Navigation Links
Molecular battle in cancer cells offers clues for treatment
Date:1/19/2011

CHAPEL HILL, N.C. Scientists around the world have been hot on the trail of a genetic mutation closely associated with some brain cancers and leukemia since the mutation's discovery in 2008. The hunt is now yielding fruit. In the Jan. 18, 2011 issue of Cancer Cell, researchers reveal how the mutation contributes to cancer development and suggest potential ways to counter its effects.

About 75 percent of people with low-grade brain tumors and 20 percent of people with acute myeloid leukemia have a mutated version of a gene known as IDH. IDH helps cells metabolize, or eat, food. "We now know that IDH represents the most frequently mutated metabolic gene in human cancer. And that changes the landscape of cancer research in metabolism quite a lot," said Yue Xiong, PhD, William R. Kenan Jr. professor of biochemistry and biophysics at the UNC Lineberger Comprehensive Cancer Center.

Xiong and collaborators at UNC, the University of California San Diego, and the Shanghai Medical College of Fudan University in China discovered that the IDH mutation sets off a battle inside cells between two metabolites, small molecules produced by metabolic enzymes. On the good sidethe side that leads to normal cell growthis a molecule called ?-KG. On the bad sidethe side that leads to canceris a molecule called 2-HG.

The researchers discovered that cells with the IDH mutation produce less ?-KG and more 2-HG than normal cells. 2-HG then outcompetes ?-KG, disabling a whole family of enzymes that depend on ?-KG to do their jobs in the cell. Normal cell functions break down, contributing to the development of cancer.

Two of the affected enzymes are also involved in controlling gene expression, so if 2-HG wins the battle, it can also activate other genes that lead to cancer growth.

Bolstering ?-KG to help fight 2-HG could offer a new treatment option for patients with the mutation. "?-KG is a natural product of the body. So we know we can survive it, we know it's not toxic. That gives us a window of opportunity," said Xiong.

"In terms of future therapeutic interventions for IDH-mutated tumors, there are two directions we could go," Xiong said. "One is developing a drug that inhibits the ability of the mutant enzyme from producing 2-HG. Another is to somehow provide ?-KG back to the patients with mutated IDH to battle 2-HG."

Such therapies would help only those cancer patients with IDH mutations. "We no longer believe there will be a single silver bullet, a drug to treat and cure all types of cancers," Xiong said. "Instead, we are looking into the therapeutic treatment of individual types of cancer. Therefore, a specific agent that is targeting a very specific event such as tumor with mutated IDH now becomes much more valuable."

In 2010, more than 13,000 people died from brain and other nervous system cancers, and more than 20,000 died from leukemia. A drug that helps even a portion of patients with these cancers can still affect a lot of people, said Xiong.


'/>"/>

Contact: Les Lang
llang@med.unc.edu
919-966-9366
University of North Carolina School of Medicine
Source:Eurekalert  

Related medicine news :

1. Molecular pathways linked to sex, age affect outcomes in lung cancer
2. SNMs Conjoint Mid-Winter Meetings continue to advance molecular imaging
3. Scientists Discover Molecular Pathway for Organ Tissue Regeneration and Repair
4. The Association for Molecular Pathology celebrates ruling in DNA patent case
5. USC researchers discover new molecular subtype of brain cancer
6. Molecular discovery points to new therapies for brain tumors
7. Molecular marker could help spot pancreatic cancer early
8. News from Molecular Medicine
9. Scientists discover the molecular heart of collective behavior
10. Salt Lake City proclaims Molecular Imaging Days during SNMs Annual Meeting in June
11. Acupunctures molecular effects pinned down
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Molecular battle in cancer cells offers clues for treatment
(Date:6/25/2016)... ... June 25, 2016 , ... ... and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the Hynes ... important health care topics including advance care planning, healthcare costs and patient and ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, ... and his M.D from the David Geffen School of Medicine at UCLA. He trained ... Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where ...
(Date:6/24/2016)... ... 24, 2016 , ... Those who have experienced traumatic events may suffer from ... avenues, such as drug or alcohol abuse, as a coping mechanism. To avoid this ... coping following a traumatic event. , Trauma sufferers tend to feel a range of ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. Amanda Cheng, an ... Cheng has extensive experience with all areas of orthodontics, including robotic Suresmile technology, ... , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. It can be ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... is proud to recognize Dr. Barry M. Weintraub as a prominent plastic surgeon ... beautiful women in the world, and the most handsome men, look naturally attractive. ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... June 26, 2016 Story ... operating models within the health care industry is causing ... efficiency , Deloitte offers a suite of solutions ... issues impacting efficient cost optimization: labor resource analysis, revenue ... services facilitate better outcomes and better economics ...
(Date:6/24/2016)... 24, 2016 ... the addition of the " Global Markets for ... This report focuses on ... updated review, including its applications in various applications. The ... which includes three main industries: pharmaceutical and biotechnology, food ...
(Date:6/24/2016)... 24, 2016 Research and Markets has ... Companion Diagnostic Tests" report to their offering. ... Diagnostics The World Market for Companion Diagnostics ... diagnostics. Market analysis in the report includes the following: ... Vitro Diagnostic Kits) by Region (N. America, EU, ROW), 2015-2020 ...
Breaking Medicine Technology: