Navigation Links
New model may help predict response to chemotherapy for colorectal cancer
Date:1/16/2013

PHILADELPHIA Scientists may be able to better predict which patients with colorectal cancer will respond to chemotherapy using a new mathematical model that measures the amount of stress required for a cancer cell to die without harming healthy tissue. The results of this study are published in Cancer Research, a journal of the American Association for Cancer Research.

"Our study demonstrates that systems medicine approaches (i.e., quantitative analysis of multiple factors in patients' samples combined with mathematical modeling) have a significant advantage over other approaches in predicting therapy responses in patients," said Jochen J.M. Prehn, Ph.D., director of the Centre for Systems Medicine at the Royal College of Surgeons in Ireland.

Apoptosis, or programmed cell death, is believed to be a hallmark of cancer resistance to chemotherapy. Prior research has shown that the key step in apoptosis, the process that leads to mitochondrial outer membrane permeabilization (MOMP) is controlled by different members of the BCL-2 family of proteins. Some family members promote apoptosis and some prevent it. In addition, those proteins that have the same effects on apoptosis work in parallel and can substitute for each other, which makes it difficult to predict whether cells are likely or unlikely to die.

To better inform decision-making in chemotherapy for colorectal cancer, Prehn and colleagues developed a tool that would incorporate patient-specific, molecular data sets. They studied the BCL-2 proteins, determined levels of the individual proteins and put the levels into a mathematical model that calculated what genotoxic stress level is needed to achieve apoptosis.

"Resistance of colon cancer cells in culture, as well as treatment responses of patients with stages 2 and 3 colon cancer, were critically determined by the calculated stress level required to undergo apoptosis," Prehn said. "We found that individ
'/>"/>

Contact: Jeremy Moore
jeremy.moore@aacr.org
215-446-7109
American Association for Cancer Research
Source:Eurekalert

Page: 1 2

Related medicine news :

1. UK-Based Laminin Solutions and NLP Logix Formalize Agreement to Leverage the Power and Flexibility of M-Files with Big Data Predictive Modeling
2. Just what the doctor ordered for the New Year- New Talent with Nancy Di Nino’s BRAVADO, Branding, Marketing & Management Services for athletes & models
3. New Model [ZT-F1012-31221A] T10 Tube has been Added to Zhongtian Lighting’s Production Line
4. American Crane's Website Now Includes 3D Models!
5. New rat model for muscle regeneration after trauma-related soft tissue injury
6. NLP Logix Signed to Provide Predictive Modeling Services for Worker Compensation Physical Therapy Provider
7. Supportive role models, coping lead to better health in poor teens
8. Researchers find model system to study promising cancer drug
9. Predicting risk of arrhythmias and sudden cardiac death: Theres a computer model for that
10. New hormone therapy shows promise for menopausal symptoms in animal model
11. Kentucky team inhibits Alzheimers biomarkers in animal model by targeting astrocytes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/22/2014)... 22, 2014: The Association for Molecular Pathology (AMP) ... of Molecular Diagnostics on recommendations for a ... master,s levels of education. The report was prepared ... Force of the AMP Training and Education Committee. ... of educating future medical laboratory scientists appropriately in ...
(Date:4/22/2014)... NY, April 22, 2014Hemoglobin A1c is the standard measurement ... diabetes. Blood levels of A1c are typically measured every ... developed a data-based model that accurately estimates A1c using ... Diabetes Technology & Therapeutics ( DTT ), a ... article is available free on the DTT ...
(Date:4/22/2014)... To help rein in massive health care spending, a ... urgently find ways to incentivize pharmaceutical companies and device ... Instead of examining existing medical technologies and their use, ... affect what drugs and medical devices get created in ... health care spending with as little loss of health ...
(Date:4/22/2014)... 10 Americans support mandated coverage of birth control medications, ... the University of Michigan Health System. , Women, blacks, ... at home, and adults with private or public insurance ... universal coverage of birth control medications, according to the ... American Medical Association ( JAMA ). , Individuals ...
(Date:4/22/2014)... German . Scientists ... Vienna and the Medical University of Vienna, together with colleagues ... RNA, such as viral genetic information, is prevented from entering ... viral infection, the protein ADAR1 moves from the cell nucleus ... inhibit reproduction of the virus. But how is the human ...
Breaking Medicine News(10 mins):Health News:AMP publishes curriculum recommendations for medical laboratory scientists 2Health News:US medical innovation needs smarter incentives to cut health spending, study finds 2Health News:US medical innovation needs smarter incentives to cut health spending, study finds 3Health News:More than two-thirds of Americans support mandated coverage of birth control in health plans 2Health News:How the body fights against viruses 2Health News:How the body fights against viruses 3
... government, through the U.S. Agency for International Development (USAID), is ... Assistance Response Team (DART) to help combat the cholera outbreak ... than $4.6 million for emergency water, sanitation, and hygiene program ... , This new funding will provide additional ...
... 11 Mary Beth Bolton, MD, FACP, a Detroit internal ... by the Michigan State Medical Society (MSMS). , ... Chief Medical Officer with Health Alliance Plan (HAP) since 2000, ... career-long commitment to improving primary patient care through increasing access, ...
... to "Tell Their Stories" , , ... that healthcare reform will be a top priority in his ... serve as health and human services secretary, is the leader ... to help with reform efforts by sharing their healthcare experiences ...
... million people die every year from infectious diseases, ... The discovery of penicillin to treat bacterial ... previously incurable virus diseases such as polio and ... mid-20th century. , Recently, spectacular advances in medical ...
... company, announced today that beginning January 1, 2009, ... for incomplete spinal cord injury patients suffering from ... Medicare and Medicaid Services (CMS) establishes a new ... devices including the NESS L300™ Foot Drop System. ...
... GLENVIEW, IL, Dec. 11, 2008 Federal funding for pain research ... according to a new study published in The Journal of ... only 0.6 percent of all grants awarded by the National Institutes ... the U.S. , "This startling finding shows the government,s ...
Cached Medicine News:Health News:USAID Provides Additional $6.2M for Zimbabwe Cholera Outbreak 2Health News:Mary Beth Bolton, MD, Named 'Woman Physician of the Year' by Michigan State Medical Society 2Health News:Hospice Community Encouraged to Respond to Daschle Request to Participate in Information Gathering about Healthcare Concerns 2Health News:Mathematical models of adaptive immunity 2Health News:Mathematical models of adaptive immunity 3Health News: Medicare to Reimburse for the Bioness L300™ Foot Drop System for Spinal Cord Injury 2Health News: Medicare to Reimburse for the Bioness L300™ Foot Drop System for Spinal Cord Injury 3Health News:Study shows major pain research funding decline at NIH 2
(Date:1/15/2014)... , Jan. 15, 2014 As health officials across ... virus, select Meijer pharmacies in Michigan ... to eligible patients, enabling Meijer pharmacists to administer tests and, ... set by a physician participating in the study. ...
(Date:1/15/2014)... , Jan. 15, 2014  Celsion Corporation (the "Company") (NASDAQ: ... received commitments from institutional investors to purchase an aggregate ... in an at-the-market registered direct offering, led by a ... into definitive purchase agreements with these investors pursuant to ...
(Date:1/15/2014)...  Humberto C. Antunes,  Galderma  worldwide CEO, will receive a ... of Drugs in Dermatology (JDD) at the upcoming ... is January 17-20, 2014, at the Omni Orlando Resort at ChampionsGate ... The ODAC is a distinguished event that delivers a ...
Breaking Medicine Technology:Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 2Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 3Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 2Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 3Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 2Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 3Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 4
... 2011 BioSpecifics Technologies Corp. (Nasdaq: BSTC ... class collagenase-based products, today announced that its Board of ... the Company is authorized to repurchase up to $2 ... the Company,s continued commitment to increasing value for its ...
... 2011 Reportlinker.com announces that a new ... catalogue: Top Medical Devices ... http://www.reportlinker.com/p0558499/Top-Medical-Devices-and-Imaging-Technologies-2011.html?utm_source=prnewswire&utm_medium=pr&utm_campaign=Medical_Devices This research ... technologies that have excellent growth potential in ...
Cached Medicine Technology:BioSpecifics Technologies Corp. Announces Board Authorization of up to $2 Million Share Repurchase Program 2BioSpecifics Technologies Corp. Announces Board Authorization of up to $2 Million Share Repurchase Program 3Reportlinker Adds Top Medical Devices and Imaging Technologies 2011 2
MDI will work with your facility to determine the best interim lab to fit your needs and your site....
... large number of mobile, modular and transportable ... fleet. The labs are typically leased to ... The Cath Lab Leasing Company allows hospitals ... upgrading existing equipment, initiating a new service ...
... PowerSuite holmium laser combines excellent cutting, ... virtually bloodless procedures. It is also ... gall bladder stones of all compositions, ... tool. Because its laser light is ...
... technology has allowed for perfecting mini-invasive endoscopic ... various pathologies with a considerable social impact. ... reducing the post-operatory times and represents a ... in all hospital structures.,DEKAs family of Nd:YAG ...
Medicine Products: