Navigation Links
NYU College of Nursing receives 450 thousand dollar NIH grant to research post-breast cancer lymphedema
Date:10/27/2011

New York University College of Nursing (NYUCN) received a two-year, $452,218.00 grant from the national Institutes of Health (NIH) to research ""Proinflammatory Biomarkers and Post-Breast Cancer Lymphedema." Post-breast cancer lymphedema (LE), a syndrome of abnormal swelling and multiple distressing symptoms, is caused by injuries to the lymphatic system from cancer treatment. As advances in cancer treatment lengthen survival, LE has emerged as a high-impact long-term morbidity that profoundly impairs survivors' quality of life.

According to Fu, the purpose of this exploratory project is to prospectively examine levels and patterns of proinflammatory biomarkers and genetic variations in relation to limb volume change measured with the infra-red perometer-350S over a 12-month period in breast cancer survivors who are at risk for lymphedema.

"Among the 2.5 million breast cancer survivors in the U.S. more than 40% of them have developed lymphedema," said NYUCN Assistant Professor Mei Fu, PhD, RN, APRN-BC. "All women undergoing breast cancer treatment are at lifetime risk for lymphedema."

While removal of lymph nodes, surgery, and radiation are the major causal factors for lymphedema, cancer treatment is necessary for life-saving. Recent research has revealed that inflammation-infection and higher body mass index (BMI) are the main predictors of lymphedema besides treatment-related risk.

Unfortunately, these studies did not evaluate biomarkers known for inflammation, and thus the role of inflammation-infection in limb volume change and lymphedema development could not be ascertained.

Elevated levels of proinflammatory biomarkers have been speculated to be associated with inflammation in patients with lymphedema. Moreover, genetic variations may be one of the important factors that influence breast cancer survivors' responses to inflammatory processes and vulnerability to lymphedema, including survivors' responses to treatment-related trauma (such as surgery and radiation) and triggering factors (such as infection, burns, minor injuries, and higher BMI or obesity).

The project will employ a prospective, descriptive, and repeated-measure design. A sample of 120 women who are newly diagnosed and treated for invasive breast cancer will be recruited. Data will be collected to evaluate levels and patterns of proinflammatory biomarkers and genotypes known for inflammation in relation to limb volume change.

"This project is an important first step toward gaining necessary knowledge and insights into breast cancer survivors' susceptibility, which may help to identify survivors at higher risk based on individual survivors' biomarker patterns and genetic factors," said Fu. "Findings of the project are fundamental in developing and testing more intense and personalized interventions to prevent and treat LE among the breast cancer survivors."


'/>"/>
Contact: christopher James
christopher.james@nyu.edu
212-998-6876
New York University
Source:Eurekalert

Related medicine news :

1. Einstein College of Medicine receives $5.7 million for developmental disabilities research
2. Campus Smoking Bans May Help College Students Quit
3. City College of New York-led research could lead to wearable sensors for the blind
4. When it comes to college hookups, more is said than done
5. College Students Not Getting Enough Zs
6. College Football Players Get Bigger, Stronger With Age
7. Teens, College-Age Youth at High Risk of Suicide, Expert Says
8. College Students Missing Out on Fruits, Veggies: Survey
9. Many Military Vets in College Plagued By Thoughts of Suicide
10. Survey Suggests Sexting Rampant in College
11. Drinking until you forget leads to injuries for college kids
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... , ... June 27, 2016 , ... ... edge technology to revolutionize the emergency ambulance transport experience for the millions of ... of how Uber has disrupted the taxi industry through the use of technology. ...
(Date:6/26/2016)... Viejo, California (PRWEB) , ... June 26, 2016 , ... ... Final Cut Pro X. , "Film editors can give their videos a whole new ... said Christina Austin - CEO of Pixel Film Studios. , ProSlice Levels contains ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... ... health policy issues and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, ... work on several important health care topics including advance care planning, healthcare costs ...
(Date:6/25/2016)... ... June 25, 2016 , ... First Choice Emergency Room , the largest ... as the Medical Director of its new Mesquite-Samuell Farm facility. , “We are ... Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits ... terms of the latter, setting the bar too high can result in disappointment, perhaps ... slow progress toward their goal. , Research from PsychTests.com reveals that ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 2016 Revolutionary technology includes multi-speaker ... , industry leaders in advanced audiology and hearing aid ... Opn ™, the world,s first internet connected hearing aid ... devices.      (Photo: http://photos.prnewswire.com/prnh/20160622/382240 ) ... of ,world firsts,: , TwinLink™ - the ...
(Date:6/23/2016)... DUBLIN , June 23, 2016 ... the "Surgical Procedure Volumes: Global Analysis (United States, ... Australia, Canada)" report to their offering. ... an essential tool for healthcare business planners, provides surgical ... looks at surgery trends with an in-depth analysis of ...
(Date:6/23/2016)...  The National Pharmaceutical Council (NPC) today announced ... research organization as its newest member.  ... president and chief scientific officer, Mallinckrodt Pharmaceuticals, will ... Board of Directors. ... us in support of our efforts to conduct ...
Breaking Medicine Technology: