Navigation Links
New drug target identified for multiple sclerosis and Alzheimer's disease
Date:1/30/2013

(Boston)Researchers at Boston University School of Medicine (BUSM) led by Carmela Abraham, PhD, professor of biochemistry, along with Cidi Chen, PhD, and other collaborators, report that the protein Klotho plays an important role in the health of myelin, the insulating material allowing for the rapid communication between nerve cells. These findings, which appear online in Journal of Neuroscience, may lead to new therapies for multiple sclerosis (MS) and Alzheimer's disease (AD), in which white matter abnormalities are also common but have been largely ignored.

MS is an inflammatory disease which damages the fatty myelin sheaths around the axons of the brain and spinal cord. This destruction, loss or scarring of the sheaths results in a broad spectrum of symptoms. Disease onset usually occurs in young adults, most commonly women.

In MS the myelin is attacked by the immune system and may not be completely restored by myelin-producing cells (mature oligodendrocytes). The researchers discovered that the addition of Klotho protein to immature oligodendrocytes causes them to mature and manufacture proteins needed for the production of healthy myelin.

"These results taken together indicate that Klotho could become a drug target for multiple sclerosis and other white matter diseases, including AD," explained Abraham.

Abraham and her colleagues have identified, and are working on optimizing, a number of small molecules that could form the basis for the development of therapeutic drugs, which would increase the amount of Klotho protein in the brain.

Since Klotho is not only an age suppressor but also a tumor suppressor, as shown by other research groups, interventions with Klotho-enhancing drugs may solve some of the most treatment-resistant human ailments according to Abraham.

Klotho was named after the Greek Goddess and daughter of Zeus, who spins the thread of life. Abraham's lab was the first to publish
'/>"/>

Contact: Gina DiGravio
gina.digravio@bmc.org
617-638-8480
Boston University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Targeted therapeutics for colon cancer to be presented at AACR meeting
2. First targeted nanomedicine to enter human clinical studies
3. SMART heart eases heart ache, targets cardiac patients emotional well-being
4. Target set on cancer gene MCL1
5. Scientists tailor cell surface targeting system to hit organelle ZIP codes
6. IBN discovers human neural stem cells with tumor targeting ability
7. A closer look at PARP-1 reveals potential new drug targets
8. Highly targeted irradiation as good as whole breast radiotherapy in early stage cancer
9. Breathing during radiotherapy - how to hit the treatment target without causing collateral damage
10. Scientists identify new target to battle rheumatoid arthritis
11. Scientists identify possible drug target for acute pancreatitis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2015)... NY (PRWEB) , ... August 01, 2015 , ... Calvary ... scroll currently housed at their Bronx campus. The goal is to bring this Torah ... again be used in Jewish rituals and religious services. , Scroll No. 515, ...
(Date:8/1/2015)... ... ... and Lita Hart, icons of the network marketing industry and founders of the Healthy ... Movement of EvolvHealth. In what has been a long-term relationship between the companies for ... of purpose together to change the course of the network marketing industry. , “This ...
(Date:8/1/2015)... (PRWEB) , ... August 01, 2015 , ... On Tuesday, ... group , who are thought to have been behind the attack on Anthem Inc. ... covered were zero day exploits, watering hole attacks and spear phishing campaigns. ...
(Date:8/1/2015)... ... August 01, 2015 , ... BeverlyD, owner and founder ... foundation, making hers the very first small business donation to kick off the campaign ... over thirty years. Her legacy includes a complete line of raw, organic hair care ...
(Date:8/1/2015)... ... 01, 2015 , ... On March 19, 2015 Phil Valentine – the Executive Director of Connecticut ... Trail by stepping off Springer Mountain and heading north. Since that day, Phil has ... Connecticut and was greeted by friends and family. He visited CCAR and left an ...
Breaking Medicine News(10 mins):Health News:Calvary Hospital Announces Plans to Restore Historic Torah 2Health News:Calvary Hospital Announces Plans to Restore Historic Torah 3Health News:Looking for HOPE? Healthy Home Has Evolv’d 2Health News:Looking for HOPE? Healthy Home Has Evolv’d 3Health News:Frenemy at the Gates - Hackers Excel at Leveraging Trust 2Health News:Frenemy at the Gates - Hackers Excel at Leveraging Trust 3Health News:Frenemy at the Gates - Hackers Excel at Leveraging Trust 4Health News:March4thforWellBeing Foundation Kickoff 2Health News:Connecticut Executive Hikes Appalachian Trail to Raise Awareness About Recovery. 2
... makes food look more appealing is a widely held belief ... stomach, only to go home with a full basket and an ... hunger hormone ghrelin, which the body produces when it,s hungry, might ... mice by UT Southwestern Medical Center scientists suggest that ghrelin might ...
... 2009 Ben W. Strowbridge, PhD, associate professor of ... MD/PhD student in the neurosciences graduate program at ... the first to create stimulus-specific sustained activity patterns ... study, entitled, "Representing information in cell assemblies: Persistent ...
... , ATLANTA, Dec. 27 ... Social Security Disability application cases, the disability lawyers ... an upgrade to their website, nationaldisabilitylawyer.com. Leaders in helping disabled ... benefits, the legal experts at Berry & Associates have helped ...
... ... Fibrosis Worldwide (CFW) has launched a 5 year campaign to raise funds internationally ... 5 Campaign is a unique opportunity for everyone to help support children born ... and 5 US dollars. The CF Worldwide goal is to have 50,000 members ...
... joy, less anxiety, experts say , FRIDAY, Dec. 25 (HealthDay ... at the mall and preparing your home for out-of-town guests, ... especially, emotions tend to run high as they put pressure ... and taking care of children. , "During the holidays, ...
... , SEATTLE, Dec. 25 The following blog post ... the synthesis blog, winner of the 2008 Weblog award ... , There is a direct correlation between level of education and ... fitness; there is a direct correlation between fitness and healthcare cost. ...
Cached Medicine News:Health News:Researchers find clues to why some continue to eat when full 2Health News:Neuroscientists at Case Western Reserve University store information in isolated brain tissue 2Health News:Neuroscientists at Case Western Reserve University store information in isolated brain tissue 3Health News:National Disability Lawyer Gets 2010 Social Security Website Upgrade 2Health News:Cystic Fibrosis Worldwide Launches a New Campaign to Reach Thousands Who Suffer from CF 2Health News:Cystic Fibrosis Worldwide Launches a New Campaign to Reach Thousands Who Suffer from CF 3Health News:Don't Invite Holiday Stress Into Your Home 2
(Date:7/31/2015)... -- Semler Scientific, Inc. (Nasdaq: SMLR ), a company ... and physician groups, today reported financial results for the ... "In the second quarter of 2015, Semler reported continued ... quarter over quarter revenue growth of 8%, and quarter ... units of 18%," said Doug Murphy-Chutorian, M.D., chief executive ...
(Date:7/30/2015)... Calif. , July 30, 2015 Edwards Lifesciences ... science of heart valves and hemodynamic monitoring, today announced that ... Board of Directors. "Bob is an ardent champion ... a true privilege to have him on Edwards, board as ... Mussallem , Edwards, chairman and CEO.  "Bob has provided a ...
(Date:7/30/2015)... , July 30, 2015  Tandem Diabetes ... device company and manufacturer of the t:slim® and ... entered into non-exclusive Development Agreements with Dexcom, Inc. ... insulin pumps with the Dexcom G5 and G6 ... Tandem,s next generation pump platform with Dexcom,s future ...
Breaking Medicine Technology:Semler Reports Second Quarter 2015 Financial Results 2Semler Reports Second Quarter 2015 Financial Results 3Semler Reports Second Quarter 2015 Financial Results 4Semler Reports Second Quarter 2015 Financial Results 5Semler Reports Second Quarter 2015 Financial Results 6Tandem Diabetes Care Announces Development Agreement with Dexcom for Integration of Future Generation CGM Systems 2Tandem Diabetes Care Announces Development Agreement with Dexcom for Integration of Future Generation CGM Systems 3
... Entry into Oncology Market; Rosetta to Receive Milestones ... DIEGO, PHILADELPHIA and REHOVOT, Israel, April 13 ... company, and Rosetta Genomics Ltd. (Nasdaq: ... announced the execution of a license and collaboration ...
... - Additional Presentations Underscore Potency, Binding Capabilities for ... 9 InNexus Biotechnology Inc. (Toronto Stock Exchange: ... commercializing the next generation of monoclonal antibodies based ... today that the company will be presenting new ...
Cached Medicine Technology:Prometheus and Rosetta Genomics Announce License and Collaboration Agreement 2Prometheus and Rosetta Genomics Announce License and Collaboration Agreement 3Prometheus and Rosetta Genomics Announce License and Collaboration Agreement 4Prometheus and Rosetta Genomics Announce License and Collaboration Agreement 5Prometheus and Rosetta Genomics Announce License and Collaboration Agreement 6AACR Data Highlights InNexus Preclinical Antibody Candidate 2
Donor Screen & Confirmation Kit...
... antibody gives positive staining of prostatic ... hyperplasia. In cases of prostatic cancer, ... give definite but weak staining or ... cells; this pattern of staining permits ...
... comprehensive line of pregnancy tests including rapid ... convenient one-step stick and cassette formats. The ... Easy HCG is a 25 mIU urine ... HCG II provides 25mIU sensitivity for ...
For the quantitative determination of Glycohemoglobin (HbA1) in blood by,cation exchange resin. The test is to be used to monitor long-term glucose,control in diabetes mellitus....
Medicine Products: