Navigation Links
NIH scientists map gene changes driving tumors in common pediatric soft-tissue cancer
Date:1/23/2014

ex molecular events that occur in tumor cells, compare normal DNA with tumor DNA, identify mutations in genes, and determine exactly which genes are turned on (activated) or turned off (deactivated), leading to progression of this cancer.

Through their studies, they identified two distinct genotypes of rhabdomyosarcoma tumors. The first genotype is characterized by either a PAX3 or PAX7 fusion gene; a fusion gene is a gene made by joining parts of two different genes. The second genotype lacks a PAX fusion gene but harbors mutations in key signaling pathways; a signaling pathway is a group of proteins that work together to regulate one or more cell functions, such as cell division or cell death.

The researchers also found that, as in other types of pediatric cancers, the overall number of alterations in tumor DNA that develop over the children's lifespan (known as somatic mutations) were relatively low compared to DNA alterations that children were born with. The somatic mutation rate was especially low in tumors with a PAX fusion gene. Nevertheless, they did find relatively frequent somatic mutations in several genes, including NRAS, KRAS, HRAS, FGFR4, PIK3CA, CTNNB, all of which had previously been found to be mutated in rhabdomyosarcoma, as well as the genes FBXW7 and BCOR, which had not been previously associated with this disease.

Moreover, they identified mutations in additional genes in the RAS/PIK3CA signaling pathway. Overall, alterations in this pathway were found in 93 percent of rhabdomyosarcoma tumors. Intriguingly, many of the genes mutated in the tumors that did not have a PAX fusion gene were found to be turned on or off by proteins produced by PAX fusion genes.

"Although more work is needed, our study may provide researchers with the rationale to develop genomics-guided therapeutic interventions with greater efficacy and fewer side effects than the treatments options currently available for pediatric patients wi
'/>"/>

Contact: NCI Press Officers
ncipressofficers@mail.nih.gov
301-496-6641
NIH/National Cancer Institute
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Scripps Florida scientists find regulator of amyloid plaque buildup in Alzheimers disease
2. NCCS scientists discover gene regulation is dependent on protein ANP32E
3. Scientists make your stomach turn bright green if you have an ulcer
4. Scientists reduce protein crystal damage, improve pharmaceutical development
5. It's All In The Climate: New Study from Research Scientists at Florida International University Predict
6. Surviving ovarian cancer: Rutgers scientists attack drug resistant cancer cells
7. Scientists discover that short-term energy deficits increase factors related to muscle degradation
8. CNIO scientists create the first large catalog of interactions between drugs and proteins
9. Over 70 new centers to train tomorrows engineers and scientists
10. Scientists Agree: Sleep Less, Get Fat
11. UNC scientists find potential cause for deadly breast cancer relapse
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/3/2015)... ... 2015 , ... Scientists at several top US cancer centers believe they now ... Click here to read the complete story , just posted on the Surviving ... Medical Center, and New York University exposed mice with a mutation on the tumor ...
(Date:7/3/2015)... ... 03, 2015 , ... B. E. Smith, the only full-service ... a national chief nursing officer recruitment for Jane Phillips Medical Center ... industry, B. E. Smith has recently placed more than 1,000 healthcare executives into ...
(Date:7/3/2015)... ... July 03, 2015 , ... Talcum powder attorneys representing ... their existing Talcum Powder Cancer Lawsuit Center website. Just as the previous version did, ... news , offering timely lawsuit updates and ovarian cancer warning information. The site is ...
(Date:7/3/2015)... ... ... " Selfie on a Stick ” was featured on NewsWatch as part of ... consumers. Amanda Forstrom, a technology expert and special reporter for NewsWatch, conducted the review ... Almost every smartphone has an incredibly powerful camera built into it. And when someone ...
(Date:7/3/2015)... ... 03, 2015 , ... The Celebrity Dresses is currently running a promotion through ... celebrities will have the opportunity to get 10% discount on orders that are over ... not have to use coupon codes or remember redemption codes. , There is ...
Breaking Medicine News(10 mins):Health News:Study Finds Small Amounts of Asbestos May Trigger Mesothelioma in People with Genetic Mutation, According to Surviving Mesothelioma 2Health News:Jane Phillips Medical Center Retains B. E. Smith to Recruit New Chief Nursing Officer 2Health News:Jane Phillips Medical Center Retains B. E. Smith to Recruit New Chief Nursing Officer 3Health News:Talcum Powder Lawsuit News: Cancer Attorneys Launch Updated Mobile Site 2Health News:Talcum Powder Lawsuit News: Cancer Attorneys Launch Updated Mobile Site 3Health News:Learn How to Take Selfies like Kendall Jenner 2Health News:Celebrity Fashion Summer Party Dresses on sale at TheCelebrityDresses.com 2
... Medical Corporation,(CRM:TSX-V) announced today for the year ended ... its Centers for Colorectal Health compared to,1,699 patient ... Commenting on this achievement, Edward Wright, CEO of ... strong demand for the CRH,O,Regan hemorrhoid banding technology ...
... LENEXA, Kan., Feb. 5 Mediware Information,Systems, Inc. (Nasdaq: ... blood and medication management, reported total revenue for the ... $11,262,000 in the,comparable quarter in fiscal year 2007. Net ... four cents per fully diluted share, compared to net,income ...
... Trade Center had sleeplessness, other problems, study shows , , ... to the World Trade Center terrorist attacks boosted behavioral ... by researchers at the Mount Sinai School of Medicine ... 4 years of age who lived in or attended ...
... New position created to support growth at MDS ... Nordion, a leading provider,of medical isotopes and radiopharmaceuticals, ... position of Senior Vice-President Innovation.,Dr. Covitz will lead ... strategies and identifying new complimentary business,opportunities to better ...
... Access to ... Treatment, NEW YORK, ... finding a cure for breast cancer, the Avon,Foundation will bring together nearly ... Breast Cancer Forum, held February 4-6,in Houston, TX. This year,s Forum, titled ...
... Inc. (Nasdaq:,FVRL), a biopharmaceutical company developing patient-specific, active,immunotherapies ... it will,host a conference call and live webcast ... 2008 to discuss the Company,s fourth quarter and ... be issued before the U.S.,stock markets open that ...
Cached Medicine News:Health News:CRH Medical Corporation announces substantial increase in patient visits 2Health News:Mediware Reports Second Quarter Fiscal 2008 Results 2Health News:Mediware Reports Second Quarter Fiscal 2008 Results 3Health News:Mediware Reports Second Quarter Fiscal 2008 Results 4Health News:9/11 Exposure Linked to Behavior Trouble in Kids 2Health News:Dr. Peter Covitz Joins MDS Nordion as Senior Vice-President Innovation 2Health News:Avon Foundation Brings Together Breast Cancer Experts in Houston to Report Significant New Data 2Health News:Avon Foundation Brings Together Breast Cancer Experts in Houston to Report Significant New Data 3Health News:Favrille to Host Conference Call and Live Webcast to Discuss Fourth Quarter and Year End 2007 Financial Results on February 19, 2008 2
(Date:7/2/2015)... 2015 Roche,s Bloodhound technology is on ... in hematology testing, according to Kalorama Information.  The ... of its Bloodhound digital cell imaging technology –as ... hematology analyzer – is notable as a ... current leader CellaVision, but also compete more broadly ...
(Date:7/2/2015)... , June 26, 2015 Research ... "Vitamin D Market by Analog, Application, End-User & by ... to their offering. This market is projected to ... vitamin D in different applications and rising opportunities in countries ... , Italy , and ...
(Date:7/2/2015)... --  EVO Aesthetic Center and Wellness Spa prides ... in Lakeway, Texas and will ... Duality laser. The medical spa is focused on helping ... laser procedures. Their addition of the Astanza Duality will ... their tattoo regret. "The large number of ...
Breaking Medicine Technology:Kalorama: With Bloodhound, Roche Closes in on High-Growth Hematology Segment 2Kalorama: With Bloodhound, Roche Closes in on High-Growth Hematology Segment 3Vitamin D Market by Analog, Application, End-User & by Region - Global Trends & Forecast to 2020: Increasing Recommendation By Doctors & Associations 2Vitamin D Market by Analog, Application, End-User & by Region - Global Trends & Forecast to 2020: Increasing Recommendation By Doctors & Associations 3EVO Offers Advanced Laser Tattoo Removal With Astanza Duality In Lakeway, TX 2
... Technologies (OTC Bulletin Board: MCLN ), ... treatment and disposal of medical waste and the ... announced it has partnered with Triumvirate Environmental, a ... engineering and remediation. This agreement will enable Triumvirate ...
... Sequenom, Inc. (NASDAQ: SQNM ), a life sciences company ... results for the third quarter of 2011 after closing of the ... conference call hosted by Harry F. Hixson, Jr., Ph.D., Chairman and ... the same day at 5:00pm ET (2:00pm PT) and will be ...
Cached Medicine Technology:MedClean Technologies Partners With Triumvirate Environmental 2MedClean Technologies Partners With Triumvirate Environmental 3Sequenom, Inc. Announces Date of Third Quarter 2011 Financial Results and Conference Call 2
The rubber, whistle tip catheter with thumb valve has two side eyes to help minimize trauma....
Extra Long Gentle Vactrol® Connector., ,Indications For Usage: ,Removal of secretions from respiratory tract....
Gentle-Flo® Vactrol® Connector., ,Indications For Usage: ,Removal of secretions from respiratory tract....
D-Line Coude' Suction Catheter., ,Indications For Usage: , Removal of secretions from respiratory tract , For ease and greater assurance of entering and suctioning the left bronchus ...
Medicine Products: