Navigation Links
New method of drug delivery more effective at reaching brain tumors
Date:11/26/2007

New Haven, Conn. Bioengineers at Yale and Cornell have created a modified chemotherapy that more effectively reaches and remains at the site of brain tumors by adding a water-soluble polymer to the anti-cancer drug, according to a report in the November-December issue of Bioconjugate Chemistry.

This approach has the potential to increase treatment distances to more than a centimeter, which may be sufficient to prevent the recurrence of human brain tumors, said Mark Saltzman, Goizueta Foundation Professor of Chemical and Biomedical Engineering and senior author on the paper.

Although placing polymer implants directly at the site of tumor is a proven treatment for cancers of the brain, Saltzman says that success of this approach is minimized because in most cases the drug does not penetrate into the brain far enough for optimum treatment and there is rapid clearance of the drug from the site.

To increase the effectiveness of their drug, Saltzmans team attached polyethylene glycol (PEG), an inert water-soluble polymer, to it. They also identified a promising compound that could deliver 11 times more medication to the tumor than the plain drug alone.

According to Saltzman, previous work on direct delivery of chemotherapy agents to the brain has shown that drug penetration is limited by the low diffusion into tissue. To overcome this limitation, clinical investigators have pumped therapeutic agents at high pressure into the brain. However, this works only as long as the pressure-driven flow is applied, and the side effects of this continuous pumping are unknown.

We recently conjugated or bonded PEG to the chemotherapy drug camptothecin and found a substantial increase in the extent of distribution of camptothecin in the rat brain, said Saltzman. This new method using drug conjugates, which are able to diffuse through tissue and remain in the tissue for prolonged periods, allows them to penetrate significant distances without the need for pressure-driven flows and could substantially improve chances for successful treatment.


'/>"/>

Contact: Janet Rettig Emanuel
janet.emanuel@yale.edu
203-432-2157
Yale University  
Source:Eurekalert

Related medicine news :

1. Stanford study highlights cost-effective method of lowering heart disease risks
2. Different method of evaluating the urinary tract system reduces radiation dose
3. Report on patients access to cancer drugs uses flawed methods to reached flawed conclusions
4. A classic method for modeling skin cancer is featured in Cold Spring Harbor Protocols
5. Researcher developing new method for hearing loss assessment
6. Medicare Prescription Drug Benefit, Nonprofit Hospitals, Ambulatory Surgery Centers, Statistical Methods, and Pay-For-Performance Highlighted In the Latest INQUIRY Journal
7. GPS-like technology helps pinpoint best methods for moving injured players
8. New Seminar Series from Activator Methods Teaches Doctors a Unique Approach to Improving Nations Chiropractic Care: Focus on the Patients
9. Less invasive lymph node biopsy method could spare thousands unnecessary operations
10. 454 Sequencing(TM): Science Paper Describes a Novel, Highly Efficient Method of Sequencing Ancient DNA; Sequences the Mitochondria of 10 Individual Mammoths to Prove It
11. Manchester researchers announce new methods of beating breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New method of drug delivery more effective at reaching brain tumors
(Date:2/12/2016)... (PRWEB) , ... February 12, 2016 , ... ... through a world of exterior design possibilities. CertainTeed, North America’s leading brand of ... by expanding the product offerings showcased in the mobile version of the ColorView® ...
(Date:2/12/2016)... ... ... Coast Autism Spectrum Center (CCASC) invites teens ages 11-18 to its annual Winter Teen Dance. ... and without special needs to gather in a safe and supportive environment. Volunteers will be ... place on Saturday, Feb. 13 from 7 to 9:30 p.m. at Elks Lodge, 322 Elks ...
(Date:2/12/2016)... ... 2016 , ... Planet Future is a Final Cut Pro X ... for showcasing pictures, videos as well as text in an exciting cartoon environment. Planet ... and a beautiful frame overlay. Pixel Film Studios makes editing easy; simply insert media ...
(Date:2/11/2016)... ... February 11, 2016 , ... “ HEALING MIND : ... Well Managed Mind” (published by Balboa Press) teaches readers how to become their own ... profound love, author Janice McDermott, M.Ed., LCSW, offers an understanding of how to heal ...
(Date:2/11/2016)... Jersey (PRWEB) , ... February 11, 2016 , ... Registered ... a free CEU seminar titled, “Stroke Management: Time to Act, Time to Heal” on ... Community in Whippany, N.J. The presenter is Vishal Chedda, president of ANSA Consultants, ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... IRVINE, Calif., Feb. 11, 2016 PRO-DEX, INC. (NasdaqCM: ... quarter ended December 31, 2015. The Company also filed its ... fiscal year 2016 with the Securities and Exchange Commission today. ... December 31, 2015 --> --> ... 2015 increased $2.6 million, or 95%, to $5.4 million from ...
(Date:2/11/2016)... has committed to provide drug disposal kiosks in ... as part of a program to combat drug ... organization As You Sow. Conrad MacKerron , Senior ... to unneeded drugs because they lack easily accessible collection and ... Conrad MacKerron , Senior Vice President at As You ...
(Date:2/11/2016)... -- Potrero Medical, Inc., the developer of the Accuryn™ critical ... George M. Rapier, III , MD, to its Board ... WellMed is one of the nation,s largest physician owned practice ... Texas and Florida ... internal medicine practice, he has been instrumental to the company,s ...
Breaking Medicine Technology: