Navigation Links
New method of drug delivery more effective at reaching brain tumors
Date:11/26/2007

New Haven, Conn. Bioengineers at Yale and Cornell have created a modified chemotherapy that more effectively reaches and remains at the site of brain tumors by adding a water-soluble polymer to the anti-cancer drug, according to a report in the November-December issue of Bioconjugate Chemistry.

This approach has the potential to increase treatment distances to more than a centimeter, which may be sufficient to prevent the recurrence of human brain tumors, said Mark Saltzman, Goizueta Foundation Professor of Chemical and Biomedical Engineering and senior author on the paper.

Although placing polymer implants directly at the site of tumor is a proven treatment for cancers of the brain, Saltzman says that success of this approach is minimized because in most cases the drug does not penetrate into the brain far enough for optimum treatment and there is rapid clearance of the drug from the site.

To increase the effectiveness of their drug, Saltzmans team attached polyethylene glycol (PEG), an inert water-soluble polymer, to it. They also identified a promising compound that could deliver 11 times more medication to the tumor than the plain drug alone.

According to Saltzman, previous work on direct delivery of chemotherapy agents to the brain has shown that drug penetration is limited by the low diffusion into tissue. To overcome this limitation, clinical investigators have pumped therapeutic agents at high pressure into the brain. However, this works only as long as the pressure-driven flow is applied, and the side effects of this continuous pumping are unknown.

We recently conjugated or bonded PEG to the chemotherapy drug camptothecin and found a substantial increase in the extent of distributi
'/>"/>

Contact: Janet Rettig Emanuel
janet.emanuel@yale.edu
203-432-2157
Yale University  
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Stanford study highlights cost-effective method of lowering heart disease risks
2. Different method of evaluating the urinary tract system reduces radiation dose
3. Report on patients access to cancer drugs uses flawed methods to reached flawed conclusions
4. A classic method for modeling skin cancer is featured in Cold Spring Harbor Protocols
5. Researcher developing new method for hearing loss assessment
6. Medicare Prescription Drug Benefit, Nonprofit Hospitals, Ambulatory Surgery Centers, Statistical Methods, and Pay-For-Performance Highlighted In the Latest INQUIRY Journal
7. GPS-like technology helps pinpoint best methods for moving injured players
8. New Seminar Series from Activator Methods Teaches Doctors a Unique Approach to Improving Nations Chiropractic Care: Focus on the Patients
9. Less invasive lymph node biopsy method could spare thousands unnecessary operations
10. 454 Sequencing(TM): Science Paper Describes a Novel, Highly Efficient Method of Sequencing Ancient DNA; Sequences the Mitochondria of 10 Individual Mammoths to Prove It
11. Manchester researchers announce new methods of beating breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New method of drug delivery more effective at reaching brain tumors
(Date:12/21/2014)... Concept Plus, LLC. a SDB and 8(a) certified ... today announced it has been recognized by Washington Technology ... the fastest growing government contracting small businesses by calculating their ... is the first year that Concept Plus, LLC., participated in ... 95.92% compound annual growth rate. “For Concept Plus to be ...
(Date:12/20/2014)... BambooIndustry.com is a leading eco-friendly ... announced its bamboo flooring promotion for the coming ... certified suppliers, and offers the best bamboo products ... current promotion, all customers can enjoy a special ... they know BambooIndustry.com from press releases. , The ...
(Date:12/20/2014)... 20, 2014 Weddingshe.com has recently announced ... a site-wide promotion of special occasion dresses for the ... supplier of special occasion dresses for global women. Now, ... big discounts, up to 80% off. Among the new ... Short Sweet 16 Dress) is very popular. What’s more, ...
(Date:12/20/2014)... December 20, 2014 Dress company LunaDress has ... and announced its Christmas Sale, offering big discounts on all ... girl has an idea to own a perfect wedding gown. ... your wedding dress, then come to LunaDress. Many different wedding ... you. Visit our website now and enjoy the current special ...
(Date:12/20/2014)... The print component of Healthy Aging is distributed within ... copies and an estimated readership of 420,000. The digital ... strategy and across a network of top news sites ... the campaign, click here . , The publication ... CTV’s The Social. Lainey Lui, Melissa Grelo, Traci ...
Breaking Medicine News(10 mins):Health News:Concept Plus, LLC. Named One of Washington Technology’s Fast 50 2Health News:Eco-friendy Bamboo Flooring Manufacturer BambooIndustry.com Introduces Its Bamboo Flooring Promotion for 2015 2Health News:Tons of New-in Winter Sweet 16 Dresses from Weddingshe Online Now 2Health News:2015 Collection of Wedding Dresses from LunaDress Online on Sale Now 2Health News:The ladies of The Social urge Canadian women to put themselves first over the holiday season and into the new year in Mediaplanet’s “Women’s Health” campaign 2
... ... , ... March 31, 2010 -- Thanks to the Oscar-winning movie Slumdog Millionaire, the desperate living ... world attention. No one seems to escape except the miraculous but fictional star of ...
... ... recognized the nonprofit Tostan for its innovative work in bringing about positive, scalable community-led ... ... the Skoll Foundation named nonprofit Tostan as a 2010 recipient ...
... Kingdom are reporting evidence that consumption of insects contaminated ... the mysterious global decline of meat-eating, or carnivorous, plants. ... adverse effects on the plants. It appears in ACS, ... Iain Green and Christopher Moody note that many ...
... paradox for Passover and year-round: With observant Jews numbering barely ... why are 40-50 percent of food items on supermarket shelves ... growing popularity of kosher foods appear in an article in ... C&EN Senior Editor Bethany Halford notes that the ...
... to more careful cancer screening , WEDNESDAY, March 31 (HealthDay ... can be improved if doctors use a simple form, a ... percent and 17 percent of breast cancers. That,s why a ... health. But because of time constraints, many primary-care doctors don,t ...
... The HLP and ... Taking a proactive stance with respect to data management and search terms - as well ... ... Integration (“HLP”) and Pat Taylor and Associates, Inc. (“PTA”) are pleased to announce a project ...
Cached Medicine News:Health News:Slumdog Millionaire Put Spotlight on Slums in Developing World Now, Health Visionary Helps Turn Urban Blight into Hope 2Health News:Slumdog Millionaire Put Spotlight on Slums in Developing World Now, Health Visionary Helps Turn Urban Blight into Hope 3Health News:Tostan and Molly Melching Receive 2010 Skoll Award for Social Entrepreneurship 2Health News:Tostan and Molly Melching Receive 2010 Skoll Award for Social Entrepreneurship 3Health News:Tostan and Molly Melching Receive 2010 Skoll Award for Social Entrepreneurship 4Health News:Simple Forms Help Docs Do Better Breast Exams 2Health News:HLP Integration and Pat Taylor and Associates, Inc. Announce a Project Alliance. 2
(Date:12/19/2014)... 18, 2014 Somewhere between dropping five pounds ... forgotten. But Audicus , a next-generation hearing aids ... new year. Hearing loss is the third ... though it is often unaddressed. Forty-eight million Americans have ... hearing aid, mainly due to price. Hearing aids traditionally ...
(Date:12/19/2014)... 2014 Capnia, Inc. (NASDAQ: ... diagnostics based on its proprietary Sensalyze™ Technology Platform ... financial results for the third quarter and nine ... the completion of our initial public offering (IPO), ... recently initiated CoSense® commercial launch," said Anish Bhatnagar, ...
(Date:12/19/2014)... , Dec. 18, 2014   Aratana Therapeutics, ... biopharmaceutical company focused on the licensing, development and ... announced positive results from its pivotal field study ... treating pain in dogs with osteoarthritis.  In the ... assessment scores that were statistically significant compared to ...
Breaking Medicine Technology:Audicus Will Help People Resolve to Hear Better in 2015 2Capnia Reports Third Quarter 2014 Financial Results 2Capnia Reports Third Quarter 2014 Financial Results 3Capnia Reports Third Quarter 2014 Financial Results 4Capnia Reports Third Quarter 2014 Financial Results 5Capnia Reports Third Quarter 2014 Financial Results 6Capnia Reports Third Quarter 2014 Financial Results 7Capnia Reports Third Quarter 2014 Financial Results 8Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 2Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 3Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 4Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 5
... nation,s economic slowdown, America,s pharmaceutical research and biotechnology ... in the research and development of new life-changing ... $2 billion from 2007, according to analyses by ... and Burrill & Company. PhRMA-member companies alone ...
... DIEGO, March 10 Avineuro Pharmaceuticals, Inc. announced today ... a potent and selective small molecule antagonist of 5-HT6 ... I studies are expected to be available in April ... Inc. plans to advance AVN-211 into Phase II clinical ...
Cached Medicine Technology:R&D Spending by U.S. Biopharmaceutical Companies Reaches Record Levels in 2008 Despite Economic Challenges 2R&D Spending by U.S. Biopharmaceutical Companies Reaches Record Levels in 2008 Despite Economic Challenges 3R&D Spending by U.S. Biopharmaceutical Companies Reaches Record Levels in 2008 Despite Economic Challenges 4
... system device is comprised of the following ... access port are also packaged in the ... cone with 12 mm Step™ cannula assembly ... 12 mm locking cone with 10/12 mm ...
... and Mini Step™ device components are supplied sterile. ... Use System is supplied sterile in 2/3, 5, ... various configurations and combinations. They are used in ... and the Step™ radially Expandable Sleeve. The 5, ...
BLUNTPORT Plus Single Use Converterless 5 mm - 12 mm Trocar System for Open Laparoscopy....
... 5 mm and VersaStep™ PLUS Reposable system components for ... The radial expandable sleeve is packaged sterile together ... valve. Insufflation and access needle is packaged non-sterile; ... mm dilators are packaged non-sterile; 5 mm, 7/8 ...
Medicine Products: