Navigation Links
NIH scientists map gene changes driving tumors in common pediatric soft-tissue cancer
Date:1/23/2014

Scientists have mapped the genetic changes that drive tumors in rhabdomyosarcoma, a pediatric soft-tissue cancer, and found that the disease is characterized by two distinct genotypes. The genetic alterations identified in this malignancy could be useful in developing targeted diagnostic tools and treatments for children with the disease. The study, by researchers at the National Cancer Institute (NCI), part of the National Institutes of Health, and their colleagues, appeared in the Jan. 23, 2014, issue of the journal Cancer Discovery.

Rhabdomyosarcoma is the most common soft-tissue sarcoma in children and affects muscles in any part of the body. Among patients diagnosed with non-metastasized disease, about 80 percent survive at least five years, although they may experience substantial treatment-related toxic effects. However, for those with metastatic disease, the five-year survival rate is about 30 percent even with aggressive treatment.

NCI's effort to characterize the genetic events that contribute to rhabdomyosarcoma was led by Javed Khan, M.D., head of the Oncogenomics Section, Pediatric Oncology Branch, Center for Cancer Research, and Jack Shern, M.D., a clinical fellow.

"These studies are very difficult to do because tissue acquisition and validation is so complex," said Khan. "It must be noted therefore that this work would not have been possible without our brave pediatric patients and their families. In the face of their life-threatening disease, they offered their tumors for study knowing that they would not personally benefit from this work but in the hope that investigators might learn lessons that would help children diagnosed with rhabdomyosarcoma in the future."

Khan's team used a number of advanced sequencing techniques to investigate the genetic changes in a total of 147 rhabdomyosarcoma tumors which were paired with normal tissue samples. These sequencing tools allowed them to unravel the compl
'/>"/>

Contact: NCI Press Officers
ncipressofficers@mail.nih.gov
301-496-6641
NIH/National Cancer Institute
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Scripps Florida scientists find regulator of amyloid plaque buildup in Alzheimers disease
2. NCCS scientists discover gene regulation is dependent on protein ANP32E
3. Scientists make your stomach turn bright green if you have an ulcer
4. Scientists reduce protein crystal damage, improve pharmaceutical development
5. It's All In The Climate: New Study from Research Scientists at Florida International University Predict
6. Surviving ovarian cancer: Rutgers scientists attack drug resistant cancer cells
7. Scientists discover that short-term energy deficits increase factors related to muscle degradation
8. CNIO scientists create the first large catalog of interactions between drugs and proteins
9. Over 70 new centers to train tomorrows engineers and scientists
10. Scientists Agree: Sleep Less, Get Fat
11. UNC scientists find potential cause for deadly breast cancer relapse
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/31/2014)... MedixSafe has become very popular in the United ... lockers . Electronic Security Specialists has now ... “We have now shipped multiple orders to Canada and ... , MedixSafe is a division of Electronic Security Specialists, ... with over 30 years in the security arena. The ...
(Date:8/31/2014)... Just in time for Washington’s Indian Summer, Dukes ... Salmon, award winning chowder and legendary sourdough bread ... location , Sunday, September 28, 2014 from 1 pm to ... BBQ culinary delights. Live music will add to the festive ... and Mexico will be featured. “There is no salmon ...
(Date:8/31/2014)... Recently, BambooIndustry.com, one of the most popular ... new selection of bamboo veneers . Additionally, it has ... for these high quality products. The promotion will last from ... says that its top quality veneers are hot in the ... designs of bamboo veneers. All these items are made according ...
(Date:8/31/2014)... Mesa, AZ (PRWEB) August 31, 2014 ... in Mesa, Arizona, prescribes sublingual immunotherapy to help his ... includes tree nut allergies. Dr. Agren said that it ... nut-based foods and, in many cases, restored peace of ... can lead to a host of symptoms, including rashes, ...
(Date:8/31/2014)... years of hard work, Delta has now become one of ... company has updated its wheel loader assortment with ... items are guaranteed to be great. Additionally, they are offered ... true that all items in Delta’s used cat 966 ... firm is making full efforts to help worldwide customers to ...
Breaking Medicine News(10 mins):Health News:Memphis-based Electronic Security Specialists Now Offers MedixSafe Narcotics Cabinets Internationally 2Health News:Memphis-based Electronic Security Specialists Now Offers MedixSafe Narcotics Cabinets Internationally 3Health News:Seattle Seafood Restaurant Duke's Chowder House on Green Lake Will Celebrate The Long Anticipated Indian Summer With First Annual Sizzling BBQ Salmon Tasting Event. 2Health News:High Quality Bamboo Veneers from Bambooindustry.com Receive International Attention 2Health News:Family Allergy Clinic Announces Q4 2014 Release of Oral Drops for Tree Nut Allergies 2Health News:Family Allergy Clinic Announces Q4 2014 Release of Oral Drops for Tree Nut Allergies 3Health News:Delta Updates Its Wheel Loader Assortment With A Lot Of Cheap Used Cat 966 Loaders 2
... retention, organizational relationships citedGAITHERSBURG, Md., April 20 ... facilities management services company, was named second ... for Latinos list, based on measurements of ... corporate/organizational communications from more than 400 applicants.Ricardo ...
... Mom,s Love, Contest to Award Funding For Summer Feeding ... with Share Our Strength(R) to fight childhood hunger - ... coincide with Mother,s Day, Colgate today launched a campaign ... contest to support summer feeding programs to select cities ...
... behavior can cause children real problems , , MONDAY, April ... video game players -- fully 8.5 percent -- exhibit ... found. , These kids aren,t just playing a lot. ... family and friends and poses health problems, the study ...
... The 7th annual FedEx/St. Jude Angels & ... 7:00 p.m. at the InterContinental Miami Hotel benefiting St. Jude ... research centers. This year,s event will honor Tommy Mottola ... their generous support of children in need and contributions to ...
... will help readers find healthier ways to shop, cook ... Permanente physician Preston Maring has been recognized by EatingWell, ... EatingWell books, for his work to make ... primary care physician, authored the introduction for a new ...
... Fla. , April 20 University ... the March of Dimes Florida Chapter , ... March for Babies events on April 25. Additionally, the ... a Bachelor of Science in Nursing or a Master of ...
Cached Medicine News:Health News:Sodexo Ranks Second on the 2009 DiversityInc Top Ten Companies for Latinos List 2Health News:Sodexo Ranks Second on the 2009 DiversityInc Top Ten Companies for Latinos List 3Health News:Colgate-Palmolive Partners With Share Our Strength To Host Online Contest To Combat Childhood Hunger 2Health News:Colgate-Palmolive Partners With Share Our Strength To Host Online Contest To Combat Childhood Hunger 3Health News:Almost 1 in 10 Young Video Game Users 'Addicted' 2Health News:Almost 1 in 10 Young Video Game Users 'Addicted' 3Health News:7th Annual FedEx/St. Jude Angels & Stars Gala Announces 2009 Honorees Tommy Mottola & Thalia 2Health News:7th Annual FedEx/St. Jude Angels & Stars Gala Announces 2009 Honorees Tommy Mottola & Thalia 3Health News:7th Annual FedEx/St. Jude Angels & Stars Gala Announces 2009 Honorees Tommy Mottola & Thalia 4Health News:Kaiser Permanente Physician Celebrated for Contributions to Locally Grown Food Movement 2Health News:Kaiser Permanente Physician Celebrated for Contributions to Locally Grown Food Movement 3Health News:University of Phoenix Announces March of Dimes Partnership in Florida, Offers Four Full-Tuition Nursing Scholarships 2Health News:University of Phoenix Announces March of Dimes Partnership in Florida, Offers Four Full-Tuition Nursing Scholarships 3
(Date:8/29/2014)... August 29, 2014 According ... Market by Extraction type (SFE, Cold Pressed, Organic ... Care, Pharmaceutical, Food Supplements, Fragrance, & Others) - Global ... defines and segments the Amaranth Seed Oil Market ... size in terms of value. The Amaranth Seed ...
(Date:8/29/2014)... , August 29, 2014 ... Market by Product & Services (Equipment, Reagent, Primer, ... Application (Diagnostics, PCR, QPCR, Gene Synthesis, NGS, DNA, ... MarketsandMarkets, the global Oligonucleotide Synthesis Market is expected ... Million in 2014, growing at a CAGR of ...
(Date:8/29/2014)...  In part four of a blog ... as a strategic asset, Mary Baxter, MBA, RPh ... Health,s Innovation Delivery Solutions business, discusses how expanding patient ... and patients. "Every hospital pharmacist knows that ... job in a value-based healthcare world," Baxter says. "For ...
Breaking Medicine Technology:Amaranth Seed Oil Market worth $700.6 Million by 2019 2Amaranth Seed Oil Market worth $700.6 Million by 2019 3Amaranth Seed Oil Market worth $700.6 Million by 2019 4Oligonucleotide Synthesis Market Worth $1,712.1 Million by 2019 2Oligonucleotide Synthesis Market Worth $1,712.1 Million by 2019 3Oligonucleotide Synthesis Market Worth $1,712.1 Million by 2019 4Five Ways Hospital Pharmacies Can Fulfill Their Quality Care Mission 2Five Ways Hospital Pharmacies Can Fulfill Their Quality Care Mission 3Five Ways Hospital Pharmacies Can Fulfill Their Quality Care Mission 4
... , Jan. 15 Roper Industries, Inc. (NYSE: ... due 2034 (CUSIP No. 776696AA4) (the "Notes") will accrue contingent interest for ... 2010 at an annual rate of 0.25% of the average market ... 13, 2010 . Contingent cash interest, which the Company has determined to ...
... , EDINA, Minn. , Jan. 15 ... systems, launches the Assure Brilliance Program – a comprehensive service ... , Assure® brand blood glucose monitoring systems from ARKRAY have ... Term Care for years. ARKRAY has always been committed to ...
Cached Medicine Technology:ARKRAY, Inc. Long Term Care Division Launches Comprehensive Service Program - Assure(R) Brilliance 2
Straight shafts with rounded tips. Smooth handle with dull finish....
Double-ended. 10 mm sickle shaped blade. 27 mm blunt, curved double-edged blade....
15 mm curved blade. 8 mm straight distal tip. Serrated on top of knife. Flat handle. Designated most popular model or size....
Grooved roller, on which knife oscillates....
Medicine Products: