Navigation Links
New idea for targeting the common cancer protein KRAS
Date:10/20/2013

pathways downstream of KRAS that drive cell growth and survival.

Instead, they found that a number of small molecules that attached to a special pocket in a region of SOS called the CDC25 domain and increased SOS-mediated guanine nucleotide exchange actually inhibited two of the major signaling pathways downstream of KRAS: the MAPK and PI3K signaling pathways.

The researchers are actively investigating why small molecules that increased SOS-mediated guanine nucleotide exchange in biochemical assays blocked signaling downstream of KRAS in cell lines. They are also working to optimize the small molecules before they conduct studies in preclinical models of cancer.


'/>"/>

Contact: Lauren Riley
lauren.riley@aacr.org
215-446-7109
American Association for Cancer Research
Source:Eurekalert

Page: 1 2

Related medicine news :

1. GUARDaHEART Hosts an Unforgettable Evening in Celebration of World Heart Day “Targeting Heart Disease”
2. Targeting memory T-cells in Type 1 diabetes
3. Targeting aggressive prostate cancer
4. Nanodrug targeting breast cancer cells from the inside adds weapon: Immune system attack
5. Cancer research brief: Targeting pancreatic cancer drug resistance
6. Targeting errant immune system enzyme kills myelodysplastic cells
7. hCGTreatments / Diet Doc hCG Diets & Weight Loss Plans Offer Improved hCG Diet Plans Capable of Targeting Stubborn Belly Fat Now Linked With Decreased Bone Density
8. hCGTreatments / Diet Doc hCG Diets & Weight Loss Plans Now Offer New Weight Loss Diets that Educate Patients, Targeting Weight Gained During Childhood and Adolescence
9. Overcoming resistance to anti-cancer drugs by targeting cell powerhouses
10. Study Shows Dual Targeting of HER2 and HR-positive Metastatic Breast Cancer Improves Survival Rates
11. Drugs targeting blood vessels may be candidates for treating Alzheimers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/3/2015)... ... 03, 2015 , ... First Choice Emergency Room , the largest network ... as the new Medical Director of its Frisco facility. , “We are pleased to ... said Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. ...
(Date:7/3/2015)... ... 2015 , ... Every year, One-to-1 Fitness and the Red Deer Fit ... Red Deer community with free fitness training and indoor fitness boot camp classes for ... entertainment raised thousands of charity dollars and ended with a $10,000 donation to the ...
(Date:7/2/2015)... ... ... pleased to announce the opening of its newest location in Dallas, Texas. The opening is ... chain was listed as #22 on the Inc. 500 list of fastest growing companies in ... located at:, 3701 W. Northwest Highway, STE 430, Dallas, TX 75220 , “We are excited ...
(Date:7/2/2015)... ... 2015 , ... The American Association of Poison Control Centers ... Stat (S.O.S.) Act of 2015 on June 23, 2015. Together with the Senate ... drug overdose – especially of heroin and opioid medication – by expanding the ...
(Date:7/2/2015)... ... ... summer in full swing, Americans are flocking to Canada’s many lakes to reel in their ... the world, and it’s easy to understand why. From the Pacific Northwest Coast of British ... fishing is a huge industry, and Americans make up the vast majority of anglers from ...
Breaking Medicine News(10 mins):Health News:First Choice Emergency Room Announces Dr. Mariah N. Manzanares as Medical Director of Frisco, TX Facility 2Health News:First Choice Emergency Room Announces Dr. Mariah N. Manzanares as Medical Director of Frisco, TX Facility 3Health News:Red Deer Fitness Studio Raises $10,000 for Charity Organization with 24-Hour Train-a-Thon 2Health News:Red Deer Fitness Studio Raises $10,000 for Charity Organization with 24-Hour Train-a-Thon 3Health News:sweetFrog Opens 18th Location in the Lone Star State 2Health News:AAPCC Supports the Stop Overdose Stat Act of 2015 2Health News:AAPCC Supports the Stop Overdose Stat Act of 2015 3
... THURSDAY, April 14 (HealthDay News) -- Trying to make the best ... managers cope with losing their jobs, a new United Kingdom study ... coping with their job loss were able to see the event ... work, volunteering and study. They also took a contemplative view ...
... four years old when he went to sleep on his bunk ... strangled to death the next morning with his neck caught between ... Ryan is not the only child to have strangled in the ... incidents have been reported to the Consumer Product Safety Commission (CPSC). ...
... A team of Boston University researchers has found that ... having poor oral health. They also found that opioid ... over the period of one year. These findings appear ... Public health, dental medicine and internal medicine ...
... of Cincinnati (UC) shows that urban adolescents with asthma ... and often use complementary and alternative medicine, or integrative ... These findings, being presented at the National Conference ... physicians and other providers gain insight into additional ways ...
... , THURSDAY, April 14 (HealthDay News) -- The best ... new study suggests. Supportive reactions by managers and ... to positive changes in the workplace, while chastising or ... chair of the human resource management department at Temple ...
... April 14, 2011 An enzyme essential for DNA replication ... be exploited as anti-cancer therapy, say researchers at The Scripps ... published in the April 15, 2011 issue of the journal ... called flap endonucleases, which are essential to the life of ...
Cached Medicine News:Health News:Good Attitude Critical When Coping With Layoff Trauma 2Health News:Human Factors/Ergonomics research leads to improved bunk bed safety standards 2Health News:Integrative medicine, spirituality improves outcomes in urban adolescents with asthma 2Health News:Integrative medicine, spirituality improves outcomes in urban adolescents with asthma 3Health News:Integrative medicine, spirituality improves outcomes in urban adolescents with asthma 4Health News:Compassion, Not Punishment, Helps Diffuse Workplace Anger: Study 2Health News:Study suggests enzyme crucial to DNA replication may provide potent anti-cancer drug target 2Health News:Study suggests enzyme crucial to DNA replication may provide potent anti-cancer drug target 3Health News:Study suggests enzyme crucial to DNA replication may provide potent anti-cancer drug target 4
(Date:7/2/2015)... de julio de 2015 BGI anunció hoy ... alto rendimiento en Hong Kong ... Pathologists (CAP). La instalación de BGI en Hong ... de próxima generación que recibe la certificación CAP en ... estándar en prácticas de laboratorio clínico. Junto con el ...
(Date:7/2/2015)...  AbbVie (NYSE: ABBV ) will announce its ... before the market opens. AbbVie will host ... 8 a.m. Central time (9 a.m. Eastern). It will ... www.abbvieinvestor.com . An archived edition of the call will ... About AbbVie AbbVie is a global, research-based ...
(Date:7/2/2015)... --  BioLife Solutions , Inc. (NASDAQ: BLFS ), a ... and tissue hypothermic storage and cryopreservation freeze ... chain management app for smart shippers ("BioLife" ... has included BioLife in its annual list of the ... state for 2015. Now in its ...
Breaking Medicine Technology:BGI recibe la acreditación del College of American Pathologists (CAP) 2BioLife Solutions Named One of the 100 Best Companies to Work For in Washington State 2BioLife Solutions Named One of the 100 Best Companies to Work For in Washington State 3
... 2011 Aethlon Medical, Inc., (OTCBB: AEMD) disclosed today ... issued the following letter to shareholders. ... Last December, I authored a shareholder letter ... a need for innovative new therapeutic strategies to evolve ...
... 2011 Cardinal Health plans to release fourth-quarter and full-year ... prior to the opening of trading on the New York ... and conference call for Aug. 4 at 8:30 a.m. Eastern ... slide presentation, go to the Investors page at cardinalhealth.com/investors or ...
Cached Medicine Technology:Aethlon Medical Releases Shareholder Letter 2Aethlon Medical Releases Shareholder Letter 3Aethlon Medical Releases Shareholder Letter 4Cardinal Health to Release Fourth-quarter and Full-year Results for Fiscal Year 2011 on Aug. 4 2
... ophthalmoscope, the world's only ... Heine's aspherical optical system ... with innovative design and ... Beta 200 the finest ...
... superior aspherical optics. The separation of illumination ... aspherical optical system avoids corneal and iris ... to view the whole of the illuminated ... small pupil. Conventional ophthalmoscopes often let you ...
Welch Allyn introduced halogen HPX lamp technology to provide 30% more light output than previous halogen lamps. The mix of halogen and xenon gases provide whiter, longer lasting light - making your ...
Woodlyn Refractor offers the option to either rotate the better-one better-two refinement knob, or rotate the low sphere disc....
Medicine Products: