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New research identifies modifiable risk factors for heart disease
Date:12/11/2009

ning the data to include recurrent cardiovascular events during the two-year follow up, authors found additional events were reduced by 19 percent with atorvastatin 80 mg versus pravastatin 40 mg (n = 275 vs. n = 340, respectively; p = 0.009), resulting in 138 fewer total primary events during follow-up. Based on this reanalysis which considers total events, the authors calculate that 14 patients need to be treated to prevent one eventa much smaller number than the 26 needed-to-treat to prevent the first occurrence of the primary end point.

A post-hoc analysis of the IDEAL trial provides new insights into the treatment of patients experiencing repeated occurrences of cardiovascular disease, and shows that high-dose statin therapy remains highly effective. In fact, compared with patients taking simvastatin 20 to 40 mg daily, patients receiving atorvastatin 80 mg daily had their relative risk of a first cardiovascular event reduced by 17 percent (p < 0.0001), of a second by 24 percent (p < 0.0001), of a third by 19 percent (p = 0.035), of a fourth by 24 percent (p = 0.058), and of a fifth by 28 percent (p = 0.117). There was a 17 percent overall reduction in risk across all five events.


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Contact: Amanda Jekowsky
ajekowsk@acc.org
202-375-6645
American College of Cardiology
Source:Eurekalert

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