Navigation Links
New agent strikes at respiratory syncytial virus replication
Date:5/5/2008

GALVESTON, Texas University of Texas Medical Branch at Galveston researchers have achieved promising results with a potential new weapon against respiratory syncytial virus, the most common cause of infant hospitalization in the United States.

In an effort to find an effective antiviral therapy for RSV, the scientists tested two types of complex, custom-designed molecule to interfere with the genetic machinery that RSV uses to replicate, or copy itself, within cells. Both of the so-called morpholino oligomers, created by Oregon-based AVI BioPharma, penetrated cultured human airway cells easily and produced only minimal toxicity. One of the two, designated AUG-2, significantly reduced RSV replication in both cell culture and mouse experiments.

Viral replication is one of the major pathogenetic processes of RSV, and we badly need a specific antiviral therapy, said UTMB Dr. Roberto Garofalo, senior author of a paper on the study to be published in the June issue of Molecular Therapy and now available in the Advance Online Publication section of the journals website. That's what an agent like this morpholino could give us.

RSV infects almost all children by age two, but normally causes only a cold-like upper respiratory infection. In some babies, however, it spreads to the lungs, where the inflammation it generates causes coughing, wheezing and extreme difficulty in breathing, a life-threatening clinical syndrome known as bronchiolitis.

Recent research by Garofalo and other investigators suggests that two key factors drive RSV bronchiolitis: an inflammatory overreaction by the cells that line the airways of the lungs, and a failure to respond to RSV by T lymphocytes (also known as T cells), immune system cells that ordinarily act to control viral infections.

Because a dangerous inflammatory response occurs so soon after RSV begins replicating in the lungs, Garofalo said, antiviral therapy by itself is unlikely to be suf
'/>"/>

Contact: Jim Kelly
jpkelly@utmb.edu
409-772-8791
University of Texas Medical Branch at Galveston
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Medical Futures signs North American licensing rights to New Biologic agent for Ulcerative Colitis
2. China Medical Technologies Completed the Development of Prostate Cancer FISH Reagent
3. New research shows benefits of ultrasound contrast agents outweigh potential risk to heart patients
4. Peter Burg Appointed as Co-Chair of the Plaintiffs Steering Committee and the Executive Committee for the Gadolinium-Based Contrast Agents Product Liability Multi-District Litigation
5. FluoroPharma Inc. Expands Technology Platform to Include Agents for Alzheimers Disease (AD)
6. NSAIDs: Painkillers, inflammation inhibitors, anti-cancer drugs and new de-methylating agents
7. China Medical Technologies Receives CE Mark for Two ECLIA Analyzers and 15 Reagents
8. Sagent Pharmaceuticals Launches Ciprofloxacin Injection, USP, 5% Dextrose Premix Bag
9. IUPUI scientists report first 3-D view of anti-cancer agent
10. Cardinal Health, GE Healthcare Broaden Relationship to Offer Greater Access to Myoview(TM) Imaging Agent
11. Parker Waichman Alonso LLP Files Suit Against General Electric Company on Behalf of a Man Who Developed Nephrogenic Systemic Fibrosis (NSF) from Contrast Agent Omniscan
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/3/2015)... FRANCISCO, CA (PRWEB) , ... September 03, 2015 ... ... transforming the real estate investment landscape by connecting accredited and institutional investors to ... mezzanine financing products designed to meet demand from both investors and sponsoring ...
(Date:9/3/2015)... , ... September 03, 2015 , ... The Linda ... control, the surface of a comet, the IceCube observatory at the South Pole, and ... , The Fall Lecture Series for the world's foremost independently funded research library ...
(Date:9/3/2015)... (PRWEB) , ... September 03, 2015 , ... Dr. Robert ... of Trauma, Burns, Critical and Acute Care at NewYork-Presbyterian/Weill Cornell Medical Center, effective July ... Winchell is a nationally renowned expert in care for the critically injured and the ...
(Date:9/3/2015)... ... September 03, 2015 , ... Atlantic Information Services, Inc. ... Pharmacy Benefit Strategies for a Rapidly Changing Marketplace.” In this Sept. 16 program, ... will discuss how plan sponsors are adopting bold, innovative strategies to control soaring ...
(Date:9/3/2015)... ... September 03, 2015 , ... ProScrub is a set of automated tools that ... and custom speed effects without the use of keyframes. Utilize ProScrub's powerful sliders ... tools are perfect complements to energetic video productions. ProScrub is a Final ...
Breaking Medicine News(10 mins):Health News:RealtyShares Announces Mezzanine Financing Products 2Health News:RealtyShares Announces Mezzanine Financing Products 3Health News:Facing the Frontiers of Science and Technology The Linda Hall Library Announces 2015 Fall Lecture Series Featuring Experiences from the South Pole to Outer Space 2Health News:Facing the Frontiers of Science and Technology The Linda Hall Library Announces 2015 Fall Lecture Series Featuring Experiences from the South Pole to Outer Space 3Health News:Facing the Frontiers of Science and Technology The Linda Hall Library Announces 2015 Fall Lecture Series Featuring Experiences from the South Pole to Outer Space 4Health News:Facing the Frontiers of Science and Technology The Linda Hall Library Announces 2015 Fall Lecture Series Featuring Experiences from the South Pole to Outer Space 5Health News:Trauma Expert Joins NewYork-Presbyterian Hospital and Weill Cornell Medical College 2Health News:Trauma Expert Joins NewYork-Presbyterian Hospital and Weill Cornell Medical College 3Health News:Trauma Expert Joins NewYork-Presbyterian Hospital and Weill Cornell Medical College 4Health News:Trauma Expert Joins NewYork-Presbyterian Hospital and Weill Cornell Medical College 5Health News:Speakers for Upcoming AIS Virtual Conference on Pharmacy Benefit Strategies Include Executives from CVS Health, Express Scripts 2Health News:FCPX Effects Developer Releases ProScrub for Final Cut Pro X 2
... By Amanda Gardner HealthDay Reporter , WEDNESDAY, Oct. ... outbreak first linked to tainted cantaloupes has risen to 25, ... 26 states, the U.S. Centers for Disease Control and Prevention ... the cantaloupes in question were recalled in mid-September, more cases ...
... as immunotherapies and targeted therapies that specifically target signaling ... in 20%-50% of cancer patients taking them, which can ... study published Oct. 18 in the Journal ... past two decades, novel antineoplastic agents have been introduced ...
... PROVIDENCE, R.I. [Brown University] A study published online Oct. ... provides some new but qualified support for the idea ... risk of developing deadly brain tumors. People with somewhat ... out the body,s immune response to allergens, were significantly less ...
... LeFevre, MD, Future of Family Medicine Professor and vice ... of Missouri, has been elected to the Institute of ... is considered one of the highest honors in the ... have demonstrated outstanding professional achievement and commitment to service. ...
... & White Healthcare in Temple is one of three sites ... doctoral psychology students that will help alleviate mental health workforce ... a five-year $638,853 grant from the Hogg Foundation for Mental ... will fund a new internship program that will enable students ...
... results from a large-scale Phase III trial of RTS,S*, published ... (NEJM), show the malaria vaccine candidate to provide young ... with an acceptable safety and tolerability profile. The results were ... & Melinda Gates Foundation in Seattle, Washington. Half the ...
Cached Medicine News:Health News:25 Deaths Now Blamed on Cantaloupe-Linked Listeria Outbreak 2Health News:Antineoplastic agents associated with thyroid dysfunction 2Health News:More evidence that allergies may help in fighting brain tumors 2Health News:Family and community medicine leader elected to Institute of Medicine 2Health News:Scott & White Healthcare is 1 of 3 in Texas to receive workforce development grants 2Health News:Malaria vaccine candidate, RTS,S reduces the risk of malaria by half in African children 2Health News:Malaria vaccine candidate, RTS,S reduces the risk of malaria by half in African children 3
(Date:9/3/2015)... 3, 2015 The report "Biocides ... acids, Phenolics, and Others) and by Application (Water treatment, ... coatings, and Others) - Global Trends and Forecasts to ... Market with an analysis and forecast for types and ... Browse   88 tables and   63 figures ...
(Date:9/2/2015)... 2, 2015 About Balloon ... one or more vertebral bodies, resulting in persistent ... bone disease, is a leading cause of VCF ... metastatic spinal tumors, and traumatic injuries also cause ... kyphoplasty to rectify the condition. Both procedures are ...
(Date:9/2/2015)... , Sept. 2, 2015  The report on ... market of breast cancer drugs on the basis of ... usually originates from the inner lining of milk ducts ... a malignant type of tumor that can spread to ... cancer which starts in lobules is referred as lobular ...
Breaking Medicine Technology:Biocides Market Worth 10.6 Billion USD by 2020 2Biocides Market Worth 10.6 Billion USD by 2020 3Biocides Market Worth 10.6 Billion USD by 2020 4Biocides Market Worth 10.6 Billion USD by 2020 5Global Balloon Kyphoplasty Market 2015-2019 2Breast Cancer Therapeutics: Pipeline Analysis Market - Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2015 - 2023 2Breast Cancer Therapeutics: Pipeline Analysis Market - Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2015 - 2023 3
...  "This is a significant decision in a case being ... entire pharmaceutical industry," commented Benjamin H. Anderson, Esq. "We ... hearing was not necessary and that the three-judge panel ... the diet drug Redux (commonly known as fen-phen) should ...
... EntreMed, Inc. (Nasdaq: ENMD ), a ... of cancer, today announced that it has received ... that it has regained compliance with the minimum ... requirement for continued listing on the NASDAQ Capital ...
Cached Medicine Technology:EntreMed Receives Notice of NASDAQ Compliance 2
... Addressing the key clinical and economic issues ... System is designed to maximize tension control ... The system combines efficient instrumentation with a ... Grip system is indicated for general orthopaedic ...
... The Minimally Invasive Hip Instruments ... THA through a mini-incision using ... set of instruments helps reduce ... invasive THA by optimizing exposure ...
... The Inteq TFCC ... facilitates suturing of the ... the dorsal capsule when ... The Inteq system should ...
... Series I Small Joint ... features a complete line ... instruments specifically designed for ... are available in a ...
Medicine Products: