Navigation Links
New research finds pathogenic connection between autoimmune disorders and cancer
Date:7/22/2014

WASHINGTON -- Autoimmune disorders may share certain pathogenic mechanisms with cancer, according to a new report by George Washington University (GW) researcher Linda Kusner, Ph.D., published in PLOS ONE on July 22.

This paradigm shifting work shows that the very same inhibitors of apoptosis, or cell destruction, in tumors are also expressed in cells that produce autoimmune diseases. Henry Kaminski, M.D., chair of the Department of Neurology at the GW School of Medicine and Health Sciences (SMHS), as well as colleagues from the Roswell Park Cancer Institute, collaborated with Kusner's laboratory on this research. Together they discovered that survivin, an inhibitor of apoptosis, is also expressed in the white blood cells, called lymphocytes, of patients with the autoimmune disease myasthenia gravis, but not in normal individuals. This was also the case in animal models of myasthenia gravis. Myasthenia gravis is a severe muscle disease that can lead to such weakness that patients must be placed on breathing machines.

"We found that humans with myasthenia gravis also express survivin in autoreactive lymphocytes," said Kusner, assistant research professor in the Department of Pharmacology and Physiology at SMHS. "We found these cells to be part of the dysfunction underlying the autoimmune disease."

Using a vaccine technique, the research team was able to eliminate the survivin-expressing cells and demonstrate improvement in the animal models with myasthenia gravis. Kusner's laboratory will continue to work to improve the inhibition of survivin as a treatment and one day bring survivin targeted treatment to patients.

"This study opens a new therapeutic approac
'/>"/>

Contact: Lisa Anderson
lisama2@gwu.edu
202-994-3121
George Washington University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Research brings us nearer to understanding how neuro cells turn cancerous
2. Global Molecular Diagnostics Market Expected to Reach USD 8.7 Billion through 2019: Transparency Market Research
3. SkillSurvey to Present Research on Contingent Workers at National Association for Health Care Recruitment IMAGE 2014 Conference
4. Growth of Disposable Medical Supplies Market to 2019 Report Available at RnRMarketResearch.com
5. Hypatia Research Group Publishes “Enterprise Governance, Risk & Compliance: Best Practices, Maturity Models and 2014 ProductMatrix Vendor Evaluations”
6. Communication about female condom vital to young adults, UT Arlington researchers say
7. Chocolate Production in Canada Industry Market Research Report Now Available from IBISWorld
8. New research from Africa on pharmacomicrobiomics
9. Indoor Sports Facilities Management in the US Industry Market Research Report from IBISWorld Has Been Updated
10. Global and China Handpiece Industry 2009-2019 Market Research Report Now Available at LifeScienceIndustryResearch.com
11. Benzoyl Peroxide Market Analysis for Global, China Regions – 2014 Development Trends Available at DeepResearchReports.com
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/21/2014)... AlignLife of Norton Shores is spreading Christmas joy ... helping people get their health back. Mission for area ... those persons in Muskegon County who are unable to find ... life. Dr. Michael Rykse wanted to do a Toy Drive ... he knew he found that when he heard what MAP ...
(Date:12/21/2014)... 2014 SCI explores disability ... and systemic barriers for disabled athletes with Aaron ... has a condition called juvenile macular degeneration, where he ... he adapted his athletic ambitions to his vision and ... triathlon to pioneer the way for other blind and ...
(Date:12/21/2014)... The Oncology Institute of Hope and Innovation hosted their ... offices. The Hope for the Holidays Toy Drive is a ... families during the holiday season. This year, the toy drive ... both offices. This event continues to be successful year after ... store managers and assistant managers came out and not only ...
(Date:12/20/2014)... MissyDress, a distinguished special dress supplier, has just ... has drastically cut prices to all its prom dresses ... 30, 2015. Many of the hottest styles are sold ... dresses, and more. , A spokesman for MissyDress says, ... A-line princess prom dresses or sweetheart chiffon prom dresses, ...
(Date:12/20/2014)... December 20, 2014 DePuy Pinnacle ... metal-on-metal version of the artificial hip system was ... and federal courts, Bernstein Liebhard LLP reports. According ... County Superior Court on December 2nd, counsel in ... deposition of plaintiffs on November 19, 2014, with ...
Breaking Medicine News(10 mins):Health News:AlignLife of Norton Shores Makes a Brighter Christmas for Kids in Muskegon 2Health News:Disability in Sports on SCI TV with Triathlon World Champ Aaron Scheidies 2Health News:Disability in Sports on SCI TV with Triathlon World Champ Aaron Scheidies 3Health News:MissyDress: The Prices of Prom Dresses Just Reduced 2Health News:New Jersey Court Overseeing DePuy Pinnacle Hip Lawsuits Issues New Order, Bernstein Liebhard LLP Reports 2Health News:New Jersey Court Overseeing DePuy Pinnacle Hip Lawsuits Issues New Order, Bernstein Liebhard LLP Reports 3Health News:New Jersey Court Overseeing DePuy Pinnacle Hip Lawsuits Issues New Order, Bernstein Liebhard LLP Reports 4
... Oregon Health & Science University researchers are reporting ... combination of surgery and radiation therapy is used for ... , Surgery and radiotherapy shows an early response ... potentially reasonable for the first-line treatment, said Clifton David ...
... LOS ANGELES, Oct. 28 Results from a University ... for head and neck cancer can be uniformly delivered ... community cancer centers through a centralized planning and treatment ... annual meeting of the American Society for Therapeutic Radiology ...
... Million Americans Suffer From Food Allergies and Numbers are,Climbing; More Children ... ... of Children, Hoping to Keep Allergy From ... Doc, NEW YORK, Oct. 28 Today about 11 million ...
... Software Drives Greater Efficiency and ... Treatment ... software,is helping the University of Nebraska Medical Center to save ... in,radiotherapy treatments for prostate cancer. The automatic segmentation,software developed by ...
... American Society of ... Plastic Surgeons Annual Meeting, BALTIMORE, Oct. 28 One facelift ... younger. In fact,plastic surgeons analyze facial features and configurations to,individualize results ... today at the American Society of Plastic Surgeons (ASPS) Plastic,Surgery 2007 ...
... is vital; symptoms can often mimic digestive problems , , SUNDAY, ... a reputation as a silent killer, because many people believed ... women suffering from the disease knew differently. They knew they ... , "Survivors for years have said there are symptoms for ...
Cached Medicine News:Health News:OHSU researchers: Surgery, radiation gives early survival advantage in bile duct cancer 2Health News:Integrated approach to IMRT provides quality care for head and neck cancer patients 2Health News:NEWSWEEK: Cover: Kids and the Growing Food Allergy Threat 2Health News:NEWSWEEK: Cover: Kids and the Growing Food Allergy Threat 3Health News:iPlan(R) Automatic Segmentation Saves 25 Minutes of Treatment Planning Time for Each Prostate Cancer Patient at the University of Nebraska Medical Center 2Health News:Facelift, Botox, or Both? Depends Upon Your Decade of Life 2Health News:Facelift, Botox, or Both? Depends Upon Your Decade of Life 3Health News:New Guidelines Should Improve Ovarian Cancer Detection 2Health News:New Guidelines Should Improve Ovarian Cancer Detection 3
(Date:12/17/2014)... , Dec. 17, 2014  Northstar Global Business ... Trust Company (DTC) has made their final decision ... on the Company,s stock effective December 15, 2014, ... stock for depository and book entry transfer services. All ... is now once again fully "DTC Eligible", and ...
(Date:12/17/2014)... LOS ANGELES , Dec. 17, 2014 /PRNewswire/ ... that the US Patent and Trademark Office (USPTO) ... candidate ICT-107, a dendritic cell-based immunotherapeutic vaccine targeting ... glioblastoma. The claims of US Patent No. 8,871,211, ... treating neural cancer by administering a dendritic cell ...
(Date:12/17/2014)... , Dec. 17, 2014 PCCA ... Approved ( http://bit.ly/1382OkS ) program seal for ... community. The program highlights medical practices, materials and ... "autism-community friendly." Children affected by autism ... can be exacerbated by ingredients found in food ...
Breaking Medicine Technology:Northstar announces that the DTC chill on MDIN has been officially lifted 2Northstar announces that the DTC chill on MDIN has been officially lifted 3ImmunoCellular Therapeutics Announces Issuance of Key Patent For ICT-107 Cancer Vaccine 2Parents Of Children With Autism Spectrum Disorder Have New Options When Administering Medications 2Parents Of Children With Autism Spectrum Disorder Have New Options When Administering Medications 3
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: