Navigation Links
New study suggests stem cells sabotage their own DNA to produce new tissues
Date:2/15/2010

A new study from the Ottawa Hospital Research Institute (OHRI) and the University of Ottawa suggests that stem cells intentionally break their own DNA as a way of regulating tissue development. The study, published in Proceedings of the National Academy of Science (PNAS), could dramatically change how researchers think about tissue development, stem cells and cancer.

Human cells contain 46 strands of DNA that code for all our genes. Certain chemicals and UV light can break these strands into pieces, a process that has traditionally been considered a bad thing, leading to cell death or diseases such as cancer if the damage is not repaired quickly. The new research, led by Dr. Lynn Megeney, shows for the first time that stem cells will intentionally cut and then repair their own DNA as a mechanism of activating genes that promote the development of new tissues.

The project started as an attempt to understand how stem cells give rise to new muscle fibres. In 2002, Dr. Megeney and his team discovered that this process of producing new muscle was somehow connected to another important process called programmed cell death, which the body uses to get rid of unwanted cells. When they blocked or removed a key death-promoting protein called caspase 3, they found that stem cells stopped producing new muscle fibres.

"This discovery was very controversial at the time, but dozens of research groups have now reported that cell death proteins control the maturation process of most stem cell types," says Dr. Megeney. "In the last few years, the big mystery has been how cell death proteins manage this complex process."

Now in the 2010 study Dr. Megeney and his team believe they have solved the mystery. They have discovered that the novel effect of caspase 3 in stem cells is related to its ability to activate another protein that cuts up the cell's DNA (called caspase-activated DNase) and has also traditionally been associated with pr
'/>"/>

Contact: Jennifer Paterson
jpaterson@ohri.ca
613-798-5555 x73325
Ottawa Hospital Research Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Penn study finds pro-death proteins required to regulate healthy immune function
2. New study shows promise in reducing surgical risks associated with surgical bleeding
3. Study, meta-analysis examine factors associated with death from heatstroke
4. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
5. Study says COPD testing is not measuring up
6. Preclinical study suggests organ-transplant drug may aid in lupus fight
7. Ability to cope with stress can increase good cholesterol in older white men, study finds
8. High alcohol consumption increases stroke risk, Tulane study says
9. Mailman School of Public Health study examines link between racial discrimination and substance use
10. Pitt study finds inequality in tobacco advertising
11. Stanford study highlights cost-effective method of lowering heart disease risks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/3/2015)... ... September 03, 2015 , ... Hope For The Warriors® ... 2016. Scholarships are awarded two times each year to spouses or caregivers of ... nonprofit dedicated to restoring a sense of self, restoring the family unit, and ...
(Date:9/3/2015)... (PRWEB) , ... September 03, 2015 , ... ... real estate investment landscape by connecting accredited and institutional investors to real estate ... products designed to meet demand from both investors and sponsoring real estate ...
(Date:9/3/2015)... ... ... The Linda Hall Library 2015 Fall Lecture Series will give ... at the South Pole, and the interior of life-extending stem cells – educating ... foremost independently funded research library devoted to science, engineering, and technology, will feature the ...
(Date:9/3/2015)... ... September 03, 2015 , ... Dr. Robert Winchell has been appointed ... and Acute Care at NewYork-Presbyterian/Weill Cornell Medical Center, effective July 27. He will serve ... renowned expert in care for the critically injured and the development, design and operations ...
(Date:9/3/2015)... ... September 03, 2015 , ... ... upcoming virtual conference, “Proven Pharmacy Benefit Strategies for a Rapidly Changing Marketplace.” In ... Express Scripts and Milliman, will discuss how plan sponsors are adopting bold, innovative ...
Breaking Medicine News(10 mins):Health News:Hope For The Warriors Spouse/Caregiver Scholarships Now Open for Spring 2016 2Health News:RealtyShares Announces Mezzanine Financing Products 2Health News:RealtyShares Announces Mezzanine Financing Products 3Health News:Facing the Frontiers of Science and Technology The Linda Hall Library Announces 2015 Fall Lecture Series Featuring Experiences from the South Pole to Outer Space 2Health News:Facing the Frontiers of Science and Technology The Linda Hall Library Announces 2015 Fall Lecture Series Featuring Experiences from the South Pole to Outer Space 3Health News:Facing the Frontiers of Science and Technology The Linda Hall Library Announces 2015 Fall Lecture Series Featuring Experiences from the South Pole to Outer Space 4Health News:Facing the Frontiers of Science and Technology The Linda Hall Library Announces 2015 Fall Lecture Series Featuring Experiences from the South Pole to Outer Space 5Health News:Trauma Expert Joins NewYork-Presbyterian Hospital and Weill Cornell Medical College 2Health News:Trauma Expert Joins NewYork-Presbyterian Hospital and Weill Cornell Medical College 3Health News:Trauma Expert Joins NewYork-Presbyterian Hospital and Weill Cornell Medical College 4Health News:Trauma Expert Joins NewYork-Presbyterian Hospital and Weill Cornell Medical College 5Health News:Speakers for Upcoming AIS Virtual Conference on Pharmacy Benefit Strategies Include Executives from CVS Health, Express Scripts 2
... found out that a protein called NMNAT can delay the ... level. The researchers from Baylor College of// Medicine in a ... online today said that NMNAT protects against nerve cell degeneration ... the question if a drug might be developed that could ...
... wines that belong to the vineyards of France and Italy are ... effects of fatty meals on the heart can be offset by ... has shown. Wines from these regions contain high levels of a ... have also proved the heart healthy benefits of a daily glass ...
... Center and colleagues at four other medical centers have ... that may contribute to early atherosclerosis. ,“If we ... life who have a genetic predisposition to develop atherosclerosis, ... and stroke sooner and more aggressively,” said David Herrington, ...
... a new drug that might cease men from ejaculation during ... on is that the contraction of the longitudinal muscle in ... out of the penis. ,This method of contraception ... to which researchers claim have chemicals to block male sperms. ...
... unknown immunodeficiency disease was discovered by scientists about twenty-five ... 'AIDS'. //Ever since, 'Acquired Immune Deficiency Syndrome' or AIDS, ... to the latest figures enabled by the UNAIDS/WHO 2006 ... world are grappling with the disease. ,AIDS ...
... Research, the data from Population Based Cancer Registry, Delhi ... specific// incidence rates of breast cancer below 40 years ... National Cancer Control Programme (NCCP), special emphasis is now ... awareness. Grant-in-aid is provided to Non-Governmental Organisations to create ...
Cached Medicine News:Health News:NMNAT Protein Protects Against Nerve Cell Degeneration 2Health News:Study Underway to Identify Genes Contributing to Heart Attack Risk 2Health News:'Red'y to Fight HIV – 'AbstinenceBehaviorCondom', Sacrosanct to AIDS Preventio 2Health News:'Red'y to Fight HIV – 'AbstinenceBehaviorCondom', Sacrosanct to AIDS Preventio 3Health News:'Red'y to Fight HIV – 'AbstinenceBehaviorCondom', Sacrosanct to AIDS Preventio 4
(Date:9/3/2015)... 3, 2015 Report Details ... Drugs, Industry Changes and Emerging Opportunities What,s the ... Visiongain,s new study forecasts those pharmaceutical revenues. There ... industry. You also explore trends, results, treatments, R&D, ... gives revenue predictions to 2025 at overall world ...
(Date:9/3/2015)... 2015 With a population of more than ... therefore also its single largest potential market for goods ... led all major world economies in the average rate ... government health expenditures. As an in vitro diagnostics (IVD) ... the United States, western European countries, and Japan. China ...
(Date:9/3/2015)... 3,  2015 About artificial organs ... which are implanted or integrated into individuals ... include artificial heart, kidney, pancreas, and cochlear ... polysulfone, and porous polypropylene), biologics, ceramics, and ... These organs are incorporated with different technologies ...
Breaking Medicine Technology:Ovarian Cancer Drug Therapy: Companies, R&D and Revenue Forecasts 2015-2025: Recently Approved Treatments Give High Market Potential 2Ovarian Cancer Drug Therapy: Companies, R&D and Revenue Forecasts 2015-2025: Recently Approved Treatments Give High Market Potential 3Ovarian Cancer Drug Therapy: Companies, R&D and Revenue Forecasts 2015-2025: Recently Approved Treatments Give High Market Potential 4Ovarian Cancer Drug Therapy: Companies, R&D and Revenue Forecasts 2015-2025: Recently Approved Treatments Give High Market Potential 5Ovarian Cancer Drug Therapy: Companies, R&D and Revenue Forecasts 2015-2025: Recently Approved Treatments Give High Market Potential 6IVD in China 2IVD in China 3IVD in China 4IVD in China 5IVD in China 6IVD in China 7IVD in China 8IVD in China 9IVD in China 10IVD in China 11IVD in China 12IVD in China 13Global Artificial Organ Market 2015-2019 2
... (NasdaqGS: ABAX), a medical products company manufacturing point-of-care blood ... its financial results for the third quarter of fiscal ... be at 4:15 p.m. ET on Thursday, January 26, ... third quarter of fiscal 2012 after the market closes ...
... featured at the grand opening of the Massachusetts Medical ... in Lowell. The $4 Million business incubator M2D2 provides ... ) is the first company to manufacture at M2D2. ... completed the first production run of our EchoBox Product, ...
Cached Medicine Technology:Abaxis to Report Third Quarter Fiscal Year 2012 Financial Results Thursday, January 26, 2012 2StatVideo LLC Manufactures EchoBox at University of Massachusetts Lowell 2
A system with integrated pupil camera and 7" examination monitor. An easy to use configuration....
Sinus Trocar and Cannula, 4 mm...
1.0 mm diameter head, 0.75 mm deep bite....
Kelly Punches...
Medicine Products: