Memorial Hospital, also identified a novel role for a family of key gene regulators in the uterus.

"Until now, the scientific community was looking for a genetic mutation to explain endometriosis," said Bulun, a member of the Center for Genetic Medicine and the Robert H. Lurie Comprehensive Cancer Center of Northwestern University. "This is the first conclusive demonstration that the disease develops as a result of alterations in the epigenetic landscape and not from classical genetic mutations."

The findings were recently published in PLoS Genetics.

Women develop endometriosis when cells from the lining of the uterus, usually shed during menstruation, grow in other areas of the body. The persistent survival of these cells results in chronic pelvic pain and infertility. Although the cause of the disease has remained unknown on a cellular level, there have been several different models established to explain its development.

Endometriosis only occurs in menstruating primates, suggesting that the unique evolution behind uterine development and menstruation are linked to the disease. Scientists consider retrograde menstruation cells moving up the fallopian tubes and into the pelvis as one probable cause. Previous models, however, have been unable to explain why only 10 percent of women develop the disease when most expe
'/>"/>

Contact: Marla Paul
marla-paul@northwestern.edu
312-503-8928
Northwestern University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Study casts doubt on theory that retired NFL players suffer CTE
2. Liz Deppe Joins Orangetheory Fitness
3. Orangetheory Fitness Set to Open First Southern Colorado Location in Early 2014
4. Conversations between lovers about STIs are important in theory but difficult in bed
5. Study offers new theory of cancer development
6. Study casts doubt on theory that retired NFL players suffer unique cognitive disorder
7. New theory uncovers cancers deep evolutionary roots
8. PhenObestin.com Announces Support For New Weight Loss Theory by author Dr. Khandee Ahnaimugan
9. Theory: Music underlies language acquisition
10. New Study Debunks Virus Theory for Chronic Fatigue Syndrome
11. Researchers hit back at early bodycheck theory
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... ... August 01, 2015 , ... The Honor Society of Nursing, Sigma Theta Tau ... of Nursing (GAPFON) 20-21 July 2015 in San Juan, Puerto Rico. Key nurse leaders ... Dr. Silvia Cassiani, Advisor, Nursing and Allied Health Personnel Development, Unit of Human Resources ...
(Date:7/31/2015)... ... ... Ticket Down is a reliable source for authentic tickets for the 2015 ... festival will end on Sunday, August 2nd. , Music fans have traveled ... unique and unbelievably popular festival attracts the best in entertainment from around the world. ...
(Date:7/31/2015)... ... 2015 , ... Recently touted by Becker’s Healthcare as one ... , Jvion continues to disrupt the predictive analytic and big data market using ... population level illness to drive prevention and better health outcomes. Most recently, Jvion ...
(Date:7/31/2015)... Tenn. (PRWEB) , ... July 31, 2015 , ... The ... Robert Church Park in Downtown Memphis on October 3, 2015. The Ride to Fight ... focused on cancer research between Methodist Healthcare, The West Clinic and The University of ...
(Date:7/31/2015)... (PRWEB) , ... July 31, 2015 , ... There’s no ... possible, even when it comes time to cook the next meal, making July the ... July by practicing best grilling tips and recipes. , Make the next cookout different ...
Breaking Medicine News(10 mins):Health News:Key Latin American Nurse Leaders Identify Regional Issues During Global Advisory Panel on the Future of Nursing Meeting 2Health News:Key Latin American Nurse Leaders Identify Regional Issues During Global Advisory Panel on the Future of Nursing Meeting 3Health News:Key Latin American Nurse Leaders Identify Regional Issues During Global Advisory Panel on the Future of Nursing Meeting 4Health News:Cheap 2015 Lollapalooza Tickets: Ticket Down Slashes Ticket Prices on Lollapalooza Tickets at Grant Park in Chicago for Saturday, August 1st and Sunday, August 2nd 2Health News:Jvion Showcased as Leader in the Predictive Analytic Market 2Health News:West Cancer Center Announces 2nd Annual Ride to Fight On 2Health News:West Cancer Center Announces 2nd Annual Ride to Fight On 3Health News:King Kullen Honors National Hot Dog and Blueberry Month 2Health News:King Kullen Honors National Hot Dog and Blueberry Month 3
... -- Americans who were jobless for longer than 25 weeks ... those who were continuously employed to suffer mental health issues ... Being jobless also has a greater psychological impact on people ... with less education, the researchers found. The study involved ...
... help people with Parkinson,s disease improve their gait and balance, ... School of Nursing and Red Hill Studios, a California serious ... three-month research project showed small improvements in walking speed, balance ... the first research team in the United States to receive ...
... (Oct. 19, 2011) -- A review of the genetic ... link between the widely diagnosed neurological disorder and Type ... recent decades. "It appears that both Type 2 ... impaired glucose tolerance and hyperinsulinemia," said Rice University biochemist ...
... -- Men who get moderate amounts of exercise have better ... active, a new study finds. Motility refers to the ... important factor in fertility. The study by researchers at ... samples and information about their physical activity levels. The men ...
... solutions to dangerous water quality issues in refugee camps is ... High Commissioner for Refugees an agreement that will put ... lab and on the ground in Kenya, Uganda, Liberia and ... additional SMU funds, faculty member Andrew Quicksall and his graduate ...
... Society (ACS), the American Society for Colposcopy and Cervical ... (ASCP) have proposed new guidelines for the prevention and ... are now posted for public comment, generally advise that ... their lifetime to better ensure that they receive the ...
Cached Medicine News:Health News:Long-Term Unemployment Can Tax Mental Health 2Health News:Computer games help people with Parkinson's disease 2Health News:Research proposes common link between autism, diabetes 2Health News:Research proposes common link between autism, diabetes 3Health News:Sperm Moves Best for Moderate Exercisers: Study 2Health News:SMU scientists to lead water quality study at UN refugee camps 2Health News:SMU scientists to lead water quality study at UN refugee camps 3Health News:Health groups issue proposed cervical cancer screening guidelines 2Health News:Health groups issue proposed cervical cancer screening guidelines 3
(Date:7/31/2015)... 31, 2015 According to a new ... Heat, Dry Heat, Ethylene Oxide, Filtration, E-beam, Gamma), Services (Onsite ... Pharmaceuticals) - Global Forecast to 2020", published by MarketsandMarkets, The ... Billion by 2020, at a CAGR of 7.6%.from 2015 to ... market data T ables and 37 ...
(Date:7/31/2015)... Pa. , July 31, 2015 ... fully integrated specialty pharmaceutical company focused on developing, ... the closing of its previously announced underwritten public ... at a public offering price of $11.25 per ... offering included 1,000,000 shares issued upon the exercise ...
(Date:7/31/2015)... Calif. , July 31, 2015  Xencor, Inc. ... engineered monoclonal antibodies for the treatment of autoimmune diseases, ... appointment of Yujiro S. Hata to its ... experience in business and corporate development is a tremendous ... Ph.D., president and chief executive officer of Xencor. "Xencor ...
Breaking Medicine Technology:Sterilization Equipment Market is Expected to Reach USD 6.1 Billion by 2020 2Sterilization Equipment Market is Expected to Reach USD 6.1 Billion by 2020 3Sterilization Equipment Market is Expected to Reach USD 6.1 Billion by 2020 4Egalet Announces Closing of Public Offering of Common Stock and Exercise in Full of Underwriters' Option to Purchase Additional Shares 2Egalet Announces Closing of Public Offering of Common Stock and Exercise in Full of Underwriters' Option to Purchase Additional Shares 3Egalet Announces Closing of Public Offering of Common Stock and Exercise in Full of Underwriters' Option to Purchase Additional Shares 4Xencor Appoints Yujiro S. Hata to Board of Directors 2Xencor Appoints Yujiro S. Hata to Board of Directors 3
...  July 12 Bedford Laboratories™, a division of Ben ... of  Dactinomycin for Injection USP 500 mcg (0.5 mg) ... was approved earlier this year by the U.S. Food ... equivalent to Cosmegen ® by Lundbeck Inc.  Each ...
... , July 12 /PRNewswire-Asia-FirstCall/ -- Concord Medical Services,Holdings ... ), the,operator of the largest network of radiotherapy and diagnostic ... of July 1, 2010 it has entered,into a ... cancer treatment facilities by acquiring a 52% equity interest in,Xi,an ...
Cached Medicine Technology:Bedford Laboratories™ to Begin Shipping Dactinomycin for Injection USP 500 mcg (0.5 mg) 2Bedford Laboratories™ to Begin Shipping Dactinomycin for Injection USP 500 mcg (0.5 mg) 3Concord Medical Enters into Joint Venture Agreement with Chang'An Hospital 2Concord Medical Enters into Joint Venture Agreement with Chang'An Hospital 3Concord Medical Enters into Joint Venture Agreement with Chang'An Hospital 4
... Quick & Easy Adjustment Of Blade Separation ... And Patient Comfort (Unlike Spring Action Speculum ... The Blades. No Laborious, Tedious, Slow Screw ... , ,Available In Either Solid Blade Or ...
... Hourglass Jaw Design Holds The Lens ... Incision.,Mirror Polished Blades Keep The Optic ... Offers Control Over Release Of The ... From Tilting During Insertion.,Reusable, Autoclaveable, Made ...
... The 0.1mm Pierce Tip Opening ... Flap, Without The Need For A Separate Cystotome. ... Grasping Positions Without Elevating The Incision.,The Distal Jaws ... Blades Help To Prevent Inadvertent Pick Up Of ...
2.5V Halogen source, fiber-optic delivery, 3X magnification, pocket-sized....
Medicine Products: