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New research identifies modifiable risk factors for heart disease
Date:12/11/2009

ach 60-minute session included 30 minutes of aerobic exercise at a heart rate corresponding to 55 to 65 percent of individual maximal cardiorespiratory fitness, followed by 20 minutes of strength work and 10 minutes of stretching and cool-down.

Diet-Induced Weight Loss in Obese Patients Appears to Promote Early and Beneficial Changes in Heart and Blood Vessel Structure and Function

In this study of 60 obese men and women (body mass index: 37 +/- 3 kg/m2), modest weight loss (an average of 22 lbs) led to early improvements in four important subclinical traits previously associated with adverse cardiovascular outcomes, including a reduction in the thickness of the heart muscle and blood vessel wall and improvements in left ventricular diastolic and systolic function. Although some studies have shown improvement in heart function among patients with morbid obesity who have undergone surgeries such as gastric bypass or gastric banding (where weight loss is typically >50 lbs), fewer studies have found benefit in obese individuals who have achieved modest weight loss by lifestyle modifications including diet and exercise.

While maximal weight loss occurred at 6 months, the maximal cardiovascular benefits lagged behind by 3 to 12 months for all measured variables. According to authors, this finding suggests that previous studies of obese subjects undergoing moderate weight losswhich typically involved smaller groups followed for a few months up to a yearmay have failed to show cardiovascular benefit.

All participants underwent a medical history, physical exam, and cardiac and vascular ultrasound studies at baseline and at 3, 6, 12 and 24 months after the start of the intervention. Two years after starting the diet intervention, subjects regained over half of the weight that had been lost. Although the maximum benefits of weight loss were somewhat diminished with subsequent weight regain, there was still a significant improvement
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Contact: Amanda Jekowsky
ajekowsk@acc.org
202-375-6645
American College of Cardiology
Source:Eurekalert

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