Navigation Links
New theory on cause of endometriosis
Date:3/7/2014

Changes to two previously unstudied genes are the centerpiece of a new theory regarding the cause and development of endometriosis, a chronic and painful disease affecting 1 in 10 women.

The discovery by Northwestern Medicine scientists suggests epigenetic modification, a process that enhances or disrupts how DNA is read, is an integral component of the disease and its progression. Matthew Dyson, research assistant professor of obstetrics and gynecology at Northwestern University Feinberg School of Medicine and and Serdar Bulun, MD, chair of obstetrics and gynecology at Feinberg and Northwestern Memorial Hospital, also identified a novel role for a family of key gene regulators in the uterus.

"Until now, the scientific community was looking for a genetic mutation to explain endometriosis," said Bulun, a member of the Center for Genetic Medicine and the Robert H. Lurie Comprehensive Cancer Center of Northwestern University. "This is the first conclusive demonstration that the disease develops as a result of alterations in the epigenetic landscape and not from classical genetic mutations."

The findings were recently published in PLoS Genetics.

Women develop endometriosis when cells from the lining of the uterus, usually shed during menstruation, grow in other areas of the body. The persistent survival of these cells results in chronic pelvic pain and infertility. Although the cause of the disease has remained unknown on a cellular level, there have been several different models established to explain its development.

Endometriosis only occurs in menstruating primates, suggesting that the unique evolution behind uterine development and menstruation are linked to the disease. Scientists consider retrograde menstruation cells moving up the fallopian tubes and into the pelvis as one probable cause. Previous models, however, have been unable to explain why only 10 percent of women develop the disease when most expe
'/>"/>

Contact: Marla Paul
marla-paul@northwestern.edu
312-503-8928
Northwestern University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Study casts doubt on theory that retired NFL players suffer CTE
2. Liz Deppe Joins Orangetheory Fitness
3. Orangetheory Fitness Set to Open First Southern Colorado Location in Early 2014
4. Conversations between lovers about STIs are important in theory but difficult in bed
5. Study offers new theory of cancer development
6. Study casts doubt on theory that retired NFL players suffer unique cognitive disorder
7. New theory uncovers cancers deep evolutionary roots
8. PhenObestin.com Announces Support For New Weight Loss Theory by author Dr. Khandee Ahnaimugan
9. Theory: Music underlies language acquisition
10. New Study Debunks Virus Theory for Chronic Fatigue Syndrome
11. Researchers hit back at early bodycheck theory
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... HealthDay Reporter TUESDAY, Oct. 21, 2014 (HealthDay ... (IVF) -- the incubation of embryos in a laboratory dish ... vagina, new research suggests. Scientists from the United States ... sharply cut costs for pricey IVF procedures among certain women. ... who don,t live near big-city assisted reproduction centers, the researchers ...
(Date:10/22/2014)... HealthDay Reporter TUESDAY, Oct. 21, 2014 (HealthDay News) ... for NBC News in Liberia has cleared the virus ... Nebraska Medical Center in Omaha, where he had been treated for ... test confirmed by the U.S. Centers for Disease Control and Prevention ... NBC News reported Tuesday night. "Recovering from Ebola ...
(Date:10/20/2014)... Allegheny General Hospital’s (AGH) Cardiovascular Institute is ... repair a damaged mitral valve as the heart continues ... by Abbott Vascular , is designed to treat ... in which the heart’s mitral valve leaflets fail to ... heart’s left ventricle into the left atrium. The heart ...
(Date:10/20/2014)... (PRWEB) October 20, 2014 Women’s health ... in Obstetrics & Gynecology of Columbus, Inc., A Division ... healthcare services to more than 100,000 patients annually. Dr. ... all ages and stages of a women’s life. She ... locations in Westerville and Dublin. , Dr. Murphy ...
(Date:10/20/2014)... October 20, 2014 Zereana Jess-Huff, a 34-year-old ... Maryland 2014 on a platform to think outside the bra. ... uses her position to raise awareness about women’s other lady ... breast cancer. You say the color pink and everybody knows ... for a fact that it has not been won when ...
Breaking Medicine News(10 mins):Health News:Experimental Infertility Treatment Seems Effective, Cheaper 2Health News:Experimental Infertility Treatment Seems Effective, Cheaper 3Health News:Experimental Infertility Treatment Seems Effective, Cheaper 4Health News:U.S. Cameraman Treated for Ebola 'Free' of the Virus 2Health News:U.S. Cameraman Treated for Ebola 'Free' of the Virus 3Health News:Allegheny General Hospital Introduces New, Beating-Heart Procedure for Mitral Valve Repair 2Health News:Allegheny General Hospital Introduces New, Beating-Heart Procedure for Mitral Valve Repair 3Health News:OhioHealth Welcomes New Women’s Health Specialist to MaternOhio Specialists in Obstetrics & Gynecology of Columbus, Inc. 2Health News:OhioHealth Welcomes New Women’s Health Specialist to MaternOhio Specialists in Obstetrics & Gynecology of Columbus, Inc. 3Health News:Ovarian Cancer Survivor Mrs. Maryland Urges Media to Think Outside the Bra 2Health News:Ovarian Cancer Survivor Mrs. Maryland Urges Media to Think Outside the Bra 3
... receptor involved in triggering cell death is capable ... injury//. This discovery could have implications for early ... cirrhosis or hepatitis. ,This research was ... California, San Diego (UCSD) School of Medicine. Katerina ...
... popular for its abundant health benefits. Now, British scientists, ... benefits of a vital element in green tea, which ... published in the Journal of Allergy and Clinical Immunology. ... have discovered that an important element in green tea ...
... has no additional effect when given to depressed ... a mood stabilizer//, according to a recent study. ... large-scale, multi-site Systematic Treatment Enhancement Program for Bipolar ... by the National Institutes of Health's National Institute ...
... that freezing kidney tumors through percutaneous cryoablation shows promise ... Their early findings showing short-term success in more than ... month’s issue of Radiology. ,The standard treatment ... of a long-term cure. For some patients, surgery is ...
... led by scientists from the University of North Carolina ... involved// in the development of schizophrenia. ... had been diagnosed with schizophrenia, the researchers found that ... among schizophrenia patients than in persons who were free ...
... in the United States living with the Alzheimer’s disease//. ... at the early stages, struggling to pass for normal. ... and behavior, such as anxiety, suspiciousness or agitation, as well ... years though, those with the affliction could try and lead ...
Cached Medicine News:Health News:Hepatic Stellate Cells Found Capable of Tissue Repair 2Health News:Antidepressant Medication Has No Effect on Bipolar Patients 2Health News:Cryoablation: A New Treatment Option for Some Kidney Tumor Patients 2Health News:Cryoablation: A New Treatment Option for Some Kidney Tumor Patients 3Health News:Brain Tissue Reveals Possible Genetic Trigger for Schizophrenia 2Health News:Alzheimer’s Patients Plead for Greater Understanding and Suppor 2
(Date:10/22/2014)... RPh, of Vernak Farms Pharmacy in Skaneateles, ... Roentsch Scholarship by the Professional Compounding Centers of America ... during PCCA,s International Seminar, held October 8-10, ... pharmacist and PCCA member who embodies the innovative and ... pharmacist in the compounding community. George ...
(Date:10/22/2014)... Oct. 22, 2014  Paper Pak Industries, a ... APLS ® Body Guard Bio, a disposable, ... of bacteria and virus while protecting service providers ... Bio features a rugged, external nylon shell, watertight ... a leak-proof inner chamber that contains contaminated and ...
(Date:10/22/2014)... 22, 2014  CryoLife, Inc. (NYSE: CRY ... focused on cardiac and vascular surgery, announced today that ... Executive Officer, has been elected to the Company,s Board ... Steven G. Anderson , Executive Chairman of CryoLife, stated, "Since ... be an excellent leader who is well positioned to ...
Breaking Medicine Technology:PCCA Awards Charlene Vernak, RPh, the George Roentsch Scholarship 2New, State-Of-The-Art Body Bag Minimizes The Spread Of Bacteria And Virus 2Pat Mackin Joins CryoLife Board of Directors 2Pat Mackin Joins CryoLife Board of Directors 3
... Cyberonics, Inc. (Nasdaq: CYBX ) today announced that the ... 23, 2009 of its fiscal year ending April 30, 2010 on ... will conduct a conference call to discuss those results on Thursday, ... Year 2010 Second Quarter Results Conference Call Instructions , ...
... November 6 , - ... for the,Treatment of Multi-Resistant Staphylococcus Aureus (MRSA) Infections , ... focused on the discovery and,development of novel antibiotics designed ... today that its most advanced oral,antibacterial NXL103 (flopristin/linopristin), has ...
Cached Medicine Technology:Cyberonics Announces Conference Call to Discuss Fiscal Year 2010 Second Quarter Financial Results 2Novexel Starts Phase II Clinical Trial With NXL103 in Adults With Acute Bacterial Skin and Skin Structure Infections (ABSSSI) 2Novexel Starts Phase II Clinical Trial With NXL103 in Adults With Acute Bacterial Skin and Skin Structure Infections (ABSSSI) 3Novexel Starts Phase II Clinical Trial With NXL103 in Adults With Acute Bacterial Skin and Skin Structure Infections (ABSSSI) 4
... A fixed pipette is ideal ... single volume. Fixed volume FInnpipettes ... advantages as other Finnpipette Digital ... Super blow-out (1-40ul), Soft-touch tip ...
This fixed-volume digital micropipet is used to accurately measure and transfer 10 microliters of solution....
... Focus from Thermo Labsystems was ... with uncompromising performance. The ... a custom fit for different ... tip cones allow easier and ...
... Eppendorf Reference Series 2000 Pipette is a ... a compact and robust design, and superior ... used to operate the measuring stroke and ... Product features:Eppendorf "pipette/tip" system ensures utmost accuracy ...
Medicine Products: