Navigation Links
Molecular battle in cancer cells offers clues for treatment
Date:1/19/2011

CHAPEL HILL, N.C. Scientists around the world have been hot on the trail of a genetic mutation closely associated with some brain cancers and leukemia since the mutation's discovery in 2008. The hunt is now yielding fruit. In the Jan. 18, 2011 issue of Cancer Cell, researchers reveal how the mutation contributes to cancer development and suggest potential ways to counter its effects.

About 75 percent of people with low-grade brain tumors and 20 percent of people with acute myeloid leukemia have a mutated version of a gene known as IDH. IDH helps cells metabolize, or eat, food. "We now know that IDH represents the most frequently mutated metabolic gene in human cancer. And that changes the landscape of cancer research in metabolism quite a lot," said Yue Xiong, PhD, William R. Kenan Jr. professor of biochemistry and biophysics at the UNC Lineberger Comprehensive Cancer Center.

Xiong and collaborators at UNC, the University of California San Diego, and the Shanghai Medical College of Fudan University in China discovered that the IDH mutation sets off a battle inside cells between two metabolites, small molecules produced by metabolic enzymes. On the good sidethe side that leads to normal cell growthis a molecule called ?-KG. On the bad sidethe side that leads to canceris a molecule called 2-HG.

The researchers discovered that cells with the IDH mutation produce less ?-KG and more 2-HG than normal cells. 2-HG then outcompetes ?-KG, disabling a whole family of enzymes that depend on ?-KG to do their jobs in the cell. Normal cell functions break down, contributing to the development of cancer.

Two of the affected enzymes are also involved in controlling gene expression, so if 2-HG wins the battle, it can also activate other genes that lead to cancer growth.

Bolstering ?-KG to help fight 2-HG could offer a new treatment option for patients with the mutation. "?-KG is a natural product of the body. So we know
'/>"/>

Contact: Les Lang
llang@med.unc.edu
919-966-9366
University of North Carolina School of Medicine
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Molecular pathways linked to sex, age affect outcomes in lung cancer
2. SNMs Conjoint Mid-Winter Meetings continue to advance molecular imaging
3. Scientists Discover Molecular Pathway for Organ Tissue Regeneration and Repair
4. The Association for Molecular Pathology celebrates ruling in DNA patent case
5. USC researchers discover new molecular subtype of brain cancer
6. Molecular discovery points to new therapies for brain tumors
7. Molecular marker could help spot pancreatic cancer early
8. News from Molecular Medicine
9. Scientists discover the molecular heart of collective behavior
10. Salt Lake City proclaims Molecular Imaging Days during SNMs Annual Meeting in June
11. Acupunctures molecular effects pinned down
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Molecular battle in cancer cells offers clues for treatment
(Date:5/23/2015)... May 23, 2015 Injury lawyer Steven H. ... been passed by the Maryland legislature but which has not ... General Assembly passed HB 449 with overwhelming bipartisan ... not signed it into law. This bill ensures that fracking ... growing that demonstrates the danger of fracking to our water ...
(Date:5/22/2015)... Pioneer Millworks, the largest reclaimed wood ... designing with reclaimed wood, introducing their latest reclaimed wood ... Their newest offerings, Vat 35, Reclaimed Teak , ... to America's largest design event. , “Designers, architects, builders, ... anxious to see and feel the variety of wood ...
(Date:5/22/2015)... Mountain Point Medical Center, a campus of Jordan ... Friday, May 29, 2015 at 11 a.m., followed by a ... medical center, set to officially open on June 1, 2015, ... , “The opening of Mountain Point Medical Center is ... community,” said Kent Loosle, CEO of Mountain Point Medical Center. ...
(Date:5/22/2015)... 22, 2015 Hundreds of federal ... of individuals who allegedly experienced serious internal bleeding ... to move forward in the U.S. District Court, ... Order dated May 4, 2015, the Court has ... electronically stored information. Among other things, the Order ...
(Date:5/22/2015)... Hershey, Pa. (PRWEB) May 22, 2015 ... has been selected to participate in the 2015 Congress ... event is described as a gathering of “America’s highest ... about new areas of healthcare, set new goals and ... will include a live surgery, during which we can ...
Breaking Medicine News(10 mins):Health News:Baltimore Attorney Urges Governor Hogan to Sign the Fracking Moratorium Bill 2Health News:Baltimore Attorney Urges Governor Hogan to Sign the Fracking Moratorium Bill 3Health News:Pioneer Millworks to Reveal New Design Trends with Reclaimed Wood at Dwell on Design in LA 2Health News:Pioneer Millworks to Reveal New Design Trends with Reclaimed Wood at Dwell on Design in LA 3Health News:Mountain Point Medical Center, a Campus of Jordan Valley Medical Center, Hosts Ribbon Cutting Ceremony and Community Celebration on Friday, May 29, 2015 2Health News:Court Overseeing Federal Xarelto Lawsuits Establishes Procedures Governing Preservation of Documents, Electronically Stored Information 2Health News:Court Overseeing Federal Xarelto Lawsuits Establishes Procedures Governing Preservation of Documents, Electronically Stored Information 3Health News:Court Overseeing Federal Xarelto Lawsuits Establishes Procedures Governing Preservation of Documents, Electronically Stored Information 4Health News:Milton Hershey School Student Chosen for Congress of Future Medical Leaders 2
... for Increased Awareness of Disease, Funding for Research, SAN ... of 40,000 people in the U.S. who will lose,their lives ... will die from breast cancer. Yet, most people have never ... has no FDA approved treatment, no known cause and no ...
... BENSALEM, Pa., Oct. 31 Law Offices of Howard ... been filed on behalf,of purchasers of the common stock ... WCG ) between May 8, 2006 and October,24, 2007, ... in the United States District Court for the Middle ...
... Group Uses PETA Talking Points, Discourages Donations to,Legitimate ... health reporters,cover today,s report on global causes of ... nonprofit Center for Consumer Freedom is urging,them to ... animal,rights group calling itself "The Cancer Project." A ...
... Insurers Outline Features of their Countries, Models at,Event Sponsored ... Switzerland and The,Netherlands are among countries in Europe ... private sector plays a central role,in making care better ... countries have taken to cover all of their citizens, ...
... their risk of dying of the disease in half ... their cancer, compared to those who dont receive active ... diagnosed with localized prostate cancer, according to a study ... Therapeutic Radiology and Oncologys 49th Annual Meeting in Los ...
... says exercise and diet can lower chances of malignancies ... exercise and proper nutrition are key to reducing your ... adopt these practices, the better off you,ll be, a ... childbearing, breast-feeding, and adult height and weight also influence ...
Cached Medicine News:Health News:Goulet's Life Lost to Untreatable Lung Disease That Claims as Many Lives as Breast Cancer Each Year 2Health News:Consumer Alert: 'Cancer Project' Organization Is a Deceptive Animal Rights Group 2Health News:Forum Highlights Role of Private Sector in Achieving Universal Health Coverage in Europe 2Health News:Forum Highlights Role of Private Sector in Achieving Universal Health Coverage in Europe 3Health News:Radiation seed implant decreases risk of death over watchful waiting 2Health News:Obesity Linked to Increased Cancer Risk 2Health News:Obesity Linked to Increased Cancer Risk 3
(Date:5/22/2015)... Fla. , May 22, 2015 ... Heart Institute recently traveled to Boston, ... procedure at the 2015 Heart Rhythm Society conference. ... together to focus on the ideas, people and ... Convergent is a hybrid, minimally invasive cardiac ...
(Date:5/22/2015)... KING OF PRUSSIA, Pa. , May 22, 2015 ... CSL Behring its 2015 Corporate Leadership Award as ... science and improving the care of the bleeding disorders community.  ... and Managing Director, CSL Limited, during the NHF Annual Spring ... May 21. "The National Hemophilia Foundation is dedicated ...
(Date:5/22/2015)... , May 22, 2015   InspireMD, Inc. ... stent embolic protection systems ("EPS"), today announced that its CGuard ... lead by principle investigator Prof. Piotr Musialek , at ... Paris, France . PARADIGM, an ... R cutaneous c A roti D revascularization I ...
Breaking Medicine Technology:St. Joseph's Hospital Heart Institute Physician Presents at Heart Rhythm Society 2St. Joseph's Hospital Heart Institute Physician Presents at Heart Rhythm Society 3National Hemophilia Foundation Honors CSL Behring with Corporate Leadership Award 2National Hemophilia Foundation Honors CSL Behring with Corporate Leadership Award 3National Hemophilia Foundation Honors CSL Behring with Corporate Leadership Award 4InspireMD's CGuardTM Highlighted at Clinical Presentation at EuroPCR 2015 Conference 2InspireMD's CGuardTM Highlighted at Clinical Presentation at EuroPCR 2015 Conference 3InspireMD's CGuardTM Highlighted at Clinical Presentation at EuroPCR 2015 Conference 4
... - Data presented at the 2008 ASCO Annual Meeting - - ... to ... discuss results -, BRANFORD, Conn., June 1 ... Phase,I/II study of CR011-vcMMAE for the treatment of unresectable Stage III or,Stage ...
... June 1 Researchers at the Barbara ... findings that show,immunotherapy with armed targeted T ... with metastatic breast cancer., (Logo:, ... Phase I immunotherapy in women with metastatic ...
Cached Medicine Technology:CuraGen Announces Data From Ongoing Phase I/II Trial Showing Clinical Activity of CR011-vcMMAE in Metastatic Melanoma 2CuraGen Announces Data From Ongoing Phase I/II Trial Showing Clinical Activity of CR011-vcMMAE in Metastatic Melanoma 3CuraGen Announces Data From Ongoing Phase I/II Trial Showing Clinical Activity of CR011-vcMMAE in Metastatic Melanoma 4CuraGen Announces Data From Ongoing Phase I/II Trial Showing Clinical Activity of CR011-vcMMAE in Metastatic Melanoma 5CuraGen Announces Data From Ongoing Phase I/II Trial Showing Clinical Activity of CR011-vcMMAE in Metastatic Melanoma 6Karmanos Cancer Institute Researchers Show Phase I Immunotherapy with Armed T Cells Improve Overall Survival of Metastatic Breast Cancer Patients 2Karmanos Cancer Institute Researchers Show Phase I Immunotherapy with Armed T Cells Improve Overall Survival of Metastatic Breast Cancer Patients 3
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: