Navigation Links
New method identifies genes that can predict prognoses of cancer patients
Date:1/25/2013

BOSTON In recent years, it has been thought that select sets of genes might reveal cancer patients' prognoses. However, a study published last year examining breast cancer cases found that most of these "prognostic signatures" were no more accurate than random gene sets in determining cancer prognoses. While many saw this as a disappointment, investigators at Beth Israel Deaconess Medical Center (BIDMC), the Dana-Farber Cancer Institute, and the Institut de Recherches Cliniques de Montral (IRCM) saw this as an opportunity to design a new method to identify gene sets that could yield more significant prognostic value.

Led by Andrew Beck, MD, Director of the Molecular Epidemiology Research Laboratory at BIDMC, the team has developed SAPS (Significance Analysis of Prognostic Signatures), a new algorithm that makes use of three specific criteria to more accurately identify prognostic signatures associated with patient survival.

Their results, the largest analysis of its kind ever performed, are reported in the January 24 on-line issue of the journal PLOS Computational Biology.

"SAPS makes use of three specific criteria," explains Beck, who is also an Assistant Professor of Pathology at Harvard Medical School. "First, the gene set must be enriched for genes that are associated with survival. In addition, the gene set must separate patients into groups that show survival differences. Lastly, it must also perform significantly better than sets of random genes at these tasks."

In the new study, the scientific team applied the SAPS algorithm to gene expression profiling data from the study's senior author Benjamin Haibe-Kains, PhD, Director of the Bioinformatics and Computational Genomics Laboratory at IRCM and an Assistant Research Professor at the University of Montreal. The first collection of data was obtained from 19 published breast cancer studies (including approximately 3800 patients), and the second included 12 publ
'/>"/>

Contact: Bonnie Prescott
bprescot@bidmc.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. New Book The MELT Method Offers a Breakthrough Self-Treatment System to Eliminate Chronic Pain, Erase the Signs of Aging, and Feel Fantastic in Just 10 Minutes a Day!
2. Kantar Health Further Strengthens Its Advanced Methods and Client Consulting Capabilities in the UK
3. Developed new method to diagnose hereditary breast and ovarian cancer
4. When Can You Get Pregnant? Many Women Don’t Know, But a Simple Family Planning Method Now Available from Cycle Technologies Can Help
5. Research Reveals Which Learning Methods Get an A
6. New Research Survey Indicates That Natural Family Planning Method CycleBeads® Helps Women Planning Pregnancies
7. Targeted gene silencing drugs are more than 500 times more effective with new delivery method
8. Methodist Retirement Communities Set to Open the First Memory Support Community in Huntsville, TX Area
9. Method developed by VTT targets diagnosis of early Alzheimers disease
10. Researchers explore social media as preventative method for infectious diseases
11. New method helps target Parkinsons disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/1/2014)... small protein beta-amyloid is strongly associated with Alzheimer,s disease; ... this peptide is the causal agent of the onset ... such confirmation is that beta-amyloid is not harmful when ... is when it self-assembles to form the so-called amyloid ... target, beta-amyloid alone, but with multiple ones because each ...
(Date:10/1/2014)... and Physical Sciences Research Council (EPSRC) will focus ... control systems which run, for example, manufacturing plants, ... network. , The research will help understand ... the systems behind our critical national infrastructure. ... Systems (RITICS), based at Imperial College London, is ...
(Date:10/1/2014)... Familylifeinsurancequotes.org has released a new blog post ... , Senior citizens can qualify for affordable term ... seniors who are over 50 years old. Some term ... medical examination. , Term life insurance with a simplified ... qualify. Having life insurance during retirement is important for ...
(Date:10/1/2014)... Lifeinsurance-policy.com has released a new ... insurance prices for smokers. , Smoking will always have ... quotes is the best method to find affordable coverage. ... who need coverage. , Whole life insurance premiums ... policy. Since the coverage is permanent, the initial ...
(Date:10/1/2014)... 2014 Farmington Company today announced ... mission and visual identity helping brokers, consultants and ... them to create greater benefit communication synergies. They ... on empowering customers to better leverage Farmington Company’s ... jewel of the rebrand is the refreshed tagline: ...
Breaking Medicine News(10 mins):Health News:Laying siege to beta-amyloid, the key protein in Alzheimer's disease 2Health News:£2.5 million to recognize and reduce cyber-attack threats to critical infrastructure 2Health News:Affordable Term Life Insurance - Senior Citizens Can Qualify for Coverage! 2Health News:Affordable Whole Life Insurance Premiums for Smokers! 2Health News:Farmington Company Launches Rebrand and New Positioning 2
... NEW YORK, Oct. 7 The Mount Sinai Adolescent ... to 10,000 teenagers each year, announced the launch of ... , and a Facebook page to promote the important ... Legends, benefit co-chairs Stacy and Mouli Cohen designed and ...
... (BUSM) have identified genes which may influence the onset age ... in BMC Medical Genetics , are the first to ... may help identify mechanisms and therapeutic targets capable of delaying ... common neurodegenerative disorder usually occurring late in life. It ...
... , WEDNESDAY, Oct. 7 (HealthDay News) -- Could birth control ... possibly detrimental, direction? , A review of past research finds ... of mates among members of both genders in a way ... use of the pill by women, by changing her mate ...
... ... , a very common medical condition, can turn to endovenous laser therapy for treatment ... Phoenix, Arizona (PRWEB) ... affecting approximately 15 percent of men and approximately 25 percent of women. More than ...
... 7 It,s that time of year again. The annual ... Plans, large group clients, (50 or more eligible employees), began ... For this year,s enrollment season, AvMed has partnered with the ... theme of "What,s Cooking at AvMed," Client Services staff began ...
... and smart health care reform targeting AR, LA, ... Institute for Liberty today announced the launch of Keeping Small ... any health care reform legislation passed by Congress addresses the ... , "The nation faces serious economic challenges and any credible ...
Cached Medicine News:Health News:Katie Couric and the Mount Sinai Adolescent Health Center Celebrate the Launch of Breakfast of Legends Website Donated by Stacy and Mouli Cohen 2Health News:Researchers identify genes associated with onset age of Parkinson's disease 2Health News:Birth Control Pills Might Alter Mate Selection: Study 2Health News:Birth Control Pills Might Alter Mate Selection: Study 3Health News:Endovenous Laser Therapy Used for Treatment of Varicose Veins 2Health News:AvMed Health Plans' Open Enrollment Under Way 2Health News:Institute for Liberty Announces the Launch of Keeping Small Business Healthy 2
(Date:9/30/2014)... This report analyzes the worldwide markets for Enteral ... Enteral Feeding Pumps, Nasogastric Tubes, and Others. The ... Japan , Europe , ... and Rest of World. Annual estimates and forecasts are provided ... analysis is provided for these markets. The report ...
(Date:9/30/2014)... MiMedx Group, Inc. (NASDAQ: MDXG ... tissue and patent-protected processes to develop and market advanced ... Spinal, Sports Medicine, Ophthalmic and Dental sectors of healthcare, ... Scientific Officer, will present at the Stem Cell Meeting ... October 7, 2014, at 5:00PM Pacific Daylight Time. ...
(Date:9/30/2014)... -- STUDY OBJECTIVES The objective of BCC ... overview of the current and future characteristics of ... objective is to present a comprehensive analysis and ... tool in the treatment of various diseases. ... the protein therapeutics market, which includes peptide hormones, ...
Breaking Medicine Technology:Global Enteral Feeding Devices Industry 2Global Enteral Feeding Devices Industry 3Global Enteral Feeding Devices Industry 4Global Enteral Feeding Devices Industry 5Global Enteral Feeding Devices Industry 6Global Enteral Feeding Devices Industry 7Global Enteral Feeding Devices Industry 8Global Enteral Feeding Devices Industry 9Global Enteral Feeding Devices Industry 10Global Enteral Feeding Devices Industry 11Global Enteral Feeding Devices Industry 12Global Enteral Feeding Devices Industry 13Global Enteral Feeding Devices Industry 14Global Enteral Feeding Devices Industry 15Global Enteral Feeding Devices Industry 16Global Enteral Feeding Devices Industry 17Global Enteral Feeding Devices Industry 18Global Enteral Feeding Devices Industry 19MiMedx to Present at the Stem Cell Meeting on the Mesa 2Global Markets and Manufacturing Technologies for Protein Drugs -- Focus on Cytokines and Monoclonal Antibodies 2Global Markets and Manufacturing Technologies for Protein Drugs -- Focus on Cytokines and Monoclonal Antibodies 3Global Markets and Manufacturing Technologies for Protein Drugs -- Focus on Cytokines and Monoclonal Antibodies 4
... WOONSOCKET, R.I., Jan. 6, 2011 A new CVS ... a three-year period for patients with one or more ... medications as doctors direct may save the health care ... study findings revealed robust reductions in emergency department visits ...
... DIEGO, Jan. 6, 2011 Arena Pharmaceuticals, Inc. (Nasdaq: ... is scheduled to present at the 29th Annual J.P. Morgan ... Pacific Time (7:00 p.m. Eastern Time) at the Westin St. ... and Chief Executive Officer, is scheduled to provide a corporate ...
Cached Medicine Technology:CVS Caremark Study Finds Medication Adherence Leads to Lower Health Care Costs, Even After Accounting for Increased Prescription Drug Spending 2CVS Caremark Study Finds Medication Adherence Leads to Lower Health Care Costs, Even After Accounting for Increased Prescription Drug Spending 3Arena Pharmaceuticals to Present at the 29th Annual J.P. Morgan Healthcare Conference 2Arena Pharmaceuticals to Present at the 29th Annual J.P. Morgan Healthcare Conference 3
... Made with elastic fabric, these head ... you need to begin testing. Each Electro-Cap ... to the International 10-20 System. When you ... you are using with your head cap ...
... When testing takes you into the OR, ER, ... protection of Cadwells new shielded electrodes. Keeping noise ... and paired disc electrode has a special shielded ... the damaging effects of 60-cycle interference. That means ...
... orbital implant was conceived by Arthur C. ... a comprehensive review of the literature on ... dating back to 1885 (Mules 1885). This ... the performance of contemporary implants, allowed Perry ...
... Viewing System was developed in New ... the surgical supervision of Professor Stanley Chang, ... New York Cornell Medical Center and later ... on the market and immediately revolutionized the ...
Medicine Products: