Navigation Links
Morbidity higher in obese liver transplant recipients with diabetes
Date:1/23/2014

Researchers from New Zealand report that morbidity following liver transplant is highest among obese patients with diabetes, but these risk factors do not influence post-transplant survival. According to the study published in Liver Transplantation, a journal of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, body mass index (BMI) is effective for assessing obesity in liver transplant patients.

One of the greatest health concerns in developed countries is the increase in obesity, diabetes, and metabolic syndrome, which is a combination of high blood pressure (hypertension), blood sugar (hyperglycaemia), and cholesterol (dyslipidemia) along with increased belly fat. In fact, the World Health Organization (WHO) reported in 2008 that 1.4 billion adults were overweight, and of these 200 million men and 300 million women were obese.

Prior research shows that liver transplant recipients who develop post-transplant diabetes and metabolic syndrome are at increased risk of cardiovascular disease. Moreover, while death and graft loss resulting from organ rejection has improved in past 30 years, up to 42% of non-graft related deaths are attributed to cardiovascular disease according to a 2002 study by Vogt et al.

"There is much evidence on post-transplant obesity and metabolic syndrome. However, the impact of pre-transplant obesity, hypertension and coronary artery disease on post-transplant outcomes has received less attention and is the focus of our study." said lead author Dr. Adam Bartlett with the New Zealand Liver Transplant Unit at Auckland City Hospital.

For the present study, researchers recruited 202 consecutive patients undergoing liver transplantation at a New Zealand center between 2000 and 2010. BMI and percentage of body fat were measured before the transplant to compare methods. Analyses of pre-transplant risk factors such as obesity, diabetes, coronary artery disease were conducted.

Participants undergoing liver transplant had a mean age of 51 years and 67% were male with most common reason for being hepatitis C cirrhosis. The BMI was available for 192 patients4% were underweight, 27% normal weight, 26% overweight, 28% obese, 9% severely obese and 6% morbidly obese. Researchers determined that BMI and measured body fat were similar in 86% of the study group.

Further analyses indicate that obesity was an independent risk factor for diabetes and post-transplant complications. Diabetes in conjunction with obesity was the strongest predictor of complications following transplant and longer hospital stays. Metabolic risk factors did not affect 30-day, 1-year or 5-year survival for liver transplant recipients.

"Our study confirms that BMI is an appropriate measure of body fat and obesity alone should not prevent patients from receiving liver transplants," concludes Dr. Bartlett. "Identifying modifiable risk factors during the pre-transplant assessment allows for earlier interventions including weight control, diabetes management, and coronary interventions such as stenting, all which may improve long-term outcomes following liver transplantation."


'/>"/>
Contact: Dawn Peters
sciencenewsroom@wiley.com
781-388-8408
Wiley
Source:Eurekalert

Related medicine news :

1. Lowering the national ozone standard would significantly reduce mortality and morbidity
2. Higher-spending hospitals have fewer deaths for emergency patients
3. Taller, Heavier Women May Face Higher Ovarian Cancer Risk
4. Heart failure patients with diabetes may benefit from higher glucose levels
5. Cancer Care Costs Higher in U.S. Than Europe, But Survival Longer
6. Children Born to Obese Moms May Face Higher Autism Risk: Study
7. Could Menthol Cigarettes Pose Even Higher Stroke Risk?
8. Certain Birth Control Pills May Carry Higher Blood Clot Risk: FDA
9. Mental Illness Tied to Higher Rates of Physical Problems: Report
10. Overweight Pregnant Women at Higher Risk for Complications
11. Depression Linked to Higher Odds for Poor Leg Circulation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/21/2017)... (PRWEB) , ... September 21, 2017 , ... ... Sept. 26, 2017 — 1:30 p.m. – 3:00 p.m. ET, http://www.fdanews.com/processcapabilityindices      ... easy to get things wrong, run afoul of The Quality System Regulation (§820.250), ...
(Date:9/21/2017)... ... September 21, 2017 , ... The ... Behavioral Health Services for professionals in the addiction treatment industry entitled: Special ... , Insurance companies and state and federal governments are increasingly scrutinizing the ...
(Date:9/21/2017)... ... September 21, 2017 , ... Hair ... new member survey conducted by the International Society of Hair Restoration Surgery ... to 2016 rose 60 percent, with 635,189 procedures performed in 2016. , ...
(Date:9/21/2017)... ... , ... Bill Howe Plumbing’s mission is to create an employee friendly company, ... For over 37 years, they have operated with their mission at the foundation and ... Diego. They were chosen as the Best San Diego plumber in 2016, named a ...
(Date:9/21/2017)... ... September 21, 2017 , ... ... LVS 7510 at the Global GS1 Healthcare Conference 2017 in Chicago, IL on ... industry for ensuring label quality and improving patient safety. , Microscan ...
Breaking Medicine News(10 mins):
(Date:9/19/2017)... 2017 HistoSonics, Inc., a venture-backed medical device company developing a non-invasive, robotically assisted, ... three leadership team developments today:   ... ... Tom Tefft ... Veteran medical device executive Josh Stopek , PhD, who has ...
(Date:9/18/2017)... KALAMAZOO, Mich. , Sept. 18, 2017  PMD ... OptiMed Specialty Pharmacy of Kalamazoo, Mich. ... strategic hub service that expedites and streamlines patient and ... Spiro PD 2.0, and wellness management services.  ... medical device used to measure lung function for a ...
(Date:9/13/2017)... , Sept. 13, 2017   OrthoAtlanta has been ... Atlanta Football Host Committee (AFHC) for the 2018 College Football ... 8, 2018, at Mercedes-Benz Stadium in Atlanta, Georgia ... the AFHC "I,m In" campaign, participating in many activities leading ... ...
Breaking Medicine Technology: