Navigation Links
New drug target in obesity: Fat cells make lots of melanin
Date:10/29/2008

As millions of Americans gear up for the Thanksgiving holiday, a new research report published online in The FASEB Journal (http://www.fasebj.org), may provide some relief for those leery of having a second helping. In the report, researchers describe a discovery that may allow some obese people avoid common obesity-related metabolic problems without actually losing weight: they make a common antioxidant, melanin, in excess. Even more promising is that some of the antioxidant drugs that can mimic the melanin effect are FDA-approved and available. This availability would greatly speed the development of new treatments, should they prove effective in clinical trials.

The researchers made the unexpected discovery--fat cells in obese people produce melanin in excess--when they were comparing fat cells of obese people to those of people with normal weight. After the comparison, they found that the gene responsible for making melanin was working in "overdrive" in the fat cells of obese people. The finding was then confirmed using additional laboratory tests. Melanin is a common antioxidant responsible for skin and eye color.

Ancha Baranova, one of the study's researchers from George Mason University and INOVA Fairfax Hospital says, "Most scientific efforts aim at making obese individuals lose weight, but this has proven difficult. Hopefully, this study will lead to a drug that keeps obese individuals healthy, reducing the cost-burden to society as well as some of the stigma associated with this condition."

According to the U.S. Centers for Disease Control and Prevention, the prevalence of obesity in 2005� was about 1 in 3 for men and women. Obesity increases the risk of diseases and health conditions, such as high blood pressure, osteoarthritis, dyslipidemia, Type 2 diabetes, coronary heart disease, stroke, gallbladder disease, sleep apnea and respiratory problems, and some cancers.

"No pill can replace a healthy diet and exercise, yet," said Gerald Weissmann, MD, Editor-in-Chief of The FASEB Journal, "but this could be a major advance for physicians looking for a safe drug target in their search to keep obese patients healthy while their weight becomes normal."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related medicine news :

1. What Boomers Need to Know About Digestion; Enzymatic Therapy's CompleteGest1 Renew targets special digestive issues
2. A potential targets for the prevention or treatment of esophageal carcinoma
3. Preliminary Clinical Data Presented at the 20th EORTC-NCI-ACR Symposium on Molecular Targets and Cancer Therapeutics Demonstrate Superior Profile of S*BIOs Novel Anti-Cancer Drug SB939
4. Vista Partners Updates Coverage on MediciNova Inc. (NASDAQ: MNOV); Maintains $8.50 Price Target
5. Samplify Evolves Business Model From IP Developer to Semiconductor Supplier; Now Targets Multi-Billion Dollar Market
6. Cardiogenesis Announces Successful Educational Symposium Targeted at Cardiologists at the TCT Meeting in Washington, D.C.
7. Norwegian American Hospital Launches Awareness Campaign Targeting Hispanic, African-American and General-Market Moms
8. Annual report targets chronic kidney disease in the United States
9. ProGenTech Targets Clinical Diagnostics and Applied Sciences Markets with Human Genetic Signatures Deal
10. Breast Cancer Action Targets Yoplait in Think Before You Pink Campaign; Calls for Yogurt Without Artificial Hormones
11. World Alzheimer's Day 2008 Special Report: New Alzheimer Targets Take Center Stage
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/27/2020)... ... January 26, 2020 , ... ResMed Launches AirFit F30i, Its First Tube-up Full ... announces the launch of the AirFit F30i, Its First Tube-up Full Face ResMed CPAP ... tube-up or tube-down connection, compact under-the-nose or traditional over-the-nose cushion styles, and even memory ...
(Date:1/24/2020)... (PRWEB) , ... January 24, 2020 , ... ... and managed services company, announced today that it has completed its spin-off of ... generation Healthcare technology cloud products, while Devcool Inc continues its growth and focuses ...
(Date:1/23/2020)... NEW YORK (PRWEB) , ... January 23, 2020 ... ... international leader in medical and scientific training, biomedical research, and patient care—today announced ... by the Office of Gender Equity in Science and Medicine. The awards aim ...
(Date:1/23/2020)... , ... January 23, 2020 , ... ... RespirCare, LLC, a first-of-its-kind, full-service pulmonology clinic based in Tulsa, to provide patients ... agreement, MCNDOH patients will also have access to HGE Health’s digital symptom management ...
(Date:1/23/2020)... ... January 23, 2020 , ... Three leading healthcare ... action to improve diagnostic quality and safety by joining the Coalition to ... in healthcare and patient advocacy. , “Diagnostic error is one of the most ...
Breaking Medicine News(10 mins):
(Date:1/12/2020)... ... January 10, 2020 , ... Nearly 250 Central Valley farmers ... Safe, a stewardship program that promotes effective prevention of accidental pesticide drift from ... officials and high-ranking regulators, participants received training in how to calibrate their equipment, ...
(Date:1/12/2020)... ... January 11, 2020 , ... New Life Hiking Spa ... and information on how to book an affordable option. , Improved health and happiness: ... frenetic pace of everyday life, sight see and a try a new cuisine, the ...
(Date:1/10/2020)... ... January 10, 2020 , ... Reach Higher ... Association, will celebrate high school counselors and award the first annual Excellence in ... Championship weekend and Extra Yard for Teachers Summit celebration on Saturday, January 11th. ...
Breaking Medicine Technology: