Navigation Links
New method of drug delivery more effective at reaching brain tumors
Date:11/26/2007

New Haven, Conn. Bioengineers at Yale and Cornell have created a modified chemotherapy that more effectively reaches and remains at the site of brain tumors by adding a water-soluble polymer to the anti-cancer drug, according to a report in the November-December issue of Bioconjugate Chemistry.

This approach has the potential to increase treatment distances to more than a centimeter, which may be sufficient to prevent the recurrence of human brain tumors, said Mark Saltzman, Goizueta Foundation Professor of Chemical and Biomedical Engineering and senior author on the paper.

Although placing polymer implants directly at the site of tumor is a proven treatment for cancers of the brain, Saltzman says that success of this approach is minimized because in most cases the drug does not penetrate into the brain far enough for optimum treatment and there is rapid clearance of the drug from the site.

To increase the effectiveness of their drug, Saltzmans team attached polyethylene glycol (PEG), an inert water-soluble polymer, to it. They also identified a promising compound that could deliver 11 times more medication to the tumor than the plain drug alone.

According to Saltzman, previous work on direct delivery of chemotherapy agents to the brain has shown that drug penetration is limited by the low diffusion into tissue. To overcome this limitation, clinical investigators have pumped therapeutic agents at high pressure into the brain. However, this works only as long as the pressure-driven flow is applied, and the side effects of this continuous pumping are unknown.

We recently conjugated or bonded PEG to the chemotherapy drug camptothecin and found a substantial increase in the extent of distribution of camptothecin in the rat brain, said Saltzman. This new method using drug conjugates, which are able to diffuse through tissue and remain in the tissue for prolonged periods, allows them to penetrate significant distances without the need for pressure-driven flows and could substantially improve chances for successful treatment.


'/>"/>

Contact: Janet Rettig Emanuel
janet.emanuel@yale.edu
203-432-2157
Yale University  
Source:Eurekalert

Related medicine news :

1. Stanford study highlights cost-effective method of lowering heart disease risks
2. Different method of evaluating the urinary tract system reduces radiation dose
3. Report on patients access to cancer drugs uses flawed methods to reached flawed conclusions
4. A classic method for modeling skin cancer is featured in Cold Spring Harbor Protocols
5. Researcher developing new method for hearing loss assessment
6. Medicare Prescription Drug Benefit, Nonprofit Hospitals, Ambulatory Surgery Centers, Statistical Methods, and Pay-For-Performance Highlighted In the Latest INQUIRY Journal
7. GPS-like technology helps pinpoint best methods for moving injured players
8. New Seminar Series from Activator Methods Teaches Doctors a Unique Approach to Improving Nations Chiropractic Care: Focus on the Patients
9. Less invasive lymph node biopsy method could spare thousands unnecessary operations
10. 454 Sequencing(TM): Science Paper Describes a Novel, Highly Efficient Method of Sequencing Ancient DNA; Sequences the Mitochondria of 10 Individual Mammoths to Prove It
11. Manchester researchers announce new methods of beating breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New method of drug delivery more effective at reaching brain tumors
(Date:2/23/2017)... (PRWEB) , ... February 23, 2017 , ... ... pre-eminent publication and community for those in the fight against cancer, has produced ... in their success. HRA will release top-line findings in a webinar, Defining ...
(Date:2/23/2017)... ... 2017 , ... CALNOC, the nation’s first and only nursing quality indicators database ... Empowerment, Value and Collaboration – in Seattle, WA on October 23, 2017. , Dr. ... System in Seattle since 2000. In addition to his role at Virginia Mason, Dr. ...
(Date:2/23/2017)... ... February 23, 2017 , ... HealthPostures, the desk for standing ... sit stand solutions representative to the Minneapolis Home and Garden Show which is being ... that is garnering national attention is the Minneapolis Convention Center. , From its ...
(Date:2/22/2017)... ... February 22, 2017 , ... When it ... healthcare contact center in Georgia, PENETRON Specialty Products (PSP) provided the solution. January’s ... systems recently invested $51 million to purchase and renovate the 185,000 square-foot office ...
(Date:2/22/2017)... ... February 22, 2017 , ... Stem cell ... years. The technology is so cutting edge, in fact, the U.S. Food and ... cell procedures. However, successful patient outcomes in certain clinical stem cell procedures have ...
Breaking Medicine News(10 mins):
(Date:2/23/2017)...  As National Nutrition Month approaches, USA Medical is ... helping people live healthier lives by providing discounts ... in all 50 states including:  Texas Prescription Assistance ... Prescription Assistance Program . USA Medical also ... for nutritious eating habits: ...
(Date:2/23/2017)... , February 23, 2017 On ... of day as four out of nine sectors finished the ... sector managed a flat closing. Major US indices were also ... ended the day at 5,860.63, slightly down by 0.09%; the ... 20,775.60; and the S&P 500 closed at 2,362.82, down 0.11%. ...
(Date:2/23/2017)... 2017  Spheryx, Inc. will present two ... PittCon 2017 Conference and Exposition at McCormick ... largest annual premier conference and exposition on ... of industry, academic and government communities encompassing ... safety, environmental, bioterrorism and other emerging markets.  ...
Breaking Medicine Technology: