Navigation Links
New research finds pathogenic connection between autoimmune disorders and cancer
Date:7/22/2014

WASHINGTON -- Autoimmune disorders may share certain pathogenic mechanisms with cancer, according to a new report by George Washington University (GW) researcher Linda Kusner, Ph.D., published in PLOS ONE on July 22.

This paradigm shifting work shows that the very same inhibitors of apoptosis, or cell destruction, in tumors are also expressed in cells that produce autoimmune diseases. Henry Kaminski, M.D., chair of the Department of Neurology at the GW School of Medicine and Health Sciences (SMHS), as well as colleagues from the Roswell Park Cancer Institute, collaborated with Kusner's laboratory on this research. Together they discovered that survivin, an inhibitor of apoptosis, is also expressed in the white blood cells, called lymphocytes, of patients with the autoimmune disease myasthenia gravis, but not in normal individuals. This was also the case in animal models of myasthenia gravis. Myasthenia gravis is a severe muscle disease that can lead to such weakness that patients must be placed on breathing machines.

"We found that humans with myasthenia gravis also express survivin in autoreactive lymphocytes," said Kusner, assistant research professor in the Department of Pharmacology and Physiology at SMHS. "We found these cells to be part of the dysfunction underlying the autoimmune disease."

Using a vaccine technique, the research team was able to eliminate the survivin-expressing cells and demonstrate improvement in the animal models with myasthenia gravis. Kusner's laboratory will continue to work to improve the inhibition of survivin as a treatment and one day bring survivin targeted treatment to patients.

"This study opens a new therapeutic approac
'/>"/>

Contact: Lisa Anderson
lisama2@gwu.edu
202-994-3121
George Washington University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Research brings us nearer to understanding how neuro cells turn cancerous
2. Global Molecular Diagnostics Market Expected to Reach USD 8.7 Billion through 2019: Transparency Market Research
3. SkillSurvey to Present Research on Contingent Workers at National Association for Health Care Recruitment IMAGE 2014 Conference
4. Growth of Disposable Medical Supplies Market to 2019 Report Available at RnRMarketResearch.com
5. Hypatia Research Group Publishes “Enterprise Governance, Risk & Compliance: Best Practices, Maturity Models and 2014 ProductMatrix Vendor Evaluations”
6. Communication about female condom vital to young adults, UT Arlington researchers say
7. Chocolate Production in Canada Industry Market Research Report Now Available from IBISWorld
8. New research from Africa on pharmacomicrobiomics
9. Indoor Sports Facilities Management in the US Industry Market Research Report from IBISWorld Has Been Updated
10. Global and China Handpiece Industry 2009-2019 Market Research Report Now Available at LifeScienceIndustryResearch.com
11. Benzoyl Peroxide Market Analysis for Global, China Regions – 2014 Development Trends Available at DeepResearchReports.com
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/20/2014)... 2014 Allegheny General Hospital’s (AGH) Cardiovascular ... physicians to repair a damaged mitral valve as the ... system, developed by Abbott Vascular , is designed ... life-threatening condition in which the heart’s mitral valve leaflets ... from the heart’s left ventricle into the left atrium. ...
(Date:10/20/2014)... T.E.N., a technology and information security ... William H. Murray, renowned author and industry visionary, ... Award winner. Presented annually, the ISE® Luminary Leadership ... and industry practitioner for his or her distinguished ... security industry. , Formerly with IBM, Murray is ...
(Date:10/20/2014)... WA (PRWEB) October 20, 2014 My ... workflow management software application. The new module enables ... patients receive full life-cycle quality care. , This application ... others within their practice, attach a to-do item to ... fit, and even set up reoccurring reminders for follow-ups. ...
(Date:10/20/2014)... (PRWEB) October 20, 2014 Rockynol ... Living Center on Oct. 14. The $11 million project ... services, and a cooked-to-order kitchen with full-service restaurant style ... premier choice for first class Assisted Living apartments,” said ... residents deserve the highest quality of care and this ...
(Date:10/20/2014)... Aliso Viejo, California (PRWEB) October 20, 2014 ... have announced the release of the Citrus theme for ... words I would use to describe the Citrus theme” Says ... been so easy to look so professional.” , Citrus comes ... . Included with the template are: four transitions for added ...
Breaking Medicine News(10 mins):Health News:Allegheny General Hospital Introduces New, Beating-Heart Procedure for Mitral Valve Repair 2Health News:Allegheny General Hospital Introduces New, Beating-Heart Procedure for Mitral Valve Repair 3Health News:Bill Murray named 2014 ISE® Luminary Leadership Award Winner 2Health News:Bill Murray named 2014 ISE® Luminary Leadership Award Winner 3Health News:Bill Murray named 2014 ISE® Luminary Leadership Award Winner 4Health News:My Clients Plus Announces New Workflow Management Software 2Health News:Rockynol Retirement Community Expands Assisted Living Center 2Health News:Today Pixel Film Studios Announced the Release of the Citrus theme for Final Cut Pro X 2
... a comprehensive new study of mental health status and the ... for Health Policy Research found that nearly one in five ... said they needed help for a mental or emotional health ... or more than 1 million, reported symptoms associated with serious ...
... likely to use walkers, canes and other mobility devices at ... them incorrectly, according to new research from Purdue University. ... epidemic for this population as well," said Karis Pressler, a ... author. "This research shows that if obesity continues at this ...
... passion fruit pathologist, a catfish breeder, and a pigeon ... scientists from 10 African countries who received a fellowship ... (AWARD). The fellowship will help these top researchers strengthen ... to poverty alleviation and food security across the continent. ...
... 2010) Errors in diagnosis place a heavy financial ... can be devastating for affected patients. Strengthening certain ... and coordinated primary care could potentially address this highly ... Baylor College of Medicine ( www.bcm.edu ) and Stony ...
... results in 2 million injuries among women in the ... and Human Services. University of Missouri researchers are reducing ... women experiencing abuse develop individualized safety plans and better ... current Internet resources, the decision-aid program provides women with ...
... News) -- Weight-loss surgery, also known as bariatric surgery, ... of serious complications, a new study suggests. The ... that do the highest number of bariatric surgeries, according to ... Journal of the American Medical Association . Rates ...
Cached Medicine News:Health News:Nearly 1 in 5 Californians report need for mental health services, study finds 2Health News:Study: Weight issues move up need for walkers, canes, other devices 2Health News:Study: Weight issues move up need for walkers, canes, other devices 3Health News:AWARD Fellowship highlights critical role of African women in agricultural research 2Health News:AWARD Fellowship highlights critical role of African women in agricultural research 3Health News:Reform of primary care could reduce diagnostic errors 2Health News:Reform of primary care could reduce diagnostic errors 3Health News:Reform of primary care could reduce diagnostic errors 4Health News:Use of decision-aid program increases safety for women experiencing abuse, researchers find 2Health News:Complications From Weight-Loss Surgery 'Relatively Low' 2
(Date:10/19/2014)... 19, 2014  Henry Schein, Inc. (NASDAQ: ... products and services to office-based dental, animal health and ... Iwase Dental Supply, Inc., a leading full-service provider of ... Henry Schein,s entrance into Japan , ... increases to 28 the number of countries in which ...
(Date:10/17/2014)... Oct. 17, 2014  Training market researchers to ... success factor in today,s highly competitive global marketplace. ... organizations that effectively and efficiently produce high performing ... area. Effective training programs can ... recognition from internal clients by developing analysts who ...
(Date:10/17/2014)... DUBLIN , October 17, 2014 /PRNewswire/ ... Markets ( http://www.researchandmarkets.com/research/7jx6nq/china ) has announced the addition ... Report,2014-2017"  report to their offering.  ... of cardiovascular disease in China ... population and changes in consumption concept, dietary ...
Breaking Medicine Technology:Henry Schein Enters Japan With Investment in Iwase Dental Supply 2Henry Schein Enters Japan With Investment in Iwase Dental Supply 3Henry Schein Enters Japan With Investment in Iwase Dental Supply 4Henry Schein Enters Japan With Investment in Iwase Dental Supply 5Effective Training Programs for Market Research Groups can Boost Overall Organizational Success 2China Interventional Cardiovascular Device Industry Report 2014-2017 2China Interventional Cardiovascular Device Industry Report 2014-2017 3
... 03, 2007 /PRNewswire/ -- Bayer HealthCare,Pharmaceuticals announced ... Betaseron(R) (interferon beta-1b), presented this week,at the ... Meeting,demonstrating early efficacy, long-term tolerability, and high,patient ... of multiple sclerosis (MS). , "Collectively, these ...
... EDMONTON, May 02, 2007 /PRNewswire-FirstCall/ - Quest PharmaTech,Inc. ... provide an,update on the pre-clinical development of SL052 ... is the second leading cause of cancer death ... 30,000 deaths,per year. Current therapeutic modalities for localized ...
Cached Medicine Technology:Studies Presented at Neurology Conference Highlight Early Efficacy,Long-Term Tolerability, and High Patient Satisfaction with,Betaseron 2Studies Presented at Neurology Conference Highlight Early Efficacy,Long-Term Tolerability, and High Patient Satisfaction with,Betaseron 3Studies Presented at Neurology Conference Highlight Early Efficacy,Long-Term Tolerability, and High Patient Satisfaction with,Betaseron 4Quest PharmaTech's Prostate Cancer Program Update 2Quest PharmaTech's Prostate Cancer Program Update 3
Coronary angiographic catheter...
... Merit has a complete offering of cardiology ... brands, these catheters are designed with excellent ... strength and better push-ability, and large inner ... 4, 5, 6 and 7 French sizes ...
The CRW system epitomizes simplicity, quality assurance, and versatility....
Hydrosteer wires are intended for use in the percutaneous introduction of catheters....
Medicine Products: