Navigation Links
New method identifies genes that can predict prognoses of cancer patients
Date:1/25/2013

BOSTON In recent years, it has been thought that select sets of genes might reveal cancer patients' prognoses. However, a study published last year examining breast cancer cases found that most of these "prognostic signatures" were no more accurate than random gene sets in determining cancer prognoses. While many saw this as a disappointment, investigators at Beth Israel Deaconess Medical Center (BIDMC), the Dana-Farber Cancer Institute, and the Institut de Recherches Cliniques de Montral (IRCM) saw this as an opportunity to design a new method to identify gene sets that could yield more significant prognostic value.

Led by Andrew Beck, MD, Director of the Molecular Epidemiology Research Laboratory at BIDMC, the team has developed SAPS (Significance Analysis of Prognostic Signatures), a new algorithm that makes use of three specific criteria to more accurately identify prognostic signatures associated with patient survival.

Their results, the largest analysis of its kind ever performed, are reported in the January 24 on-line issue of the journal PLOS Computational Biology.

"SAPS makes use of three specific criteria," explains Beck, who is also an Assistant Professor of Pathology at Harvard Medical School. "First, the gene set must be enriched for genes that are associated with survival. In addition, the gene set must separate patients into groups that show survival differences. Lastly, it must also perform significantly better than sets of random genes at these tasks."

In the new study, the scientific team applied the SAPS algorithm to gene expression profiling data from the study's senior author Benjamin Haibe-Kains, PhD, Director of the Bioinformatics and Computational Genomics Laboratory at IRCM and an Assistant Research Professor at the University of Montreal. The first collection of data was obtained from 19 published breast cancer studies (including approximately 3800 patients), and the second included 12 publ
'/>"/>

Contact: Bonnie Prescott
bprescot@bidmc.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. New Book The MELT Method Offers a Breakthrough Self-Treatment System to Eliminate Chronic Pain, Erase the Signs of Aging, and Feel Fantastic in Just 10 Minutes a Day!
2. Kantar Health Further Strengthens Its Advanced Methods and Client Consulting Capabilities in the UK
3. Developed new method to diagnose hereditary breast and ovarian cancer
4. When Can You Get Pregnant? Many Women Don’t Know, But a Simple Family Planning Method Now Available from Cycle Technologies Can Help
5. Research Reveals Which Learning Methods Get an A
6. New Research Survey Indicates That Natural Family Planning Method CycleBeads® Helps Women Planning Pregnancies
7. Targeted gene silencing drugs are more than 500 times more effective with new delivery method
8. Methodist Retirement Communities Set to Open the First Memory Support Community in Huntsville, TX Area
9. Method developed by VTT targets diagnosis of early Alzheimers disease
10. Researchers explore social media as preventative method for infectious diseases
11. New method helps target Parkinsons disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... University researchers have developed a way to detect and ... tiny gold particles with tails of synthetic DNA., A ... biological engineering, used gold nanoparticles to target and bind ... RNA splice variants, which can indicate the presence and ... splice variants in a cell can be determined by ...
(Date:4/23/2014)... A novel compound that targets an important brain receptor ... addiction behaviors, including relapse behavior, a University at Buffalo ... evidence that this may be a novel lead compound ... exist., The UB research was published as an online ... In the study, the compound, RO5263397, severely blunted a ...
(Date:4/23/2014)... 23, 2014Men whose testosterone falls below normal levels are ... overweight and have heart disease and type 2 diabetes. ... men for further testing and possible treatment is described ... , a peer-reviewed publication from Mary Ann Liebert, Inc., ... Journal of Men,s Health website at http://www.liebertpub.com/jmh ...
(Date:4/23/2014)... "simple and accessible detection methods that can rapidly ... of a single cell inside that population has ... Chang Lu. , In the Royal Society of ... announced that he and his coworkers have developed ... of a protein ( Chem. Sci. , 2014, ...
(Date:4/23/2014)... health benefits of probiotics, antioxidants and other nutritional compounds, ... chemical industry is getting in on the action. But ... so the industry is responding with clinical research to ... in Chemical & Engineering News (C&EN), the ... Melody M. Bomgardner, a senior editor at C&EN, writes ...
Breaking Medicine News(10 mins):Health News:Gold nanoparticles help target, quantify breast cancer segments in a living cell 2Health News:Novel compound halts cocaine addiction and relapse behaviors 2Health News:Following a protein's travel inside cells is key to improving patient monitoring, drug development 2
... they travel, they pack a lunch. In results ... evolutionary biologists Joan Strassmann and David Queller of Rice ... known as slime molds) increase their odds of survival ... lead author Debra Brock, a graduate student at Rice, ...
... News) -- Many U.S. transplant surgeons unnecessarily shun organs ... safeguards that would protect and inform transplant recipients, a ... in the nation "overreacted" to a 2007 case in ... organs from a single donor unknowingly infected with HIV, ...
... HealthDay Reporter , TUESDAY, Jan. 18 (HealthDay News) -- A ... II colon cancer face a higher risk of recurrence, German ... doctors in determining which patients need follow-up treatment after initial ... improvement on existing ways to predict recurrence, according to cancer ...
... who had not discussed life support measures with critically ... to forego further medical intervention than those who had ... the University of Pittsburgh School of Medicine and the ... in a poster presentation at the Society of Critical ...
... have been hot on the trail of a genetic mutation ... mutation,s discovery in 2008. The hunt is now yielding fruit. ... , researchers reveal how the mutation contributes to cancer development ... 75 percent of people with low-grade brain tumors and 20 ...
... January 18, 2011 HIV-positive head and neck cancer ... similar toxicity rates as non-HIV-positive patients, despite prior reports ... January issue of the International Journal of Radiation ... for Radiation Oncology (ASTRO). , Patients with HIV have ...
Cached Medicine News:Health News:Like humans, amoebae pack a lunch before they travel 2Health News:Gene Test Might Predict Colon Cancer's Return 2Health News:Gene Test Might Predict Colon Cancer's Return 3Health News:Pitt study: End-of-life decisions take longer if patient hasn't shared wishes with family 2Health News:Molecular battle in cancer cells offers clues for treatment 2Health News:HIV-positive head and neck cancer patients benefit from radiation therapy 2
(Date:1/15/2014)... 15, 2014  In an unprecedented effort to curb the spread of ... other transport vehicles, an advanced and portable UV germicidal lamp manufactured ... first time. In order to prevent EMS paramedics ... West Palm Beach Fire Rescue is the ...
(Date:1/15/2014)...  According to Millennium Research Group (MRG), the global ... the United States and European transcatheter ... moderately through 2022, with embolization particles representing one ... in drug-eluting beads (DEBs) and radioembolization spheres in ...
(Date:1/15/2014)... 15, 2014 Reportlinker.com announces that ... available in its catalogue: ... for Advanced Drug Delivery Systems -- ... http://www.reportlinker.com/p01941928/Global-Markets-and-Technologies-for-Advanced-Drug-Delivery-Systems----Focus-on-Routes-of-Administration.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Drug_Delivery_Technology ...
Breaking Medicine Technology:Superbugs No Longer Ride In Rescue Vehicles 2US and European Transcatheter Embolization and Occlusion Device Market to Surpass $1.6 Billion by 2022 2US and European Transcatheter Embolization and Occlusion Device Market to Surpass $1.6 Billion by 2022 3Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 2Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 3Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 4Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 5Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 6Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 7Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 8Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 9Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 10Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 11Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 12Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 13Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 14Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 15Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 16
... -- WuXi PharmaTech (Cayman) Inc. (NYSE: WX ... outsourcing company with operations in China and the United ... for the second quarter of 2011 after the New ... (which will be Thursday morning, August 11, 2011 Shanghai ...
... 19, 2011 Cookstr, the world,s #1 collection of ... offering of curated recipe content exclusively on Apple,s iBookstore. ... publishers, the company,s iBookstore offering includes curated sets of ... ($9.99) that invite readers to choose between whole books ...
Cached Medicine Technology:WuXi PharmaTech Schedules Second-Quarter 2011 Earnings Release 2Cookstr Launches New Digital Recipe Collections Exclusively on Apple's iBookstore 2Cookstr Launches New Digital Recipe Collections Exclusively on Apple's iBookstore 3Cookstr Launches New Digital Recipe Collections Exclusively on Apple's iBookstore 4
This storage freezer, which is based on our premium freezer line, maintain red cells safely below regulatory standards at -86C (-123F). Recorder is standard for model 8627. Model 8627 is UL Listed, C...
The TBR-360-1-GD is a large capacity upright style operating temperature +4C. It is specially designed refrigerators for the storage of blood in standard 500ml bags, complying with Australian Standar...
Refrigerator specially designed for the storage of blood in standard 500ml bags, complying with Australian Standard AS3864 1997....
TBR-720-2-GD is large capacity upright style operating temperature +4C. It is specially designed refrigerators for the storage of blood in standard 500ml bags, complying with Australian Standard AS38...
Medicine Products: