Navigation Links
NIH scientists map gene changes driving tumors in common pediatric soft-tissue cancer
Date:1/23/2014

ex molecular events that occur in tumor cells, compare normal DNA with tumor DNA, identify mutations in genes, and determine exactly which genes are turned on (activated) or turned off (deactivated), leading to progression of this cancer.

Through their studies, they identified two distinct genotypes of rhabdomyosarcoma tumors. The first genotype is characterized by either a PAX3 or PAX7 fusion gene; a fusion gene is a gene made by joining parts of two different genes. The second genotype lacks a PAX fusion gene but harbors mutations in key signaling pathways; a signaling pathway is a group of proteins that work together to regulate one or more cell functions, such as cell division or cell death.

The researchers also found that, as in other types of pediatric cancers, the overall number of alterations in tumor DNA that develop over the children's lifespan (known as somatic mutations) were relatively low compared to DNA alterations that children were born with. The somatic mutation rate was especially low in tumors with a PAX fusion gene. Nevertheless, they did find relatively frequent somatic mutations in several genes, including NRAS, KRAS, HRAS, FGFR4, PIK3CA, CTNNB, all of which had previously been found to be mutated in rhabdomyosarcoma, as well as the genes FBXW7 and BCOR, which had not been previously associated with this disease.

Moreover, they identified mutations in additional genes in the RAS/PIK3CA signaling pathway. Overall, alterations in this pathway were found in 93 percent of rhabdomyosarcoma tumors. Intriguingly, many of the genes mutated in the tumors that did not have a PAX fusion gene were found to be turned on or off by proteins produced by PAX fusion genes.

"Although more work is needed, our study may provide researchers with the rationale to develop genomics-guided therapeutic interventions with greater efficacy and fewer side effects than the treatments options currently available for pediatric patients wi
'/>"/>

Contact: NCI Press Officers
ncipressofficers@mail.nih.gov
301-496-6641
NIH/National Cancer Institute
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Scripps Florida scientists find regulator of amyloid plaque buildup in Alzheimers disease
2. NCCS scientists discover gene regulation is dependent on protein ANP32E
3. Scientists make your stomach turn bright green if you have an ulcer
4. Scientists reduce protein crystal damage, improve pharmaceutical development
5. It's All In The Climate: New Study from Research Scientists at Florida International University Predict
6. Surviving ovarian cancer: Rutgers scientists attack drug resistant cancer cells
7. Scientists discover that short-term energy deficits increase factors related to muscle degradation
8. CNIO scientists create the first large catalog of interactions between drugs and proteins
9. Over 70 new centers to train tomorrows engineers and scientists
10. Scientists Agree: Sleep Less, Get Fat
11. UNC scientists find potential cause for deadly breast cancer relapse
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Juvent Sports ( http://www.juventsports.com ) and David ... Show to bestow a Juvent Sports Achievement award upon ... McKitrick. The award commemorated and congratulated McKitrick for her ... won her first amateur tournament in 1979 and most ...
(Date:1/22/2015)... Oceanside,CA (PRWEB) January 22, 2015 For over 20 ... the Oceanside and Vista area has treated just about ... other personal injury circumstances. And for those same twenty-plus years, ... victims of all those injuries with the best possible doctor. ...
(Date:1/22/2015)... 2015 Yesterday, Senator Holly Mitchell ... Kristin Olsen (R-Modesto) were honored by the California ... biotechnology, biomedical science, medical device and pharmaceutical innovation ... the “2014 Life Sciences Champion” award from CHI ...
(Date:1/22/2015)... Payday lending practices in four southern ... financial distress to the states that permit them, according ... Center on Race and Wealth. , While they generate ... loans at the same time substantially depress economic activity, ...
(Date:1/22/2015)... a new blog post presenting a list of vehicles that cannot ... Some types of vehicles cannot be covered under an ordinary auto ... see if their vehicle qualifies for auto insurance coverage. , ... that cannot be covered by a plan. Clients have little options ...
Breaking Medicine News(10 mins):Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 3Health News:Industry Leading Chiropractor in Oceanside Joins the Doctors on Liens Network 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 3Health News:Howard University Spotlights the Economic Impact of Payday Lending in Southern States 2Health News:Some Vehicles Cannot Be Covered By An Auto Insurance Policy! 2
... January 26, 2009 ROANOKE, Va., Jan. 21 ... - www.stuttering.org ), a leading center for ... successful trials using Apple,s iPhone as a stuttering ... fluency skills from the clinical setting into real-life ...
... 21 , Fourth Quarter Highlights, -- ... -- Record income before income taxes of $5.1 million, up 14 percent., ... $0.25 per diluted share., Fiscal 2008 Highlights, ... -- Record income before income taxes of $16.4 million, up ...
... and Triaminic(R) send Sick Day Guidelines home to help guide ... children get six to 10 colds every year and some ... Jan. 21 Parents just know when their children aren,t ... and sniffles warrant keeping them home from school. In fact, ...
... , Who: PlanetHospital(TM), the leader and pioneer ... tourism., What: A highly informative meet and greet ... singles, and infertile couples in Los Angeles and New York, ... Allahbadia. Admission is FREE., ...
... first quarter of 2009, Auerbach International is offering discounted rates on ... global marketing agencies in the United States, Auerbach International offers an ... , ... (PRWEB) January 21, 2009 -- Auerbach International Inc., ...
... "All About Me" Children,s Health Journal has just come out. In it,s ... their childrens, immunizations and developmental progress. It is both a keepsake, and ... been using it since its inception. A diaper bag must. , ... ...
Cached Medicine News:Health News:Photos: Apple's iPhone Finds New Use in Treating Stuttering at Hollins Communications Research Institute 2Health News:Photos: Apple's iPhone Finds New Use in Treating Stuttering at Hollins Communications Research Institute 3Health News:Somanetics Reports Record Net Revenues and Income Before Income Taxes for Fourth Quarter and Fiscal 2008 2Health News:Somanetics Reports Record Net Revenues and Income Before Income Taxes for Fourth Quarter and Fiscal 2008 3Health News:Somanetics Reports Record Net Revenues and Income Before Income Taxes for Fourth Quarter and Fiscal 2008 4Health News:Somanetics Reports Record Net Revenues and Income Before Income Taxes for Fourth Quarter and Fiscal 2008 5Health News:Somanetics Reports Record Net Revenues and Income Before Income Taxes for Fourth Quarter and Fiscal 2008 6Health News:Somanetics Reports Record Net Revenues and Income Before Income Taxes for Fourth Quarter and Fiscal 2008 7Health News:Somanetics Reports Record Net Revenues and Income Before Income Taxes for Fourth Quarter and Fiscal 2008 8Health News:Somanetics Reports Record Net Revenues and Income Before Income Taxes for Fourth Quarter and Fiscal 2008 9Health News:Somanetics Reports Record Net Revenues and Income Before Income Taxes for Fourth Quarter and Fiscal 2008 10Health News:Somanetics Reports Record Net Revenues and Income Before Income Taxes for Fourth Quarter and Fiscal 2008 11Health News:New Sick Day Guidelines Help Parents Make the Right Call This Cold Season 2Health News:New Sick Day Guidelines Help Parents Make the Right Call This Cold Season 3Health News:New Sick Day Guidelines Help Parents Make the Right Call This Cold Season 4Health News:PlanetHospital(TM) Helps Gay Couples Discover Having Children Via Surrogacy in India 2Health News:PlanetHospital(TM) Helps Gay Couples Discover Having Children Via Surrogacy in India 3Health News:Spanish On-Sale: Auerbach International Offers Discounted Rates for Spanish Translations 2Health News:Spanish On-Sale: Auerbach International Offers Discounted Rates for Spanish Translations 3Health News:Pocket Reference Journals Releases Latest Edition of "All About Me" Leading Children's Immunization Journal for New Moms 2Health News:Pocket Reference Journals Releases Latest Edition of "All About Me" Leading Children's Immunization Journal for New Moms 3
(Date:1/23/2015)... Jan. 23, 2015  Today the U.S. Food and Drug ... the prevention of serogroup B meningococcal disease ... vaccine Trumenba®, which received FDA approval in October, represent ... disease. "I have heard over and ...
(Date:1/23/2015)... 23, 2015 Research and Markets ( http://www.researchandmarkets.com/research/5dh22x/urinary_catheters ... Catheters Market (Indwelling or Foley Catheters, Intermittent Catheters and ... Size, Share, Growth, Trends and Forecast 2014 - 2020" ... At present, the global market for urinary catheters is ...
(Date:1/23/2015)... BETHESDA, Md. , Jan. 23, 2015  Northwest Biotherapeutics, Inc. ... developing DCVax® personalized immune therapies for operable and inoperable solid ... will present at the 7 th Annual Phacilitate Immunotherapy ... NW Bio,s presentation at Phacilitate will take place on January ...
Breaking Medicine Technology:The National Meningitis Association (NMA) Applauds FDA Approval of Second Vaccine To Protect Against Serogroup B Meningococcal Disease 2Urinary Catheters Market (Indwelling or Foley Catheters, Intermittent Catheters and Male External or Condom Catheters) - Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 2Urinary Catheters Market (Indwelling or Foley Catheters, Intermittent Catheters and Male External or Condom Catheters) - Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 3NW Bio To Present At The 7th Annual Phacilitate Immunotherapy Forum 2NW Bio To Present At The 7th Annual Phacilitate Immunotherapy Forum 3
... 2011 ChromaDex® Corp. (OTCBB: CDXC) today announced ... ChromaDex® the exclusive rights to a joint patent ... the method of inducing UDP-glucuronosyltransferase (UGT) activity using ... found in blueberries and demonstrated to have multiple ...
... Sept. 8, 2011 Abaxis, Inc. (NasdaqGS: ABAX), a ... today that Clint Serverson, chief executive officer,  will present ... Tuesday, September 13, 2011 at 10:20 a.m. ET at ... AbaxisAbaxis develops, manufactures, markets and sells portable blood analysis ...
Cached Medicine Technology:ChromaDex®'s Novel Ingredient pTeroPure® to be Studied as Potential Treatment for Fighting Skin Cancers 2ChromaDex®'s Novel Ingredient pTeroPure® to be Studied as Potential Treatment for Fighting Skin Cancers 3Abaxis to Present at 2011 Morgan Stanley Global Healthcare Unplugged Conference 2
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: