Navigation Links
New drug strategy attacks resistant leukemia and lymphoma
Date:5/29/2012

BOSTON--Scientists at the Dana-Farber/Children's Hospital Cancer Center have developed an anti-cancer peptide that overcomes the stubborn resistance to chemotherapy and radiation often encountered in certain blood cancers when the disease recurs following initial treatment.

The strategy could pave the way for much needed new therapies to treat relapsed and refractory blood cancers, which are difficult to cure because their cells deploy strong protein "deflector shields" to neutralize the cell death signals that chemotherapy agents used against them initially, say the researchers.

The prototype compound, called a "stapled BIM BH3 peptide," is designed to disable the cancer's defenses by hitting a family of protein targets that regulate cell death.

In proof-of-concept studies in mice with transplanted, drug-resistant leukemia tumors, the compound alone suppressed cancer growth, and when paired with other drugs, showed synergistic anti-cancer activity, say researchers led by Loren Walensky, MD, PhD, of Dana-Farber/Children's Hospital Cancer Center.

Their paper has been posted online by the Journal of Clinical Investigation and will appear in the journal's June issue. Walensky is the senior author and James LaBelle, MD, PhD, is the first author.

A cell's "fate" when and whether it lives or dies depends on a tug-of-war between pro-death and anti-death forces within the cell that serve as a check-and-balance system to maintain orderly growth. The system is regulated by the BCL-2 family of proteins, which contains both pro-death and pro-survival members.

When cells are no longer needed or are damaged beyond repair, the body activates pro-death BCL-2 proteins to shut down mitochondria the power plants of the cell resulting in an orchestrated cellular destruction known as apoptosis, or programmed cell death.

Many cell-killing cancer treatments work by triggering these "executioner proteins" t
'/>"/>

Contact: Bill Schaller
william_schaller@dfci.harvard.edu
617-632-5357
Dana-Farber Cancer Institute
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Strategy discovered to activate genes that suppress tumors and inhibit cancer
2. Discovery suggests new combination therapy strategy for basal-like breast cancers
3. White House Drug Policy Shifts Strategy
4. Scripps research scientists illuminate cancer cells survival strategy
5. Scientists report first step in strategy for cell replacement therapy in Parkinsons disease
6. Novel strategy stymies SARS et al.
7. UCSF tapped for US National AIDS Strategy initiative
8. Federal government releases environmental, health, and safety research strategy for nanotechnology
9. Miriam Hospital researchers pilot new acute hepatitis C screening strategy for HIV-infected patients
10. Strategy for improving health care for uninsured, low-income, and minorities in the US
11. New strategy likely to speed drug development for rare cancers
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New drug strategy attacks resistant leukemia and lymphoma
(Date:10/20/2014)... hc1.com today announced the launch ... that enables healthcare organizations of all sizes to ... relationship management (“CRM”) solution. , Designed from the ... the healthcare industry, the hc1 Healthcare Relationship Cloud™ ... by combining healthcare CRM, HIPAA-compliant collaboration, and real-time ...
(Date:10/20/2014)... Angeles, CA (PRWEB) October 20, 2014 ... fitness expertise, nutritional coaching, corporate wellness programming, authorship, international ... CPT, is excited to announce the release of the ... , After many years of coaching thousands of individuals ... nutrition tracking app that does not require calorie counting ...
(Date:10/20/2014)... October 20, 2014 Principle Business Enterprises, ... pride in manufacturing top-of-the-line absorbent products. The company ... its most popular brand, Tranquility® Premium Protection absorbent products. ... new website, gave its packaging a new look, and ... brand message to the public. , The new website, ...
(Date:10/20/2014)... (PRWEB) October 20, 2014 ... Voicheck as Assistant Director of their CentralSource ... in managing the innovative turnkey drug sourcing, distribution, ... Matthew brings over 12 years of industry experience, ... Myoderm at the peak of their international success ...
(Date:10/20/2014)... Succeed is proud to announce that they ranked in the ... Every Body Walk! campaign by Kaiser Permanente. Every ... to be more active outside of the workplace. This ... end of September, was a friendly competition between organizations across ... companies gave their staff pedometers and each day, for the ...
Breaking Medicine News(10 mins):Health News:Healthcare Relationship Management (HRM) Leader hc1.com® Launches hc1® Quick Start™ 2Health News:JZ Fitness Nutrition App Launches on iTunes 2Health News:JZ Fitness Nutrition App Launches on iTunes 3Health News:Tranquility® Premium Protection Incontinence Products Releases New Logo and Website 2Health News:Myoderm Hires Matthew Voicheck to Lead Turnkey Drug Sourcing Service 2Health News:Succeed Management Solutions, LLC Competes in Walking Challenge and Achieves 12th Place in Portland 2
... Ohio, April 7, 2008 Chemical Abstracts,Service (CAS) ... SciFinder research,tool. CAS announced and demonstrated the new ... in New Orleans, April 6, 2008., (Logo: ... find using the new version of SciFinder an,important ...
... Put Medical Equipment Providers Out of Business and,Disrupt Services ... Dallas Area;, Austin, Beaumont, El Paso, Houston, McAllen, ... 7, 2008 A new Medicare,bidding program for durable ... Worth metropolitan area on July 1, 2008, will,put many ...
... finds olanzapine changes metabolism in weeks , , MONDAY, April ... olanzapine may put a person at an increased risk ... show. , A team of French researchers studying the ... olanzapine over several weeks, the rodents, blood sugar ...
... Health Record to actively engage diabetes patients in their ... levels, better vaccination compliance and increased tobacco cessation rates, ... Health System launched an Electronic Health Record-driven care program ... published in Aprils Journal of General Internal Medicine showed ...
... Cons of Approach to Eliminating HAIs, ORLANDO, Fla., ... drive to eliminate infections acquired in hospitals -,is provoking ... the approach is overly simplistic and potentially dangerous to,praise ... experts will,discuss the hot-button issue at the Annual Meeting ...
... The critical lack of,family and paraprofessional caregivers ... renewal of the Community College Caregiver Training,Initiative for ... Foundation, The Caregiving Project for Older,Americans, a project ... a Request for Proposals (RFP) and will award ...
Cached Medicine News:Health News:CAS' New SciFinder(R) Enhances the Research Experience Via the Web 2Health News:Medicare Bidding Program for Dallas, Texas is Rife with Errors, Says American Association for Homecare 2Health News:Medicare Bidding Program for Dallas, Texas is Rife with Errors, Says American Association for Homecare 3Health News:Antipsychotic Drug Boosts Risk of Heart Disease, Diabetes 2Health News:Geisinger improves care for thousands of diabetics through use of the Electronic Health Record 2Health News:The 'Zero' Mentality: Is It Good for Infection Control? 2Health News:ILC-USA and MetLife Foundation Launch Second Year of Community College Caregiver Training Grants 2
(Date:10/17/2014)... UBM Medica US announces that Neurology Times ... for neurologists and other healthcare providers, features special coverage on ... discussions of the latest developments in approaches to diagnosis. ... , more than the total of those who have multiple ... can be difficult because there are no confirmatory medical tests. ...
(Date:10/17/2014)... -- A victim of medical negligence at the hands of ... history of alcohol abuse, a physician and consumer advocates unveiled ... highlighting how Prop 46 will identify and deter physician substance ... The ad pictures a doctor drinking at a bar as ... will enact the first law in the nation requiring random ...
(Date:10/17/2014)... InnFocus, Inc ., reported on results of 59 glaucoma patients ... up to 3 years with the InnFocus MicroShunt® at the ... . The Summit was held ... American Academy of Ophthalmology . The Company also said ... 6 countries by early 2015. Logo - ...
Breaking Medicine Technology:Neurology Times Features Coverage of Parkinson and Alzheimer Disease 2Neurology Times Features Coverage of Parkinson and Alzheimer Disease 3Victim Of Negligence At Hands Of A Drunk Doctor, A Physician and Consumer Advocates Release New Yes on 46 TV Ad, "On Call" 2Victim Of Negligence At Hands Of A Drunk Doctor, A Physician and Consumer Advocates Release New Yes on 46 TV Ad, "On Call" 3Victim Of Negligence At Hands Of A Drunk Doctor, A Physician and Consumer Advocates Release New Yes on 46 TV Ad, "On Call" 4InnFocus Featured at the Ophthalmology Innovation Summit In Chicago 2
... June 1, 2010 MediSapiens, world,s first,software company for personalized cancer ... ( EUR 0.8 million ) seed round,investment from Veraventure, ETFIII advised by ... , , ... at the VTT Technical Research,Centre of Finland and its collaborators. ...
... TEL AVIV, Israel , May 31, 2010 ... for the first,quarter of 2010. , , ... Loss for the first quarter of 2010 attributable to the ... minority interest,totaled to NIS 170 million ), as compared to gain attributable ...
Cached Medicine Technology:MediSapiens Gets $ 1 Million for World's First Personalized Cancer Medicine Software 2MediSapiens Gets $ 1 Million for World's First Personalized Cancer Medicine Software 3MediSapiens Gets $ 1 Million for World's First Personalized Cancer Medicine Software 4Elbit Imaging Ltd. Announces First Quarter Results for 2010 2Elbit Imaging Ltd. Announces First Quarter Results for 2010 3Elbit Imaging Ltd. Announces First Quarter Results for 2010 4Elbit Imaging Ltd. Announces First Quarter Results for 2010 5Elbit Imaging Ltd. Announces First Quarter Results for 2010 6Elbit Imaging Ltd. Announces First Quarter Results for 2010 7Elbit Imaging Ltd. Announces First Quarter Results for 2010 8Elbit Imaging Ltd. Announces First Quarter Results for 2010 9Elbit Imaging Ltd. Announces First Quarter Results for 2010 10Elbit Imaging Ltd. Announces First Quarter Results for 2010 11Elbit Imaging Ltd. Announces First Quarter Results for 2010 12
3.2 mm Keratome, double bevel, sharp sides, ang. 1 Ea as quantity....
... 50Hz/60Hz is the most powerful isolated ESU on ... Coag. It is the only ESU that allows ... surgical field with a standard ES pencil. Excalibur ... maintains minimum necessary voltage for smooth cutting through ...
Microcontroller-based isolated electrosurgical generator, designed for all general purpose surgical procedures. Unit includes: Instant Response technology, adaptive REM system, isolated output, CEM c...
Lorgnette pinhole occluder...
Medicine Products: