Navigation Links
New drug shows promise against multiple sclerosis
Date:11/1/2011

mune system attacks the myelin sheath that insulated nerve fibers in the brain and spinal cord. Most of these attacks have no associated symptoms, but damage to these sheaths can short circuit signals traveling along the nerve fibers. This disrupts the normal flow of communication from the brain and can cause a range of symptoms including visual impairment, weakness, sensory disturbance, fatigue, cognitive difficulties, and loss of coordination.

For decades, work in the field has focused on targeting one component of the immune system the T cells which were always seen as the "smoking gun" of the disease because they attack nerve fibers in the brain, causing the lesions and ultimately the symptoms of multiple sclerosis. Ocrelizumab, in contrast, targets a molecule called CD20 found on the surface of B cells, a separate component of the immune system.

Although the mechanism is not exactly clear, said Hauser, the B cells seem to induce the T cells to attack. If T cells are pulling the trigger on nerve fibers in the brain, B cells seem to be the ones that are loading the gun. The Phase 2 trial showed, in essence, that if you block one, you may be able to stop the other.

Hauser said the recently concluded trial validated the idea that targeting the B cells could ultimately help people with multiple sclerosis an idea that Hauser has championed for more than a decade after basic research in his laboratory in the 1990s suggested that these cells play a role in the disease.

"This is a great example of lessons learned at the bench bringing us to an experiment at the bedside that completely transformed our understanding of what we needed to do to develop more selective and more effective therapy for MS" he said.


'/>"/>
Contact: Jason Socrates Bardi
jason.bardi@ucsf.edu
415-502-4608
University of California - San Francisco
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Preterm birth rate shows three year improvement in most states
2. Study shows no increased risk of breast cancer for non-carriers in families with BRCA gene mutation
3. Novel approach to treat proliferative vitreoretinopathy shows promise
4. New therapy shows promise for treating cardiovascular disease
5. More Evidence Shows Newer Forms of Pill Raise Clot Risk, FDA Says
6. New oncolytic virus shows improved effectiveness in preclinical testing
7. Clinical trial shows first evidence that anal cancer is preventable
8. Through-the-nipple breast cancer therapy shows promise in early tests
9. Compound found in common wart treatment shows promise as leukemia therapy
10. Study shows why underrepresented men should be included in binge eating research
11. HIV Medication Patch Shows Promise in Early Trial
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/27/2015)... TX (PRWEB) , ... July 27, 2015 , ... A ... in actual and punitive damages against Canadian stock promoter Robert Kubbernus based on findings ... by a twelve-person jury and accepted by the court in Cause No. 2010-09675; Jo ...
(Date:7/27/2015)... ... ... Throughout its 20 year history, Doctors on Liens has pioneered ... basis. As the personal injury and medical industries have changed, Doctors on Liens ... pain management physicians, to psychologists and more. And while many of these offices ...
(Date:7/27/2015)... ... , ... According to an article published by the Times Free Press ... stemming from intravenous drug use. Intravenous drug use causes more overdoses and is responsible ... including Hepatitis B and C and HIV. Drug treatment facilities in Tennessee have witnessed ...
(Date:7/27/2015)... ... , ... SupplyLogic, a marketing execution partner based in metro New York and ... the blog, Founder and CEO Kevin Sherlock discusses the value in supply chain visibility ... ‘Why is it the closer you get to the ocean, the more seafood costs?’ ...
(Date:7/27/2015)... ... July 27, 2015 , ... Continuing their ongoing community improvement ... greater San Antonio area, is launching a joint charity effort with the South ... Big Sister Organization of South Texas is committed to serving underprivileged and poverty-stricken ...
Breaking Medicine News(10 mins):Health News:Fryar Law Firm Announces: Jury Awards $19 Million to Investors in Houston Space Teleport 2Health News:Fryar Law Firm Announces: Jury Awards $19 Million to Investors in Houston Space Teleport 3Health News:Fryar Law Firm Announces: Jury Awards $19 Million to Investors in Houston Space Teleport 4Health News:Fryar Law Firm Announces: Jury Awards $19 Million to Investors in Houston Space Teleport 5Health News:Fryar Law Firm Announces: Jury Awards $19 Million to Investors in Houston Space Teleport 6Health News:Doctors on Liens Adds Highly Respected Physical Therapy Office in Los Angeles 2Health News:Tennessee Sees an Increase in Hepatitis C Infections from Intravenous Heroin Use 2Health News:Tennessee Sees an Increase in Hepatitis C Infections from Intravenous Heroin Use 3Health News:SupplyLogic Releases First Executive Blog on Supply Chain Management Issues 2Health News:Shacklett Insurance Team Joins Local Chapter of Big Brother Big Sister Organization to Initiate Joint Charity Effort to Benefit Children in San Antonio 2Health News:Shacklett Insurance Team Joins Local Chapter of Big Brother Big Sister Organization to Initiate Joint Charity Effort to Benefit Children in San Antonio 3
... Duke University Medical Center have found that a ... cells could be a pioneering treatment for leukemias, ... cells are the main producers of antibodies, the ... uncontrolled production of these B cells is responsible ...
... in Pakistani Kashmir to provide surgery and medical treatment to ... in just 2 hours//. The unit comprises of a total ... unit was transported to Muzaffarabad, the Kashmir capital, in four ... to be a boon to the victims of the natural ...
... with obsessive-compulsive disorder (OCD) have received increased attention ... about whether OCD is characterized by deficits in ... ,Following from a recent study that ... a virtual computerized stove, researchers from the Department ...
... genetically modified mosquito has been created that wipe out natural ... of the world such as India and South Asia. ... the wild in an attempt to combat malaria that is ... ,A similar attempt was made in India in 1970s ...
... since ages, regarded as a mirror of the inner self. However, ... of a stroke and stroke-related death. // ,The study, ... non-invasive diagnostic tool using the eyes to determine whether people have ... study, people who have tiny lesions on the back of the ...
... chromosome 15 regulates inflammation according to scientists. Inflammation has ... disorders, including cancer, cardiovascular disease, diabetes, obesity, Alzheimer’s besides ... of the study said: “Practically every common disease involves ... Foundation for Biomedical Research (SFBR) in San Antonio., ...
Cached Medicine News:Health News:Lesions in the eyes may forecast a stroke 2
(Date:7/27/2015)... SALT LAKE CITY , July 27, 2015 Dynatronics ... Mark approval for its Solaris therapeutic modality products. This approval allows ... and many other countries around the world. "Receiving ... our international sales efforts," stated Kelvyn H. Cullimore Jr. , ... have expanded our distribution network into China , ...
(Date:7/27/2015)... , July 27, 2015 Bloomage BioTechnology Corporation ... a strategic cooperation with the South Korean BioTech Company ... joint venture Medybloom to develop and promote Type A ... . Medytox, the Botulinum Toxin ... is also the fourth company in the world successfully ...
(Date:7/27/2015)... July 27, 2015 Varian Medical Systems UK Ltd ... Service to equip and service two new national NHS proton ... Varian ProBeam ® proton therapy system. Earlier this year, ... for two three-room NHS centers to be constructed in ... Varian expects to book the equipment portion of the order ...
Breaking Medicine Technology:Dynatronics Awarded CE Mark Approval for Its Solaris Products 2Bloomage (00963.HK) and Medytox Inc. set up a Joint Venture To Jointly Develop Botulinum Toxin Market in China 2Bloomage (00963.HK) and Medytox Inc. set up a Joint Venture To Jointly Develop Botulinum Toxin Market in China 3Varian Signs Contracts to Equip Two National Proton Therapy Centers in England 2Varian Signs Contracts to Equip Two National Proton Therapy Centers in England 3Varian Signs Contracts to Equip Two National Proton Therapy Centers in England 4
... Determine How Chest X-Ray CAD Could ... High-Tech Tool for Early Detection, Increased Patient ... and Riverain Medical,today announced the establishment of the ... chest X-ray CAD (computer-aided detection) can improve,practical early ...
... 26 CuraGen Corporation,(Nasdaq: CRGN ), a ... (Copenhagen Stock Exchange: TOPO) announced,today that updated preliminary ... belinostat for T-cell lymphomas, and new preclinical data,evaluating ... presented,at the 2007 American Society of Hematology (ASH) ...
Cached Medicine Technology:Cleveland Clinic Leading Clinical Program to Improve Early-Stage Lung Cancer Detection 2Cleveland Clinic Leading Clinical Program to Improve Early-Stage Lung Cancer Detection 3Cleveland Clinic Leading Clinical Program to Improve Early-Stage Lung Cancer Detection 4Cleveland Clinic Leading Clinical Program to Improve Early-Stage Lung Cancer Detection 5Cleveland Clinic Leading Clinical Program to Improve Early-Stage Lung Cancer Detection 6Cleveland Clinic Leading Clinical Program to Improve Early-Stage Lung Cancer Detection 7CuraGen and TopoTarget Announce Presentations on Belinostat at the Upcoming American Society of Hematology 49th Annual Meeting 2CuraGen and TopoTarget Announce Presentations on Belinostat at the Upcoming American Society of Hematology 49th Annual Meeting 3CuraGen and TopoTarget Announce Presentations on Belinostat at the Upcoming American Society of Hematology 49th Annual Meeting 4CuraGen and TopoTarget Announce Presentations on Belinostat at the Upcoming American Society of Hematology 49th Annual Meeting 5
Full plate covers seal all 24 MicroAmp tubes...
Omniseal TD mat. Reusable rubber mat for sealing PCR plates. 5 pk....
Inquire...
... A soft, heat-resistant, aluminum foil film ... AlumaSeal II minimizes evaportaion and vapor ... need for heat-sealing devices or mats. ... sovents and reagents. Compared to other ...
Medicine Products: