Navigation Links
Nano drug crosses blood-brain tumor barrier, targets brain-tumor cells and blood vessels
Date:7/17/2013

  • The blood-brain barrier protects the brain from poisons but also prevents drugs from reaching brain tumors; innovative new treatments are needed.
  • This laboratory study shows that a nanotechnology drug called SapC-DOPS crosses that barrier and targets brain-tumor cells and retards growth of tumor blood vessels.
  • The findings also show how the agent targets tumor cells and recommend its further development as a novel treatment for glioblastoma.

COLUMBUS, Ohio An experimental drug in early development for aggressive brain tumors can cross the blood-brain tumor barrier and kill tumor cells and block the growth of tumor blood vessels, according to a study led by researchers at the Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC James).

The laboratory and animal study also shows how the agent, called SapC-DOPS, targets tumor cells and blood vessels. The findings support further development of the drug as a novel treatment for brain tumors.

Glioblastoma multiforme is the most common and aggressive form of brain cancer, with a median survival of about 15 months. A major obstacle to improving treatment for the 3,470 cases of the disease expected in the United States this year is the blood-brain barrier, the name given to the tight fit of cells that make up the blood vessels in the brain. That barrier protects the brain from toxins in the blood but also keeps drugs in the bloodstream from reaching brain tumors.

"Few drugs have the capacity to cross the tumor blood-brain barrier and specifically target tumor cells," says principal investigator Balveen Kaur, PhD, associate professor of neurological surgery and chief of the Dardinger Laboratory of Neurosciences at the OSUCCC James. "Our preclinical study indicates that SapC-DOPS does both and inhibits the growth of new tumor blood vessels, suggesting that this agent could one day b
'/>"/>

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. A new European network crosses the boundaries for excellence in language and perception research
2. E-Store India Crosses the 1-million Mark for Number of Registered Online Buyers
3. Nano-devices that cross blood-brain barrier open door to treatment of cerebral palsy
4. Improved Stem Cell Line May Avoid Tumor Risk: Study
5. Normalizing tumor blood vessels improves delivery of only the smallest nanomedicines
6. Dental X-Rays May Be Linked to Benign Brain Tumors
7. Live imaging shows response to cancer drugs can be boosted by altering tumor microenvironment
8. Brain Tumor Vaccine Shows Promise in Early Trial
9. Kidney Cancer Patients Fare Better With Tumor Removal Only
10. IBN discovers human neural stem cells with tumor targeting ability
11. Protein prevents DNA damage in the developing brain and might serve as a tumor suppressor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... Give a loved one the greatest gift ... and vitality. , For a limited time, HealthiPlus ( ... in special Holiday Wellness gift packages at drastically reduced ... bottle contains cutting-edge, proven nutritional support for joints, mental ... as we age. , Joint Health Plus ...
(Date:12/22/2014)... December 22, 2014 Pasadena sleep ... consultations for sleep apnea. Drowsy drivers are 15 times ... who are well-rested, and some experts believe that sleep-deprived ... as intoxicated drivers. Unfortunately, millions of Americans may be ... Academy of Sleep Medicine, about 18 million Americans have ...
(Date:12/22/2014)... Branch, TX (PRWEB) December 22, 2014 ... revolutionary work glove with many useful features. Customers of ... and can have the new gloves delivered to their ... work gear and hand tools that incorporate heavy duty ... Utility Magnetic Glove allows workers to store metal parts ...
(Date:12/22/2014)... December 22, 2014 NAPW ... Professional Woman of the Year. Ms. Foley is recognized ... the largest, most-recognized networking organization of professional women in ... National Association of Professional Women is a powerfully vibrant ... Local Chapters. , “As a nurse, I felt like ...
(Date:12/22/2014)... 2014 The NLN’s 2015 ... programs this month. Faculty have been selected through ... educators fast-tracked for administrative leadership roles within their ... for Simulation Educators, featuring a curriculum uniquely devised ... education. , Twenty nurse educators were chosen ...
Breaking Medicine News(10 mins):Health News:You Still Have Time to Give the Gift of Health and Vitality to a Mature Loved One 2Health News:Pasadena Dentist, Dr. Marine Martirosyan, Now Offers Consultations for Sleep Apnea 2Health News:MagnoGrip Pro Utility Magnetic Gloves on Sale at TheHardwareCity.com 2Health News:National Association of Professional Women Announces Michelle M. Foley, Vice President of Operations of OTTR Chronic Care Solutions, a 2014 Professional Woman of the Year 2Health News:NLN Leadership Institute Announces 2015 Cohorts 2Health News:NLN Leadership Institute Announces 2015 Cohorts 3
... to researchers, new bandages developed by US researchers take ... mice show that hydrogel bandages speed up healing.They look ... times and become pliable when wet.// Unlike regular bandages, ... hydrogel dressings actually penetrate the wound and enhance the ...
... have observed that, people suffering from heat diseases are better ... but for a few it might prove too much.People who ... still safe to enjoy a game of golf.// Researchers at ... 15 male golfers, aged between 50 and 75, half of ...
... studied on African tribe, most of the things being equal ... to be healthier for the heart than eating a vegetarian ... the body control blood levels of leptin,// a substance secreted ... increased risk for heart attack and stroke. ,Lead author ...
... has found that caffeine is often used to treat ... is a condition characterized by cessation in breathing and ... growing concern over caffeine's effects on a baby's circulatory ... caffeine on cardiac output, specifically studying the effects on ...
... important tips regarding splitting a pill and ways of taking care ... a whole one. one might be neglecting off a medication, or ... way, you may need to split a pill into two or ... some advice on how to go about pill splitting. First, you ...
... offer some valuable advice on how to make sure your ... bones and teeth, and helps prevent osteoporosis and any bone ... produce vitamin D.// Just10 to 15 minutes of natural sunlight ... many factors can reduce sunlight exposure, such as windows, sunscreen, ...
Cached Medicine News:Health News:Fish rich diet lowers leptin 2Health News:Caffeine reduces infant blood flow 2
(Date:12/19/2014)... TODAY, AEGATE, the leader in ... the appointment of Peter Fox as Chief ... and Partner Officer. Peter has served as ... acquisition by Oracle in 2011. Prior to ... and subsequently Convergys, a world renowned billing ...
(Date:12/19/2014)... Dec. 19, 2014   Hospira, Inc. (NYSE: ... injectable drugs and infusion technologies, today announced that the ... Healthcare Conference on Wednesday, Jan. 14, 2015, in ... to begin at 10:30 a.m. Pacific time on Wednesday, ... interested parties through a live audiocast accessible via the ...
(Date:12/19/2014)... WORTH, Texas , December 18, 2014 /PRNewswire/ ... a networked software application/module that is used to ... related images. RIS comprises a patient tracking and ... system. The integration of RIS with HIS and ... used for patient registration and patient scheduling, patient ...
Breaking Medicine Technology:Aegate Appoints new CTO and Chief Channels & Partner Officer 2Aegate Appoints new CTO and Chief Channels & Partner Officer 3Aegate Appoints new CTO and Chief Channels & Partner Officer 4The Global Radiology Information Systems Market is Expected to Grow at a CAGR of 7.5% from 2014 to 2019 2The Global Radiology Information Systems Market is Expected to Grow at a CAGR of 7.5% from 2014 to 2019 3
... 9, 2012 GlySure Limited, developer of ... close of its $10.9 million Series C financing round. ... to supportregulatory approval in the United States and Europe. ... Venture, as well as existing investors Amadeus Capital Partners, ...
... FORD, Pa., Jan. 9, 2012 Endo Pharmaceuticals (Nasdaq: ... result of a temporary shut-down of Novartis Consumer Health ... short-term supply constraint of OPANA® ER.  The company also ... facility may experience short-term supply disruptions.  Endo is working ...
Cached Medicine Technology:GlySure Secures $10.9 Million in Series C Financing Round 2Endo Announces Potential Short-Term Supply Constraints of Certain Analgesic Medications as a Result of Temporary Shut Down of Novartis Facility 2Endo Announces Potential Short-Term Supply Constraints of Certain Analgesic Medications as a Result of Temporary Shut Down of Novartis Facility 3
The Maverick Over-The-Wire balloon catheter delivers a new level of performance to meet the changing demands of interventional cardiology....
The Maverick Over-The-Wire balloon catheter delivers a new level of performance to meet the changing demands of interventional cardiology....
... Phoroptor features lighted dials to make it ... in the darkened setting of the exam ... leave the lights off throughout the entire ... cylinder power and cylinder axis scales that ...
... The Reichert CT200 Tonometer ... the XCEL 250 and XCEL ... also compatible with other Zeiss-style ... mounted on the top of ...
Medicine Products: