Navigation Links
NIH scientists map gene changes driving tumors in common pediatric soft-tissue cancer
Date:1/23/2014

Scientists have mapped the genetic changes that drive tumors in rhabdomyosarcoma, a pediatric soft-tissue cancer, and found that the disease is characterized by two distinct genotypes. The genetic alterations identified in this malignancy could be useful in developing targeted diagnostic tools and treatments for children with the disease. The study, by researchers at the National Cancer Institute (NCI), part of the National Institutes of Health, and their colleagues, appeared in the Jan. 23, 2014, issue of the journal Cancer Discovery.

Rhabdomyosarcoma is the most common soft-tissue sarcoma in children and affects muscles in any part of the body. Among patients diagnosed with non-metastasized disease, about 80 percent survive at least five years, although they may experience substantial treatment-related toxic effects. However, for those with metastatic disease, the five-year survival rate is about 30 percent even with aggressive treatment.

NCI's effort to characterize the genetic events that contribute to rhabdomyosarcoma was led by Javed Khan, M.D., head of the Oncogenomics Section, Pediatric Oncology Branch, Center for Cancer Research, and Jack Shern, M.D., a clinical fellow.

"These studies are very difficult to do because tissue acquisition and validation is so complex," said Khan. "It must be noted therefore that this work would not have been possible without our brave pediatric patients and their families. In the face of their life-threatening disease, they offered their tumors for study knowing that they would not personally benefit from this work but in the hope that investigators might learn lessons that would help children diagnosed with rhabdomyosarcoma in the future."

Khan's team used a number of advanced sequencing techniques to investigate the genetic changes in a total of 147 rhabdomyosarcoma tumors which were paired with normal tissue samples. These sequencing tools allowed them to unravel the compl
'/>"/>

Contact: NCI Press Officers
ncipressofficers@mail.nih.gov
301-496-6641
NIH/National Cancer Institute
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Scripps Florida scientists find regulator of amyloid plaque buildup in Alzheimers disease
2. NCCS scientists discover gene regulation is dependent on protein ANP32E
3. Scientists make your stomach turn bright green if you have an ulcer
4. Scientists reduce protein crystal damage, improve pharmaceutical development
5. It's All In The Climate: New Study from Research Scientists at Florida International University Predict
6. Surviving ovarian cancer: Rutgers scientists attack drug resistant cancer cells
7. Scientists discover that short-term energy deficits increase factors related to muscle degradation
8. CNIO scientists create the first large catalog of interactions between drugs and proteins
9. Over 70 new centers to train tomorrows engineers and scientists
10. Scientists Agree: Sleep Less, Get Fat
11. UNC scientists find potential cause for deadly breast cancer relapse
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/4/2015)... May 04, 2015 Los Angeles ... offering a more comfortable and attractive alternative for patients ... choice for those who have lost teeth. Unfortunately, they ... insecure or slip at the worst possible moment and ... talks. They can also painfully pinch or rub gums, ...
(Date:5/4/2015)... Chicago, Ill., (PRWEB) May 04, 2015 ... the American Brain Tumor Association (ABTA) show that people ... their diagnosis and treatment options, including clinical trials, at ... of days to make difficult decisions about their course ... the launch of the first nationwide brain tumor volunteer ...
(Date:5/4/2015)... San Diego Fertility Center (SDFC) ... new, 13,700 square foot facility scheduled to open in ... only provide fertility treatment and services for the center’s ... educational events to a number of local and international ... to their current Carmel Valley/Del Mar location and will ...
(Date:5/4/2015)... New West Medicare is excited to announce ... manage outpatient advanced imaging services for its members. Care ... members are provided the right test at the right ... New West Medicare’s physicians and hospitals, Care to Care ... imaging and provide an objective basis for informed evidence-based ...
(Date:5/4/2015)... Dr. Richard Champagne, DMD, MAGD is pleased to ... America’s Best Dentist Award, given by the National Consumer ... dentist is a reflection of his vast experience in ... for his patients. , Each year, the National Consumer ... field. These nominees are dentists who have exceptionally high ...
Breaking Medicine News(10 mins):Health News:Los Angeles Dental Implants Doctor, Kevin Sands DDS, Now Offers a More Comfortable and Aesthetically-Pleasing Solution to Denture-Wearers 2Health News:American Brain Tumor Association Poll Underscores Need for Greater Awareness and Education at Time of Diagnosis 2Health News:American Brain Tumor Association Poll Underscores Need for Greater Awareness and Education at Time of Diagnosis 3Health News:San Diego Fertility Center Hosted a Ribbon Cutting Ceremony at Its New, Expanded Facility 2Health News:San Diego Fertility Center Hosted a Ribbon Cutting Ceremony at Its New, Expanded Facility 3Health News:New West Medicare Partners with Care to Care, LLC to Manage Advanced Imaging Services 2Health News:New Jersey Dentist Dr. Richard Champagne Nominated for America’s Best Dentist Award 2
... Goodwin HealthDay Reporter , MONDAY, Dec. 12 (HealthDay ... other children, a finding that researchers say may provide a ... see. Blinking is largely an involuntary process that helps ... that your eyes are closed, you are temporarily blinded. And ...
... US Prostate Cancer Prevention Trial found cancer in many men ... which PSA level should lead to a biopsy recommendation. ... considerable controversy, that the evidence does not support recommending PSA ... the risks outweigh the benefits. Now, a study shows ...
... News) -- ,Cancer patients receiving chemotherapy most often develop ... according to a large new study. Efforts to ... treatment should focus on outpatients -- not those still ... blood clot, also called a venous thromboembolism (VTE), is ...
... retrospective study shows that children of childhood cancer survivors ... ovaries and/or chemotherapy with alkylating agents do not have ... of survivors who did not have such cancer treatment. ... defects are unlikely for cancer survivors who are concerned ...
... HealthDay Reporter , MONDAY, Dec. 12 (HealthDay News) -- When she ... pound, Madeline Mann was the world,s smallest surviving baby. At ... of world,s tiniest infant, weighing in at 0.57 pounds. She was ... in the neonatal intensive care unit at Loyola University Medical Center ...
... , MONDAY, Dec. 12 (HealthDay News) -- The poet Emily ... that she "never met this fellow/Attended or alone/Without a tighter ... in her ophidiophobia (fear of snakes) and, it turns out, ... it is found in the grass or elsewhere. A ...
Cached Medicine News:Health News:Blink Patterns May Be a Window Into Autistic Mind 2Health News:Blink Patterns May Be a Window Into Autistic Mind 3Health News:Biopsy referral after PSA screening stays consistent over time 2Health News:Cancer Outpatients at Greater Risk for Blood Clots 2Health News:Childhood cancer survivors' exposure to chemotherapy, radiation does not increase risk of birth defects in their children 2Health News:Childhood cancer survivors' exposure to chemotherapy, radiation does not increase risk of birth defects in their children 3Health News:Childhood cancer survivors' exposure to chemotherapy, radiation does not increase risk of birth defects in their children 4Health News:World's Tiniest 'Preemies' Growing Up Healthy: Report 2Health News:World's Tiniest 'Preemies' Growing Up Healthy: Report 3Health News:Snakes Make Your Skin Crawl? Study Suggests Why 2
(Date:5/4/2015)... N.J. , May 4, 2015  Oncobiologics, ... commercializing monoclonal antibody (mAb) biosimilars, has completed the ... at its headquarters in Cranbury, New ... Cranbury facility is designed to utilize ... manufacturing at commercial scale.  Through the use of ...
(Date:5/4/2015)... 2015  Isis Pharmaceuticals, Inc. (NASDAQ: ISIS ) ... HealthCare (Bayer) to develop and commercialize ISIS-FXI Rx ... the agreement, Isis is eligible to receive up to ... million up-front payment and a $55 million payment upon ... in patients with compromised kidney function. Isis is also ...
(Date:5/4/2015)... 2015  Geneia, a company of experienced healthcare ... improve healthcare efficiencies, today announced a first-of-its-kind partnership ... (BNRC) use Geneia,s advanced analytics solution coupled with ... and lower the cost of patient care. ... and utilization data from multiple sources to create ...
Breaking Medicine Technology:Oncobiologics opens commercial launch manufacturing facility in Cranbury, New Jersey 2Oncobiologics opens commercial launch manufacturing facility in Cranbury, New Jersey 3Isis Pharmaceuticals Licenses ISIS-FXI Rx to Bayer to Develop and Commercialize for the Prevention of Thrombosis 2Isis Pharmaceuticals Licenses ISIS-FXI Rx to Bayer to Develop and Commercialize for the Prevention of Thrombosis 3Isis Pharmaceuticals Licenses ISIS-FXI Rx to Bayer to Develop and Commercialize for the Prevention of Thrombosis 4Isis Pharmaceuticals Licenses ISIS-FXI Rx to Bayer to Develop and Commercialize for the Prevention of Thrombosis 5Geneia Launches First-of-its-Kind Partnership to Use Advanced Analytics to Improve the Quality and Cost of Care for Skilled Nursing and Rehabilitation Patients 2Geneia Launches First-of-its-Kind Partnership to Use Advanced Analytics to Improve the Quality and Cost of Care for Skilled Nursing and Rehabilitation Patients 3
... Privigen®, the first and only ... proline, is effective and well tolerated in patients ... data presented today at the XIVth Meeting of ... that Privigen offers significant protection against ...
... CHAPEL HILL, N.C., Oct. 6 Pharmaceutical and biotech ... they ensure strong partnerships between R&D and marketing, balancing ... product development. It requires companies to break down the ... instead leverage the strengths of both talented medical researchers ...
Cached Medicine Technology:Privigen® Demonstrates Efficacy and Tolerability Among Patients With Various Immunodeficiencies, Data Show 2Privigen® Demonstrates Efficacy and Tolerability Among Patients With Various Immunodeficiencies, Data Show 3Creating Partnerships Across R&D and Marketing to Ensure a Successful Global Launch 2
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: