Navigation Links
New drug candidate starves dormant cancer cells
Date:2/18/2014

In a study published in Nature Communications, researchers at Karolinska Institutet and Uppsala University in Sweden present a new drug candidate, which selectively kills dormant cells within a cancer tumour through starvation. These tumour cells, which are found in less oxygenated parts of solid tumours, are resistant to conventional treatments.

In solid tumours larger than a few millimetres, there is usually a lack of both oxygen and nutrients due to insufficient blood vessel growth. This in turn results in cancer cells falling into a state of dormancy. After treatment, such dormant cells will start to divide and tumours will grow. This phenomenon therefore contributes to resistance of solid tumour to radio- and chemotherapy.

In their newly published study, the researchers show that cancer cells located in tumour regions that are poorly oxygenated and lack nutrition are unable to compensate for deficient mitochondrial energy production.

"We have identified a small molecule that we call VLX600, which in various in vitro and in vivo models has proven effective against dormant colon cancer cells that are otherwise very difficult to treat. VLX600 is a mild inhibitor of mitochondrial respiration, and we have found that dormant cancer cells have a limited possibility to compensate decreased mitochondrial function by increased glycolysis. The dormant cancer cells therefore die by starvation" says Stig Linder, the professor of experimental oncology leading the study.


'/>"/>

Contact: Press Office
pressinfo@ki.se
46-852-486-077
Karolinska Institutet
Source:Eurekalert

Page: 1

Related medicine news :

1. Maricopa Community Colleges Consider Five Candidates for Top Human Resources Job
2. New drug candidates show promise for cure for Chagas disease
3. Innovative Screening Strategy Swiftly Uncovers New Drug Candidates, New Biology
4. Promising results for Swedish cancer drug candidate
5. Dissertation Pal Introduces Statistics Help for Doctoral Candidates
6. OHSU AIDS vaccine candidate appears to completely clear virus from the body
7. Women's Strike Force Announces First Fund Distribution to Virginia House of Delegates Candidates for November Race
8. Issue III registry defines best syncope candidates for cardiac pacing
9. Genetic variations may help identify best candidates for preventive breast cancer drugs
10. Candidate drug provides benefit in SMA animal models
11. Drugs targeting blood vessels may be candidates for treating Alzheimers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/21/2017)... ... February 21, 2017 , ... Robins ... Clinic in Durant, Oklahoma, on Feb. 21. , The celebration began with a ... members, clinic employees, the construction team and tribal leadership. , Choctaw Nation ...
(Date:2/21/2017)... ... February 21, 2017 , ... ... five new hospital-grade power extension cords that meet the most current standards. , ... 2012 edition of the National Fire Protection Association (NFPA) 101 – Life Safety ...
(Date:2/21/2017)... ... February 21, 2017 , ... Hanna Boys ... at PolicyLink, will be the keynote speaker at its second Professional Networking Breakfast ... Color Framework, which develops comprehensive strategies to create and expand opportunities for boys ...
(Date:2/21/2017)... ... February 21, 2017 , ... Doctors on Liens has announced ... Dr. Kendell Mendonca , to its growing network of doctors in Central and ... stemming from car accidents such as whiplash, back pain, neck pain, hip and knee ...
(Date:2/21/2017)... , ... February 21, 2017 , ... As recently as ... according to the American Society of Plastic Surgeons. Some patients want to make a ... of their nose and improve their breathing ability. The team at usrhinoplasty.org ...
Breaking Medicine News(10 mins):
(Date:2/21/2017)... Australia , Feb. 21, 2017  IBM (NYSE: IBM ... Watson,s ability to detect abnormalities of the eye,s retina. The ... a research version of Watson to recognize abnormalities in retina ... and speed in their early identification of patients who may ... a leading cause of blindness in the developed world. ...
(Date:2/21/2017)... Feb. 21, 2017 Auburn University College of Veterinary ... acquire a Hyperbaric Veterinary Medicine (HVM) Chamber.  The University of ... in its small animal hospital, and now Auburn University will ... oxygen chamber that is engineered exclusively for the treatment of ... chambers in such highly revered universities like Auburn ...
(Date:2/21/2017)...  Luminex Corporation (NASDAQ: LMNX ) (the "Company") ... initiation of a quarterly cash dividend to its shareholders, the ... be payable on April 14, 2017 to shareholders of record ... The board of directors intends for the ... to holders of its common stock, representing a planned annual ...
Breaking Medicine Technology: