Navigation Links
New idea for targeting the common cancer protein KRAS
Date:10/20/2013

pathways downstream of KRAS that drive cell growth and survival.

Instead, they found that a number of small molecules that attached to a special pocket in a region of SOS called the CDC25 domain and increased SOS-mediated guanine nucleotide exchange actually inhibited two of the major signaling pathways downstream of KRAS: the MAPK and PI3K signaling pathways.

The researchers are actively investigating why small molecules that increased SOS-mediated guanine nucleotide exchange in biochemical assays blocked signaling downstream of KRAS in cell lines. They are also working to optimize the small molecules before they conduct studies in preclinical models of cancer.


'/>"/>

Contact: Lauren Riley
lauren.riley@aacr.org
215-446-7109
American Association for Cancer Research
Source:Eurekalert

Page: 1 2

Related medicine news :

1. GUARDaHEART Hosts an Unforgettable Evening in Celebration of World Heart Day “Targeting Heart Disease”
2. Targeting memory T-cells in Type 1 diabetes
3. Targeting aggressive prostate cancer
4. Nanodrug targeting breast cancer cells from the inside adds weapon: Immune system attack
5. Cancer research brief: Targeting pancreatic cancer drug resistance
6. Targeting errant immune system enzyme kills myelodysplastic cells
7. hCGTreatments / Diet Doc hCG Diets & Weight Loss Plans Offer Improved hCG Diet Plans Capable of Targeting Stubborn Belly Fat Now Linked With Decreased Bone Density
8. hCGTreatments / Diet Doc hCG Diets & Weight Loss Plans Now Offer New Weight Loss Diets that Educate Patients, Targeting Weight Gained During Childhood and Adolescence
9. Overcoming resistance to anti-cancer drugs by targeting cell powerhouses
10. Study Shows Dual Targeting of HER2 and HR-positive Metastatic Breast Cancer Improves Survival Rates
11. Drugs targeting blood vessels may be candidates for treating Alzheimers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... The American Society of ... engaged in the field of organ transplantation, today ... Immunology Research Network (TIRN), a professional network ... modern organ transplantation continues to diversify, AST determined ... more opportunities for physicians, scientists and researchers to ...
(Date:7/28/2014)... Research into improving treatment for patients with one of ... 810,000 funding boost. , Chronic obstructive pulmonary disease (COPD) ... cause breathing difficulties due to long-term damage to the ... for 10 per cent of all hospital admissions in ... readmitted to hospital after they are discharged. ...
(Date:7/28/2014)... Malibu, CA (PRWEB) July 28, 2014 ... upon us, it is welcome news that a ... effective than current protection is under development by SunSeeker ... by NASA to protect spacecraft from the extreme heat ... protection to both firefighters and homes. , “Our firefighters ...
(Date:7/28/2014)... 28, 2014 Drorit Silverman, a professional ... plans to raise investment capital through her crowd funding ... in the United States. , According to a statement ... fitness centers provide a great window of opportunity for ... space. In addition to this, Silverman looks at the ...
(Date:7/28/2014)... (Boston)-- Researchers from Boston University School of Medicine (BUSM) ... increase the risk of developing Alzheimer,s disease (AD). The ... new drug treatment options that target PLXNA4 specifically. These ... , AD is the most frequent age-related dementia affecting ... 65 and older, and more than 40 percent of ...
Breaking Medicine News(10 mins):Health News:American Society of Transplantation (AST) Launches Transplantation and Immunology Research Network (TIRN); Aims to Expand Research Collaboration & Funding 2Health News:American Society of Transplantation (AST) Launches Transplantation and Immunology Research Network (TIRN); Aims to Expand Research Collaboration & Funding 3Health News:New research to tackle treatment for lung disease 2Health News:New research to tackle treatment for lung disease 3Health News:Revolutionary Fire Blanket Offers Over 200 Percent More Fire Protection to Firefighters and Homes 2Health News:Pro Bodybuilder Drorit Silverman Confirms Plans to Raise Money for Investment in the Popular 24/7 Fitness Concept 2Health News:Researchers identify potential biomarker for AD 2
... and Treatment Centers Seek Competitive Advantage by Leveraging ... to make ends meet, the ability to do ... gain efficiencies comes from two converging market forces: ... recession-proof healthcare industry, and the national push to ...
... will be made available closer to the meeting date. ... the meeting as well as during the meeting. , ... Council of the National Academy of Sciences. The Society,s ... and to encourage applications of research findings. Its membership ...
... QC, April 2 /PRNewswire-FirstCall/ - Labopharm Inc. (TSX: ... the results of its recently completed North American ... of tramadol and acetaminophen (study 06CCL3-001). , Study ... that compared the efficacy and safety of Labopharm,s ...
... connect, exchange information and ,speak, HL7. , ... Toronto, ... - a core need in modern healthcare - has never been ... HL7 Interface Engine . This easy-to-use yet powerful tool, ...
... through common symptoms during pregnancy, such as morning sickness, fatigue and weight ... when they come. At Gurgle, we offer a guide to women in ... , ... London, England (PRWEB) April 2, 2009 -- Around half of ...
... NY -- Biomedical informatics researchers at Mayo Clinic ... the newly founded Open Health Natural Language Processing ... space to promote past and current development efforts, ... records. , As part of the launch, Mayo ...
Cached Medicine News:Health News:Hospitals Turn to Vendors Like Elekta for Help in Squeezing Most From Existing Technologies 2Health News:Hospitals Turn to Vendors Like Elekta for Help in Squeezing Most From Existing Technologies 3Health News:Labopharm reports results for Phase III study on twice-daily tramadol-acetaminophen formulation 2Health News:Labopharm reports results for Phase III study on twice-daily tramadol-acetaminophen formulation 3Health News:Talking Iguana - Helping the Healthcare Sector Speak HL7 2Health News:Talking Iguana - Helping the Healthcare Sector Speak HL7 3Health News:Gurgle's Guide on How to Beat Morning Sickness and Pregnancy Fatigue 2Health News:Gurgle's Guide on How to Beat Morning Sickness and Pregnancy Fatigue 3Health News:Gurgle's Guide on How to Beat Morning Sickness and Pregnancy Fatigue 4Health News:Gurgle's Guide on How to Beat Morning Sickness and Pregnancy Fatigue 5Health News:Mayo Clinic and IBM host medical language initiative 2Health News:Mayo Clinic and IBM host medical language initiative 3Health News:Mayo Clinic and IBM host medical language initiative 4
(Date:7/28/2014)... Reportlinker.com announces that a new market ... Portugal Pharmaceuticals and Healthcare Report Q3 ... Includes 3 FREE quarterly updates ... last quarter has led us to revise our ... previously, BMI expects Portugal,s ...
(Date:7/28/2014)... CLEVELAND , July 28, 2014  Surgical ... new members to its Business Advisory Board. New ... Senior Vice President for Business Development and New ... (Jim) Fulton , former Senior Vice President and ... unit. Surgical Theater applies flight simulation technology to ...
(Date:7/28/2014)... , July 28, 2014  Serco Inc., a ... the Company has been awarded a re-compete contract ... (NEMSCOM) and its Deployable Medical Systems.  Serco will ... personnel to provide world-class healthcare to meet warfighter ... across the globe. The five year contract has ...
Breaking Medicine Technology:Portugal Pharmaceuticals and Healthcare Report Q3 2014 2Portugal Pharmaceuticals and Healthcare Report Q3 2014 3Portugal Pharmaceuticals and Healthcare Report Q3 2014 4Surgical Theater Names Former Given Imaging Ltd. and Philips Healthcare Executives to Business Advisory Board 2Surgical Theater Names Former Given Imaging Ltd. and Philips Healthcare Executives to Business Advisory Board 3Surgical Theater Names Former Given Imaging Ltd. and Philips Healthcare Executives to Business Advisory Board 4Surgical Theater Names Former Given Imaging Ltd. and Philips Healthcare Executives to Business Advisory Board 5Serco Awarded $22.7 Million Contract to Support Deployable Medical Systems 2
... , ATLANTA, Dec. 23 MiMedx Group, Inc. ... launched its first product, Paradis Vaso Shield(TM). In April ... for use as a cover for vessels following anterior vertebral ... hydrogel product protected by multiple patents and patent applications, as ...
... FRANCISCO, Dec. 23 Jennerex Biotherapeutics, a clinical-stage biotherapeutics company developing ... that management will present at the following upcoming investor conferences. , ... January 12, 2010, 9:40 a.m. PT, ... OneMedForum 2010, Wednesday, January 13, 2010, ...
Cached Medicine Technology:MiMedx Group Announces Launch of its Paradis Vaso Shield(TM) Device 2MiMedx Group Announces Launch of its Paradis Vaso Shield(TM) Device 3
...
... Bio-Rad isotopic anemia ... and minimal ,pipetting steps ... information about the processes ... and the benefit to ...
The MESACUP ANA Test Kit is a semi-quantitative enzyme-linked immunosorbent assay,(ELISA) for the detection of specific anti-nuclear antibodies in human serum as an aid in,the determination of autoim...
... a patented HEp-2 cell line that has ... to SS-A/Ro autoantibodies, without affecting the other ... been published worldwide on the HEp-2000 ANA ... autoantibodies when used in place of standard ...
Medicine Products: