Navigation Links
New theory on cause of endometriosis
Date:3/7/2014

Changes to two previously unstudied genes are the centerpiece of a new theory regarding the cause and development of endometriosis, a chronic and painful disease affecting 1 in 10 women.

The discovery by Northwestern Medicine scientists suggests epigenetic modification, a process that enhances or disrupts how DNA is read, is an integral component of the disease and its progression. Matthew Dyson, research assistant professor of obstetrics and gynecology at Northwestern University Feinberg School of Medicine and and Serdar Bulun, MD, chair of obstetrics and gynecology at Feinberg and Northwestern Memorial Hospital, also identified a novel role for a family of key gene regulators in the uterus.

"Until now, the scientific community was looking for a genetic mutation to explain endometriosis," said Bulun, a member of the Center for Genetic Medicine and the Robert H. Lurie Comprehensive Cancer Center of Northwestern University. "This is the first conclusive demonstration that the disease develops as a result of alterations in the epigenetic landscape and not from classical genetic mutations."

The findings were recently published in PLoS Genetics.

Women develop endometriosis when cells from the lining of the uterus, usually shed during menstruation, grow in other areas of the body. The persistent survival of these cells results in chronic pelvic pain and infertility. Although the cause of the disease has remained unknown on a cellular level, there have been several different models established to explain its development.

Endometriosis only occurs in menstruating primates, suggesting that the unique evolution behind uterine development and menstruation are linked to the disease. Scientists consider retrograde menstruation cells moving up the fallopian tubes and into the pelvis as one probable cause. Previous models, however, have been unable to explain why only 10 percent of women develop the disease when most expe
'/>"/>

Contact: Marla Paul
marla-paul@northwestern.edu
312-503-8928
Northwestern University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Study casts doubt on theory that retired NFL players suffer CTE
2. Liz Deppe Joins Orangetheory Fitness
3. Orangetheory Fitness Set to Open First Southern Colorado Location in Early 2014
4. Conversations between lovers about STIs are important in theory but difficult in bed
5. Study offers new theory of cancer development
6. Study casts doubt on theory that retired NFL players suffer unique cognitive disorder
7. New theory uncovers cancers deep evolutionary roots
8. PhenObestin.com Announces Support For New Weight Loss Theory by author Dr. Khandee Ahnaimugan
9. Theory: Music underlies language acquisition
10. New Study Debunks Virus Theory for Chronic Fatigue Syndrome
11. Researchers hit back at early bodycheck theory
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2015)... ... , ... The Kentucky State Department of Workforce Investment Commissioner Beth Kuhn recently ... for, they are unable to pass the initial drug test and therefore unable to ... order to be able to hire long-term, skilled talent. (1) Will Wesch, Director of ...
(Date:8/28/2015)... ... August 28, 2015 , ... For Dallas, the time is ... with their subsidiary USPI Tenet Health. , The American Heart Association hosts their well-known ... stroke. They believe that together, a difference can be made. Walkers can participate in ...
(Date:8/28/2015)... ... August 28, 2015 , ... The 6th Annual Survivor ... Aneurysm Foundation has added yet another accolade to its cadre of widespread support—an official ... , “With the help of the medical community and the University of Illinois at ...
(Date:8/28/2015)... ... 2015 , ... Saint Petersburg, FL —Pocket Protein™, a protein ... sugar, gluten, lactose or caffeine in a convenient 2 oz. pouch that never ... Choice Awards. , Five consumer packaged goods (CPG) products were selected by the ...
(Date:8/28/2015)... ... August 28, 2015 , ... ... specialist, Dr. James Strawbridge, gives a new approach on solutions in his new ... with the employer and employees getting together for meaningful group meetings. "This would ...
Breaking Medicine News(10 mins):Health News:Hiring Obstacles: Drug Abuse a Problem for Workforce 2Health News:Hiring Obstacles: Drug Abuse a Problem for Workforce 3Health News:Hiring Obstacles: Drug Abuse a Problem for Workforce 4Health News:North Central Surgical Center’s Subsidiary Participates in Walk 2Health News:Chicago Mayor Pens Official Support of Annual Survivor in the City Event Benefitting Brain Aneurysm Foundation 2Health News:Chicago Mayor Pens Official Support of Annual Survivor in the City Event Benefitting Brain Aneurysm Foundation 3Health News:Pocket Protein™ Named 2015 CPG Editor’s Choice Award Finalist by Informa’s SupplySide 2Health News:Pocket Protein™ Named 2015 CPG Editor’s Choice Award Finalist by Informa’s SupplySide 3
... right form of counseling can reverse seasonal ... stress-related ... of reproductive medical specialists are encouraged by new research,pointing toward ... -- the year-end holiday blues, which doctors say can,actually have ...
... The Centers for Disease,Control and Prevention (CDC), ... in Infection Control and Epidemiology (APIC), is,developing ... (HAI) data from existing commercial,software systems to ... vendor-neutral solution enables hospitals to provide data ...
... Directors of,MSA (NYSE: MSA ) has elected William ... company,s President and Chief Operating Officer,and will succeed John ... retirement in May of 2008. Mr. Lambert, 49, joined ... http://www.newscom.com/cgi-bin/prnh/20071213/NETH072 ), "The Board of Directors and ...
... Associates, Inc. ("MQ,Associates" or the "Company"), and MedQuest, ... announced today that it completed,its tender offers (the ... of the,outstanding $136 million aggregate principal amount at ... (CUSIP No. 55345RAC2) (the "Discount Notes"),issued by MQ ...
... out to patients in ... need of care worldwide, EL SEGUNDO, Calif., ... life-saving by 16 year-old,Juan Carlos and his family living in Guayaquil, Ecuador. ... days away from dying.,This past December, DaVita -- one of the nation,s ...
... Richardson is a psychiatrist with Parkwood Hospital, part of ... the Schulich School of Medicine & Dentistry at The ... random, national survey of more than a thousand Canadian ... below the age of 65 and had served with ...
Cached Medicine News:Health News:Doctors: Talk Therapy Newest Hope for Treating One Physical Side Effect of Holiday Blues 2Health News:Doctors: Talk Therapy Newest Hope for Treating One Physical Side Effect of Holiday Blues 3Health News:CDC Uses New Technical Approach to Enable Hospital Reporting of Healthcare-Associated Infections 2Health News:MSA Elects William M. Lambert to Board 2Health News:MSA Elects William M. Lambert to Board 3Health News:MQ Associates, Inc. Announces Expiration of its Tender Offers for its 12 1/4% Senior Discount Notes Due 2012 (CUSIP No. 55345RAC2) and Medquest, Inc.'s 11 7/8% Senior Subordinated Notes Due 2012 (CUSIP No. 58505DAD1) 2Health News:MQ Associates, Inc. Announces Expiration of its Tender Offers for its 12 1/4% Senior Discount Notes Due 2012 (CUSIP No. 55345RAC2) and Medquest, Inc.'s 11 7/8% Senior Subordinated Notes Due 2012 (CUSIP No. 58505DAD1) 3Health News:16-Year-Old Ecuadorian Boy in Dire Need of Dialysis Treatments Thanks One of Nation's Leading Providers for Saving His Life 2Health News:16-Year-Old Ecuadorian Boy in Dire Need of Dialysis Treatments Thanks One of Nation's Leading Providers for Saving His Life 3
(Date:8/28/2015)... and PITTSBURGH , Aug. ... ) today announced that its shareholders have approved ... PRGO ; TASE) and the related issuance ... an extraordinary general meeting of shareholders held today. ... cast at the extraordinary general meeting. In addition, ...
(Date:8/28/2015)... -- The report "Eubiotics Market by Type (Probiotics, Prebiotics, Organic ... & by Region ( North America , ... Rest of the World) - Global Trends and Forecast to ... valued at USD 4.62 Billion in 2014 and is projected ... of 7.4% from 2015 to 2020. Browse ...
(Date:8/28/2015)... Massachusetts and LONDON , August ... approach seamlessly connects ... continuum improving outcomes and the ...  (NYSE: PHG AEX: PHIA) today announced its presence at  ... latest cardiology solutions, including Heart Model A.I. , EchoNavigator and ...
Breaking Medicine Technology:Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 2Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 3Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 4Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 5Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 6Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 7Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 8Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 9Eubiotics Market Worth 7.05 Billion USD by 2020 2Eubiotics Market Worth 7.05 Billion USD by 2020 3Eubiotics Market Worth 7.05 Billion USD by 2020 4Eubiotics Market Worth 7.05 Billion USD by 2020 5Philips Showcases New Integrated Cardiology Solutions to Advance Minimally Invasive Procedures at ESC Congress 2015 2Philips Showcases New Integrated Cardiology Solutions to Advance Minimally Invasive Procedures at ESC Congress 2015 3Philips Showcases New Integrated Cardiology Solutions to Advance Minimally Invasive Procedures at ESC Congress 2015 4
... Boehringer Ingelheim Pharmaceuticals, Inc. (BIPI) today announced that ... received preferred Tier 2 formulary status with all ... benefits manager, Prescription Solutions ® .  The AARP ... MedicareComplete from Secure Horizons, provide prescription drug access ...
... Omeros Corporation (NASDAQ: OMER ) ... its product candidates from its PharmacoSurgery™ platform – ... lens replacement surgery – into Phase 3 clinical ... added to standard irrigation solutions and delivered intra-operatively ...
Cached Medicine Technology:Pradaxa® (dabigatran etexilate mesylate) Capsules Gains Preferred Formulary Status with AARP®, Nation's Largest Provider of Medicare Part D Coverage 2Pradaxa® (dabigatran etexilate mesylate) Capsules Gains Preferred Formulary Status with AARP®, Nation's Largest Provider of Medicare Part D Coverage 3Pradaxa® (dabigatran etexilate mesylate) Capsules Gains Preferred Formulary Status with AARP®, Nation's Largest Provider of Medicare Part D Coverage 4Pradaxa® (dabigatran etexilate mesylate) Capsules Gains Preferred Formulary Status with AARP®, Nation's Largest Provider of Medicare Part D Coverage 5Pradaxa® (dabigatran etexilate mesylate) Capsules Gains Preferred Formulary Status with AARP®, Nation's Largest Provider of Medicare Part D Coverage 6Omeros Announces Clinical Development Programs for OMS103HP and OMS302 2Omeros Announces Clinical Development Programs for OMS103HP and OMS302 3Omeros Announces Clinical Development Programs for OMS103HP and OMS302 4Omeros Announces Clinical Development Programs for OMS103HP and OMS302 5
For the qualitative detection of Hepatitis B surface Antigen (HBsAG) in human serum, plasma and whole blood specimens...
For the qualitative detection of group A streptococcal antigen from throat swabs....
For the qualitative detection of group A streptococcal antigen from throat swabs....
For the measurement of vaginal pH as part of a self examination programme to help reduce the risk of pre-term birth...
Medicine Products: