Navigation Links
New research finds pathogenic connection between autoimmune disorders and cancer
Date:7/22/2014

WASHINGTON -- Autoimmune disorders may share certain pathogenic mechanisms with cancer, according to a new report by George Washington University (GW) researcher Linda Kusner, Ph.D., published in PLOS ONE on July 22.

This paradigm shifting work shows that the very same inhibitors of apoptosis, or cell destruction, in tumors are also expressed in cells that produce autoimmune diseases. Henry Kaminski, M.D., chair of the Department of Neurology at the GW School of Medicine and Health Sciences (SMHS), as well as colleagues from the Roswell Park Cancer Institute, collaborated with Kusner's laboratory on this research. Together they discovered that survivin, an inhibitor of apoptosis, is also expressed in the white blood cells, called lymphocytes, of patients with the autoimmune disease myasthenia gravis, but not in normal individuals. This was also the case in animal models of myasthenia gravis. Myasthenia gravis is a severe muscle disease that can lead to such weakness that patients must be placed on breathing machines.

"We found that humans with myasthenia gravis also express survivin in autoreactive lymphocytes," said Kusner, assistant research professor in the Department of Pharmacology and Physiology at SMHS. "We found these cells to be part of the dysfunction underlying the autoimmune disease."

Using a vaccine technique, the research team was able to eliminate the survivin-expressing cells and demonstrate improvement in the animal models with myasthenia gravis. Kusner's laboratory will continue to work to improve the inhibition of survivin as a treatment and one day bring survivin targeted treatment to patients.

"This study opens a new therapeutic approac
'/>"/>

Contact: Lisa Anderson
lisama2@gwu.edu
202-994-3121
George Washington University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Research brings us nearer to understanding how neuro cells turn cancerous
2. Global Molecular Diagnostics Market Expected to Reach USD 8.7 Billion through 2019: Transparency Market Research
3. SkillSurvey to Present Research on Contingent Workers at National Association for Health Care Recruitment IMAGE 2014 Conference
4. Growth of Disposable Medical Supplies Market to 2019 Report Available at RnRMarketResearch.com
5. Hypatia Research Group Publishes “Enterprise Governance, Risk & Compliance: Best Practices, Maturity Models and 2014 ProductMatrix Vendor Evaluations”
6. Communication about female condom vital to young adults, UT Arlington researchers say
7. Chocolate Production in Canada Industry Market Research Report Now Available from IBISWorld
8. New research from Africa on pharmacomicrobiomics
9. Indoor Sports Facilities Management in the US Industry Market Research Report from IBISWorld Has Been Updated
10. Global and China Handpiece Industry 2009-2019 Market Research Report Now Available at LifeScienceIndustryResearch.com
11. Benzoyl Peroxide Market Analysis for Global, China Regions – 2014 Development Trends Available at DeepResearchReports.com
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2015)... New York, NY (PRWEB) April 18, 2015 ... their Internal Security Threat Report , which they say, “exposes ... on how many new malware variants were introduced in 2014 ... it took for Zero Day threats to be identified and ... – it is abundantly clear that doing business in a ...
(Date:4/18/2015)... 18, 2015 PHOENIX, ARIZONA – In ... with 11 other secure destruction professionals across the United ... (CSDS). He will now display “CSDS” as a professional ... before the National Association of Information Destruction 2015 Annual ... Grapevine, Texas. Of the 20 people who took the ...
(Date:4/17/2015)... John Evans, a Gardant affordable assisted living community, ... p.m. to 3 p.m. on April 24. , The ... Pekin, Illinois, serves older adults of all incomes, including ... their independence. , Becky Baker will entertain guests on ... during the luau. , For more information, call 309-477-8800. ...
(Date:4/17/2015)... (PRWEB) April 17, 2015 Riviera ... Dr. Kevin Sadati of the Gallery of Cosmetic ... County’s top beauty experts. The publication focused on ... facial stem cell fat grafting, eyelid surgery, laser resurfacing ... facial plastic surgery has resulted in thousands of ...
(Date:4/17/2015)... “We have seen healing, a lot of healing, and ... Chaplain Shawn Kafader of Friendship Village. “People have found ... to contribute have created beautiful pieces of art.” For the ... program that was launched to benefit residents of the retirement ... the Art Institute in Chicago, worked as an intern at ...
Breaking Medicine News(10 mins):Health News:Cyber Attackers Continue to Fine Tune Deception and Stealth Tactics According to New Report 2Health News:Cyber Attackers Continue to Fine Tune Deception and Stealth Tactics According to New Report 3Health News:Cyber Attackers Continue to Fine Tune Deception and Stealth Tactics According to New Report 4Health News:Cyber Attackers Continue to Fine Tune Deception and Stealth Tactics According to New Report 5Health News:John Evans Supportive Living Community Prepares for Party on the Patio 2Health News:Orange County Facial Plastic Surgeon Featured in Premier Magazine Focused on Beauty 2Health News:Orange County Facial Plastic Surgeon Featured in Premier Magazine Focused on Beauty 3Health News:Healing At Friendship Village Due To Art Therapy 2
... (HealthDay News) -- Having "Jack Frost nipping at your nose" ... and frostbite can be serious cold weather hazards, experts say. ... constrict, reducing blood flow to the ears, nose, and the ... shifting blood flow to the vital organs. "The body ...
... professor Jannick Rolland has developed an optical technology that ... of the technology is to detect and examine skin ... without having to cut the suspected tumor out of ... the tip of a roughly one-foot-long cylindrical probe is ...
... CA - Patients receiving anterior cruciate ligament (ACL) knee reconstruction ... graft were less likely to suffer from pain and mobility ... at the American Orthopaedic Society for Sports Medicine,s Specialty Day ... we have seen excellent results in terms of knee symptoms ...
... The American Cancer Society has been selected to receive ... and Palliative Medicine (AAHPM) recognizing the Society,s commitment to ... to promote patient-centered care. The award was received by ... officer at a ceremony at the AAHPM Annual Assembly ...
... as young as 5 can learn how to manipulate a computer ... than age in mastering the device. Researchers tested the computer ... largest increases in the children,s computer mouse accuracy and speed occurred ... appears to plateau between ages 9 and 10. While older ...
... , FRIDAY, Feb. 18 (HealthDay News) -- Many people consider ... pooches feel otherwise. Each year, approximately 4.5 million people ... bites needing emergency treatment. Over a 16-year period, in fact, ... doubled, increasing from 5,100 in 1993 to 9,500 in 2008, ...
Cached Medicine News:Health News:Frostnip, Frostbite Can Take the Fun Out of Winter 2Health News:A new high-resolution method for imaging below the skin using a liquid lens 2Health News:Hamstring grafts prove more effective in ACL knee reconstruction, study says 2Health News:American Cancer Society honored for work in palliative care 2Health News:Rise in Dog Bites Has Experts Concerned 2Health News:Rise in Dog Bites Has Experts Concerned 3
(Date:4/16/2015)... , April 16, 2015  Hologic, Inc. ... cervical cancer screening study i published on-line ... peer-reviewed journal of the American Cancer Society. ... and the University of Pittsburgh Medical Center, supports current consensus ... recommend that women 30-65 years of age be ...
(Date:4/16/2015)... 2015 Mallinckrodt plc (NYSE: MNK ... that it has completed its acquisition of Ikaria, ... billion. The Ikaria acquisition extends Mallinckrodt,s footprint in ... neonatal critical care with INOMAX ® (inhaled ... highly vulnerable patient population. It also accelerates Mallinckrodt,s ...
(Date:4/16/2015)... Colo. , April 16, 2015  Rosewind ... completed a reverse merger with a newly formed ... an initial focus on addressing urological disorders. The ... Aytu BioScience Inc., has commenced operations and incorporates ... Luoxis Diagnostics.  The Company,s strategy is to build ...
Breaking Medicine Technology:Hologic Comments on Important Cervical Cancer Screening Study Published in the American Cancer Society Journal, Cancer Cytopathology 2Hologic Comments on Important Cervical Cancer Screening Study Published in the American Cancer Society Journal, Cancer Cytopathology 3Hologic Comments on Important Cervical Cancer Screening Study Published in the American Cancer Society Journal, Cancer Cytopathology 4Mallinckrodt Completes Acquisition Of Ikaria 2Mallinckrodt Completes Acquisition Of Ikaria 3Mallinckrodt Completes Acquisition Of Ikaria 4Mallinckrodt Completes Acquisition Of Ikaria 5Rosewind Corporation Shifts Focus to Develop Late-Stage Therapeutics for Urological and Related Conditions 2Rosewind Corporation Shifts Focus to Develop Late-Stage Therapeutics for Urological and Related Conditions 3
... IOWA CITY, Iowa and ST. LOUIS, Nov. 29 ... for the advanced analysis of pulmonary diseases, and Veran ... interventional oncology therapies, announced the companies have signed a ... endobronchial lung navigation and biopsy system. , "Veran,s ...
... , CHICAGO, Nov. 29 ... Digital Mammography (FFDM) with over 7,000 installations, is pleased to debut ... US. The Aspire HD combines the use of advanced dual ... pixel size to deliver lower noise and higher spatial resolution at ...
Cached Medicine Technology:VIDA Diagnostics and Veran Medical Sign Definitive Agreement for Joint Development of Endobronchial Navigation System 2VIDA Diagnostics and Veran Medical Sign Definitive Agreement for Joint Development of Endobronchial Navigation System 3VIDA Diagnostics and Veran Medical Sign Definitive Agreement for Joint Development of Endobronchial Navigation System 4FUJIFILM's DR-based FFDM System Makes US Debut at RSNA 2FUJIFILM's DR-based FFDM System Makes US Debut at RSNA 3FUJIFILM's DR-based FFDM System Makes US Debut at RSNA 4
For the qualitative detection of group A streptococcal antigen from throat swabs....
For the qualitative detection of group A Streptococcal antigen from throat swabs...
For the qualitative detection of human Chorionic Gonadotrophin (hCG) in urine specimens...
For the qualitative detection of human Chorionic Gonadotrophin (HCG) in urine or urine and serum specimens...
Medicine Products: