Navigation Links
New method of drug delivery more effective at reaching brain tumors
Date:11/26/2007

New Haven, Conn. Bioengineers at Yale and Cornell have created a modified chemotherapy that more effectively reaches and remains at the site of brain tumors by adding a water-soluble polymer to the anti-cancer drug, according to a report in the November-December issue of Bioconjugate Chemistry.

This approach has the potential to increase treatment distances to more than a centimeter, which may be sufficient to prevent the recurrence of human brain tumors, said Mark Saltzman, Goizueta Foundation Professor of Chemical and Biomedical Engineering and senior author on the paper.

Although placing polymer implants directly at the site of tumor is a proven treatment for cancers of the brain, Saltzman says that success of this approach is minimized because in most cases the drug does not penetrate into the brain far enough for optimum treatment and there is rapid clearance of the drug from the site.

To increase the effectiveness of their drug, Saltzmans team attached polyethylene glycol (PEG), an inert water-soluble polymer, to it. They also identified a promising compound that could deliver 11 times more medication to the tumor than the plain drug alone.

According to Saltzman, previous work on direct delivery of chemotherapy agents to the brain has shown that drug penetration is limited by the low diffusion into tissue. To overcome this limitation, clinical investigators have pumped therapeutic agents at high pressure into the brain. However, this works only as long as the pressure-driven flow is applied, and the side effects of this continuous pumping are unknown.

We recently conjugated or bonded PEG to the chemotherapy drug camptothecin and found a substantial increase in the extent of distributi
'/>"/>

Contact: Janet Rettig Emanuel
janet.emanuel@yale.edu
203-432-2157
Yale University  
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Stanford study highlights cost-effective method of lowering heart disease risks
2. Different method of evaluating the urinary tract system reduces radiation dose
3. Report on patients access to cancer drugs uses flawed methods to reached flawed conclusions
4. A classic method for modeling skin cancer is featured in Cold Spring Harbor Protocols
5. Researcher developing new method for hearing loss assessment
6. Medicare Prescription Drug Benefit, Nonprofit Hospitals, Ambulatory Surgery Centers, Statistical Methods, and Pay-For-Performance Highlighted In the Latest INQUIRY Journal
7. GPS-like technology helps pinpoint best methods for moving injured players
8. New Seminar Series from Activator Methods Teaches Doctors a Unique Approach to Improving Nations Chiropractic Care: Focus on the Patients
9. Less invasive lymph node biopsy method could spare thousands unnecessary operations
10. 454 Sequencing(TM): Science Paper Describes a Novel, Highly Efficient Method of Sequencing Ancient DNA; Sequences the Mitochondria of 10 Individual Mammoths to Prove It
11. Manchester researchers announce new methods of beating breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New method of drug delivery more effective at reaching brain tumors
(Date:4/17/2015)... Bradley, Illinois (PRWEB) April 17, 2015 ... host a Party on the Patio from 2 p.m. ... which is located at 1320 Executive Ct. in Pekin, ... on Medicaid, who need some help to maintain their ... steel drums, and tropical treats will be served during ...
(Date:4/17/2015)... Oklahoma (PRWEB) April 17, 2015 Alcohol ... Drug Dependence (NCADD) notes that drinking and driving has ... At the same time, the link between alcohol ... as domestic abuse and violence and sexual assault, and ... According to the NCADD, 5.3 million adults in America ...
(Date:4/17/2015)... 17, 2015 In Defense of Christians ... statement: “On Wednesday April 15th, the European Parliament joined ... resolution recognizing the Armenian Genocide, “paying tribute, on the ... one-and-a-half million innocent Armenian victims who perished in the ... the EU for this timely and needed recognition of ...
(Date:4/17/2015)... 17, 2015 As a board-certified orthopedic ... new offering of platelet-rich plasma (PRP) and ... is known for its world-class care of injury-caused ... surgical experience lacking in many other physicians offering regenerative ... are utilized for pain management and rehabilitation. Dr. Meier ...
(Date:4/17/2015)... Fla. (PRWEB) April 17, 2015 Baptist ... Center have signed a partnership agreement designed to transform ... , The institutions have agreed to create a joint ... treatment protocols and translational research. Baptist MD Anderson Cancer ... 2015, providing a single destination for highly coordinated, multidisciplinary ...
Breaking Medicine News(10 mins):Health News:John Evans Supportive Living Community Prepares for Party on the Patio 2Health News:Narconon Arrowhead Raises Awareness on Alcohol Related Prevention 2Health News:Narconon Arrowhead Raises Awareness on Alcohol Related Prevention 3Health News:In Defense of Christians Condemns Armenian Genocide 2Health News:In Defense of Christians Condemns Armenian Genocide 3Health News:Platelet-Rich Plasma, Stem Cell Therapy Now Offered By Dr. Meier At MOSM in Beverly Hills, California 2Health News:Platelet-Rich Plasma, Stem Cell Therapy Now Offered By Dr. Meier At MOSM in Beverly Hills, California 3Health News:Baptist Health and MD Anderson Finalize Agreement to Transform Cancer Care in Region 2Health News:Baptist Health and MD Anderson Finalize Agreement to Transform Cancer Care in Region 3
... few decades ago, sudden cardiac arrest was a death sentence. ... once every six hours in Sweden, reveals a thesis from ... all cases of sudden cardiac arrest over a 30-year period. ... treatment of victims of sudden cardiac arrest, shows a thesis ...
... -- Some patients with inflammatory bowel disease may be ... use of immunosuppressant drugs to treat the intestinal disorder, ... The studies, published in the November issue of the ... used to treat patients with irritable bowel disease, or ...
... School of Medicine in St. Louis have obtained new ... by mutations in a gene governing not speech, but ... Beyond a simple association, the study provides the ... lysosomes actually play a role in causing some people ...
... Alan Mozes HealthDay Reporter , TUESDAY, Nov. 22 ... of coffee may reduce their risk for endometrial cancer, new ... the largest study to date to explore the impact of ... is cancer that originates in the lining of the uterus. ...
... , TUESDAY, Nov. 22 (HealthDay News) -- ,A ... to turn off areas of the brain associated with daydreaming ... more about how meditation works could help advance research into ... Brewer, an assistant professor of psychiatry at Yale University. ...
... believed to be the first study of its kind ... without anxiety) and the amount of time to diagnostically ... Boston University School of Medicine (BUSM) have found suffering ... to diagnostic resolution in a vulnerable population of urban ...
Cached Medicine News:Health News:Sharp decrease in deaths from sudden cardiac arrest 2Health News:Chronic Bowel Disease Drugs Linked to Skin Cancer Risk 2Health News:Surprising pathway implicated in stuttering 2Health News:Surprising pathway implicated in stuttering 3Health News:Study Links Coffee to Lower Risk of Endometrial Cancer 2Health News:Study Links Coffee to Lower Risk of Endometrial Cancer 3Health News:Meditation Can 'Turn Off' Regions of the Brain 2Health News:Depression and anxiety not linked to delayed resolution of abnormal mammograms, Pap tests 2
(Date:4/17/2015)... , April 17, 2015  In Detroit, where three out ... rate is two and one half times of the national ... of 10 infants that die in Detroit ... statistics that Covenant Community Care, a faith-based, charitable non-profit Community ... to change thanks to a charitable donation by Konica Minolta ...
(Date:4/17/2015)... Apr. 17, 2015 Steven Rash , the ... and its operating subsidiary American Seed & Oil Company, ... to investors yesterday in New York City.  Mr. Rash,s ... The American Seed & Oil Company has recently announced ... Butter Hemp Seed Foods , the EpiVape , ...
(Date:4/17/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/kh5kqg/the_corporate ) ... Corporate Reputation of Pharma - The Patient Perspective ... to their offering. The Corporate Reputation ... its fourth edition. This report contains the latest ... annual Corporate Reputation report, the author surveys a ...
Breaking Medicine Technology:Covenant Community Care to Receive Donated SONIMAGE P3 Handheld Ultrasound from Konica Minolta Medical Imaging 2Covenant Community Care to Receive Donated SONIMAGE P3 Handheld Ultrasound from Konica Minolta Medical Imaging 3Covenant Community Care to Receive Donated SONIMAGE P3 Handheld Ultrasound from Konica Minolta Medical Imaging 4American Seed & Oil Company Benchmarks its Consumer Product Development Strategy Against Proctor & Gamble 2American Seed & Oil Company Benchmarks its Consumer Product Development Strategy Against Proctor & Gamble 3The Corporate Reputation of Pharma - The Global Patient Perspective in 2014 2
... Biopure Corporation,(Nasdaq: BPUR ) announced today that ... a new protocol for review by the Food ... trial of Hemopure(R),[hemoglobin glutamer - 250 (bovine)], or ... hemorrhagic shock without,availability of blood transfusions. The proposed ...
... Leukemia & Lymphoma,Society (LLS) and Memgen jointly announced an ... trial. The trial will use Memgen,s,ISF35, an active immunotherapy ... its alliance with LLS, Memgen plans to begin a ... patients who have 17p-, refractory or,resistant CLL with limited ...
Cached Medicine Technology:U.S. Navy Submits Protocol for Field Trauma Trial of Hemopure(R) 2U.S. Navy Submits Protocol for Field Trauma Trial of Hemopure(R) 3The Leukemia & Lymphoma Society and Memgen Collaborate on CLL Clinical Trial 2The Leukemia & Lymphoma Society and Memgen Collaborate on CLL Clinical Trial 3
... DRE-200 ESU units use dedicated digital hardware ... processing data. This hardware allows parallel data ... throughput, measuring tissue impedance 5000 times per ... digitally, being converted to analog only in ...
... Mitek is the Market leader in soft ... Suture, DePuy Mitek has developed the latest ... open shoulder repair. ORTHOCORD Suture is as ... the market. Most importantly, ORTHOCORD Suture handles ...
... surgical gloves were designed with the surgeon ... barrier protection, and value. It offers comfort ... and dry hands. The broader, anatomical design ... micro-rough surface offers sensitivity and an effective ...
The Next Generation in Operating Room Equipment and Management Solutions is here Today. NuBoom is a self-contained, pedestal-mounted boom that houses medical, audio and visual equipment....
Medicine Products: