Navigation Links
Molecular battle in cancer cells offers clues for treatment
Date:1/19/2011

CHAPEL HILL, N.C. Scientists around the world have been hot on the trail of a genetic mutation closely associated with some brain cancers and leukemia since the mutation's discovery in 2008. The hunt is now yielding fruit. In the Jan. 18, 2011 issue of Cancer Cell, researchers reveal how the mutation contributes to cancer development and suggest potential ways to counter its effects.

About 75 percent of people with low-grade brain tumors and 20 percent of people with acute myeloid leukemia have a mutated version of a gene known as IDH. IDH helps cells metabolize, or eat, food. "We now know that IDH represents the most frequently mutated metabolic gene in human cancer. And that changes the landscape of cancer research in metabolism quite a lot," said Yue Xiong, PhD, William R. Kenan Jr. professor of biochemistry and biophysics at the UNC Lineberger Comprehensive Cancer Center.

Xiong and collaborators at UNC, the University of California San Diego, and the Shanghai Medical College of Fudan University in China discovered that the IDH mutation sets off a battle inside cells between two metabolites, small molecules produced by metabolic enzymes. On the good sidethe side that leads to normal cell growthis a molecule called ?-KG. On the bad sidethe side that leads to canceris a molecule called 2-HG.

The researchers discovered that cells with the IDH mutation produce less ?-KG and more 2-HG than normal cells. 2-HG then outcompetes ?-KG, disabling a whole family of enzymes that depend on ?-KG to do their jobs in the cell. Normal cell functions break down, contributing to the development of cancer.

Two of the affected enzymes are also involved in controlling gene expression, so if 2-HG wins the battle, it can also activate other genes that lead to cancer growth.

Bolstering ?-KG to help fight 2-HG could offer a new treatment option for patients with the mutation. "?-KG is a natural product of the body. So we know we can survive it, we know it's not toxic. That gives us a window of opportunity," said Xiong.

"In terms of future therapeutic interventions for IDH-mutated tumors, there are two directions we could go," Xiong said. "One is developing a drug that inhibits the ability of the mutant enzyme from producing 2-HG. Another is to somehow provide ?-KG back to the patients with mutated IDH to battle 2-HG."

Such therapies would help only those cancer patients with IDH mutations. "We no longer believe there will be a single silver bullet, a drug to treat and cure all types of cancers," Xiong said. "Instead, we are looking into the therapeutic treatment of individual types of cancer. Therefore, a specific agent that is targeting a very specific event such as tumor with mutated IDH now becomes much more valuable."

In 2010, more than 13,000 people died from brain and other nervous system cancers, and more than 20,000 died from leukemia. A drug that helps even a portion of patients with these cancers can still affect a lot of people, said Xiong.


'/>"/>

Contact: Les Lang
llang@med.unc.edu
919-966-9366
University of North Carolina School of Medicine
Source:Eurekalert  

Related medicine news :

1. Molecular pathways linked to sex, age affect outcomes in lung cancer
2. SNMs Conjoint Mid-Winter Meetings continue to advance molecular imaging
3. Scientists Discover Molecular Pathway for Organ Tissue Regeneration and Repair
4. The Association for Molecular Pathology celebrates ruling in DNA patent case
5. USC researchers discover new molecular subtype of brain cancer
6. Molecular discovery points to new therapies for brain tumors
7. Molecular marker could help spot pancreatic cancer early
8. News from Molecular Medicine
9. Scientists discover the molecular heart of collective behavior
10. Salt Lake City proclaims Molecular Imaging Days during SNMs Annual Meeting in June
11. Acupunctures molecular effects pinned down
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Molecular battle in cancer cells offers clues for treatment
(Date:4/28/2016)... (PRWEB) , ... April 28, 2016 , ... University of ... McDonald to the role of vice president of Student Engagement. In addition to ... facilities, athletics and student life areas. , “In the space of just one ...
(Date:4/28/2016)... CA (PRWEB) , ... April 28, 2016 , ... Cosmetic ... its website, cosmetictown.com . The forum section was recently revamped and upgraded to ... latest surgical techniques in use across the country. , According to the senior editor ...
(Date:4/28/2016)... ... ... In many parts of the world, contamination from human waste is a ... in underdeveloped parts of Africa where clean sources of food and water are scarce. ... will examine this global health issue and consider how it compares to other major ...
(Date:4/28/2016)... ... April 28, 2016 , ... ... Data Center Infrastructure Management solutions, announces today the availability of its latest ... the area of capacity management and optimization, providing new analytical capabilities that ...
(Date:4/28/2016)... ... 28, 2016 , ... Amada Senior Care, premier provider of non-medical in-home care ... its San Antonio West location. Prior to entering the senior care industry, Amada franchise ... of Amada San Antonio West will take place on Friday, April 29th. ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... 2016 Dr. ... und Stephen Schmidt werden ... ArisGlobal®, ein führender Anbieter cloudbasierter Softwarelösungen für ... dass neue Führungskräfte zum Team Sicherheit und ... vielfältige Erfahrungen mitbringen.  Dies wird die Geschäftseinheit ...
(Date:4/28/2016)... 2016 , Net Sales of $1.90 billion ... the prior year period, and an increase of 1.2% on ... EPS for the first quarter were $0.52 reported, a decrease ... an increase of 29.9% over the prior year period ... guidance for 2016 Zimmer Biomet Holdings, Inc. (NYSE ...
(Date:4/28/2016)... 28, 2016   Acsis , a leading provider ... IT market research and advisory firm IDC has named ... MarketScape: Worldwide Pharmaceutical Track and Trace Software 2016 Vendor ... an assessment of the capabilities and business strategies of ... market. Logo - http://photos.prnewswire.com/prnh/20160427/360791LOGO ...
Breaking Medicine Technology: