Navigation Links
New idea for targeting the common cancer protein KRAS
Date:10/20/2013

BOSTON Patients with cancers driven by the protein KRAS, which are particularly hard to treat, may benefit from small molecules that attach to and disrupt the function of a KRAS-containing protein complex, according to results presented here at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, held Oct. 19-23.

Mutant forms of the protein KRAS are found in approximately 30 percent of all cancers. They are responsible for many of the hallmarks of these cancers, and KRAS is, therefore, considered an important therapeutic target. However, attempts to develop clinically useful KRAS-targeted drugs have been unsuccessful.

"KRAS is a molecular switch," said Michael Burns, a doctor of medicine and doctor of philosophy candidate at Vanderbilt School of Medicine in Nashville, Tenn. "In the 'on' state it transmits signals that drive cell growth and survival. In many cancers, KRAS is permanently in the on state, and it is a highly validated therapeutic target.

"KRAS switches from off to on most efficiently when it is attached to a protein called SOS," explained Burns. "Each SOS protein attaches to two KRAS proteins, and we have identified a number of small molecules that bind to a particular part of SOS when it is in a complex with two KRAS proteins. These small molecules disrupt the function of the complex, ultimately causing inhibition of the signaling pathways downstream of KRAS that drive cell growth and survival. Although our data were generated in biochemical assays and cell lines, they suggest a potential way to therapeutically target KRAS, which has not been possible to date."

KRAS switches from off to on during a process called guanine nucleotide exchange, and SOS increases the rate at which this process occurs. Burns and colleagues hypothesized that small molecules that blocked SOS-mediated guanine nucleotide exchange would prevent KRAS switching on and, therefore, inhibit the signaling
'/>"/>

Contact: Lauren Riley
lauren.riley@aacr.org
215-446-7109
American Association for Cancer Research
Source:Eurekalert

Page: 1 2

Related medicine news :

1. GUARDaHEART Hosts an Unforgettable Evening in Celebration of World Heart Day “Targeting Heart Disease”
2. Targeting memory T-cells in Type 1 diabetes
3. Targeting aggressive prostate cancer
4. Nanodrug targeting breast cancer cells from the inside adds weapon: Immune system attack
5. Cancer research brief: Targeting pancreatic cancer drug resistance
6. Targeting errant immune system enzyme kills myelodysplastic cells
7. hCGTreatments / Diet Doc hCG Diets & Weight Loss Plans Offer Improved hCG Diet Plans Capable of Targeting Stubborn Belly Fat Now Linked With Decreased Bone Density
8. hCGTreatments / Diet Doc hCG Diets & Weight Loss Plans Now Offer New Weight Loss Diets that Educate Patients, Targeting Weight Gained During Childhood and Adolescence
9. Overcoming resistance to anti-cancer drugs by targeting cell powerhouses
10. Study Shows Dual Targeting of HER2 and HR-positive Metastatic Breast Cancer Improves Survival Rates
11. Drugs targeting blood vessels may be candidates for treating Alzheimers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... Dallas, TX (PRWEB) September 17, 2014 ... they were recently granted several awards for their top-notch ... regarding patient experience, orthopedic care and GYN surgery. , ... Patient Safety Excellence Award™. They have received this award ... ranked among the top 5 percent in the nation ...
(Date:9/17/2014)... News, VA (PRWEB) September 17, 2014 ... will host recruit757’s scholarship workshop for football players ... on Tuesday, Sept. 23. , Doors open at 6:30 ... Performance Center and speak to trainers and physical therapists. ... until 9 p.m. , The Newport News Tidewater Performance ...
(Date:9/17/2014)... messages about the health benefits of quitting smoking may ... suggests. Although smokers who think quitting will be ... effects of smoking, researchers found smokers who believe they ... or positive, messages about how quitting will improve their ... of both types of messages might get more people ...
(Date:9/17/2014)... September 17, 2014 Prevention is the ... is hospitalizing scores of infants, children and teenagers in ... Kirk Mahon, medical director of Legacy ER & Urgent ... been no reported cases of EV-D68 so far in ... that could change,” he said. “Implementing prevention strategies now ...
(Date:9/17/2014)... 17, 2014 Boston Children’s Museum ... a monthly concert series, introducing young Museum visitors ... Top, America’s premier national platform celebrating the stories, ... of the young musicians featured will also be ... Children’s Museum is fortunate to partner with the ...
Breaking Medicine News(10 mins):Health News:North Central Surgical Center Receives Several Accolades 2Health News:Tidewater Physical Therapy and Performance Services and recruit757 To Host Football Scholarship Seminar 2Health News:Tidewater Physical Therapy and Performance Services and recruit757 To Host Football Scholarship Seminar 3Health News:More Than One Kind of Message May Convince Smokers to Quit, Study Says 2Health News:Legacy ER & Urgent Care Warns North Texans about Dangers of Enterovirus D68 2Health News:Boston Children's Museum Partners with From the Top to Offer Monthly Concert Series 2Health News:Boston Children's Museum Partners with From the Top to Offer Monthly Concert Series 3
... News) -- Body-building and weight-loss products are the types of ... a small new study. Liver injury from medication is ... and herbal supplements -- which do not require a prescription ... are used by up to 40 percent of people in ...
... (ICUs) that have no or limited access to critical care ... the specialists, called intensivists, staff the unit at night, according ... Pittsburgh School of Medicine and UPMC. However, the researchers were ... ICUs that were robustly staffed with the specialists during the ...
... Va. (May 22, 2012) The Food and Drug Administration ... group of rare cell disorders. The test, or assay, was ... field of mast cells. Lawrence Schwartz, M.D., Ph.D., chair ... Charles and Evelyn Thomas Professor of Medicine at VCU, has ...
... , TUESDAY, May 22 (HealthDay News) -- Got hair? If ... cancer, a preliminary study suggests. Researchers are reporting ... more likely to have cancer than were those with more ... that they may benefit from being screened earlier and perhaps, ...
... are not effective in determining which asthma patients are ... (ICS) medications without risk of flare-ups or exacerbations, according ... United Kingdom. The study also showed that nearly three-quarters ... use of ICS medications once their symptoms are under ...
... The new blood thinner Xarelto appears to lower the chances ... U.S. Food and Drug Administration review has found. The ... advance of an FDA advisory panel meeting Wednesday, at which ... of Xarelto for treating people with acute coronary syndrome (a ...
Cached Medicine News:Health News:Body Building, Diet Supplements Linked to Liver Damage: Study 2Health News:Intensivists at night improve patient outcomes in some ICUs, says Pitt/UPMC team 2Health News:FDA clears test developed in partnership with VCU researcher 2Health News:Do Bald Men Face Higher Risk of Prostate Cancer? 2Health News:Do Bald Men Face Higher Risk of Prostate Cancer? 3Health News:Identifying asthma patients who tolerate lower doses of steroids remains problematic 2Health News:Identifying asthma patients who tolerate lower doses of steroids remains problematic 3Health News:New Blood Thinner May Lower Chances of Clots in High-Risk Heart Patients: FDA 2
(Date:9/17/2014)... 17, 2014 The ambulance equipment ... decade due to the recession, an unstable ... advancements. This BCC Research report analyzes present ... the ambulance and emergency medical services equipment ... hemorrhage control devices, equipment used for burn ...
(Date:9/17/2014)... , Sept. 17, 2014  Dr. Stephen ... the White House today for National Recovery Month, stars ... consumer advocates released today. Consumer advocates were also joined ... who spoke out after losing her fiancée because of ... the doctor had a history of crack cocaine abuse. ...
(Date:9/17/2014)... Sept. 17, 2014 /PRNewswire-iReach/ -- ChemImage announced ... discussing improvements in the development of imaging ... both normal and diseased tissue that minimizes ... surgical procedures, lowers surgical costs and potentially ... The clinical and scientific ...
Breaking Medicine Technology:Ambulance and Emergency Equipment: Global Markets 2Ambulance and Emergency Equipment: Global Markets 3Ambulance and Emergency Equipment: Global Markets 4Doctor Recovering From 100-Pill-A-Day Addiction Stars In New Ad Supporting Prop 46; Appears At White House for National Recovery Month, Says Consumer Watchdog Campaign 2Doctor Recovering From 100-Pill-A-Day Addiction Stars In New Ad Supporting Prop 46; Appears At White House for National Recovery Month, Says Consumer Watchdog Campaign 3Patient Outcomes Improve When Molecular Chemical Imaging Technology Is Used to Aid Robotic Surgical Procedures, According to New White Paper 2
... 4 Novartis Vaccines & Diagnostics Inc. and Novartis ... to resolve civil False Claims Act allegations arising from the ... announced today. The settlement resolves allegations that, between Jan. ... and its predecessor, Chiron Corporation, caused false claims to be ...
... Joseph F. Finn, Jr. , C.P.A. ("Finn"),  Assignee for ... that the MRI imaging intellectual properties of the EP-3600 MRI imaging ... assets of Epix were transferred to him on July 20, ... Epix creditors.  He recently reached an agreement with Bayer Schering Pharma ...
Cached Medicine Technology:Novartis Vaccines & Diagnostics to Pay More Than $72 Million to Resolve False Claims Act Allegations Concerning TOBI 2Novartis Vaccines & Diagnostics to Pay More Than $72 Million to Resolve False Claims Act Allegations Concerning TOBI 3Epix Pharmaceuticals, Inc. Announces the May 28, 2010 Auction Sale of EP-3600 MRI Imaging Agent 2
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: