Navigation Links
New drug strategy attacks resistant leukemia and lymphoma
Date:5/29/2012

BOSTON--Scientists at the Dana-Farber/Children's Hospital Cancer Center have developed an anti-cancer peptide that overcomes the stubborn resistance to chemotherapy and radiation often encountered in certain blood cancers when the disease recurs following initial treatment.

The strategy could pave the way for much needed new therapies to treat relapsed and refractory blood cancers, which are difficult to cure because their cells deploy strong protein "deflector shields" to neutralize the cell death signals that chemotherapy agents used against them initially, say the researchers.

The prototype compound, called a "stapled BIM BH3 peptide," is designed to disable the cancer's defenses by hitting a family of protein targets that regulate cell death.

In proof-of-concept studies in mice with transplanted, drug-resistant leukemia tumors, the compound alone suppressed cancer growth, and when paired with other drugs, showed synergistic anti-cancer activity, say researchers led by Loren Walensky, MD, PhD, of Dana-Farber/Children's Hospital Cancer Center.

Their paper has been posted online by the Journal of Clinical Investigation and will appear in the journal's June issue. Walensky is the senior author and James LaBelle, MD, PhD, is the first author.

A cell's "fate" when and whether it lives or dies depends on a tug-of-war between pro-death and anti-death forces within the cell that serve as a check-and-balance system to maintain orderly growth. The system is regulated by the BCL-2 family of proteins, which contains both pro-death and pro-survival members.

When cells are no longer needed or are damaged beyond repair, the body activates pro-death BCL-2 proteins to shut down mitochondria the power plants of the cell resulting in an orchestrated cellular destruction known as apoptosis, or programmed cell death.

Many cell-killing cancer treatments work by triggering these "executioner proteins" t
'/>"/>

Contact: Bill Schaller
william_schaller@dfci.harvard.edu
617-632-5357
Dana-Farber Cancer Institute
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Strategy discovered to activate genes that suppress tumors and inhibit cancer
2. Discovery suggests new combination therapy strategy for basal-like breast cancers
3. White House Drug Policy Shifts Strategy
4. Scripps research scientists illuminate cancer cells survival strategy
5. Scientists report first step in strategy for cell replacement therapy in Parkinsons disease
6. Novel strategy stymies SARS et al.
7. UCSF tapped for US National AIDS Strategy initiative
8. Federal government releases environmental, health, and safety research strategy for nanotechnology
9. Miriam Hospital researchers pilot new acute hepatitis C screening strategy for HIV-infected patients
10. Strategy for improving health care for uninsured, low-income, and minorities in the US
11. New strategy likely to speed drug development for rare cancers
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New drug strategy attacks resistant leukemia and lymphoma
(Date:4/24/2015)... On February 21st, 2015, Per Wickstrom had the ... contributor Karen Salkin at Durkin Entertainment’s EcoLuxe Lounge, sponsored ... of which Wickstrom is the founder. Making appearances at ... EcoLuxe Lounge is a gathering of some of the ... and services. Among the many roles that she has ...
(Date:4/24/2015)... Anchor Health Administrators (Anchor), specialists in Long-Term Care ... exclusive agreement with LTC Solutions for All LLC (SFA) ... , Anchor has more than 18 years of experience ... and is currently the designated advocate for the American ... member benefit. , “I am very pleased to be ...
(Date:4/24/2015)... (PRWEB) April 24, 2015 With years ... , UGA is now proud to be partnered with ... of 16,000 animals a year. This partnership has brought ... their animals. , After providing an in-house payment ... Medical Teaching Hospital (VMTH) wanted to increase financing options ...
(Date:4/24/2015)... (PRWEB) April 24, 2015 “ Opera ” ... Report, which features the latest and coolest technology products available ... of NewsWatch, conducted the review and shared with viewers how ... Without web browsers, surfing the internet would not be in ... other and the Opera browser is no different. Celebrating their ...
(Date:4/24/2015)... April 24, 2015 Qualis Health, ... organizations, has published a new resource for practicing ... The guide to Quality and Resource Use Reports ... & Medicare Services (CMS) to help practices interpret ... streamline resources, and identify care coordination opportunities to ...
Breaking Medicine News(10 mins):Health News:Karen Salkin Talks with Per Wickstrom at the 2015 EcoLuxe Lounge and the "Salute to the Oscars" Celebration 2Health News:University of Missouri Veterinary Medical Teaching Hospital Teams with UGA 2Health News:A Web Browser That Connects over 350 Million People was Featured on NewsWatch Television 2Health News:Qualis Health Publishes Guide to Help Physician Practices Assess and Improve Quality 2
... variants in the DNA of 486 people infected with HIV that ... virus and delay the onset of full-blown AIDS. ... for an HIV vaccine that would work by boosting the protective ... bodys own immune system overcome an infection. One of the genes ...
... may have ended 150 years ago but that need not ... ambience in a majestic 17th century garden . ... has made known plans to open up a part of ... for weddings. ,The magnificently laid and maintained gardens, ...
... passed snide remarks about her, claiming that the actress is too ... Ashton Kutcher tied the knot in September 2005, and the actress ... ,Lesley Guynes, who is separated from Moores half-brother commented that the ... she was old. ,I think Demi is getting too ...
... study by researchers has claimed that Chinas desire to ... monkeys in their infancy in the Mount Huangshan Scenic ... ,According to National Geographic, the skyrocketing infant mortality of ... to a restricted range and regularly competing for corn ...
... toughen anti-smoking laws, restricting smoking in public places and ... further approved a Health and Family Welfare Ministry proposal ... Act in the first week of the monsoon session ... told reporters after a Cabinet meeting in New Delhi. ...
... food cravings and keeping them in check may be ... first six-month phase of the study provides new insights ... their role in weight control. ,Cravings are ... Susan Roberts, PhD, director of the USDA HNRCAs Energy ...
Cached Medicine News:Health News:Experts Identify Vaccine Target for HIV 2Health News:Experts Identify Vaccine Target for HIV 3Health News:Now You can Marry in a Mughal Ambience, If You Wish to 2Health News:Chinese Eco-tourism Causing Infanticide Among Tibetan Monkeys 2Health News:Government to Toughen Its Anti-smoking Laws 2Health News:Weight Management Achieved by Controlling and Not Suppressing Food Cravings 2
(Date:4/24/2015)... , April 24, 2015 ... portfolio of automated, indication-specific planning tools for radiosurgery/SBRT ... focused software applications aimed at enhancing the workflow ... and spine introduced in 2013 - comes full ... (SRS) planning tools. These new Elements enable on-the-fly ...
(Date:4/24/2015)... , April 24, 2015 The ... (part of the National Institutes of Health [NIH])  ... nine research projects for the development of diagnostic ... recent HAI outbreaks at U.S. health facilities , ... research into rapid, multiplexed and effective tests using ...
(Date:4/24/2015)... , April 24, 2015  Lannett Company, Inc. ... amended and increased its five-year revolving credit facility to ... an accordion feature that will allow the company to ... additional $30.0 million, subject to securing additional commitments from ... of the credit facility remains December 18, 2018.   ...
Breaking Medicine Technology:Brainlab Introduces New Generation of VMAT* for Brain and Spine at 3rd ESTRO in Barcelona 2Kalorama: NIAID Rewards HAI Innovators with Grants 2Kalorama: NIAID Rewards HAI Innovators with Grants 3Kalorama: NIAID Rewards HAI Innovators with Grants 4Lannett Expands Revolving Credit Facility To $120 Million 2
... 10, 2012 Elsevier, a world-leading provider ... announced it will organize an extra Tetrahedron Symposium in ... speakers in bioorganic and organic medicinal chemistry closer to ... in two locations, one in Europe and one in ...
... The Ministry of Health and Welfare and Korea Health Industry ... Health Authority-Abu Dhabi (HAAD) arrived in South Korea on Dec. ... government arranged for domestic hospitals to sign a pact on ... Chairman Mohammed Sultan Al Hameli and CEO Zaid Daoud Al ...
Cached Medicine Technology:Elsevier Announces Two Tetrahedron Symposia for 2012 2Elsevier Announces Two Tetrahedron Symposia for 2012 3First Patient from Abu Dhabi Arrives in South Korea for Medical Treatment 2
... BP 900 offers three magnifications ... routine practice, the BP 900 ... and progressive functionality. Two optional ... one for digital photography, are ...
... 400 System is an automated multiplexing platform ... SNP detection, pathogen sequence detection and pharmacogenetics ... be applied to an open and flexible ... be reused until all tests sites have ...
... for venous pressure monitoring, blood sampling, ... Turbo-Flo polyurethane PICC line sets offer:, ... Micropuncture Introducer Needle, Biocompatible ... trimmed to patient specific anatomy. Remove ...
Cable connections for 5 different adapters: Storz, ACMI, Pentax, Wolf and Olympus....
Medicine Products: