Navigation Links
New mechanism for long-term memory formation discovered
Date:3/25/2013

Irvine, Calif., March 25, 2013 UC Irvine neurobiologists have found a novel molecular mechanism that helps trigger the formation of long-term memory. The researchers believe the discovery of this mechanism adds another piece to the puzzle in the ongoing effort to uncover the mysteries of memory and, potentially, certain intellectual disabilities.

In a study led by Marcelo Wood of UC Irvine's Center for the Neurobiology of Learning & Memory, the team investigated the role of this mechanism a gene designated Baf53b in long-term memory formation. Baf53b is one of several proteins making up a molecular complex called nBAF.

Mutations in the proteins of the nBAF complex have been linked to several intellectual disorders, including Coffin-Siris syndrome, Nicolaides-Baraitser syndrome and sporadic autism. One of the key questions the researchers addressed is how mutations in components of the nBAF complex lead to cognitive impairments.

In their study, Wood and his colleagues used mice bred with mutations in Baf53b. While this genetic modification did not affect the mice's ability to learn, it did notably inhibit long-term memories from forming and severely impaired synaptic function.

"These findings present a whole new way to look at how long-term memories form," said Wood, associate professor of neurobiology & behavior. "They also provide a mechanism by which mutations in the proteins of the nBAF complex may underlie the development of intellectual disability disorders characterized by significant cognitive impairments."

How does this mechanism regulate gene expression required for long-term memory formation? Most genes are tightly packaged by a chromatin structure chromatin being what compacts DNA so that it fits inside the nucleus of a cell. That compaction mechanism represses gene expression. Baf53b, and the nBAF complex, physically open the chromatin structure so specific genes required for long-term memory format
'/>"/>

Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Fungus uses copper detoxification as crafty defense mechanism
2. BUSM authors propose potential epigenetic mechanisms for improved cancer therapy
3. A new mechanism that contributes to the evolution of cancer
4. Singapore scientists led by A*STARs GIS identify 4 mechanisms that contribute to gastric cancers
5. Cancer scientists determine mechanism of 1 of the most powerful tumor-suppressor proteins, Chd5
6. Research sheds new light on mechanisms of T-ALL, a form of leukemia that primarily affects children
7. Scientists discover mechanism that could reduce obesity
8. New mechanism for cancer progression discovered by UNC and Harvard researchers
9. Novel mechanism through which normal stromal cells become cancer-promoting cells identified
10. Mechanism of breathing muscle paralysis in dreaming sleep identified
11. New mechanism of action for PARP inhibitors discovered
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/28/2014)... diabetes face a number of challenges over the holidays, but ... "With the holidays coming, take some time to think ... be visiting and all of the to-dos," Joan Bardsley, president ... association news release. "By planning ahead. you can enjoy the ... make a healthy eating contract with yourself. Before a big ...
(Date:11/28/2014)... Agein.com, the Internet’s premier anti-aging web site ... the foremost experts in the industry, is releasing its top ... winter. , “The official start of winter is still three ... hit with an icy blast. After one of the worst ... will usher in another brutal winter,” says Dr. Kevin J. ...
(Date:11/28/2014)... BambooFlooringChina.com has been recognized as a ... the business has announced its new strand woven ... discount on these new models. , Based on the ... without carpenter machines involved. It is crafted on strand ... for do-it-yourselfers without hard work on installation, also available ...
(Date:11/28/2014)... Now that the holiday season is here, ... nation's leading cash-for-junk-cars companies, is improving their cash offers ... competitive and help bring a little bit more joy ... year. , Along with purchasing expensive gifts for family ... deal with large travel expenses during the holiday season. ...
(Date:11/28/2014)... 28, 2014 Dr. Diane Walder, one ... announced the addition of Dr. Bridgit Nolan to her ... practice after having completed her dermatology residency at the ... Walder invited Dr. Nolan to join her ... and cosmetic dermatology. Not only does Dr. Nolan strive ...
Breaking Medicine News(10 mins):Health News:Holiday Eating Tips for People With Diabetes 2Health News:Agein Corporation, a Leading Anti-Aging Company, Releases Top Diet and Personal Care Tips for Preventing Dry Skin this Season 2Health News:BambooFlooringChina.com Introduces Its New Strand Woven Bamboo Flooring Collection 2Health News:Rusty's Auto Salvage Increasing Their Cash Offers to Help Drivers Save Throughout the Busy Holiday Season 2Health News:Dr. Diane Walder Welcomes New Cosmetic Dermatologist to Practice 2
... Treatment ... Worldwide, LOS ANGELES, Nov. ... develop an AIDS vaccine have,announced that their efforts have stumbled or, in ... was halted last week,when its vaccine was suspected of actually making some ...
... erosive gastroesophageal reflux disease ... (GERD) who cannot swallow tablets, COLLEGEVILLE, Pa., ... WYE ), announced today that the,U.S. Food and Drug Administration ... new addition,to the Protonix family of prescription medications. "The ...
... The prognosis for individuals with metastatic melanoma (MM) is ... have some clinical benefit; however, most patients eventually succumb ... known as dendritic cells (DCs) fail to sustain an ... in vitro using human melanoma cell lines and resected ...
... YORK, Nov. 15 Danny Wright, Chief Executive ... (http://www.alliancehealthcard.com ) will be featured in an exclusive ... at 2 p.m. EST. The interview,will be posted ... on November 16. The interview will cover ...
... will serve as Digital,s Medical Director for ... Ophthalmology, ... company specializing in retinal risk assessment for diabetics,announced today that Suber S. ... provide the company expert,advice and counsel regarding product development and development. ...
... consumption of these foods lowered odds up to 60%, study ... that includes plenty of fish, omega-3 rich oils, fruits and ... while high intake of omega-6 rich oils may boost the ... They looked at the diets of 8,085 people older than ...
Cached Medicine News:Health News:AIDS Vaccine Failures Highlight Need to Focus on Lifesaving Treatment, Says AHF 2Health News:Wyeth Receives FDA Approval of Protonix for Delayed-Release Oral Suspension 2Health News:Wyeth Receives FDA Approval of Protonix for Delayed-Release Oral Suspension 3Health News:WallSt.net Announces Upcoming Interview With CEO of Alliance HealthCard 2Health News:Digital Healthcare Announces Appointment of Dr. Suber Huang as Medical Director 2Health News:Digital Healthcare Announces Appointment of Dr. Suber Huang as Medical Director 3Health News:Fish, Fruits, Veggies May Cut Dementia Risk 2
(Date:11/28/2014)... -- Chinese magnesium alloy maker DongGuan Eontec Co., Ltd ... bone fixation screw has received Chinese regulatory inspection approval ... and that the company acknowledges receipt of the approval ... and Technology Daily journalists Wang Xiangming and ... Professor Li Yangde , has been a pioneer ...
(Date:11/27/2014)... - New Solution That Makes JINS MEME,s Raw ... Ltd. will launch JINS MEME "ACADEMIC PACK" in late April, ... (without tax /including two pairs of JINS MEME and designated ... of "JINS MEME" to academic researchers, and it enables them ... and six-axis sensors without API. (*Physiological data that can be ...
(Date:11/26/2014)... Company plc ("Perrigo") (NYSE: PRGO ; TASE), ... today announced the closing of Perrigo,s previously announced registered ... shares at a public offering price of $152.00 per ... purchase up to an additional 888,157 ordinary shares by ... representatives of the several underwriters. Perrigo ...
Breaking Medicine Technology:Chinese magnesium alloy manufacturer Eontec expects to have its medical magnesium alloy available for clinical trial in 2015 2Chinese magnesium alloy manufacturer Eontec expects to have its medical magnesium alloy available for clinical trial in 2015 3Chinese magnesium alloy manufacturer Eontec expects to have its medical magnesium alloy available for clinical trial in 2015 4JIN to Launch JINS MEME ACADEMIC PACK in Late April 2015 2JIN to Launch JINS MEME ACADEMIC PACK in Late April 2015 3Perrigo Company plc Announces The Closing Of Its Registered Public Offering Of Ordinary Shares 2Perrigo Company plc Announces The Closing Of Its Registered Public Offering Of Ordinary Shares 3Perrigo Company plc Announces The Closing Of Its Registered Public Offering Of Ordinary Shares 4
... Texas, Nov. 18, 2010 OCuSOFT, Inc., an ... to announce that ZYTAZE™ is now available in ... but are not limited to: Walgreens, CVS, Wal-Mart, ... In an early pilot study, ZYTAZE™ demonstrated marked ...
... FORD, Pa., Nov. 18, 2010 Endo Pharmaceuticals Holdings ... it priced $400 million aggregate principal amount of 7.00% ... of 99.10 percent in connection with its previously announced ... of the Company and will be guaranteed by certain ...
Cached Medicine Technology:Endo Pharmaceuticals Holdings Inc. Announces Pricing of Private Offering of Senior Notes 2
... Practice management software for eyecare ... true multi-tasking, multi-office practice management ... database technology- Winx Pro is ... assist you in effectively managing ...
... Working with over 2,500 ... proud to serve one ... client bases in the ... PM Ophthalmology, we are ...
... EMR Ophthalmology is a comprehensive electronic ... for ophthalmology practices. Intuition EMR Ophthalmology ... provides the tools to evaluate your ... to make better decisions and to ...
... in advanced cartridge mixing and delivery systems. ... mechanically injects all types of bone cement ... line-up includes a large selection of nozzles ... difficult to access areas. A new, anatomically ...
Medicine Products: