Navigation Links
New research could pave the way to safer treatments for arthritis
Date:7/4/2013

The increased risk of heart attack or stroke associated with many arthritis drugs may be avoidable, according to a new international study co-authored by researchers at Imperial College London.

Drugs such as Vioxx, diclofenac, ibuprofen and Celebrex operate by blocking an enzyme known as COX-2, whose presence in blood vessels has up until now been held responsible for these side effects. New research carried out on mice has revealed that COX-2 is largely absent from the major blood vessels and instead found in the brain, gut, and kidney as well as the thymus gland in the chest.

Now that researchers know where in the body the drug is acting, they can begin to develop safer, more targeted drugs for patients with arthritis as well as cancer.

Arthritis drugs have long been associated with potentially fatal cardiovascular side-effects in patients. Health concerns led to the anti-inflammatory Vioxx being withdrawn from the market in 2004, and this week medical regulators have advised some patients to stop using the painkiller diclofenac.

Researchers have always believed that COX-2 was found in the blood vessels where it was central to preventing the formation of clots. This meant that any drug that inhibited the enzyme was thought to lead to an increased risk of clotting.

The new study, published today in the journal PLOS ONE, reveals that COX-2 is largely absent from the major blood vessels. Instead COX-2 appears to be present in the brain, kidney, thymus and gut, where it may well be affecting the cardiovascular health.

Lead author, Professor Jane Mitchell of Imperial's Faculty of Medicine said: "Now we know the true sites of COX-2, we can begin to develop new ideas that will lead to better drugs for arthritis and cancer with fewer side effects."

The new research suggests future development of COX-2 inhibitors that carry reduced risk of stroke or heart attack may be possible. Professor Mitchell
'/>"/>

Contact: Gilead Amit
gda07@imperial.ac.uk
Imperial College London
Source:Eurekalert

Page: 1 2

Related medicine news :

1. UCLA Brain Injury Research Center gets NCAA funding for research on sports concussions
2. NIH awards $20 million over 5 years to train next generation of global health researchers
3. Researchers develop a new cell and animal model of inflammatory breast cancer
4. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
5. Sexually abused boys at risk for more unsafe sex: UBC research
6. Researchers Find Gene Mutations That May Be a Key to Autism
7. LSUHSC research finds HPV-related head & neck cancers rising, highest in middle-aged white men
8. Researchers find evidence of banned antibiotics in poultry products
9. Presidential keynote address and new research highlights from the American Society of Pediatric Otolaryngology meeting
10. Scientific session and new research highlights
11. NJ stroke researchers report advances in spatial neglect research at AAN Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/28/2014)... 28, 2014 Nipomo Family Dentistry ... Do, recently opened its doors at 195 N. Thompson ... with preventative care like teeth cleanings, oral exams, fillings, ... Invisalign, teeth whitening (and Kor whitening), laser whitening, gum ... Nipomo Family Dentistry’s five-person team also takes a philanthropic ...
(Date:11/28/2014)... (PRWEB) November 28, 2014 ... is lowering prices and offering savings in abundance ... hair care, hair loss and cosmetic products such ... and Bosley, TheBeautyPlace.com offers competitive discounts on already ... sold at affordable prices giving customers savings year ...
(Date:11/27/2014)... 2014 Ericdress.com today announced a ... up to 85% off, on all its clothing, shoes and ... Dec. 1 – 7, 2014 only. , At the special ... Orders above $109 can enjoy an extra $10 discount. Moreover, ... The business specially recommended its new collection of 2015 evening ...
(Date:11/27/2014)... knows, Cyber Monday is a crazy shopping day. Owing to ... now providing many big promotions on its website. Customers can ... current prices. The discount are up to 80% off. So ... orders above $88) from Dec. 1 – 4 2014. , ... are willing to shop on the internet. As a leading ...
(Date:11/27/2014)... Recently, DressVe , the well-known trendy young women’s clothing ... valid during Nov. 29 – Dec. 3 2014. In the ... up to 90% off. In addition, free delivery is provided ... http://www.dressve.com/ , Dresses that combine trendy styles and ... somebody’s personality and figure. The designers of DressVe.com know this ...
Breaking Medicine News(10 mins):Health News:Nipomo Family Dentistry Opens New Dental Office in Nipomo 2Health News:Nipomo Family Dentistry Opens New Dental Office in Nipomo 3Health News:TheBeautyPlace.com Announces Double Savings 2Health News:Ericdress.com Special Monday Sales Are Ready For Everyone 2Health News:Tidebuy.com Launching Overcoats Sales for the Special Monday in 2014 2Health News:DressVe.com Introduces Its 2014 Special Monday Sales To The Global Customers 2
... TUESDAY, Jan. 25 (HealthDay News) -- It,s hard to help ... long-term is even tougher. But obese children whose parents took ... weight and kept it off for the next two years, ... study shows that targeting parents -- rather than the children ...
... a friendly bartender can be the source of more than ... suggests that some bartenders may be in a good position ... help connect them to the appropriate agency. Researchers at ... Foreign Wars posts in Ohio. The results showed that ...
... Colo. (Jan. 25, 2011) A new study led ... at The Children,s Hospital and Colorado Health Outcomes Program ... explores the barriers, facilitators and alternative approaches to providers ... immunization registry. Reminder or recall messages, usually in the ...
... by further developing a culture of safety in which all ... can work together to maximize safety, according to an invited ... (PRO), a new medical journal whose mission is to ... official journal of the American Society for Radiation Oncology (ASTRO). ...
... 25 (HealthDay News) -- Epilepsy was the likely cause of ... to a new study. Researchers reached the conclusion that ... descriptions of his hallucinations -- including his description of a ... life written by pupils and friends such as George Sand. ...
... cardiovascular surgery, resulting in elevated circulating levels of cell-free ... and gut wall integrity is unclear. A research ... the World Journal of Gastroenterology addresses this ... levels similar to those found during cardiovascular surgery. The ...
Cached Medicine News:Health News:Changing Parental Behavior May Help Obese Kids Lose Weight 2Health News:Changing Parental Behavior May Help Obese Kids Lose Weight 3Health News:Bartenders may have role in assisting troubled war veterans 2Health News:Bartenders may have role in assisting troubled war veterans 3Health News:New study finds reminders for immunizations challenging for pediatric practices 2Health News:New study finds reminders for immunizations challenging for pediatric practices 3Health News:Culture of safety key to reducing chances for medical errors 2
(Date:11/26/2014)... CITY, Calif. , Nov. 26, 2014  Genomic ... Kim Popovits , Chairman, Chief Executive Officer and ... Piper Jaffray Healthcare Conference at The New York Palace ... Wednesday, December 3 at 11:30 am Eastern Time (ET). ... webcast of the conference call, go to the  Investor ...
(Date:11/26/2014)... , November 26, 2014 Investor-Edge has ... VVUS ), Horizon Pharma PLC (NASDAQ: HZNP ... Johnson (NYSE: JNJ ), and Theravance Inc. (NASDAQ: ... can be accessed at: http://investor-edge.com/register . On ... up 0.07%, the Dow Jones Industrial Average edged 0.02% lower, ...
(Date:11/26/2014)... , Nov. 26, 2014  CARsgen, a leader in ... immunotherapy to treat a variety of cancers, today announced ... BVCF, a China -based healthcare private ... company focused on the development of new therapeutics for ... Shanghai Cancer Institute and Shanghai Renji Hospital, the company ...
Breaking Medicine Technology:Genomic Health to Present at the 26th Annual Piper Jaffray Healthcare Conference 2Genomic Health to Present at the 26th Annual Piper Jaffray Healthcare Conference 3Pharma Stocks Highlight - VIVUS, Horizon Pharma, Endocyte, Johnson and Johnson, and Theravance 2Pharma Stocks Highlight - VIVUS, Horizon Pharma, Endocyte, Johnson and Johnson, and Theravance 3Pharma Stocks Highlight - VIVUS, Horizon Pharma, Endocyte, Johnson and Johnson, and Theravance 4Pharma Stocks Highlight - VIVUS, Horizon Pharma, Endocyte, Johnson and Johnson, and Theravance 5CARsgen Completes Series A Financing 2
... 25, 2011 Savient Pharmaceuticals, Inc. (Nasdaq: SVNT ... John H. Johnson as Chief Executive Officer, effective January 31, ... Savient,s board of directors. Mr. Johnson brings significant ... a Senior Vice President of Eli Lilly and Company and ...
... recently launched eCS Inpatient EHR V1.2 (eCS), the first ... medium hospitals. eCS,s uniqueness is the tight linkage of ... a single web-based software solution. The solution is offered ... simplified deployment. "eCS is an affordable solution ...
Cached Medicine Technology:Savient Pharmaceuticals Names John H. Johnson Chief Executive Officer 2Savient Pharmaceuticals Names John H. Johnson Chief Executive Officer 3Savient Pharmaceuticals Names John H. Johnson Chief Executive Officer 4eCareSoft Launches Comprehensive EHR for Small & Medium Hospitals 2
Transcranial vascular DWL doppler....
The Natural Selection family of specialty allografts is spinal concepts response to surgeon requests for spinal allograft devices to eliminate the need for painful autograft harvesting....
Transcranial vascular DWL doppler....
Transcranial vascular DWL doppler....
Medicine Products: