Navigation Links
New drug shows promise against multiple sclerosis
Date:11/1/2011

mune system attacks the myelin sheath that insulated nerve fibers in the brain and spinal cord. Most of these attacks have no associated symptoms, but damage to these sheaths can short circuit signals traveling along the nerve fibers. This disrupts the normal flow of communication from the brain and can cause a range of symptoms including visual impairment, weakness, sensory disturbance, fatigue, cognitive difficulties, and loss of coordination.

For decades, work in the field has focused on targeting one component of the immune system the T cells which were always seen as the "smoking gun" of the disease because they attack nerve fibers in the brain, causing the lesions and ultimately the symptoms of multiple sclerosis. Ocrelizumab, in contrast, targets a molecule called CD20 found on the surface of B cells, a separate component of the immune system.

Although the mechanism is not exactly clear, said Hauser, the B cells seem to induce the T cells to attack. If T cells are pulling the trigger on nerve fibers in the brain, B cells seem to be the ones that are loading the gun. The Phase 2 trial showed, in essence, that if you block one, you may be able to stop the other.

Hauser said the recently concluded trial validated the idea that targeting the B cells could ultimately help people with multiple sclerosis an idea that Hauser has championed for more than a decade after basic research in his laboratory in the 1990s suggested that these cells play a role in the disease.

"This is a great example of lessons learned at the bench bringing us to an experiment at the bedside that completely transformed our understanding of what we needed to do to develop more selective and more effective therapy for MS" he said.


'/>"/>
Contact: Jason Socrates Bardi
jason.bardi@ucsf.edu
415-502-4608
University of California - San Francisco
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Preterm birth rate shows three year improvement in most states
2. Study shows no increased risk of breast cancer for non-carriers in families with BRCA gene mutation
3. Novel approach to treat proliferative vitreoretinopathy shows promise
4. New therapy shows promise for treating cardiovascular disease
5. More Evidence Shows Newer Forms of Pill Raise Clot Risk, FDA Says
6. New oncolytic virus shows improved effectiveness in preclinical testing
7. Clinical trial shows first evidence that anal cancer is preventable
8. Through-the-nipple breast cancer therapy shows promise in early tests
9. Compound found in common wart treatment shows promise as leukemia therapy
10. Study shows why underrepresented men should be included in binge eating research
11. HIV Medication Patch Shows Promise in Early Trial
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2015)... 19, 2015 For some people, tattoos are ... for the rest of their lives, as they have spent ... put in a great amount of thought on their designs. ... have outgrown them or simply want them removed for personal ... their tattoo, and in 2012-13 there was a 43 percent ...
(Date:4/18/2015)... Carinsurancesavings.biz has released a new blog post explaining ... Spring. , Spring can be a great season ... sure they compare the newest policies before deciding on ... about Spring car insurance offers by reading the newly ... becoming more and more popular. Many insurance brokerage websites ...
(Date:4/18/2015)... NEW YORK (PRWEB) April 18, 2015 ... (AMO) are hosting a ‘Strategies for Success’ program for ... Refractive Surgeons meeting in San Diego, where eye surgeon ... Moderator’ for this invitation-only event. Dr. Martin is the ... and Review of Ophthalmology chose Dr. Martin to lead ...
(Date:4/18/2015)... 2015 Patients who undergo radiation for ... later in life, but the disease is likely to ... unrelated to radiation. Surviving Mesothelioma has just posted the ... Click here to read it now. , Scientists ... of 45 patients who had both a hematologic cancer ...
(Date:4/18/2015)... April 18, 2015 On April 14th, 2015, ... Report , which they say, “exposes a tactical shift by ... malware variants were introduced in 2014 - almost a million ... Day threats to be identified and patched by prominent manufacturers ... clear that doing business in a digital world can be ...
Breaking Medicine News(10 mins):Health News:Dennis Dass, M.D. is Shattering the Past While Revealing the Future 2Health News:Auto Insurance Plans Are Cheaper During Spring! 2Health News:Dr. Jeffrey Martin Invited to Share Latest Breakthroughs in Cataract Care During Roundtable Discussion at National 2015 ASCRS Meeting In San Diego 2Health News:New Study Examines Relationship Between Radiation for Hematologic Cancers and Development of Mesothelioma, According to Surviving Mesothelioma 2Health News:Cyber Attackers Continue to Fine Tune Deception and Stealth Tactics According to New Report 2Health News:Cyber Attackers Continue to Fine Tune Deception and Stealth Tactics According to New Report 3Health News:Cyber Attackers Continue to Fine Tune Deception and Stealth Tactics According to New Report 4Health News:Cyber Attackers Continue to Fine Tune Deception and Stealth Tactics According to New Report 5
... 22 percent as a result of My Health ... Benefits Institute (IBI) and the National Business Coalition ... with the 2009 IBI/NBCH Healthy Workforce Productivity Award ... February 9-11 in Los Angeles. The award, sponsored ...
... Director of the Division of Gynecologic Oncology and Ira ... the Washington University School of Medicine in ... of the Society of Gynecologic Oncologists (SGO) at the ... San Antonio, Texas. Dr. Mutch received a Bachelor of ...
... Ga. A genetic risk factor that increases the likelihood ... by high levels of involved and supportive parenting, according to ... in the February issue of the Journal of Consulting ... group of youth over time to see how a genetic ...
... announced today the results from an ongoing Phase I/II ... Conference on Retroviruses and Opportunistic Infections (CROI) in Montreal. ... for the treatment of HIV infection. During the ... a controlled scheduled treatment interruption (STI) from their current ...
... Primary Wave Media, one of the nations leading ... creation of its new 1-800-HOSPICE marketing program. ... has become very competitive and these companies are ... marketing package provides individual hospices with exclusive use ...
... Yields Results in Heart Care for MinoritiesPRINCETON, N.J., Feb. ... of National Heart Failure Week, the New Jersey Hospital ... is rapidly approaching its goal of reducing heart failure ... Americans have higher death rates than whites for both ...
Cached Medicine News:Health News:Nationwide Receives IBI/NBCH Healthy Workforce Productivity Award 2Health News:Nationwide Receives IBI/NBCH Healthy Workforce Productivity Award 3Health News:David G. Mutch Elected 41st President of the Society of Gynecologic Oncologists 2Health News:David G. Mutch Elected 41st President of the Society of Gynecologic Oncologists 3Health News:Study: Genetic risk for substance use can be neutralized by good parenting 2Health News:Penn Medicine presents HIV gene therapy trial data at CROI 2009 2Health News:Primary Wave Media Launches 1-800-HOSPICE 2Health News:NJHA Marks National Heart Failure Week 2Health News:NJHA Marks National Heart Failure Week 3
(Date:4/17/2015)... 2015   IBA Molecular, a global leader ... that it has signed a definitive agreement to sell ... NA), to Illinois Health and Science (IHS). Under IHS ownership, ... company headquartered in Dulles, Virginia , ... new product and footprint synergies. IBA Molecular is jointly ...
(Date:4/17/2015)... , April 17, 2015 Bionomics Limited (ASX:BNO, ... development of innovative therapeutics for the treatment of cancer ... the presentation of data from three of its most ... Cancer Research (AACR) 106 th Annual Meeting being ... PA USA. The presentation ...
(Date:4/16/2015)... WASHINGTON , April 16, 2015 A drug ... the eyesight of people with multiple sclerosis (MS), according to ... American Academy of Neurology,s 67th Annual Meeting in ... "About half of people with MS experience at ... neuritis, in which the nerve carrying vision from the eye ...
Breaking Medicine Technology:Health Care System to Acquire IBA Molecular North America 2Health Care System to Acquire IBA Molecular North America 3Bionomics Showcases Oncology Drug Development Programs at 2015 AACR Annual Meeting 2Bionomics Showcases Oncology Drug Development Programs at 2015 AACR Annual Meeting 3Bionomics Showcases Oncology Drug Development Programs at 2015 AACR Annual Meeting 4Bionomics Showcases Oncology Drug Development Programs at 2015 AACR Annual Meeting 5Epilepsy Drug May Preserve Eyesight for People with MS 2
... Cephalon, Inc. (Nasdaq: CEPH ) today reported 2010 ... to net sales of $2.152 billion for 2009.  Basic income ... expense and certain other items, adjusted net income for full ... the previous year.  This exceeded the company,s adjusted net income ...
... are reporting problems receiving medically required home medical equipment ... Medicare,s "competitive" bidding program in Cleveland and Cincinnati. The ... and people living with disabilities in Cleveland and Cincinnati ... program began in nine areas on January 1 and ...
Cached Medicine Technology:Cephalon Reported Record Sales, Adjusted Net Income and Cash From Operations in 2010 2Cephalon Reported Record Sales, Adjusted Net Income and Cash From Operations in 2010 3Cephalon Reported Record Sales, Adjusted Net Income and Cash From Operations in 2010 4Cephalon Reported Record Sales, Adjusted Net Income and Cash From Operations in 2010 5Cephalon Reported Record Sales, Adjusted Net Income and Cash From Operations in 2010 6Cephalon Reported Record Sales, Adjusted Net Income and Cash From Operations in 2010 7Cephalon Reported Record Sales, Adjusted Net Income and Cash From Operations in 2010 8Cephalon Reported Record Sales, Adjusted Net Income and Cash From Operations in 2010 9Cephalon Reported Record Sales, Adjusted Net Income and Cash From Operations in 2010 10Cephalon Reported Record Sales, Adjusted Net Income and Cash From Operations in 2010 11Cephalon Reported Record Sales, Adjusted Net Income and Cash From Operations in 2010 12Cephalon Reported Record Sales, Adjusted Net Income and Cash From Operations in 2010 13Cephalon Reported Record Sales, Adjusted Net Income and Cash From Operations in 2010 14Cephalon Reported Record Sales, Adjusted Net Income and Cash From Operations in 2010 15Seniors in Ohio Report Problems With Access to Home Medical Equipment and Services Under Controversial Medicare Bidding System 2Seniors in Ohio Report Problems With Access to Home Medical Equipment and Services Under Controversial Medicare Bidding System 3
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: